CVM Annual Research Forum and Litwack Lecture
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CVM Research Forum Jan January 20, 2012 CVM Annual Research Forum and Litwack Lecture Friday, January 20, 2012 The Litwack Lectures are supported by the Martin Litwack Fund, an endowment created by family and friends as a living memorial to Dr. Litwack, who was an acknowledged leader in establishing the College of Veterinary Medicine at North Carolina State University. Dr. Litwack was a charter member of the North Carolina Veterinary Medical Foundation and was active in many professional organizations including the North Carolina Veterinary Medical Association, the American Animal Hospital Association and the American Veterinary Medical Association. He served as president of the Triangle, Eastern North Carolina and North Carolina Veterinary Medical Associations. Dr. Litwack was also very active in community affairs and received many awards in recognition of his service and leadership, including the North Carolina Association of the Professions Special Recognition Award. Dr. Litwack is perhaps best remembered for his love of his family and profession, his deep commitment to education and to North Carolina State University, and his strong sense of obligation to the North Carolina livestock industry and to the general public. 2012 Litwack Lecturer : Dr. Oliver Smithies Dr. Oliver Smithies, Excellence Professor of Pathology and Laboratory Medicine at the University of North Carolina School of Medicine, Weatherspoon Eminent Distinguished Professor, and co-recipient of the 2007 Nobel Prize in physiology or medicine Schedule of Events 9:00am – 11:30am Oral Presentations 11:30am-1:00pm Posters Judged (Lunch) 1:00pm – 3:00pm Oral Presentations 3:00pm-4:00pm Informal session with Dr. Smithies for Grad Students 4:00pm-5:00pm Litwack Lecture – Dr. Oliver Smithies 5:00pm – 5:30pm Awards Ceremony (presented by Dr. Smithies) Poster Presentations Author Poster Abstract (Classification- Title # on Page Mentor) Cassandra Bare 1 (VS-Bailey) THE USE OF CARBETOCIN FOR 1 LONG-TERM ESTRUS SUPPRESSION LAMP: A NOVEL DETECTION 2 Adam Beard METHOD FOR RICKETTSIAL 2 (VS-Breitschwerdt) DISEASES NOVEL COMPOUNDS THAT ALTER Leslie Beck TGFΒ-INDUCED EPITHELIAL- 3 3 (VS-Sannes) MESENCHYMAL TRANSITION IN A549 CELLS AN INVESTIGATION OF CELLULAR Kathleen Bedard PROLIFERATION IN DOGS WITH 4 4 (VS-Mariani) MENINGOENCEPHALITIS OF UNKNOWN ETIOLOGY (MUE) Javier Benito EVALUATION OF MELOXICAM AND 5 5 (GS-Lascelles) TEPOXALIN IN CATS Javier Benito OWNER-ASSESSED INDICES OF 6 (GS-Lascelles) QUALITY OF LIFE IN CATS AND THE 6 RELATIONSHIP TO THE PRESENCE OF DEGENERATIVE JOINT DISEASE. PRACTICAL MORPHOMETRICS IN VARIOUS STRANDED MARINE Heather Beveridge MAMMAL SPECIES IN THE NORTH 7 7 (VS-Correa) ATLANTIC: REFERENCE VALUES FOR NECROPSY AND DRUG DOSAGE APPLICATIONS. MICROBUBBLE DELIVERY OF DII TO Sydney Cartiff THE OCULAR POSTERIOR SEGMENT: 8 (VS) COMPARISON OF INTRAVITREAL 8 AND SUPRACHOROIDAL INJECTION ROUTES PRACTICES AND PERSPECTIVES OF Caitlin Cavanaugh 9 NORTH CAROLINA VETERINARIANS 9 (VS-Cowen) TOWARD WILDLIFE CARE LACK OF GENOMIC Jaewook Chung IMPRINTING OF DNA PRIMASE, 10 10 (GS-Piedrahita) POLYPEPTIDE 2 (PRIM2) IN HUMAN TERM PLACENTA AND WHITE BLOOD CELLS. Carolyn Collier NEUTROPHIL RESPONSE AND MMP9 11 11 (VS-Yoder) EXPRESSION IN ZEBRAFISH (DANIO RERIO) EMBRYOS EXPOSED TO IMMUNE AGONISTS Katelyn Cordle INHIBITION OF CYCLOOXYGENASE-1 12 (VS-Fogle) AND -2 IN EQUINE BLOOD BY 12 PHENYLBUTAZONE, FLUNIXIN, MELOXICAM AND FIROCOXIB: AN EX VIVO ANALYSIS IS THE INHIBITORY ROLE OF MHCI IN 13 Hayley Dirscherl NATURAL CYTOTOXICITY 13 (GS-Yoder) EVOLUTIONARILY CONSERVED? CYTAUXZOON FELIS CYTOCHROME Megan Downey B GENOTYPE IS ASSOCIATED WITH 14 14 (GS-Birkenheuer) SURVIVAL IN DOMESTIC CATS WITH CYTAUXZOONOSIS EXPLORATION OF WILD CANID GENOMES USING CHROMOSOME- Shannon Duke 15 SPECIFIC PROBES SHOW THEY 15 Becker (GS-Breen) SHARE EVOLUTIONARY BREAKPOINTS Brett Gulledge COMPARISON OF SELECTED STRETCH POSITIONS OF THE 16 (VS-Marcellin- 16 PIRIFORMIS MUSCLE USING Little) COMPUTED TOMOGRAPHY AND BIOMODELING T REGULATORY CELLS HAVE A Jennifer Hendricks HIGHER PRODUCTIVE VIRAL LOAD 17 (VS-Fogle, THAN T HELPER CELLS DURING 17 Tompkins) BOTH A CHRONIC AND ACUTE FIV INFECTION IN CATS. Amanda Jeffries OLFACTORY THRESHOLD OF 18 (VS- Dorman) C4/TOLUENE BY EXPLOSIVE 18 DETECTION DOGS MOUSE KERATINOCYTE SIDE- POPULATION PLAYS A UNIQUE ROLE Sun Hye Kim (GS- 19 DURING MALIGNANT PROGRESSION 19 Rodriguez-Puebla) TO SKIN SQUAMOUS CELL CARCINOMAS EFFECT OF ASYMPTOMATIC FELINE David Kleisch HYPERTROPHIC CARDIOMYOPATHY 20 20 (VS-DeFrancesco) ON ACTIVITY LEVELS AND QUALITY OF LIFE PHYLOGENETIC ANALYSIS OF CAMPYLOBACTER FROM Leanne Magestro COMMERCIAL AND 21 (VS-Thakur) ANTIMICROBIAL-FREE (ABF) 21 PRODUCTION SYSTEMS REVEALS COMMON ANCESTRY AND A NON- CLONAL POPULATION RELEASE RATE OF CRYSTALLINE Megan Mathias RAPAMYCIN IN VITRO AND 22 22 (VS-Gilger) INTRAVITREALLY IN EX VIVO HORSE EYES. TORIN1 IS A POTENT INHIBITOR OF Kathleen McGinnis 23 MTOR-MEDIATED CELL SIGNALING 23 (VS-Sannes) AND LIPOGENESIS IN H292 CELLS GARP-BOUND TGFB COMPLEXES ON Michelle Miller FELINE TREGS ARE UPREGULATED 24 (GS- Tompkins) DURING ACUTE FIV INFECTION AND 24 CONTRIBUTE TO IMMUNE SUPPRESSION OF CD4 TH VIA LIGATION OF TH TGFBRII. OPTIMIZATION OF REAL TIME Momo Tanaka MICROSCOPY FOR ASSESSMENT OF 25 (VS-Piedrahita) RATE OF HISTONE EXCHANGE 25 AFTER SOMATIC CELL NUCLEAR TRANSFER (SCNT) USING GFP- LABELED HISTONE 2B Christina Park BACTERIAL COUNTS IN BEDDING 26 (VS-Anderson) MAY PREDICT BULK TANK 26 BACTERIAL POPULATION CANINE ORAL MELANOMA - CYTOGENETIC CHARACTERIZATION 27 Kelsey Poorman OF FRESH TISSUE, CELL LINES AND 27 (GS-Breen) ARCHIVAL TISSUES DEVELOPMENT OF A NOVEL Jessica Tarter COGNITIVE/MOTOR PARADIGM TO 28 28 (VS-Sherman) DOCUMENT FIV DISEASE IN LABORATORY CATS Bradley Waffa CLINICAL ANATOMY OF THE BALL 29 29 (VS-Stoskopf) PYTHON (PYTHON REGIUS) Jessica Wofford SEQUENCING ANTIDIURETIC 30 (VS-Hauck) HORMONE IN CATS WITH CENTRAL 30 DIABETES INSIPIDUS Guanxi Xiao THE ROLE OF EPIDERMAL GROWTH 31 (GS-Ghashghaei) FACTOR RECEPTOR IN 31 NEUROGENESIS AND GLIOGENESIS Oral Presentations Author Abstract Time (Classification- Title on Page Mentor) Joanne Fernandez- ANGIOPOIETIN-2 SERUM LEVELS IN 9:00-9:10 Lopez 32 CANINE MALIGNANT MELANOMA (VS-Hauck) PATIENTS INCIDENCE OF ONYCHECTOMY IN Laura Lockhart CATS PRESENTED FOR VETERINARY 9:10-9:20 (VS-Posner) CARE NEAR RALEIGH, NC AND 33 EDUCATIONAL ATTITUDES TOWARDS THE PROCEDURE Ryan Bray STARGAZERS AND STEM CELLS: A (VS- POTENTIAL THERAPEUTIC 9:20-9:30 34 Ghashghaei) APPROACH TO TREATING IDIOPATHIC SEIZURES Sehwon Koh GENERATION OF PUTATIVE (GS- INDUCED PLURIPOTENT STEM CELLS 9:30-9:40 35 Piedrahita) (IPS) FROM ADULT CANINE FIBROBLAST THE TRANSCRIPTION FACTOR Huixuan Liang SPECIFICITY PROTEIN 2 (SP2) IS (GS- 9:40-9:50 REQUIRED FOR PROGRESSION 36 Ghashghaeis) THROUGH THE CELL CYCLE OF NEURAL PROGENITORS Laura MECHANISMS OF VESICULAR Sommerville 9:50-10:00 TRAFFICKING IN THE NEURAL STEM 37 (GS- CELL NICHE Ghashghaei) Nagendran A PHARMACOGENETIC TOOL TO Muthasamy STUDY PHYSIOLOGICAL FUNCTIONS 10:00-10:10 (GS- 38 OF POSTNATAL NEUROGENESIS IN Ghashghaei) THE OLFACTORY BULBS. MITOCHONDRIAL GENOME SEQUENCES RESULT IN IMPROVED Megan Downey UNDERSTANDING OF THE 10:10-10:20 (GS- 39 PHYLOGENETIC RELATIONSHIPS OF Birkenheuer) PIROPLASMA THAT INFECT COMPANION ANIMALS Rachael PROTECTING THE HEART: HSP25 AS Stebbing 10:20-10:30 AN INNATE RESPONSE TO VIRAL 40 (GS-Sherry) INFECTION Kristin THE SEDATIVE EFFECTS OF Messenger ORAL-TRANSMUCOSAL 10:30-10:40 41 (GS-Papich) DETOMIDINE GEL IN COMPARISON WITH INTRAVENOUS DEXMEDETOMIDINE IN DOGS. Kate Medl EFFECTS OF MS 222 ON Bailey 10:40-10:50 ELECTRORETINOGRAPHY (ERG) IN 42 (HO-Posner) KOI FISH A.J. Van Wettere ACTIVATION OF THE TGF-Β 10:50-11:00 (GS-Kullman, SIGNALING PATHWAY IN A DMN- 43 Law) INDUCED FISH MODEL OF HEPATIC FIBROSIS MAST CELL CORTICOTROPIN- Amelia Gibson RELEASING FACTOR RECEPTORS 1:00-1:10 (GS-Moeser) PLAY OPPOSING ROLES IN 44 MEDIATING STRESS-INDUCED BARRIER DYSFUNCTION THE DEVELOPMENT OF A LARGE Liara Gonzalez ANIMAL MODEL FOR 1:10-1:20 (GS-Blikslager) TRANSLATIONAL STUDIES OF 45 INTESTINAL DISEASE FOCUSING ON INTESTINAL STEM CELLS Brittney EARLY WEANING IMPAIRS GUT McLamb MUCOSAL DEFENSES AND 1:20-1:30 46 (VS-Moeser) EXACERBATES CLINICAL DISEASE IN F18 E. COLI INFECTION CRF-MEDIATED MAST CELL Laura Riggs ACTIVATION AND INTESTINAL 1:30-1:40 47 (VS-Moeser) BARRIER INJURY IS MEDIATED BY THE ENTERIC NERVOUS SYSTEM EVALUATION OF DOPPLER AS A Jason Heitzman TECHNIQUE TO DETECT CHANGES 1:40-1:50 (VS-Bailey) ASSOCIATED WITH ASCENDING 48 BACTERIAL PLACENTITIS IN THE MARE Meghann ELASTOGRAPHIC EVALUATION OF 1:50-2:00 Lustgarten 49 THE EQUINE DISTAL FORELIMB (HO-Seiler) THE CANINE MHC CLASS I ALLELE, Peter Ross DLA-88*50801, PRESENTS PEPTIDES 2:00-2:10 50 (GS-Hess) OF VARYING LENGTHS WITH FOUR KEY ANCHOR RESIDUES CLINICAL ANATOMY OF THE Emily Wayne 2:10-2:20 BEARDED DRAGON (POGONA 51 (VS-Stoskopf) VITTICEPS) DEVELOPMENT OF A QUESTIONNAIRE TO ASSESS Javier Benito 2:20-2:30 CHRONIC PAIN ASSOCIATED WITH 52 (GS-Lascelles) FELINE DEGENERATIVE JOINT DISEASE. CHANGES IN VON FREY QUANTITATIVE SENSORY Alexander THRESHOLDS AS A RESULT OF 2:30-2:40 Bennett 53 TOTAL HIP REPLACEMENT IN THE (HO-Lascelles) TREATMENT OF COXOFEMORAL JOINT OSTEOARTHRITIS Morika 54 COMPARISON OF THERMAL Williams & THRESHOLD LATENCIES BETWEEN Amy 2:40-2:50 NORMAL DOGS AND DOGS WITH Kirkpatrick HINDLIMB OSTEOARTHRITIC (VS-Lascelles) ASSOCIATED PAIN THE USE OF CARBETOCIN FOR LONG-TERM ESTRUS SUPPRESSION Cassandra A. Bare, Anne R. Schramme, C. Scott Bailey, Jason M. Heitzman, Renan