Safety Assessment of Alkyl Betaines as Used in Cosmetics Status: Draft Tentative Report for Panel Review Release Date: November 15, 2013 Panel Meeting Date: December 9-10, 2013 The 2013 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; Ronald A. Hill, Ph.D. James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is Lillian J. Gill, DPA. This safety assessment was prepared by Christina L. Burnett, Scientific Analyst/Writer, and Bart Heldreth, Ph.D., Chemist CIR. © Cosmetic Ingredient Review 1101 17th Street, NW, Suite 412 Washington, DC 20036-4702 ph 202.331.0651 fax 202.331.0088
[email protected] Distributed for Comment Only -- Do Not Cite or Quote Commitment & Credibility since 1976 Memorandum To: CIR Expert Panel Members and Liaisons From: Christina L. Burnett Scientific Writer/Analyst Date: November 15, 2013 Subject: Draft Tentative Report on Alkyl Betaines At the September 2013 CIR Expert Panel Meeting, the Panel issued an insufficient data announcement on the safety assessment of alkyl betaine ingredients. The data needs included: (1) method of manufacturing; and (2) impurities. Since the announcement, we have received method of manufacturing and impurities data from a supplier of coco- betaine. This data along with basic composition data on a betaine analog from the European Chemicals Agency (ECHA) database and basic method of manufacturing data on food-grade betaine have been incorporated in the report.