The Laureate Lecture

24 April 2013, 17:00 – 20:00

The Nordic Embassies in Berlin, Rauchstraße 1, 10787 Berlin-Tiergarten

In co-operation with:

Berlinffff

The Kavli Prize is a partnership between

The Norwegian Academy of Science and Letters,

The Kavli Foundation and

The Norwegian Ministry of Education and Research

Programme:

16:30 Registration Please be seated by 16:55

17:00 Welcome Sven E. Svedman, Norwegian Ambassador to

17:05 ”The Kavli Prize: fostering scientific excellence and international cooperation” Ms Kristin Halvorsen, Norwegian Minister of Education and Research

17:20 „Internationale Herausforderungen – internationale Kooperationen: Der Auftrag der Wissenschaft“ Prof. Dr. Johanna Wanka, Federal Minister of Education and Research

17:35 Short remarks Prof. Dr. Herbert Jäckle, Vice President of the

17:40 Short remarks Professor Kirsti Strøm Bull President of The Norwegian Academy of Science and Letters

17:45 Lecture: “Following the Brain’s Wires” Kavli Prize Laureate Prof. Dr. Max Planck Institute for Medical Research, Heidelberg

18:10 Lecture: “Towards an Understanding of Neural Codes” Prof. Dr. Gilles Laurent Director of the Max Planck Institute for Brain Research, Frankfurt

18:35 Reception Exhibition Hall of the Nordic Embassies in Berlin

“Following the Brain’s Wires”

Kavli Prize Laureate Prof. Dr. Winfried Denk To understand neural circuits we need to know how neurons are connected. Over the past decade we have developed methods that allow the reconstruction of neural wiring diagrams via the acquisition and analysis of high-resolution three-dimensional electron microscopic data. We have applied these methods to the retina in order to explore, for example, how direction-selective signals are computed.

“Towards an Understanding of Neural Codes”

Prof. Dr. Gilles Laurent

Understanding the brain requires a knowledge of the fine structure of neural circuits and of the functional rules governing their action. One difficult challenge is that brains and neural circuits are dynamical systems, whose emergent properties can be hard to predict from the knowledge of the parts alone. For example, two neurons reciprocally interconnected by inhibitory junctions can operate in relation to one another in a number of different ways (sometimes literally opposite ways), based on small differences in coupling parameters. Describing, understanding and predicting the behaviors of tens to millions of interconnected neurons (circuits) is therefore that much more difficult; as physicists have observed before, in different contexts: "more is different". In this talk, I will focus on two problems related to the study of neural circuits: in the first, I will examine how we can deal with large datasets of neural activity and find interesting structure in them. In the second, I will address the issue of modes of representation in sensory circuits, to illustrate the non-obvious relationship between network structure and emergent function. Curriculum Vitae Prof. Dr. Winfried Denk

1978-1981: Ludwig-Maximilians-Universität, Munich 1981-1984: Eidgenoessische Technische Hochschule (ETH), Zurich, Switzerland 1984-1989: , Ithaca, NY, USA 1989: PhD in physics (1990) 1989-1991: IBM Research Lab in Rueschlikon, Switzerland, postdoctoral fellow 1991-1999: Bell Laboratories, Murray Hill NJ, independent research 1999-: Max-Planck Institute for Medical Research, Department of Biomedical Optics; Director 2002-: Professor, Faculty of Physics, University of Heidelberg Research Grants 2004-2007: Title: Functional imaging of neural networks with non-linear optics Agency: Human Frontier Science Program Honors and Awards 1986-1989: IBM Graduate Research Fellowship 1998: Young Investigator Award of the Biophysical Society 2000: Rank Prize for Opto-Electronics 2003: Leibniz prize of the DFG (German Research Council) 2005: Heller Lecture (Hebrew University, Jerusalem) 2006: Kavli Lecture (Society for ) 2008: Henri Sack Lecture (Cornell University, Ithaca) 2012: Kavli Prize in Neuroscience [email protected] http://www.neuro.mpg.de

Banners along Karl Johansgate in during the Kavli Prize Week. Photo: E. F.Baardsen Curriculum Vitae Prof. Dr. Gilles Laurent

Laurent, Gilles, Prof., D.V.M., Ph.D., Director at the Max Planck Institute for Brain Research, Frankfurt/Main

Born 9/8/1960, Casablanca Morocco, French National, married (to Erin Schuman), three daughters. 1985: Ph. D. in Neuroethology (Université Paul Sabatier, Toulouse, France); 1985: Doctorate in Veterinary Medicine, National School of Veterinary Medicine, Toulouse, France; 1985-1987: Postdoc, , UK; 1987-1990: Royal Society Locke Research Fellow, University of Cambridge, UK; 1990-2002: Assistant, Associate and Full Professor of , Computation & Neural Systems, Institute of Technology, Pasadena, USA; 2002-2010: Lawrence A. Hanson Professor of Biology, Computation & Neural Systems, California Institute of Technology, Pasadena, USA; 2009-: Director, Max Planck Institute for Brain Research, Frankfurt/Main. [email protected] http://www.brain.mpg.de

Guests gathered outside Oslo Concert Hall for the Award Ceremony. Photo: Scanpix Kavli Prize Laureates in Astrophysics 2008 , , USA Donald Lynden-Bell, University of Cambridge, UK 2010 Jerry E. Nelson, UC Santa Cruz, USA Raymond N. Wilson, European Southern Observatory, Germany , , USA 2012 David Jewitt, UCLA, USA , MIT, USA Michael E. Brown, Caltech, USA

Kavli Prize Laureates in Nanoscience 2008 Louis Brus, Columbia University, USA , Meijo University, Japan 2010 Donald M. Eigler, IBM Almaden Research Center, USA Nadrian C. Seeman, , USA 2012 , MIT, USA

Kavli Prize Laureates in Neuroscience 2008 , , Thomas M. Jessell, Columbia University, USA , , USA 2010 Richard M. Scheller, Genentech, USA Thomas C. Südhof, , USA James E. Rothman, Yale University, USA 2012 Cornelia Isabella Bargmann, The , USA Ann M. Graybiel, MIT, USA Winfried Denk, Max Planck Institute for Medical Research, Germany

The 2012 Kavli Prize Laureates in Neuroscience receive the award from HM the King. Photo: Scanpix

500 guests attended The Government’s Banquet in Oslo City Hall to honor the Kavli Prize Laureates Photo: Scanpix

The Kavli Prize

The Kavli Prize recognizes scientists for their seminal advances in three research areas: astrophysics, nanoscience and neuroscience. The Kavli Prize consists of USD 1,000,000 in each of the scientific fields. In addition to the prize money the laureates receive a scroll and a gold medal.The Kavli Prize is awarded every second year by The Norwegian Academy of Science and Letters at a ceremony in Oslo, .

The Kavli Prize was established to: Recognise outstanding scientific research Honour highly creative scientists • Promote public understanding of scientists and their work • Foster international cooperation among scientists •The agreement to establish the Kavli Prize was signed in 2005 by the founder of The •Kavli Foundation, , Kristin Clemet, Norwegian Minister of Education and Research and Jan Fridthjof Bernt, President of The Norwegian Academy of Science and Letters. The Kavli Prize was awarded for the first time in 2008.