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Management of Oropharyngeal Cancer in the HPV Era Definitive cancercontroljournal.org Vol. 23, No. 3, July 2016 H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, AN NCI COMPREHENSIVE CANCER CENTER Management of Oropharyngeal Cancer in the HPV Era Arash O. Naghavi, MD, Tobin J. Strom, MD, Kamran A. Ahmed, MD, et al Definitive Radiotherapy for Squamous Cell Carcinoma of the Glottic Larynx William M. Mendenhall, MD, Roi Dagan, MD, Curtis M. Bryant, MD, et al Clinical Benefits of Proton Beam Therapy for Tumors of the Skull Base Kamran A. Ahmed, MD, Stephanie K. Demetriou, Mark McDonald, MD, et al Management of BCC and SCC of the Head and Neck Tobin J. Strom, MD, Jimmy J. Caudell, MD, PhD, and Louis B. Harrison, MD Treatment of Head and Neck Paragangliomas Kenneth Hu, MD, and Mark S. Persky, MD Multidisciplinary Management of Salivary Gland Cancers Matthew J. Mifsud, MD, Jon N. Burton, MD, Andy M. Trotti, MD, et al Cancer Control is included in Index Medicus/MEDLINE Editorial Board Members Editor: Conor C. Lynch, PhD Production Team: Assistant Member Lodovico Balducci, MD Veronica Nemeth Tumor Biology Senior Member Editorial Coordinator Program Leader, Senior Adult Oncology Program Kristen J. Otto, MD Sherri Damlo Moffitt Cancer Center Associate Member Medical Copy Editor Head and Neck and Endocrine Oncology Diane McEnaney Deputy Editor: Graphic Design Consultant Julio M. Pow-Sang, MD Michael A. Poch, MD Senior Member Assistant Member Associate Editor of Chair, Department of Genitourinary Oncology Genitourinary Oncology Educational Projects Director of Moffitt Robotics Program Jeffery S. Russell, MD, PhD John M. York, PharmD Moffitt Cancer Center Assistant Member Akita Biomedical Consulting Endocrine Tumor Oncology 1111 Bailey Drive Editor Emeritus: Elizabeth M. Sagatys, MD Paso Robles, CA 93446 John Horton, MB, ChB Assistant Member Phone: 805-238-2485 Professor Emeritus of Medicine & Oncology Pathology - Clinical Fax: 949-203-6115 Saïd M. Sebti, PhD E-mail: [email protected] Moffitt Cancer Center Senior Member Journal Advisory Committee: Drug Discovery For Consumer and Daniel A. Anaya, MD Bijal D. Shah, MD General Advertising Associate Member Assistant Member Information: Gastrointestinal Oncology Malignant Hematology Veronica Nemeth Aliyah Baluch, MD Lubomir Sokol, MD, PhD Editorial Coordinator Assistant Member Senior Member Cancer Control: Journal of the Moffitt Cancer Center Infectious Diseases Hematology/Oncology Dung-Tsa Chen, PhD 12902 Magnolia Drive – MBC-JRNL Hatem H. Soliman, MD Associate Member Tampa, FL 33612 Assistant Member Biostatistics Phone: 813-745-1348 Breast Oncology Fax: 813-449-8680 Hey Sook Chon, MD E-mail: [email protected] Assistant Member Jonathan R. Strosberg, MD Gynecological Oncology Assistant Member Gastrointestinal Oncology Jasreman Dhillon, MD Assistant Member Jennifer Swank, PharmD Pathology - Anatomic Clinical Pharmacist - Medical Oncology/Internal Medicine Jennifer S. Drukteinis, MD Associate Member Sarah W. Thirlwell, MSc, MSc(A), RN Diagnostic Radiology Nurse Director Clement K. Gwede, PhD Supportive Care Medicine Program Associate Member Eric M. Toloza, MD, PhD Health Outcomes and Behavior Assistant Member Sarah E. Hoffe, MD Thoracic Oncology Associate Member Nam D. Tran, MD Radiation Oncology Assistant Member John V. Kiluk, MD Neuro-Oncology Associate Member Jonathan S. Zager, MD Breast Oncology Senior Member Cancer Control is a member of Richard D. Kim, MD Cutaneous Oncology the Medscape Publishers’ Circle®, Associate Member an alliance of leading medical Gastrointestinal Oncology publishers whose content is Bela Kis, MD, PhD featured on Medscape Assistant Member (www.medscape.com). Diagnostic Radiology Rami Komrokji, MD Most issues and supplements of Associate Member Cancer Control are available at Malignant Hematology cancercontroljournal.org CANCER CONTROL: JOURNAL OF THE MOFFITT CANCER CENTER (ISSN 1073-2748) is published by H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612. Telephone: 813-745-1348. Fax: 813-449-8680. E-mail: [email protected]. Internet address: cancercontroljournal.org. Cancer Control is included in Index Medicus ®/MEDLINE® and EMBASE®/ Excerpta Medica, Thomson Reuters Science Citation Index Expanded (SciSearch®) and Journal Citation Reports/Science Edition. Copyright 2016 by H. Lee Moffitt Cancer Center & Research Institute. All rights reserved. Cancer Control: Journal of the Moffitt Cancer Center is a peer-reviewed journal that is published to enhance the knowledge needed by professionals in oncology to help them minimize the impact of human malignancy. Each issue emphasizes a specific theme relating to the detection or management of cancer. The objectives of Cancer Control are to define the current state of cancer care, to integrate recently generated information with historical practice patterns, and to enlighten readers through critical reviews, commentaries, and analyses of recent research studies. DISCLAIMER: All articles published in this journal, including editorials and letters, represent the opinions of the author(s) and do not necessarily reflect the opinions of the editorial board, the H. Lee Moffitt Cancer Center & Research Institute, Inc, or the institutions with which the authors are affiliated unless clearly specified. The reader is advised to independently verify the effective- ness of all methods of treatment and the accuracy of all drug names, dosages, and schedules. Dosages and methods of administration of pharmaceutical products may not be those listed in the package insert and solely reflect the experience of the author(s) and/or clinical investigator(s). July 2016, Vol. 23, No. 3 Cancer Control 189 Table of Contents Editorial Maximizing Cures and Preserving Function in Head and Neck Cancers 192 Louis B. Harrison, MD, and Jimmy J. Caudell, MD, PhD Articles Management of Oropharyngeal Cancer in the HPV Era 197 Arash O. Naghavi, MD, Tobin J. Strom, MD, Kamran A. Ahmed, MD, Michelle I. Echevarria, MD, Yazan A. Abuodeh, MD, Puja S. Venkat, MD, Jessica M. Frakes, MD, Louis B. Harrison, MD, Andy M. Trotti, MD, and Jimmy J. Caudell, MD, PhD Definitive Radiotherapy for Squamous Cell Carcinoma of the Glottic Larynx 208 William M. Mendenhall, MD, Roi Dagan, MD, Curtis M. Bryant, MD, Robert J. Amdur, MD, and Anthony A. Mancuso, MD Clinical Benefits of Proton Beam Therapy for Tumors of the Skull Base 213 Kamran A. Ahmed, MD, Stephanie K. Demetriou, Mark McDonald, MD, and Peter A.S. Johnstone, MD Management of BCC and SCC of the Head and Neck 220 Tobin J. Strom, MD, Jimmy J. Caudell, MD, PhD, and Louis B. Harrison, MD Treatment of Head and Neck Paragangliomas 228 Kenneth Hu, MD, and Mark S. Persky, MD Multidisciplinary Management of Salivary Gland Cancers 242 Matthew J. Mifsud, MD, Jon N. Burton, MD, Andy M. Trotti, MD, and Tapan A. Padhya, MD Departments Pathology Report: Practical Issues for Retroperitoneal Sarcoma 249 Vicky Pham, MS, Evita Henderson-Jackson, MD, Matthew P. Doepker, MD, Jamie T. Caracciolo, MD, Ricardo J. Gonzalez, MD, Mihaela Druta, MD, Yi Ding, MD, and Marilyn M. Bui, MD, PhD 190 Cancer Control July 2016, Vol. 23, No. 3 Table of Contents Departments, continued Infectious Diseases Report: Primary Gangrenous Cutaneous Mold Infections in a 265 Patient With Cancer and Neutropenia Abraham Yacoub, MD, Kiran K. Soni, Lysenia Mojica, MD, Jane Mai, MD, Jamie Morano, MD, C. Wayne Cruse, MD, Ramon L. Sandin, MD, Sowmya Nanjappa, MBBS, MD, Chandrashekar Bohra, MBBS, Ganesh Gajanan, MBBS, and John N. Greene, MD Case Series: Diffuse Alveolar Hemorrhage in Acute Myeloid Leukemia 272 Sowmya Nanjappa, MBBS, MD, Daniel K. Jeong, MD, Manjunath Muddaraju, MD, Katherine Jeong, MD, Eboné D. Hill, MD, and John N. Greene, MD Case Series: Marijuana Smoking in Patients With Leukemia 278 Sara Khwaja, MD, Abraham Yacoub, MD, Asima Cheema, MD, Nancy Rihana, MD, Robin Russo, MD, Ana Paula Velez, MD, Sowmya Nanjappa, MBBS, MD, Ramon L. Sandin, MD, Chandrashekar Bohra, MBBS, Ganesh Gajanan, MBBS, and John N. Greene, MD Special Report: Platelet-to-Lymphocyte Ratio and Use of NSAIDs During the Perioperative Period 284 as Prognostic Indicators in Patients With NSCLC Undergoing Surgery Brenda M. Lee, MD, Andrea Rodríguez, MD, Gabriel Mena, MD, Vijaya Gottumukkala, MB, MD, Reza J. Mehran, MD, David C. Rice, MB, Lei Feng, MS, Jun Yu, MS, and Juan P. Cata, MD Special Report: Resection of the First Rib With Preservation of the T1 Nerve Root in 295 Pancoast Tumors of the Lung Andreas K. Filis, MD, Lary A. Robinson, MD, and Frank D. Vrionis, MD, PhD Special Report: Feasibility, Preliminary Efficacy, and Lessons Learned From a Garden-Based 302 Lifestyle Intervention for Cancer Survivors Colleen K. Spees, PhD, RDN, Emily B. Hill, Elizabeth M. Grainger, PhD, RDN, Jackie L. Buell, PhD, RDN, Susan E. White, PhD, Matthew D. Kleinhenz, PhD, and Steven K. Clinton, MD, PhD Special Report: Hypofractionated Stereotactic Radiotherapy for Auditory Canal or Middle Ear Cancer 311 Taro Murai, MD, Shin-Etsu Kamata, MD, Kengo Sato, MD, Kouki Miura, MD, Mitsuhiro Inoue, Naoki Yokota, MD, Seiji Ohta, MD, Michio Iwabuchi, MD, Hiromitsu Iwata, MD, and Yuta Shibamoto, MD Ten Best Readings Relating to Head and Neck Cancers 317 About the art in this issue: Born in 1943, Arthur Spencer Pina de Alba has always been passionately involved in the arts. After completing his studies at Shaker Heights High School, Arthur was given a National Arts Award and 3 Gold Key Awards. He earned a scholarship to study at Chounard Academy, and then went on to earn a bachelor of fine arts at the California Institute of the Arts. After college he established an all-encompassing fine-arts production company. His multimedia enterprise worked with private parties to de- sign and produce large-scale murals, sculptures, and trompe l’oeil, as well as illustrations and storyboards for the film industry. Arthur's endeavors have also included art direction for album cover artwork on such documentaries as Gravity is My Enemy and Conquistadores, which was narrated by Orson Welles. Some of his clients have included Desi Arnez Jr and fashion designer Richard Blackwell. During his time in Los Angeles, Arthur held solo exhibitions at the Crest and Ryder Galleries.
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