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Pramiracetam PRAMIRACETAM Pramiracetam is a wonderful mind boosting drug which has been found to enhance memory, sharpen intelligence and boost mental energy for an overall energetic performance and vibrant mood. Belonging to the racetam class, this nootropic medicine is much more powerful and potent than its predecessor piracetam not only in improving memory but in increasing cognition and attention as well. DDEESSCCRRIIIPPTTIIIOONN Unlike other racetams, pramiracetam does White crystalline powder not seem to affect other neurotransmitter systems (GABA, serotonin, glutamate, etc.). It should be noted that although it is CCHHEEMMIIICCAALL DDAATTAA considered more potent, pramiracetam CAS No.: 68497-62-1 does not penetrate the blood-brain-barrier Formula: C14H27N3O2 as well as related compounds. This may be Molecular Weight: 269.383 a reason that clinical trials have been Structural formula: inconsistent; while some have shown marked benefits in certain disease states, others have not. Alzheimer’s disease is marked by degeneration of cholinergic pathways deep in the brain. Because pramiracetam affects this neurotransmitter system, researchers were optimistic about the possible effects of this compound on WWHHAATT IIISS IIITT?? early to mid-stage Alzheimer’s patients, but (2-(2-oxopyrrolidin-1-yl)-N-[2-(diisopropyla results were disappointing. It is possible mino)ethyl]acetamid) is another nootropic that pramiracetam is more effective in that is derived from piracetam, but is intact systems, but has little benefit once roughly 10 times more potent. considerable degeneration has taken place. HHOOWW DDOOEESS IIITT WWOORRKK?? BBEENNEEFFIIITTSS Pramiracetam is unique among the Like the other racetam compounds, racetams in that it has been shown to pramiracetam has been demonstrated to increases nitric oxide synthase activity. This positively affect cognition. It has been small molecular is a vasodilator, meaning demonstrated to enhance learning and that it enhances blood flow, which provides memory in animals; a 30-mg/kg dose more energy to neurons in the form of enhanced rats’ ability to remember objects oxygen and glucose. The net effect is that had been previously introduced into increased brain function. It also affects the their cage. For comparison, a 400-mg/kg cholinergic system by increasing neuronal dose of piracetam was necessary to elicit choline uptake and acetycholine release. the same effect. Similar results have been 1 shown in humans. A 10-month long study enhances their effects. in men with brain injuries revealed that 400 mg per day yielded cognitive improvements in just 1 month. DDOOSSAAGGEE Pramiracetam is fat-soluble and 15 mg/kg Studies in healthy volunteers showed that a of body weight is the typical recommended dose (this equates to ~400-1600 mg per 10-day pretreatment with pramiracetam day). Some pill formulations come in 600 prevented mild memory deficits that were mg doses, which are often taken twice a induced with a drug called scopolamine, day. However, the dose-response curve for which acts on the acetylcholine system. pramiracetam is an “inverted U-shaped curve”, meaning that if your ideal dose is Anecdotally, users report that exceeded you might no experience any pramiracetam enhance goal-directed and difference, or you might feel lethargic or purposeful behavior, as well as better unfocused. For some people, 2×200 mg concentration and retention. doses are more than sufficient to feel the positive effects. Therefore, it is recommended that individuals start with SSIIIDDEE EEFFFFEECCTTSS the lowest recommended dose. Pramiracetam is typically well tolerated without side effects. Like other piracetam Pramiracetam enters systemic circulation derivatives, it is nontoxic even when taken fairly rapidly and reaches peak for long periods of time. However, sensitive concentration 2-3 hours after individuals may experience anxiety, administration. Its half-life is 4.5-6.5 hours. restlessness, insomnia, headache, nausea Like other racetams, combining or heartburn. Dosage can be adjusted to pramiracetam with acetylcholine precursors minimize these side effects. Patients with such as lecithin and choline can enhance kidney disorders should take pramiracetam the compound’s effects. Users should begin with caution and at low doses, as it can to see results 1-2 months after beginning a accumulate in the renal system. Individuals pramiracetam regimen. with prescriptions for amphetamines should be aware that pramiracetam is a strong amphetamine potentiator and Wuxi Cima Science Co.,Ltd Tel: (86-510)-8518 8225 Fax: (86-510)-8518 5685 E-mail: [email protected] [email protected] 2 .
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