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CD133 Expression in Placenta Chorioangioma Presenting As a Giant Asymptomatic Mass
medicina Case Report CD133 Expression in Placenta Chorioangioma Presenting as a Giant Asymptomatic Mass Gianluca Di Massa 1,†, Guglielmo Stabile 2,† , Federico Romano 2 , Andrea Balduit 3 , Alessandro Mangogna 2,* , Beatrice Belmonte 4 , Pina Canu 1, Emma Bertucci 5, Giuseppe Ricci 2,6,‡ and Tiziana Salviato 1,‡ 1 Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy; [email protected] (G.D.M.); [email protected] (P.C.); [email protected] (T.S.) 2 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell’Istria, 65/1, 34137 Trieste, Italy; [email protected] (G.S.); [email protected] (F.R.); [email protected] (G.R.) 3 Department of Life Sciences, University of Trieste, 34127 Trieste, Italy; [email protected] 4 Tumor Immunology Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90134 Palermo, Italy; [email protected] 5 Prenatal Medicine Unit, Obstetrics and Gynecology Unit, Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, 41125 Modena, Italy; [email protected] 6 Department of Medical, Surgical and Health Science, University of Trieste, 34129 Trieste, Italy * Correspondence: [email protected]; Tel.: +39-320-612-3370 † These authors contributed equally to this article. Citation: Di Massa, G.; Stabile, G.; ‡ These authors contributed equally to this article. Romano, F.; Balduit, A.; Mangogna, A.; Belmonte, B.; Canu, P.; Abstract: Background: Placental chorioangioma is the most common benign non-trophoblastic neo- Bertucci, E.; Ricci, G.; Salviato, T. -
Placenta 111 (2021) 33–46
Placenta 111 (2021) 33–46 Contents lists available at ScienceDirect Placenta journal homepage: www.elsevier.com/locate/placenta Review Placental pathology in cancer during pregnancy and after cancer treatment exposure Vera E.R.A. Wolters a, Christine A.R. Lok a, Sanne J. Gordijn b, Erica A. Wilthagen c, Neil J. Sebire d, T. Yee Khong e, J. Patrick van der Voorn f, Fred´ ´eric Amant a,g,* a Department of Gynecologic Oncology and Center for Gynecologic Oncology Amsterdam (CGOA), Netherlands Cancer Institute - Antoni van Leeuwenhoek and University Medical Centers Amsterdam, Plesmanlaan 121, 1066, CX Amsterdam, the Netherlands b Department of Gynaecology and Obstetrics, University of Groningen, University Medical Center Groningen, CB 20 Hanzeplein 1, 9713, GZ Groningen, the Netherlands c Scientific Information Service, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066, CX Amsterdam, the Netherlands d Department of Paediatric Pathology, NIHR Great Ormond Street Hospital BRC, London, WC1N 3JH, United Kingdom e SA Pathology, Women’s and Children’s Hospital, 72 King William Road, North Adelaide, SA5006, Australia f Department of Pathology, University Medical Centers Amsterdam, Location VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands g Department of Oncology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium ARTICLE INFO ABSTRACT Keywords: Cancer during pregnancy has been associated with (pathologically) small for gestational age offspring, especially Placenta after exposure to chemotherapy in utero. These infants are most likely growth restricted, but sonographic results Cancer are often lacking. In view of the paucity of data on underlying pathophysiological mechanisms, the objective was Pregnancy to summarize all studies investigating placental pathology related to cancer(treatment). -
Diagnostic and Prognostic Potential of Biomarkers CYFRA 21.1, ERCC1, P53, FGFR3 and TATI in Bladder Cancers
International Journal of Molecular Sciences Review Diagnostic and Prognostic Potential of Biomarkers CYFRA 21.1, ERCC1, p53, FGFR3 and TATI in Bladder Cancers Milena Matuszczak and Maciej Salagierski * Department of Urology, Collegium Medicum, University of Zielona Góra, 65-046 Zielona Góra, Poland; [email protected] * Correspondence: [email protected] Received: 16 April 2020; Accepted: 5 May 2020; Published: 9 May 2020 Abstract: The high occurrence of bladder cancer and its tendency to recur in combination with a lifelong surveillance make the treatment of superficial bladder cancer one of the most expensive and time-consuming. Moreover, carcinoma in situ often leads to muscle invasion with an unfavorable prognosis. Currently, invasive methods including cystoscopy and cytology remain a gold standard. The aim of this study was to explore urine-based biomarkers to find the one with the best specificity and sensitivity, which would allow optimizing the treatment plan. In this review, we sum up the current knowledge about Cytokeratin fragments (CYFRA 21.1), Excision Repair Cross-Complementation 1 (ERCC1), Tumour Protein p53 (Tp53), Fibroblast Growth Factor Receptor 3 (FGFR3), Tumor-Associated Trypsin Inhibitor (TATI) and their potential applications in clinical practice. Keywords: biomarkers; bladder cancer; tumor markers; prognosis 1. Introduction: Bladder Cancer Issues and Biomarkers Bladder cancer is the most common urinary site of malignancy and the second most common reason of cancer deaths from the genitourinary tract after prostate cancer in the United States, with 81,400 new cases and 17,980 deaths in the year 2020 [1]. Globally there are about 430,000 new cases diagnosed each year [2]. -
NMP22) As a Tumour Marker in Bladder Cancer Patients
NOWOTWORY Journal of Oncology • 2005 • volume 55 Number 4 • 300–302 Evaluation of the urinary nuclear matrix protein (NMP22) as a tumour marker in bladder cancer patients Maria Kowalska1, Janina Kamiƒska1, Beata Kotowicz1, Ma∏gorzata Fuksiewicz1, Alicja Rysiƒska1, Tomasz Demkow 2, Tomasz Kalinowski 2 Introduction. The aim of this study was to evaluate the clinical use of the urinary nuclear matrix protein 22 (NMP22) assessment in bladder cancer patients. Patients and methods. 98 patients with bladder cancer were examined. All tumours were verified histopathologically. Urine samples were collected before cystoscopy and assayed for NMP22 levels with Diagnostic Products Corporation tests. Urine samples of 15 healthy volunteers served as controls. For the statistical analysis the Mann-Whitney test was employed. Results. Urine NMP22 concentrations were significantly higher (p<0.0003) in patients with bladder cancer than in controls. No significant differences between the NMP22 concentrations in patients with complete remission and patients with recurrent disease were found. Conclusions. Urinary NMP22 is a potential marker for the diagnosis of bladder cancer, but not for the differentiation between disease-free patients and those with recurrent disease. Ocena przydatnoÊci oznaczania NMP22 w moczu jako markera nowotworowego u chorych na raka p´cherza Ws t ´ p. Celem pracy by∏o zbadanie, czy oznaczanie markera nowotworowego NMP22 mo˝e byç pomocne w monitorowa- niu chorych na raka p´cherza. Pacjenci i metody. Do badania zakwalifikowano 98 chorych z potwierdzonym histologicznie rakiem p´cherza. Próbki moczu pobierano przed cystoskopià. St´˝enie NMP22 w moczu oznaczano zestawami firmy DPC. W∏asne normy ustalono w oparciu o oznaczenia st´˝eƒ NMP22 w grupie 15 zdrowych osób. -
Liquid Biopsy Biomarkers in Urine: a Route Towards Molecular Diagnosis and Personalized Medicine of Bladder Cancer
Journal of Personalized Medicine Review Liquid Biopsy Biomarkers in Urine: A Route towards Molecular Diagnosis and Personalized Medicine of Bladder Cancer Matteo Ferro 1,† , Evelina La Civita 2,†, Antonietta Liotti 2, Michele Cennamo 2, Fabiana Tortora 3 , Carlo Buonerba 4,5, Felice Crocetto 6 , Giuseppe Lucarelli 7 , Gian Maria Busetto 8 , Francesco Del Giudice 9 , Ottavio de Cobelli 1,10, Giuseppe Carrieri 9, Angelo Porreca 11, Amelia Cimmino 12,* and Daniela Terracciano 2,* 1 Department of Urology of European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141 Milan, Italy; [email protected] (M.F.); [email protected] (O.d.C.) 2 Department of Translational Medical Sciences, University of Naples “Federico II”, 80131 Naples, Italy; [email protected] (E.L.C.); [email protected] (A.L.); [email protected] (M.C.) 3 Institute of Protein Biochemistry, National Research Council, 80131 Naples, Italy; [email protected] 4 CRTR Rare Tumors Reference Center, AOU Federico II, 80131 Naples, Italy; [email protected] 5 Environment & Health Operational Unit, Zoo-Prophylactic Institute of Southern Italy, 80055 Portici, Italy 6 Department of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy; [email protected] 7 Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, 70124 Bari, Italy; [email protected] 8 Department of Urology and Organ Transplantation, -
California Tumor Tissue Registry
" CALIFORNIA TUMOR TISSUE REGISTRY California Tumor Tissue Registry c/o: Departme.nt of Pathology and Human Anatomy Lorna Linda University Sebool of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350 (909) 824-4788 FAX: (909) 478-4188 CON"ntiDUTOR: WllllanoTalbert, M.D. CASE NO. 1 ·NOVEMBER 1995 Long Beach, CA TISSUE FROM: Sple<on ACCESSION #27748 CLINICAL ABSTRACT: This 77-year-old maJe. bad a 1-1!2 year history of a myelodysplastic syndrome, Ilea ted with blood transfusions for anemia. G.I. bleeding with tany stools and a hemoglobin of 5.21<d to admission about two weeks prior to his death. He became febrile. Blood and urine cullures were sterile. Renal failure developed. He became obtunded and died. He did not have a leukenlic peripheral blood picture. GROSS PATHO LOGV: Autopsy revealed a 1750 gram spleen with a splenic ''abscess•• which was partially ruptured and contained by surrounding tissue. CONTRIDUTOR: William Talbert, M.D. CASE NO. 2 • NOVE~ffiER 1995 Long Beach, CA TISSUE FROM: Lung ACCESSION 1127760 CLINl CAL ABSTRACT: This 23-year-old Asian female bad hemoptysis for two years. Chest film revealed a 1.0 em mass which grew to 4 em under observation. Iron deficiency anemia was diagnosed preoperatively, with a hemoglobin of 10.7 grams. Needle biopsy of the mass revealed tissue with the same diagnosis as that made on the resected specimen. A right upper lobe lobectomy was performed . GROSS PATROLOGV: The 120 gram lung was 12 x 7 x 3.5 em. A 3.5 em well-cireuonscribed nodule was near the bronchial margin. -
Appendix E: Authorization Guidelines for Laboratory, Ob/Gyn, and Radiology Services (Auto Pay List)
KAISER PERMANENTE OF OHIO APPENDIX E: AUTHORIZATION GUIDELINES FOR LABORATORY, OB/GYN, AND RADIOLOGY SERVICES (AUTO PAY LIST) Kaiser Permanente Provider Manual APPENDIX E Revised September 2012 1 KAISER PERMANENTE OF OHIO Appendix E: Authorization Guidelines for Laboratory, Ob/Gyn, and Radiology Services (Auto Pay List) The Laboratory, Ob/Gyn, and Radiology Services listed below may be performed without a Referral if ordered by a Kaiser Permanente Plan Physician and when performed at a Kaiser Permanente Plan Facility. However, the tests or procedures must be medically appropriate for the Member’s diagnosis and the Member must be eligible for coverage on the date of Service. Reimbursement for these Services will be made in accordance with the terms of the Agreement between Kaiser Permanente and the Plan Provider. Kaiser Permanente Provider Manual APPENDIX E Revised September 2012 2 KAISER PERMANENTE OF OHIO KAISER PERMANENTE AUTO PAY LIST HCPCS EFFECTIVE Code PROCEDURE DESCRIPTION DATE 00104 ANESTHESIA FOR ELECTROCONVULSIVE THERAPY 1/1/2007 SUBCUTANEOUS HORMONE PELLET IMPLANTATION (IMPLANTATION OF ESTRADIOL AND/OR TESTOSTERONE PELLETS BENEATH THE 11980 SKIN) 1/1/2005 SIMPLE REPAIR OF SUPERFICIAL WOUNDS OF SCALP, NECK, AXILLAE, EXTERNAL GENITALIA, TRUNK AND/OR EXTREMITIES (INCLUDING 12001 HANDS AND FEE 1/1/2005 LAYER CLOSURE OF WOUNDS OF SCALP, AXILLAE, TRUNK AND/OR 12031 EXTREMITIES (EXCLUDING HANDS AND FEET); 2.5 CM OR LESS 1/1/2005 LAYER CLOSURE OF WOUNDS OF FACE, EARS, EYELIDS, NOSE, LIPS 12051 AND/OR MUCOUS MEMBRANES; 2. -
Gynecologic and Obstetric Pathology (1127-1316)
VOLUME 31 | SUPPLEMENT 2 | MARCH 2018 MODERN PATHOLOGY 2018 ABSTRACTS GYNECOLOGIC AND OBSTETRIC PATHOLOGY (1127-1316) 107TH ANNUAL MEETING GEARED TO LEARN Vancouver Convention Centre MARCH 17-23, 2018 Vancouver, BC, Canada PLATFORM & 2018 ABSTRACTS POSTER PRESENTATIONS EDUCATION COMMITTEE Jason L. Hornick, Chair Amy Chadburn Rhonda Yantiss, Chair, Abstract Review Board Ashley M. Cimino-Mathews and Assignment Committee James R. Cook Laura W. Lamps, Chair, CME Subcommittee Carol F. Farver Steven D. Billings, Chair, Interactive Microscopy Meera R. Hameed Shree G. Sharma, Chair, Informatics Subcommittee Michelle S. Hirsch Raja R. Seethala, Short Course Coordinator Anna Marie Mulligan Ilan Weinreb, Chair, Subcommittee for Rish Pai Unique Live Course Offerings Vinita Parkash David B. Kaminsky, Executive Vice President Anil Parwani (Ex-Officio) Deepa Patil Aleodor (Doru) Andea Lakshmi Priya Kunju Zubair Baloch John D. Reith Olca Basturk Raja R. Seethala Gregory R. Bean, Pathologist-in-Training Kwun Wah Wen, Pathologist-in-Training Daniel J. Brat ABSTRACT REVIEW BOARD Narasimhan Agaram Mamta Gupta David Meredith Souzan Sanati Christina Arnold Omar Habeeb Dylan Miller Sandro Santagata Dan Berney Marc Halushka Roberto Miranda Anjali Saqi Ritu Bhalla Krisztina Hanley Elizabeth Morgan Frank Schneider Parul Bhargava Douglas Hartman Juan-Miguel Mosquera Michael Seidman Justin Bishop Yael Heher Atis Muehlenbachs Shree Sharma Jennifer Black Walter Henricks Raouf Nakhleh Jeanne Shen Thomas Brenn John Higgins Ericka Olgaard Steven Shen Fadi Brimo Jason -
Department of Obstetrics, Gynecology, and Reproductive Sciences
University of Pittsburgh School of Medicine DEPARTMENT OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE SCIENCES ANNUAL REPORT – ACADEMIC YEAR 2019 Tatomir, Shannon DEPARTMENT OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE SCIENCES UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE ANNUAL REPORT Academic Year 2019 July 1, 2018 – June 30, 2019 300 Halket Street Pittsburgh, PA 15213 412.641.4212 1 TABLE OF CONTENTS YEAR IN REVIEW MISSION STATEMENT ..................................................................................................................... 3 CHAIR’S ADDRESS ........................................................................................................................... 4 RECRUITMENTS ............................................................................................................................... 6 DEPARTURES ................................................................................................................................... 7 DEPARTMENT PROFESSIONAL MEMBERS ………………………………………………………………………………...8 DIVISION SUMMARIES OF RESEARCH, TEACHING AND CLINICAL PROGRAMS DIVISION OF GYNECOLOGIC SPECIALTIES .................................................................................... 11 DIVISION OF GYNECOLOGIC ONCOLOGY ..................................................................................... 24 DIVISION OF MATERNAL FETAL MEDICINE .................................................................................. 34 DIVISION OF REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY ........................................... -
Biomarkers for Early Detection of Cancer: a Systematic Review Towards the Identification of True Cancer Biomarkers for Early Detection
Biomarkers for Early Detection of Cancer: A Systematic Review Towards the identification of true cancer biomarkers for early detection Louis-Philippe Fermon Student number: 01304166 Promotor: Prof. Inge Huybrechts Copromotor: Prof. Dr. Veronique Cocquyt A dissertation submitted to Ghent University in partial fulfilment of the requirements for the degree of Master of Medicine in Medicine. Academic year: 2017 – 2018 2 | P a g e Deze pagina is niet beschikbaar omdat ze persoonsgegevens bevat. Universiteitsbibliotheek Gent, 2021. This page is not available because it contains personal information. Ghent Universit , Librar , 2021. 4 | P a g e VOORWOORD “Sic parvis magna” “Greatness from small beginnings” After two years of intensive labour, I’m happy to finally present this dissertation. I would not have been able to do this without the help of my family, friends and of course, my promotor Prof. Dr. Inge Huybrechts. She was always eager to lend support, especially during though moments, and was available when I had any questions or needed any help. Furthermore, I would like to thank a few special people that aided me throughout this process. Firstly, my parents, without whom I would not have been able to bring it home. Secondly, I would like to thank my girlfriend Kimberley and all- time best friend Thomas, who’s advice and support were deeply appreciated. Lastly, I won’t forget all others who were there when I needed them the most. Thank you. 5 | P a g e 6 | P a g e Contents Abstract ........................................................................................................................................ 1 Abstract ........................................................................................................................................ 3 1. Introduction ............................................................................................................................... 4 1.1 Cancer as major health issue.............................................................................................. -
1 Tumor Markers Currently Utilized in Cancer Care Gaetano
Tumor markers currently utilized in cancer care Gaetano Romano (gromano at temple dot edu) Department of Biology, College of Science and Technology, Temple University, Bio-Life Science Bldg. Suite 456, 1900 N 12th Street, Philadelphia, PA 19122, U.S.A. DOI http://dx.doi.org/10.13070/mm.en.5.1456 Date last modified : 2015-10-02; original version : 2015-09-25 Cite as MATER METHODS 2015;5:1456 Abstract A review of tumor markers that are currently used in cancer care. Introduction Tumor markers are products that may derive from malignant cells and/or other cells of the organism in response to the onset of cancer [1-5]. Their production may also be induced by noncancerous benign tumors [1-5]. Some tumor markers can be detected in malignant tissues obtained from biopsies [6-19], whereas others can be analyzed in the blood, bone marrow, urine, or other body fluids [20-25]. Sometimes, tumor markers may also be observed in cancer-free subjects, but in much lower doses than oncological patients. In addition, relatively high levels of a certain tumor marker might develop from various non-malignant pathological conditions, such as liver diseases, inflammations, kidney-related dysfunctions, infections and hematological disorders. On these grounds, high levels of a certain tumor marker in the blood, or in other body fluids might indicate the presence of a malignancy. However, per se, this finding is not sufficient to substantiate the diagnosis of a cancer. For this reason, the analysis of tumor markers in the blood, or other fluids must be combined with the analysis of biopsies, or other tests in order to confirm the diagnosis. -
Review of Non-Invasive Urinary Biomarkers in Bladder Cancer
6564 Review Articles on Urothelial Carcinoma Review of non-invasive urinary biomarkers in bladder cancer Hyung-Ho Lee, Sung Han Kim Department of Urology, Urological Cancer Center, Research Institute and Hospital of National Cancer Center, Goyang, Korea Contributions: (I) Conception and design: SH Kim; (II) Administrative support: SH Kim; (III) Provision of study materials or patients: SH Kim; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Sung Han Kim. Department of Urology, Urological Cancer Center, Research Institute and Hospital of National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si Gyeonggi-do 10408, Korea. Email: [email protected]. Abstract: Bladder cancer (BC) is the sixth-most prevalent cancer. The standard diagnostic tool of BC is cystoscopy, whereas cystoscopy has several disadvantages in terms of symptomatic invasiveness and operator- dependency. The urinary markers are attractive because the testing is non-invasive and cost-efficient, and sample collection is easy. Urinary marker is thereby a good tool to detect exfoliated tumor cell in the urine samples for the diagnosis and therapeutic surveillance of BC to supplement the limitations of the cystoscopy. However, they are not recommended as a population-based screening tool because of the low rate of BC prevalence. Although both cystoscopy and urine cytology improve BC diagnostic power, the field still needs additional non-invasive, cost-effective, and highly sensitive and specific diagnostic tools. Various urinary markers with different mechanisms and different targets have been developed and under investigation in these days.