INDEX

Volume 197, April-June, 1976

Acetaldehyde, blood levels in ethanol-intoxicated treated with estrogenic agents, 362 mice, effect of pargyline and other monoamine Adniamycin, microsomal reductive glycosidase action oxidase inhibitors, 332 on, 681 Acetylcholine Age, effect on cardiotoxic action of digitalis, 10 in mouse brain, effects ofsodium pentobarbital, 245 Akera, T. -induced contractions in rabbit aorta, influence of see Ku, D. D., 458 mecamylamine, 57 see Weaver, L. C., 1 interactions with local anesthetics on guinea-pig Albumin ileum, 633 -prostaglandin interaction, 391 release from cholinergic nerves, inhibited by adeno- serum, human and bovine, noncovalent binding of sine, adenine nucleotides and morphine, antago- prostaglandins A1. E1 F2a and E2 by, 391 nism by theophylline, 379 Alcohols, ethyl, n-propyl, n-butyl and iso-amyl, elimi- response of isolated guinea-pig ileum to, effects of nation by isolated perfused rat liver, 669 metoclopramide, 633 Allen, M. A., Wrenn, J. M., Putney, J. W., Jr. and N-Acetylprocainamide, electrological and antiar- Borzelleca, J. F.: A study of the mechanism of rhythmic properties correlated with plasma and transport of diphenylhydantoin in the rat sub- tissue drug concentrations in dog, 38 maxillary gland in vitro, 408 Acetylsalicylic acid, influence on myocardial ische- Alonso, M. B., see Rosen, M. R, 594 mia in cat, 582 Altura, B. M., Edgarian, H. and Altura, B. T.: Adenine nucleotides Differential effects of ethanol and mannitol on inhibition of acetylcholine release from cholinergic contraction of arterial smooth muscle, 352 nerves by, antagonism by theophylline, 379 Altura, B. T., see Altura, B. M., 352 mitochondnial translocation of, inhibited by sulfo- Amines, biogenic bromophthalein, effects upon rat liver adenosine release and uptake in brain tissue, comparative tniphosphate and possible correlation with inhibi- actions of monomethoxyamphetamines, 263 tion of bile flow, 235 release from isolated rat brain tissue as function of Adenosine, inhibition of acetylcholine release from meta substituent of N-ethylamphetamines, 253 cholinergic nerves by, antagonism by theophyl- Aminoff, M. J., see Sampson, S. R., 119 line, 379 para-Aminohippurate, effect on renal glutamine me- Adenosine 3’,S’-monophosphate, catecholamine- tabolism in rat, 199 stimulated formation in cerebellar slices inter- Aminopyridines, as inhibitors of membrane potas- related with inhibitory effects on cerebellar Pur- sium conductance, 414 kinje cells, antagonism by neuroleptic com- Ammonia, effect of fatty acids on disposition of, 675 pounds, 280 Ammoniagenesis, from glutamine in rat, effect of Na,K-Adenosine tniphosphatase, cardiac, guinea para-aminohippurate, 199 pig and rat, effect of monovalent cations and d-Amphetamine, intermittent and repeated adminis- ouabain on, 458 tration, effects on restricted water intake in rats, Adenosine triphosphate, rat liver, effects of sulfo- 303 bromophthalein-induced inhibition of mitochon- Analgesics, narcotic and narcotic antagonist, test for dnial translocation of anions and adenine nucleo- antinociceptive activity in guinea pig, 311 tides upon, possible correlation with inhibition of Anderson, T. R., see Bartolom#{233}, J., 293 bile flow, 235 Anesthetics, local Adrenal gland (see Gland, adrenal) inhibition of platelet aggregation and secretion, 215 Adnenergic receptors interactions with spasmogens on guinea-pig ileum, alpha, in rabbit aorta, dissociation constants and 633 relative efficacies of agonists acting on, 66 suppression of ionic conductances in squid axon rabbit cerebral artery, characterization in vitro, 371 membranes by, effects of calcium, 426 Adrenergic responsiveness, beta, reduced in rats Angiotensin tachyphylaxis, 575

745 746 INDEX Vol. 197

Anions, mitochondrial translocation of, inhibited by Bagwell, E. E., Walle, T., Drayer, D. E., Reidenberg, sulfobromophthalein; effects upon rat liver aden- M. M. and Pruett, J. K.: Correlation of the osine tniphosphate and possible correlation with electrophysiological and antiarrhythmic proper- inhibition of bile flow, 235 ties of the N-acetyl metabolite of procainamide Antiallergic agent, new orally effective (Wy-16,922), with plasma and tissue drug concentrations in immunopharmacologic properties of, 725 the dog, 38 Antiarrhythmic properties of N-acetylprocainamide, Balcerzak, S. P., Melaragno, A., Flanigan, P. W. and correlated with tissue and plasma drug concen- Bromberg, P. A.: Impaired tissue oxygenation in trations in dog, 38 cyanate-treated animals, 229 Antiarthritic properties of SK&F D-39162, potential Barchas, J. D., see Patrick, R. L., 89, 97 chrysotherapeutic agent, 142 Barium chloride Antibodies, reactive with meperidine, production and interactions with local anesthetics on guinea-pig characterization, 734 ileum, 633 Anti-inflammatory agents, nonsteroidal, influence on response of isolated guinea-pig ileum to, effects of myocardial ischemia in cat, 582 metoclopramide, 641 Antinociceptive activity of narcotic and narcotic an- Bartolom#{233}, J., Seidler, F. J., Anderson, T. R. and tagonist analgesics in guinea pig, test for, 311 Slotkin, T. A.: Effects of prenatal reserpine Antiparkinsonian drugs, actions on squid axon mem- administration on development of the rat adrenal branes, 135 medulla and central nervous system, 293 Antischistosomal drugs, long-term hepatocellular Begany, A. J., see Rosenthale, M. E., 725 effects in mice infected with Schistosoma man- Behavior soni, 703 circling, after narcotic drugs and during naloxone- Aorta precipitated abstinence in rats with unilateral rabbit, alpha adrenergic receptors, dissociation nigral lesions, 503 constants and relative efficacies of agonists food-rewarded bar pressing in rat, tolerance and acting on, 66 limited cross-tolerance to effects of N,N-dime- rabbit, isolated, influence of mecamylamine on thyltryptamine and lysergic acid diethyla- contractions induced by agonists and role of mide-25 on, 495 calcium ions in, 57 Bellville, J. W., Gasser, J. C., Miyake, T. and Aqleh, rabbit, tachyphylaxis to angiotensi in, 575 K. : Tolerance to the respiratory effects of man- strips, rat, differential effects of ethanol and man- juana in man, 326 nitol on contraction of, 352 Bentley, P. J., see Yorio, T., 188, 340 Aqleh, K., see Bellville, J. W., 326 Benzocaine, suppression of ionic conductances in Arteries squid axon membranes by, effects ofcalcium, 426 cerebral, rabbit, characterization in vitro of adre- Benztropine, actions on squid axon membranes, 135 nergic receptors, 371 Besse, J. C. and Funchgott, R. F.: Dissociation con- internal and external carotid, dog, effects of sero- stants and relative efficacies of agonists acting on tonin on blood flow in, 49 alpha adrenergic receptors in rabbit aorta, 66 Arthritis, adjuvant-induced, in rats, elimination and Bevan, J. A., see Duckles, S. P., 371 distribution of phenylbutazone during, 470 Bigelow, G. E., see Gniffiths, R R., 488 ASI-222, new 4-aminosugar semisynthetic cardiac Binding glycoside, 19 noncovalent, of prostaglandins A, E, F2a and E2 Atropine mydriasis and iris pigmentation, 79 by human and bovine serum albumins, 391 Auty, R. M. and Branch, R. A.: The elimination of of cations to choroid plexus peptide HF, 402 ethyl, n-propyl, n-butyl and iso-amyl alcohols by Black, D. J., Fregly, M. J., Thrasher, T. N. and

the isolated perfused rat liver, 669 Moreland, A . F. : Reduced beta adrenergic Axon responsiveness in rats treated with estrogenic giant, Myxicola, effects of aminopyridines and agents, 362 sparteine on membrane potassium conductance Bladder, urinary, epithelium, toad, effects of ethanol of, 414 on permeability of, 188 membranes, squid, actions of trihexyphenidyl and Blood, acetaldehyde levels in ethanol-intoxicated benztropine on, 135 mice, effect of pargyline and other monoamine membranes, squid, effects of calcium on local oxidase inhibitors on, 332 anesthetic suppression of ionic conductances in, Blood flow, in internal and external carotid vascular 426 beds, effects of serotonin, 49 Bile flow, inhibition in rat, possible correlation with Bachur, N. R. and Gee, M.: Microsomal reductive effects of sulfobromophthalein-induced inhibi- glycosidase, 681 tion of mitochondnial translocation of anions and 1976 INDEX 747

adenine nucleotides on liver adenosine tniphos- (ASI-222), 19 phate, 235 Cardiac glycoside, new 4-aminosugar semisynthetic Borzelleca, J. F., see Allen, M. A., 408 (ASI-222), 19 Brain Cardiotoxic action of digitalis, effect of age, 10 artery, rabbit, characterization in vitro of adrener- Carotid body, chemoreceptor activity, cat, neurally gic receptors, 371 induced inhibition of, 119 isolated tissue, rat, release of biogenic amines from, Cat(s) as function of meta substituent of N-ethylam- carotid body chemoreceptor activity, neurally in- phetamines, 253 duced inhibition of, 119 metabolism of 5-hydroxytryptophan- 14C following effects of fatty acids on disposition of ammonia in, peripheral decarboxylase inhibition, 545 675 mouse, effects of sodium pentobarbital on acetyl- ethanol effects on muscle spindle afferent activity choline in, 245 and spinal reflexes in, 126 rat, developing, effects of 6-hydroxydopa on norad- influence of nonsteroidal anti-inflammatory agents renergic neurons in, 105 on myocardial ischemia in, 582 striatal synaptosomes, rat, correlations between isolated tenuissimus muscle, subsynaptic site of veratridine-induced dopamine synthesis stimula- action of theophylline on, 647 tion and endogenous dopamine release in, 89 monoamine oxidase inhibition and induction of striatal synaptosomes, rat, dibutyryl cyclic adeno- ponto-geniculo-occipital wave activity by reser- sine 3’ :5’-monophosphaturic acid- and 6-methyl- pine in, 556 tetrahydropterine-induced dopamine synthesis sympathetic nervous system, primary sites of di- increases without increase in endogenous dopa- goxin action on, 1 mine release in, 97 Catecholamine tissue, comparative actions of monomethoxy- secretion of transplantable rat pheochromocytoma, amphetamines on release and uptake of biogenic 615 amines in, 263 -stimulated formation of adenosine 3’,S’-monophos- Branch, R A., see Auty, R M., 669 phate in cerebellar slices, interrelated with inhib- Branisteanu, D. D., see Volle, R. L., 653 itory effects on cerebellar Purkinje cells, antago- Brase, D. A., Iwamoto, E. T., Loh, H. H. and Way, E. nism by neuroleptic compounds, 280 L.: Reinitiation of sensitivity to naloxone by a Cation(s) single narcotic injection in postaddicted mice, -binding property of choroid plexus peptide IIF, 402 317 exchange in cultured cells, effect of quinidine, 605 Brody, T. M. monovalent, effect on guinea-pig and rat cardiac see Ku, D. D., 458 Na ,K -adenosine triphosphatase and contrac- see Weaver, L. C., 1 tile force, 458 Bromberg, P. A., see Balcerzak, S. P., 229 Cells, cultured, mammalian, effect of quinidine on Brooks, D. C., see Gershon, M. D., 556 cation exchange in, 605 Bueding, E., see Haese, W. H., 703 Central nervous system (see Nervous system, central) Bumetanide, furosemide and, comparative diuretic Chalfie, M. and Perlman, R. L.: Studies of a trans- and tissue distribution study in dog, 697 plantable rat pheochromocytoma: Biochemical Bury, R. W. and Mashford, M. L.: The effects of characterization and catecholamine secretion, metoclopramide in modifying the response of 615 isolated guinea-pig ileum to various agonists, 641 Chemoreceptor activity of cat carotid body, neurally Bury, R. W. and Mashford, M. L.: Interactions induced inhibition of, 119 between local anesthetics and spasmogens on the Chick, embryonic heart, positive inotropic activity of guinea-pig ileum, 633 cholera enterotoxin on, 27 n-Butyl alcohol, elimination by isolated perfused rat Chlorisondamine, influence on response of internal liver, 669 and external carotids to serotonin in dog, 49 Byrne, D., see Preuss, H. G., 199 Cholera enterotoxin, positive inotropic activity on embryonic chick heart, 27 Calcium Chonid plexus, peptide IIF, cation-binding property, effects on local anesthetic suppression of ionic 402 conductances in squid axon membranes, 426 Chrysotherapeutic agent, potential (SK&F D-39162), ion, binding to choroid plexus peptide IIF, 402 antiarthritic properties and pharmacologic pro- ion, role in effects of mecamylamine on contractions file, 142 induced by agonists in isolated rabbit aorta, 57 Clorgyline, effect on reserpine-induced ponto- Caldwell, R. W. and Nash, C. B.: Pharmacological geniculo-occipital wave activity in cat, 556 studies of a new 4-aminosugar cardiac glycoside Cobalt, treatment in rat, neutral protease activity 748 INDEX Vol. 197

and erythropoietin production in, 714 Dibutyryl cyclic adenosine 3’:S’-monophosphaturic Codeine, test for antinociceptive activity in guinea acid-induced dopamine synthesis increases with- pig, 311 out increase in endogenous dopamine release in Cohen, M. R., Hinsch, E., Vergona, R., Ryan, J., rat brain striatal synaptosomes, 97 Kolis, S. J. and Schwartz, M. A.: A comparative Diethylstilbestrol, fate in pregnant mouse, 687 diuretic and tissue distribution study of bumeta- Digitalis, cardiotoxic action, effect of age, 10 nide and furosemide in the dog, 697 Digoxin, primary sites of action on sympathetic Conductance nervous system, 1 ionic, in squid axon membranes, effects of calcium DiMartino, M. J., see Walz, D. T., 142 on local anesthetic suppression of, 426 N,N-Dimethyltryptamine, lysergic acid diethyla- membrane, of potassium, aminopynidines and spar- mide-25 and, effects on food-rewarded bar press- teine as inhibitors of, 414 ing in rat, tolerance and limited cross-tolerance Contractile force, cardiac, guinea pig and rat, effect of to, 495 monovalent cations and ouabain on, 458 Diphenylhydantoin Cow therapeutic concentrations, effects on transmem- choroid plexus peptide IIF, cation-binding property brane potentials of normal and depressed Pun- of, 402 kinje fibers, 594 serum albumin, noncovalent binding of prosta- transport in rat submaxillary gland in vitro, 408 glandins A1. E,, F2a and E2 by, 391 Dissociation constants of agonists acting on alpha Cyanate-treated animals, impaired tissue oxygena- adrenergic receptors in rabbit aorta, 66 tion in, 229 Diuretics, comparative study of bumetanide and Cyclazocine furosemide in dog, 697 ability to produce narcotic cue, 180 Dog(s) test for antinociceptive activity in guinea pig, 311 comparative diuretic and tissue distribution study Cyclorphan, test for antinociceptive activity in guinea ofbumetanide and furosemide in, 697 pig, 311 correlation of electrophysiological and antiarrhyth- Chakrin, L. W., see Walz, D. T., 142 mic properties of N-acetylprocainamide with Chawla, R. K., see Rudman, D., 402 plasma and tissue drug concentrations in, 38 Cohen, G., see Dembiec, D., 332 effect of ASI-222 (new 4-aminosugar cardiac glyco- Colpaert, F. C., Niemegeers, C. J. E. and Janssen, P. side) in, 19 A. J.: On the ability of narcotic antagonists to heart, ventricular electrophysiology of quinidine- produce the narcotic cue, 180 propranolol combinations in, 452 Colton, C. A., see Schauf, C. L., 414 histamine-induced lipid mobilization in, 662 Colton, J. S., see Schauf, C. L., 414 internal and external carotid vascular beds, vascu- lar tone and reactivity to serotonin in, 49 Daly, J. W., see Skolnick, P., 280 nondependent and morphine-dependent chronic Danilo, P., Jr., see Rosen, M. R., 594 spinal, effects of morphine- and nalorphine-like Daunorubicin, microsomal reductive glycosidase drugs in, 517 action on, 681 Purkinje fibers, normal and depressed, effects of Davis, F. A., see Schauf, C. L., 414 therapeutic concentrations of diphenylhydantoin Decarboxylase, peripheral, inhibition, brain and pe- on transmembrane potentials of, 594 ripheral metabolism of5-hydroxytryptophan- ‘4C Domino, E. F., see Kovacic, B., 495 following, 545 Dopamine, synthesis in rat brain striatal synap- Dembiec, D., MacNamee, D. and Cohen, G.: The tosomes, 89, 97 effect of pargyline and other monoamine oxidase 3H-Dopamine inhibitors on blood acetaldehyde levels in release from isolated rat brain tissue as function of ethanol-intoxicated mice, 332 meta substituent of N-ethylamphetamines, 253 Deprenyl, effect on reserpine-induced ponto-geniculo- release and uptake in brain tissue, comparative occipital wave activity in cat, 556 actions of monomethoxyamphetamines, 263 Derr, R. F. and Zieve, L.: Effect of fatty acids on the Drayer, D. E., see Bagwell, E. E., 38 disposition of ammonia, 675 Duckles, S. P. and Bevan, J. A.: Pharmacological Dervinis, A., see Rosenthale, M. E., 725 characterization of adrenergic receptors of a rab- Diazepam, human self-administration, effects of bit cerebral artery in vitro, 371 interingestion interval and dose, 488 Diazoxide, influence on response of internal and Eades, C. G., see Martin, W. R, 517 external carotids to serotonin in dog, 49 Edgarian, H., see Altura, B. M., 352 Dibucaine, inhibition of platelet aggregation and Electrophysiological changes, induced by therapeutic secretion by, 215 concentrations of diphenylhydantoin in Purkinje 1976 INDEX 749

fibers, 594 transmitter release at, 653 Electrophysiological properties, of N-acetylprocaina- skeletal muscle, physostigmine twitch potentiation mide, correlated with tissue and plasma drug at different pH, 439 concentrations in dog, 38 skin, effects of ethanol on permeability of, 340 Electrophysiology, ventricular, of quinidine-pro- Furchgott, R. F., see Besse, J. C., 66 pranolol combinations in dog heart, 452 Furosemide, bumetanide and, comparative diuretic Enzyme, inactivation, use of 300-msec microwave and tissue distribution study in dog, 697 irradiation for, 245 Epithelial membrane, toad urinary bladder, effects of Garey, R. E., see Kostrzewa, R. M., 105 ethanol on permeability of, 188 Gasser, J. C., see Bellville, J. W., 326 Erythropoietin, production in rat after cobalt treat- Gee, M., see Bachur, N. R., 681 ment, neutral protease activity and, 714 Gershon, M. D. and Brooks, D. C.: Monoamine Estrogenic agents, treatment in rats, reduced beta oxidase inhibition and the induction of ponto- adrenergic responsiveness after, 362 geniculo-occipital wave activity by reserpine in Ethanol the cat, 556 effects on muscle spindle afferent activity and Gessner, G., see Pendleton, R G., 623 spinal reflexes, 126 Gilbert, P. E., see Martin, W. R., 517 effects on permeability of frog skin, 340 Gland effects on permeability of toad urinary bladder adrenal, medulla, rat, effects of prenatal reserpine epithelium, 188 administration on development of, 293 human self-administration, effects of interingestion adrenal, phenylethanolamine N-methyltransferase, interval and dose, 488 studies with SK&F 64139, selective inhibitor of, -intoxicated mice, effect of pargyline and other 623 monoamine oxidase inhibitors on blood acetalde- submaxillary, rat, transport in vitro of diphenyl- hyde levels in, 332 hydantoin in, 408 mannitol and, differential effects on contraction of Gluckman, M. I., see Rosenthale, M. E., 725 arterial smooth muscle, 352 Glutamine, renal metabolism in rat, effect of para- Ethyl alcohol, elimination by isolated perfused rat aminohippurate on, 199 liver, 669 Glycerol, levels in humans and dogs, effect of hista- N-Ethylamphetamines, meta substituent, release of mine, 662 biogenic amines from isolated rat brain tissue as Glycosidase, microsomal reductive, 681 function of, 253 Goldberg, N. D., see Hedtke, J. L., 27 Goninson, H. S., see Hutchings, D. E., 171 Fatty acid(s) Griffiths, R. R., Bigelow, G. E. and Liebson, I.: effect on disposition ofammonia, 675 Human sedative self-adinistration: Effects of free, levels in humans and dogs, effect of histamine, interingestion interval and dose, 488 662 Grund, V. R., Pollack, E. W. and Hunninghake, D. Feinstein, M. B., Fiekers, J. and Fraser, C.: An B.: Histamine-induced lipid mobilization in analysis of the mechanism of local anesthetic humans and dogs, 662 inhibition of platelet aggregation and secretion, Guanidine-treated frog neuromuscular junctions, sta- 215 tistical parameters of transmitter release at, 653

Fentanyl, ability to produce narcotic cue, 180 Gueriguian, J . L. : Prostaglandin-macromolecule Fibroblasts, methylcholanthrene-transformed mouse interactions. I. Noncovalent binding of prosta- BALB/3T3, effects of hydroquinone, hematin and glandins A1. E1. F, and E, by human and bovine heme-containing proteins on prostaglandin syn- serum albumins, 391 thesis by, 567 Guinea pig Fiekers, J., see Feinstein, M. B., 215 antagonism by theophylline of inhibition of acetyl- Fisher, J. W., see Smith, R. J., 714 choline release from cholinergic nerves by adeno- Fitch, F. W., see Wainer, B. H., 734 sine adenine nucleotides and morphine, 379 Flanigan, P. W., see Balcerzak, S. P., 229 effect of monovalent cations and ouabain on cardiac Fraser, C., see Feinstein, M. B., 215 Na ,K -adenosine tniphosphatase and contracile Frazier, D. T., see Narahashi, T., 426 force, 458 Freedman, R., see Skolnick, P., 280 ileum, interactions between local anesthetics and Fregly, M. J., see Black, D. J., 362 spasmogens on, 633 Fried, J., see Wainer, B. H., 734 ileum, isolated, effects of metoclopramide in modi- Frog fying response to agonists of, 641 neuromuscular junctions treated with guanidine or test for antinociceptive activity of narcotic and tetraethylammonium, statistical parameters of narcotic antagonist analgesics in, 311 750 INDEX Vol. 197

Guinosso, C., see Rosenthale, M. E., 725 release and uptake in brain tissue, comparative actions of monomethoxyamphetamines, 263 Haese, W. H. and Bueding, E.: Long-term hepatocel- release from isolated rat brain tissue as function of lular effects of hycanthone and of two other meta substituent of N-ethylamphetamines, 253 antichistosomal drugs in mice infected with 5-Hydroxytryptophan-”C, brain and peripheral me- Schistosoma mansoni, 703 tabolism of, following peripheral decarboxylase Harmaline, effect on reserpine-induced ponto- inhibition, 545 geniculo-occipital wave activity in cat, 556 IA-4, long-term hepatocellular effects in mice infected Heart with Schistosoma mansoni, 703 dog, ventricular electrophysiology of quinidine-pro- ileum pranolol combinations in, 452 guinea pig, interactions between local anesthetics embryonic, chick, positive inotropic activity of and spasmogens on, 633 cholera enterotoxin on, 27 isolated, guinea pig, effects of metoclopramide in guinea pig and rat, Na,K,-adenosine triphospha- modifying response to agonists of, 641 tase and contractile force, effect of monovalent Immunopharmacologic properties, of Wy-16,922, new cations and ouabain on, 458 orally effective anti-allergic agent, 725 Hedtke, J. L., Shideman, F. E. and Goldberg, N. D.: Indomethacin, influence on myocardial ischemia in Positive inotropic activity of cholera enterotoxin cat, 582 on the embryonic chick heart, 27 Iris, pigmentation and atropine mydriasis, 79 Hematin, effects on prostaglandin biosynthesis by Iso-amyl alcohol, elimination by isolated perfused rat methylcholanthrene-transformed mouse BALB/ liver, 669 3T3 fibroblasts, 567 Iwamoto, E. T., Loh, H. H. and Way, E. L.: Circling Heme-containing proteins, effects on prostaglandin behavior after narcotic drugs and during nalox- biosynthesis by methylcholanthrene-transformed one-precipitated abstinence in rats with unilat- mouse BALB/3T3 fibroblasts, 567 eral nigral lesions, 503 Hill, J. H., see Wainer, B. H., 734 Iwamoto, E. T., see Brase, D. A., 317 Hinsch, E., see Cohen, M. R., 697 Histamine Jacobs, R. S., see Shinnick-Gallagher, P., 647 -induced contractions in rabbit aorta, influence of Jaffe, R. A., see Sampson, S. R., 119 mecamylamine, 57 J#{228}hnchen, E., see Perrey, K., 470 -induced lipid mobilization in humans and dogs, Janssen, P. A. J., see Colpaert, F. C., 180 662 Jhamandas, K. H., see Sawynok, J., 379 interactions with local anesthetics on guinea-pig Jonen, H. G., see Perrey, K., 470 ileum, 633 response of isolated guinea-pig ileum to, effects of Kahl, G. F., see Perrey, K., 470 metoclopramide, 641 Kaiser, C., see Pendleton, R G., 623 Ho, I. K.: Systematic assessment of tolerance to Kelliher, G. J. and Roberts, J.: Effect of age on the pentobarbital by pellet implantation, 479 cardiotoxic action of digitalis, 10 Hoffer, B. J., see Skolnick, P., 280 Khairallah, P. A., see Moore, A., 575 Holtzman, S. G., see O’Callaghan, J. P., 533 Kolis, S. J., see Cohen, M. R, 697 Hong, E., see Vidrio, H., 49 Korte, D. W., Jr. and Nash, C. B.: Ventricular Hong, S.-C., see Polsky-Cynkin, R., 567 electrophysiology of quinidine-propranolol corn- Hunninghake, D. B., see Grund, V. R, 662 binations in the dog heart, 452 Hunt, H. F., see Hutchings, D. E., 171 Kostrzewa, R. M. and Garey, R. E.: Effects of Huppler, R E., see Martin, W. R., 517 6-hydroxydopa on noradrenergic neurons in de- Hutchings, D. E., Hunt, H. F., Towey, J. P., Rosen, veloping rat brain, 105 T. S. and Gorinson, H. S.: Methadone during Kovacic, B. and Domino, E. F.: Tolerance and limited pregnancy in the rat: Dose level effects on mater- cross-tolerance to the effects of N,N-dimethyl- nal and peninatal mortality and growth in the tryptamine (DMT) and lysergic acid diethyla- offspring, 171 mide-25 (LSD) on food-rewarded bar pressing in Hycanthone, long-term hepatocellular effects in mice the rat, 495 infected with Schistosoma mansoni, 703 Ku, D. D., Akera, T., Tobin, T. and Brody, T. M.: Hydroquinone, effects on prostaglandin biosynthesis Comparative species studies on the effect of by methylcholanthrene-transformed mouse monovalent cations and oubain on cardiac

BALB/3T3 fibroblasts, 567 Na K -adenosine tniphosphatase and contract - 6-Hydroxydopa, effects on noradrenergic neurons in ile force, 458 developing rat brain, 105 3H-5-Hydroxytryptamine Laperche, Y. and Oudea, P.: Inhibition by sulfobro- 1976 INDEX 751

mophthalein of mitochondrial translocation of Marijuana, respiratory effects in man, tolerance to, anions and adenine nucleotides: Effects upon 326 liver adenosine triphosphate and possible correla- Martin, W. R., Eades, C. G., Thompson, J. A., tion with inhibition of bile flow in the rat, 235 Huppler, R. E. and Gilbert, P. E.: The effect of Lathers, C. M. and Smith, C. M.: Ethanol effects on morphine- and nalorphine-like drugs in the non- muscle spindle afferent activity and spinal dependent and morphine-dependent chronic spi- reflexes, 126 nal dog, 517 Lefer, A. M., see Ogletree, M. L., 582 Mashford, M. L., see Bury, R W., 633, 641 Levine, L., see Polsky-Cynkin, R, 567 McCall, D.: Effect ofquinidine on cation exchange in Liebson, I., see Griffiths, R R, 488 cultured cells, 605 Lipid, mobilization in humans and dogs, induced by McCoy, T. H., see Modak, A. T., 245 histamine, 662 McLachlan, J. A., see Shah, H. C., 687 Lithium, selective inhibition of hormonal phosphatu- Mecamylamine, influence on contractions induced by nc responses, 206 different agonists and on role of calcium ions in Liver isolated rabbit aorta, 57 isolated perfused, rat, elimination of ethyl, n-pro- Meclofenamic acid, influence on myocardial ischemia pyl, n-butyl and iso-amyl alcohols by, 669 in cat, 582 long-term effects of hycanthone, IA-4 and oxamni- Melaragno, A., see Balcerzak, S. P., 229 quine in mice infected with Schistosoma man- Menon, M. K., Tseng, L.-F. and Loh, H. H.: Pharma- soni, 703 cological evidence for the central serotonergic microsomes, rat, reductive glycosidase in, 681 effects of monomethyoxyamphetamines, 272 rat, adenosine triphosphate, effects of sulfo- Menon, M. K., see Tseng, L.-F., 263 bromophthalein-induced inhibition of mitochon- Meperidine drial translocation of anions and adenine nucleo- antibodies reactive with, production and character- tides on, possible correlation with inhibition of ization, 734 bile flow, 235 test for antinociceptive activity in guinea pig, 311 Lobster, neuromuscular junction, effects of aminopy- Metabolism ridines and sparteine on membrane potassium brain and peripheral, of 5-hydroxytryptophan-”C conductance of, 414 following peripheral decarboxylase inhibition, Local anesthetic (see Anesthetic, local) 545 Loh, H. H. of ammonia, effect of fatty acids, 675 see Brase, D. A., 317 of stilbestrol in pregnant mouse, 687 see Iwamoto, E. T., 503 renal, of glutamine in rat, effect of para-aminohip- see Menon, M. K., 272 purate on, 199 see Tseng, L.-F., 263 Methadone Lysergic acid diethylamide-25, N,N-dimethyltrypta- during pregnancy in rat, effects on maternal and mine and, effects on food-rewarded bar pressing perinatal mortality and growth in offspring, 171 in rat, tolerance and limited cross-tolerance to, test for antinociceptive activity in guinea pig, 311 495 Methylcholanthrene-transformed mouse BALB/3T3 fibroblasts, effects of hydroquinone, hematin and MacNamee, D., see Dembiec, D., 332 heme-containing proteins on prostaglandin bio- MacPhail, R. C. and Seiden, L. S.: Effects of inter- synthesis by, 567 mittent and repeated administration of d- 6-Methyltetrahydroptenine-induced dopamine syn- amphetamine on restricted water intake in rats, thesis increases without increase in endogenous 303 dopamine release in rat brain striatal synap- Magnesium, ion, binding to choroid plexus peptide tosomes, 97 LIF, 402 Methysergide, influence on response of internal and Man external carotids to serotonin in dog, 49 effects on interingestion interval and dose on seda- Metoclopramide, effects in modifying response of tive self-administration in, 488 isolated guinea-pig ileurn to agonists, 641 histamine-induced lipid mobilization in, 662 Mice platelet aggregation and secretion, local anesthetic assessment of tolerance to pentobarbital by pellet inhibition of, 215 implantation in, 479 serum albumin, noncovalent binding of prosta- BALB/3T3 fibroblasts, methylcholanthrene-trans- glandins A1. E1 F, and E, by, 391 formed, effects of hydroquinone, hematin and tolerance to respiratory effects of marijuana in, 326 heme-containing proteins on prostaglandin bio- Mannitol, ethanol and, differential effects on contrac- synthesis by, 567 tion of arterial smooth muscle, 352 brain, effects of sodium pentobarbital on acetylcho- 752 INDEX Vol. 197

line in, 245 Mydniasis, atropine, and iris pigmentation, 79 central serotonergic effects of monomethoxyam- Myocardial ischemia, cat, influence of nonsteroidal phetarnines in, 272 anti-inflammatory agents, 582 effect of ASI-22 (new 4-aminosugar cardiac gly- Myxicola, giant axons, effects of aminopyridines and coside) in, 19 sparteine on membrane potassium conductance ethanol-intoxicated, effect of pargyline on and of, 414 other monoamine oxidase inhibitors on blood acetaldehyde levels in, 332 Nalorphine infected with Schistosoma mansoni, long-term ability to produce narcotic cue, 180 hepatocellular effects of hycanthone, IA-4 and -like drugs, effects in nondependent and morphine- oxamniquine, 703 dependent chronic spinal dog, 517 postaddicted, reinitiation of sensitivity to naloxone test for antinociceptive activity in guinea pig, 311 by single narcotic injection in, 317 Naloxone pregnant, fate of diethylstilbestrol in, 687 ability to produce narcotic cue, 180 Microsomes, rat liver, reductive glycosidase in, 681 -precipitated abstinence in rats with unilateral Misher, A., see Walz, D. T., 142 nigral lesions, circling behavior during, 503 Miyake, T., see Bellville, J. W., 326 Narahashi, T., Frazier, D. T. and Takeno, K.: Effects MK-486, peripheral decarboxylase inhibitor, brain of calcium on the local anesthetic suppression of and peripheral metabolism of 5-hydroxytrypto- ionic conductances in squid axon membranes, 426 phan- ‘4C following, 545 Narahashi, T., see Wu, C. H., 135 Modak, A. T., Weintraub, S. T., McCoy, T. H. and Narcotic agonists, effects in nondependent and mor- Stavinoha, W. B. : Use of 300-msec microwave phine-dependent chronic spinal dog, 517 irradiation for enzyme inactivation: A study of Narcotic antagonists effects of sodium pentobarbital on acetylcholine ability to produce narcotic cue, 180 concentration in mouse brain regions, 245 effects in nondependent and morphine-dependent Monoamine oxidase chronic spinal dog, 517

inhibition , reserpine- induced ponto-geniculo- Narcotic cue, ability of narcotic antagonists to pro- occipital wave activity in cat and, 556 duce, 180 inhibitors, effect on blood acetaldehyde levels in Nash, C. B. ethanol-intoxicated mice, 332 see Caldwell, R. W., 19 Monomethoxyamphetamines see Korte, D. W., Jr., 452 central serotonergic effects, 272 Nerves, cholinergic, acetylcholine release from inhib- comparative actions on release and uptake of bio- ited by adenosine, adenine nucleotides and mor- genic amines in brain tissue, 263 phine, antagonism by theophylline, 379 Monkey, squirrel, studies on adrenal phenylethanol- Nervous system amine N-methyltransferase with SK&F 64139, central, rat, effects of prenatal reserpine on devel- selective inhibitor, in, 623 opment of, 293 Moore, A. and Khairallah, P. A.: Further studies on sympathetic, primary site of digoxin action on, 1 angiotensin tachyphylaxis, 575 Neurons, noradrenergic, in developing rat brain, Moreland, A. F., see Black, D. J., 362 effects of 6-hydroxydopa, 105 Morphine Naloxone, sensitivity to, reinitiation by single nan- inhibition of acetylcholine release from cholinergic cotic injection in postaddicted mice, 317 nerves by, antagonism by theophylline, 379 Neuroleptic compounds, effect on interrelationship -like drugs, effects in nondependent and morphine- between catecholamine-stimulated formation of dependent chronic spinal dog, 517 adenosine 3’,S’ -monophosphate in cerebellar prenatal administration in rat, effect on tolerance slices and inhibitory effects on cerebellar Pur- to analgesic effect in offspring, 533 kinje cells, 280 single injection in postaddicted mice, reinitiation of Neuromuscular junction sensitivity to naloxone by, 317 lobster, effects of aminopyridines and sparteine on test for antinociceptive activity in guinea pig, 311 membrane potassium conductance of, 414 Motor system, effects of ethanol, 126 treated with guanidine or tetraethylammonium, Muscle frog, statistical parameters of transmitter release cat tenuissimus, isolated, subsynaptic site of action at, 653 of theophylline on, 647 Niemegeers, C. J. E., see Colpaert, F. C., 180 skeletal, physostigmine twitch potentiation at dif- Norepinephrine ferent pH, 439 -induced contractions in rabbit aorta, influence of smooth, arterial, differential effects of ethanol and mecamylamine, 57 mannitol on contraction of, 352 levels in developing rat brain, effects of 6-hydrox- 1976. INDEX 753

ydopa, 105 Permeability 3H-Norepinephnine of frog skin, effects of ethanol, 340 release from isolated rat brain tissue as function of of toad urinary bladder epithelium, effects of meta substituent of N-ethylamphetamines, 253 ethanol, 188 release and uptake in brain tissue, comparative Perrey, K., Jonen, H. G., Kahl, G. F. and J#{228}hnchen, actions of monomethoxyamphetamines, 263 E.: Elimination and distribution of penylbuta- t-Norepinephrine, alpha agonist, dissociation con- zone in rats during the course of adjuvant- stant and efficacy in rabbit aorta, 66 induced arthritis, 470 pH, different, twitch potentiation of skeletal mus- O’Callaghan, J. P. and Holtzman, S. G.: Prenatal cle by physostigmine at, 439 administration of morphine to the nat: Toler- Pheniprazine, effect on reserpine-induced ponto- ance to the analgesic effect of morphine in the geniculo-occipital wave activity in cat, 556 offspring, 533 Phenylbutazone, elimination and distribution, in rats Ogletree, M. L. and Lefer, A. M.: Influence of during adjuvant-induced arthritis, 470 nonsteroidal anti-inflammatory agents on myo- Phenylethanolamine N-methyltransferase, adrenal, cardial ischemia in the cat, 582 studies with SK&F 64139, selective inhibitor of, Oral contraceptives, administration in rats, effect on 623 beta adrenergic responsiveness, 362 Pheochromocytoma, transplantable, rat, biochemical Ouabain characterization and catecholamine secretion, effect of age on cardiotoxic action of, 10 615 effect on guinea-pig and rat cardiac Na,K-adeno- Phosphaturic responses, hormonal, selective lithium sine triphosphatase and contractile force, 458 inhibition of, 206 Oudea, P., see Laperche, Y., 235 Pigmentation of iris and atropine mydriasis, 79 Oxamniquine, long-term hepatocellular effects in Pippenger, C. E., see Rosen, M. R, 594 mice infected with Schistosoma mansoni, 703 Platelets, aggregation and secretion, local anesthetic Oxygenation, tissue, impaired, in cyanate-treated inhibition of, 215 animals, 229 Plasma drug concentration in dog, correlation of electrophysiological and antiarrhythmic proper- Pagala, M. K. D. and Sandow, A.: Twitch potentia- ties of N-acetylprocainamide with, 38 tion of skeletal muscle by physostigmine at Pollack, E. W., see Grund, V. R., 662 different pH, 439 Polsky-Cynkin, R., Hong, S-C. and Levine, L.: The Panathyroid hormone, phosphatunic response, selec- effects of hydroquinone, hematin and heme-con- tive lithium inhibition of, 206 taming proteins on prostaglandin biosynthesis by Pargyline, effect on blood acetaldehyde levels in methylcholanthrene-transformed mouse BALB/ ethanol-intoxicated mice, 332 3T3 fibroblasts, 567 Patil, P. N., see Salazar, M., 79 Ponto-geniculo-occipital wave activity, reserpine- Patrick, R. L. and Barchas, J. D.: Dopamine synthe- induced, in cat, monoamine oxidase inhibition sis in rat brain striatal synaptosomes. I. Correla- and, 556 tions between veratridine-induced synthesis Positive inotropic activity of cholera enterotoxin on stimulation and endogenous dopamine release, 89 embyronic chick heart, 27 Patrick, R. L. and Barchas, J. D.: Dopamine synthe- Potassium sis in rat brain striatal synaptosomes. II. Dibuty- conductance, membrane, aminopyridines and spar- ryl cyclic adenosine 3’:S’-monophosphonic acid teine as inhibitors of, 414 and 6-methyltetrahydropterine-induced synthe- exchange in cultured cells, effect of quinidine, 605 sis increases without an increase in endogenous -induced contractions in rabbit aorta, influence of dopamine release, 97 mecamylamine, 57 Pendleton, R. G., Kaiser, C. and Gessner, G.: Studies ion, binding to choroid plexus peptide IIF, 402

on adrenal phenylethanolamine N - methyl- Pregnancy, rat, methadone during, effects on mater- transferase (PNMT) with SK&F 64139, a selec- nal and perinatal mortality and growth in tive inhibitor, 623 offspring, 171 Pentazocine Preuss, H. G., Byrne, D. and Shim, P. S.: Effect of ability to produce narcotic cue, 180 para-aminohippurate on renal glutamine me- test for antinociceptive activity in guinea pig, 311 tabolism in the rat, 199 Pentobarbital, tolerance to, assessed by pellet Preutt, J. K., see Bagwell, E. E., 38 implantation, 479 Procaine, suppression of ionic conductances in squid Peptide hF, choroid plexus, cation-binding property, axon membranes by, effects of calcium, 426 402 Propranolol-quinidine combinations in dog heart, Perlman, R. L., see Chalfie, M., 615 ventricular electrophysiology, 452 754 INDEX Vol. 197 n-Propyl alcohol, elimination by isolated perfused rat brain striatal synaptosomes, dibutyryl cyclic aden- liver, 669 osine 3’:S’-monophosphaturic acid- and 6- Prostaglandin(s) methyltetrahydropterine-induced dopamine syn- A1, E1, F,0 and E2, noncovalent binding by human thesis increases without increase in endogenous and bovine serum albumins, 391 doparnine release in, 97 -albumin interaction, 391 brain tissue, comparative actions of monomethox- biosynthesis by methylcholine-transformed mouse yamphetarnines on release and uptake of biogenic BALB/3T3 fibroblasts, effects of hydroquinone, amines in, 263 hematin and heme-containing proteins, 567 central serotonergic effects of monornethoxyam- -inhibiting, nonsteroidal anti-inflammatory drugs, phetamines in, 272 influence on myocardial ischemia in cat, 582 cyanate-treated, impaired tissue oxygenation in, Protease, neutral, activity after cobalt treatment in 229 rat, erythropoietin production and, 714 effect of fatty acids on disposition of ammonia in, Purkinje fibers, normal and depressed, dog, effects of 675 therapeutic concentrations of diphenylhydantoin effect on intermittent and repeated administration on transmembrane potentials of, 594 of d-amphetamine on restricted water intake in, Putney, J. W., Jr., see Allen, M. A., 408 303 effect of methadone during pregnancy on maternal Quinidine and perinatal mortality and growth in offspring, effect on cation exchange in cultured cells, 605 171 -propranolol combinations in dog heart, ventricular effect of monovalent cations and ouabain on cardiac electrophysiology, 452 Na ,K -adenosine triphosphatase and contract- ile force, 458 Rabbit(s) effect of neuroleptic agents on interrelationship aorta, alpha adrenergic receptors, dissociation con- between catecholamine-stimulated formation of stants and relative efficacies of agonists acting adenosine 3’,S’ -monophosphate in cenebellar on, 66 slices and inhibitory effects on cerebellar Pun- aorta, isolated influence of mecamylamine on con- kinje cells, 280 tactions induced by agonists and role of calcium effect of prenatal administration of morphine on ions in, 57 tolerance to analgesic effect of in offspring, 533 aorta, tachyphylaxis to angiotensin in 575 effect of sulfobromophthalein-induced inhibition of atria, effect of ASI-222 (new 4-aminosugar cardiac mitochondnial translocation of anions and ade- glycoside) on, 19 nine nucleotides upon liver adenosine tniphos- cerebral artery adrenergic receptors, characteriza- phate and possible correlation with inhibition of tion in vitro, 371 bile flow, 235 effect of age on cardiotoxic acion of digitalis in, 10 immunopharmacologic properties of Wy-16,922, iris pigmentation and atropine mydriasis in, 79 new orally effective antiallergic agent in, 725 production and characterization of antibodies reac- isolated brain tissue, release of biogenic amines tive with mepenidine in, 734 from, as function of meta substituent of N- Radioimmunoassay for meperidine using antibodies, ethylamphetamines, 253 734 isolated perfused liver, elimination of ethyl, n-pro- Rat(s) pyl, n-butyl and iso-amyl alcohols by, 669 ability of narcotic antagonists to produce narcotic liver microsomes, reductive glycosidase in, 681 cue in, 180 neutral protease activity and enythropoietin pro- adjuvant arthritic, effect of SK&F D-39162, poten- duction after cobalt treatment in, 714 tial chrysotherapeutic agent in, 142 renal glutamine metabolsim, effect of pam- adrenal medulla and central nervous system, effects aminohippurate on, 199 of prenatal reserpine on development of, 293 selective inhibition of hormonal phosphatunic ne- arterial smooth muscle, differential effects of sponses in, 206 ethanol and mannitol on contraction of, 352 studies on adrenal phenylethanolamine N-methyl- brain, developing, effects of 6-hydroxydopa on nor- transferase with SK&F 64139, selective inhibitor, adrenergic neurons in, 105 in, 623 brain and peripheral metabolism of 5-hydroxytryp- submaxillary gland, transport in vitro of diphenyl- tophan-’4C following peripheral decarboxylase hydantoin in, 408 inhibition in, 545 tolerance and limited cross-tolerance to effects of brain striatal synaptosomes, correlations between N,N-dimethyltryptamine and lysergic acid die- veratridine-induced dopamine synthesis stimula- thylamide-25 on food-rewarded bar pressing in, tion and endogenous dopamine release in, 89 495 1976 INDEX 755

transplantable pheochromocytoma, biochemical Myxicola giant axons and the lobster neuromus- characterization and catecholamine secretion, cular junction, 414 615 Schistosoma mansoni, mice infected with, long-term treated with estrogenic agents, reduced beta adre- hepatocellular effects of hycanthone, IA-4 and nergic responsiveness in, 362 oxamniquine in, 703 uterus and stomach strip, tachyphylaxis to angi- Schwartz, M. A., see Cohen, M. R, 697 otensin in, 575 Sedatives, human self-administration, effects of with unilateral nigral lesions, circling behavior after interingestion interval and dose, 488 narcotic drugs and during naloxone-precipitated Seiden, L. S., see MacPhail, R. C., 303 abstinence in, 503 Seidler, F. J., see Bartolom#{233}, J., 293 Reidenbeng, M. M., see Bagwell, E. E., 38 Sellstedt, J., see Rosenthale, M. E., 725 Reserpine Serotonergic effects, central, of monomethoxyam- -induced ponto-geniculo-occipital wave activity in phetamines, 272 cat, monoamine oxidase inhibition and, 556 Serotonin, vascular tone and reactivity to, in internal prenatal, effects on development of rat adrenal and external carotid vascular beds of dog, 4 medulla and central nervous system, 293 Shah, H. C. and McLachlan, J. A.: The fate of Respiratory effects of marijuana in man, tolerance to, diethylstilbestrol in the pregnant mouse, 687 326 Shideman, F. E., see Hedtke, J. L., 27 Roberts, J., see Kelliher, G. J., 10 Shim, P. 5., see Preuss, H. G., 199 Robinson, C. P. and Sastry, B. V. R.: The influence of Shimada, K., see Salazar, M., 79 macamylamine on contractions induced by dif- Shinnick-Gallagher, P. and Jacobs, R. S.: An analysis ferent agonists and on the role of calcium ions in of the subsynaptic site of action of theophylline the isolated rabbit aorta, 57 on isolated cat tenuissimus muscle, 647 Rosen, M. R., Danilo, P., Jr., Alonso, M. B. and SK&F D-39162, potential chrysothetapeutic agent, Pippenger, C. E. : Effects of therapeutic concen- antiarthritic properties and pharmacologic pro- trations of diphenylhydantoin on transmembrane file, 142 potentials of normal and depressed Purkinje SK&F 64139, selective inhibitor of phenylethanol- fibers, 594 amine N-methyltransferase, 623 Rosen, T. S., see Hutchings, D. E., 171 Skin, frog, effects of ethanol on permeability of, 340 Rosenthale, M. E., Begany, A. J., Dervinis, A., Skolnick, P., Daly, J. W., Freedman, R. and Hoffer, Sellstedt, J., Guinosso, C. and Gluckman, M. I.: B. J.: Interrelationship between catecholamine- Immunopharmacologic properties of WY-16,922, stimulated formation of adenosine 3’ ,5’ -mono- a new orally effective antiallergic agent, 725 phosphate in cerebellar slices and inhibitory Rothberg, R M., see Wainer, B. H., 734 effects on cerebellar Purkinje cells: Antagonism Rubidium, effect on guinea pig and rat cardiac by neuroleptic compounds, 280

Na ,K -adenosine triphosphatase and contract - Slotkin, T. A., see Bartolom#{233}, J., 293 ile force, 458 Smith, C. M., see Lathers, C. M., 126 Rudman, D. and Chawla, R. K.: Cation-binding Smith, R. J. and Fisher, J. W.: Neutral protease property of choroid plexus peptide IIF, 402 activity and erythropoietin production in the rat Rutledge, C. 0., see Tessel, R. E., 253 after cobalt administration, 714 Ryan, J., see Cohen, M. R, 697 Sodium exchange in cultured cells, effect of quinidine, 605 Salazar, M., Shimada, K. and Patil, P. N.: Iris ion, binding to choroid plexus peptide IIF, 402 pigmentation and atropine mydriasis, 79 Sodium pentobarbital Saliva, rat, transport of diphenylhydantoin into, 408 effects on acetylcholine in mouse brain, 245 Sampson, S. R., Aminoff, M. J., Jaffe, R. A. and human self-administration, effects of interingestion Vidruk, E. H.: A pharmacological analysis of interval and dose, 488 neurally induced inhibition of carotid body Sparteine, as inhibitor of membrane potassium con- chemoreceptor activity in cats, 119 ductance, 414 Sandow, A., see Pagala, M. K. D., 439 Spasmogens, interactions with local anesthetics on Sastry, B. V. R., see Robinson, C. P., 57 guinea-pig ileum, 633 Sawynok, J. and Jhamandas, K. H.: Inhibition of Spinal reflexes, effects of ethanol, 126 acetylcholine release from cholinergic nerves by Squid adenosine, adenine nucleotides and morphine: axon membranes, actions of trihexyphenidyl and Antagonism by theophylline, 379 benztropine on, 135 Schauf, C. L., Colton, C. A., Colton, J. S. and Davis, axon membranes, effects of calcium on local anes- F. A.: Aminopyridines and sparteine as inhibitors thetic suppression of ionic conductances in, 426 of membrane potassium conductance: Effects on Stancer, H. C., see Warsh, J. J., 545 756 INDEX Vol. 197

Stavinoha, W. B., see Modak, A. T., 245 as function of meta substituent of N-ethylam- Steele, T. H.: Selective lithium inhibition of hormo- phetarnines, 253 nal phosphaturic responses, 206 oxygenation, impanied, in cyanate-treated animals, Stomach, strip, rat, tachyphylaxis to angiotensin in, 229 575 Toad, urinary bladder epithelium, effects of ethanol Substance P on permeability of, 188 interactions with local anesthetics on guinea-pig Tobin, T., see Ku, D. D., 458 ileum, 633 Tolerance response of isolated guinea-pig ileum to, effects of limited cross-tolerance and, to effects of N,N-dime- metoclopramide, 641 thyltryptamine and lysergic acid diethyla- Sulfobromophthalein-induced inhibition of mito- mide-25 on food-rewarded ban pressing in rat, 495 chondrial translocation of anions and adenine to analgesic effect of morphine in offspring of rats nucleotides in rat, effects upon liver adenosine given morphine prenatally, 533 triphosphate and possible correlation with inhibi- to pentobarbital, assessment by pellet implanta- tion of bile flow, 235 tion, 479 Sutton, B. M., see Walz, D. T., 142 to respiratory effects of marijuana in man, 326 Sympathetic nervous system (see Nervous system, Towey, J. P., see Hutchings, D. E., 171 sympathetic) Transmitter release, at frog neuromuscular junctions Synaptosomes treated with guanidine or tetraethylammonium, rat brain striatal, correlations between veratridine- statistical parameters, 653 induced dopamine synthesis stimulation and en- Tnihexyphenidyl, actions on squid axon membranes, dogenous dopamine release in, 89 135

rat brain striatal, dibutyryl cyclic adenosine 3’ :5 - Tseng, L.-F., Menon, M. K. and Loh, H. H.: Corn- monophosphaturic acid- and 6-methyltetrahy- parative actions of monomethoxyamphetamines dropterine-induced dopamine synthesis increases on the release and uptake of biogenic amines in without increase in endogenous dopamine release brain tissue, 263 in, 97 Tseng, L.-F., see Menon, M. K., 272

Tachyphylaxis, to angiotensin, 575 Urinary bladder (see Bladder, urinary) Takeno, K., see Narahashi, T., 426 Uterus, rat, tachyphylaxis to angiotensin in, 575 Teiger, D. G.: A test for antinociceptive activity of narcotic and narcotic antagonist analgesics in the Vasopressin, phosphatunic response, selective lithium guinea pig, 311 inhibition of, 206 Tessel, R. E. and Rutledge, C. 0.: Specificity of Veratnidine-induced doparnine synthesis stimulation release of biogenic amines from isolated rat brain in rat brain synaptosomes, correlations with en- tissue as a function of the meta substituent of dogenous dopamine release, 89 N-ethylamphetamine derivatives, 253 Vergona, R., see Cohen, M. R, 697 Tetracaine, inhibition of platelet aggregation and Vidrio, H. and Hong, E.: Vascular tone and reactivity secretion by, 215 to serotonin in the internal and external carotid Thallium, effect on guinea pig and rat cardiac vascular beds of the dog, 49

Na ,K -adenosine triphosphatase and contract - Vidruk, E. H., see Sampson, S. R., 119 ile force, 458 Volle, R. L. and Branisteanu, D. D.: Statistical Theophylline parameters of transmitter release at frog neuro- antagonism of inhibition of acetylcholine release muscular junctions treated with guanidine or from cholinergic nerves by adenosine, adenine tetraethylammonium, 653 nucleotides and morphine by, 379 subsynaptic site of action on isolated cat tenuis- Wainer, B. H., Wung, W. E., Hill, J. H., Fitch, F. W., simus muscle, 647 Fried, J. and Rothberg, R. M.: The production Thompson, J. A., see Martin, W. R, 517 and characterization of antibodies reactive with Thrasher, T. N., see Black, D. J., 362 mepenidine, 734 Tissue Walle, T., see Bagwell, E. E., 38 brain, comparative actions of monomethoxy- Walz, D. T., DiMartino, M. J., Chakrin, L. W., amphetamines on release and uptake of biogenic Sutton, B. M. and Misher, A.: Antiarthnitic amines in, 263 properties and unique pharmacologic profile of a drug concentration in dog, correlation of electro- potential chrysotherapeutic agent: SK&F physiological and antiarrhythmic properties of D-39162, 142 N-acetylprocainamide with, 38 Warsh, J. J. and Stancer, H. C.: Brain and peripheral isolated rat brain, release of biogenic amines from, metabolism of 5-hydnoxytryptophan- ‘4C follow- 1976 INDEX 757

ing peripheral decarboxylase inhibition, 545 branes, 135 Water, restricted intake in rats, effects of intermittent Wung, W. E., see Wainer, B. H., 734 and repeated admininstration of d-amphetamine Wy-16,922, new orally effective antiallergic agent, on, 303 immunopharmacologic properties, 725 Way, E. L. see Brase, D. A., 317 Yonio, T. and Bentley, P. J.: Effects of ethanol on the see Iwamoto, E. T., 503 permeability of frog skin, 340 Weaver, L. C., Akera, T. and Brody, T. M.: Digoxin Yonio, T. and Bentley, P. J.: Effects of ethanol on the toxicity: Primary sites of drug action on the permeability of toad urinary bladder epithelium, sympathetic nervous system, 1 188 Weintraub, S. T., see Modak, A. T., 245 Wrenn, J. M., see Allen, M. A., 408 Zieve, L., see Derr, R F., 675 Wu, C. H. and Narahashi, T.: Actions of trihexy- Zolertine, influence on response of internal and exter- phenidyl and benztropine on squid axon mem- nal carotids to serotonin in dog, 49