"

CALIFORNIA TUMOR TISSUE REGISTRY

California Tumor Tissue Registry c/o: Departme.nt of Pathology and Human Anatomy Lorna Linda University Sebool of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350 (909) 824-4788 FAX: (909) 478-4188 CON"ntiDUTOR: WllllanoTalbert, M.D. CASE NO. 1 ·NOVEMBER 1995 Long Beach, CA

TISSUE FROM: Sple

CLINICAL ABSTRACT:

This 77-year-old maJe. bad a 1-1!2 year history of a myelodysplastic syndrome, Ilea ted with blood transfusions for anemia. G.I. bleeding with tany stools and a hemoglobin of 5.21

GROSS PATHO LOGV:

Autopsy revealed a 1750 gram spleen with a splenic ''abscess•• which was partially ruptured and contained by surrounding tissue.

CONTRIDUTOR: William Talbert, M.D. CASE NO. 2 • NOVE~ffiER 1995 Long Beach, CA

TISSUE FROM: Lung ACCESSION 1127760

CLINl CAL ABSTRACT:

This 23-year-old Asian female bad hemoptysis for two years. Chest film revealed a 1.0 em mass which grew to 4 em under observation. Iron deficiency anemia was diagnosed preoperatively, with a hemoglobin of 10.7 grams. Needle biopsy of the mass revealed tissue with the same diagnosis as that made on the resected specimen. A right upper lobe lobectomy was performed .

GROSS PATROLOGV:

The 120 gram lung was 12 x 7 x 3.5 em. A 3.5 em well-cireuonscribed nodule was near the bronchial margin. Other areas of the lung parenchyma appeared unremarkable. TI1e cut surface of tbe nodule was smooth, red-brown, and bloody.

ClTR. November. t995 ..

CONTRIDIITOR: Craig Zuppao, M.D. CASENO.J-NOVEMrnERl~S Loma linda, CA

TISSUE FROM: Ovary ACCESSION #27778

CLINICAL ABSTRACT:

During work-up for a myeloproliferative syndrome, this 66-year-old Caucasian female, gravida 6, para 2, ab 4, bed incidental fi ndings of a 6 em solid mass left ovarian on aCT scan. A CA-125 was 10. The chest x-ray was consistent with COPD and no metastasis. A pap smear was within nonnal limits 1 1/2 years ago. The patient has had a TAH 20 years ago for benign problems. A bilateral salpingo· oophorectomy was performed.

GROSS PATHOLOGY:

An 8.5 x S x S em firm nodular light un mass was adjacent to a 2.5 x 1.5 x 1.0 em light tan lobulated ovary. The mass bad a nodular yellow surface with interspersed white to light tan fibrous streaks.

CONTRI BUTOR: J ozefKollin, M.D. CASE NO. 4 ·NOVEMBER 1995 Lukfwood, CA

TISSUE FROM: Endometrial polyp ACCESSION #27781

CLINICAL ABSTRACT:

This 40-year-old, G3, P2. Abl, caucasian female pJeSented with a 1·2 year history of heavy uterine bleeding. including the occasional passage of large blood clots. Physical examination showed a large pedunculated polyp apparently arising from the intrauterine cavity protruding from the cervix. The outline of the uterus was unable to be palpated due to the patient's obesity. A transvaginal intracavitary Jciomyomectomy and diagnostic dilatation and curellage were performed.

GROSS I'ATHOLOGY:

A grayish-white, whorled nodule was 3 x 2.7 x 2.6 em. On doss sectioning, it was again wborled and gr3yish·tan. No hemorrhage or necrosis was grossly idcnlified.

CTill. NoV

TISSUE FROM: ACCESSION #27783

CLTNICAL ABSTRACT:

This 38-year-old female underwent a vaginal delivery at38-weeks. The infant was live-bo.rn with APGAR scores of8 and 9. The molber's past medical history included a spontaneous abortion three years ago.

GROSS PATHOLOGY:

The 660 gram oval placenta was 23.Q x 16.5 x 2 em. A 7.0 x 6.4 x 3.5 em firm, multinodular mass was present at one edge of the placental disc, 2.5 em from the insertion of the umbilical cord. The fetal surface of this mass was blue-tan and glistening and was covered by the membranes. The maternal surface of this mass bad the appearance of the usual cotyledons. Cut sectiorung through the mass revealed deep red to black tissues with variegated areas of gray:tan. The mass was not sha!ply defined from the adjacent more normal appearing placenta.

CONTRIBUTOR: Steve Kargas, M.D. CASE NO. 6 • NOVEIIiBER 1.995 Los Angeles, CA

TISSUE FROM: Len chest wnU mass ACCESSION IIZ718S

CLINICAL ABSTRACT:

This 3 1 year-old non-smoking woman was found to have a le(l chest mas-s on a routine x-ray. The mass was removed from the chest wall through a left thoracotomy.

GROSS PATHOLOGY:

The 4.5 x 3.9 x 1.7 em ma.ss weighed !6.6 grams. The external surface was covered by a 0.2 to 0.4 em thick pink-white capsule. The cut surface of the mass was variegated with white areas of sclerosis, tan· yellow areas, focal areas of hemorrhage, and gelatinous foci.

SPECIAL STAINS:

S-100: positive

CTIR. November, t995 CONTRIBUTOR: Steve Kargas, M.D. CASE NO. 7- NOVEMBER 1995 Los Angeles, CA

TISSUE FROM: Colontrenuinal Deum ACCESSION 1127782

CLINICAL ABSTRACT:

This 37-year-old Caucasian female bad a 3 1/2 year history of intract<~ble constipation. Approximately one year ago sbe underwent a sigmoid colectomy for redundant sigmo.id colon and a rectopexy for recbl prolapse. In spite of these, sbe rell!Jiined constipated. A detailed workup included small bowel transit study via barium swallow, hydrogen breath testing wbicb normalized after treatment with antibiotics for bacterial overgrowth, colonic transit, nuclear motility studies and anorectal manometry. A subtotal colectomy was perfonned.

GROSS PATHOLOGY:

The specimen consisted of a 53 em long portion of colon with an attached 2.0 em long portion of sll!JIII bowel. The colon bad a diameter nnging from S.S em near the cecal pouch to an average of 4.0 em throughout. The mucosa was velvety, gray-jNrple with the usual folds. Discrete lesions were not identified.

CONTRIBUTOR: Samuel Yoshida, M.D. CASE NO. 8 • NOVEMBER 1995 Fresno, CA

TISSUE FROM: Right kidney ACCESSION n7823

CLINlCAL ADSTRACf:

The patient is a 68-year-old male who presented with diffuse abdominal pain. A cr scan revealed a solid hypovascular mass of the upper pole of tbe right kidney. The patient bad no voiding symptoms and no b.istory of any other urological problems. A surgical exploration found a 2.9 em tumor of the right kidney. A radical nephrectomy was performed.

GROSS PATHOLOGY:

The 176 gfam kidney was 11 x 6.5 x 3.5 em. A bulging tumor was present on tbe posterior aspect of the upper pole of the kidney. The 2.9 em tumor was well-

CTTR. November, 199$ CONTRIBUTOR: Edward Aoosta, M.D. CASE NO. 9 ·NOVEMBER 1995 Sylmar, CA

TISSUE Jo'"ROM: Small bowtl ACCESSION #27790

CLINlCAL ABSTRACT:

During work-up for an abnonnal Pap smear, this 51-year-old Black was found to be anemic with a hemoglobin of7.5. Her hemoglobin continued to drop (5.7 gm) and she developed black tarry stools. CT scan showed multiple masses in the pelvis adjacent to small bowel and right hilar lymphadenopathy. Past medical history included a hysterectomy and bilateral salpingo-oophorectomy for uterine fibroids and a 12.5 em benign ovarian cyst. A partial resection of small bowel was performed for intractable Gltract bleeding.

GROSS PATHOLOGY:

A 38 em segment of small bowel had multiple ulcerated purple to red-brown submucosal masses ranging from 1.2 to 5.0 em in greatest diameter. Two masses appeared to have perforated, producing a localized peritonitis.

SPECIAL STAINS:

PAS (with and without diastase), Kl-1, Myoglobin, LCA, S-100, Actin HMB-45, PTAH, Mucin, Desmin: all negative Keratin, Vimentin, EMA: positive

CONTRIDUfOR: Gary Poulrelli, M.D. CASE NO. 10 • NOVEMDER 1995 Veoturu, CA

TISSUE FROM: Left shoulder ACCESSION #27766

CI.INJCAL ABSTRACT:

This 41-year-old male presented with a 8.5 em cystic mass on the left shoulder, present for many years, and thought to be a sebaceous cyst. It had recently increased in size. The mass was excised .

GROSS PATHOLOGY:

Tbe 100 gram specimen consisted of a 8.0 x 7.5 x 5.0 em aggregate of soft, SOlllCWhat friable golden-yellow fatty tissue.

CT!R, No¥

SUGGESTED READING (General Topics from Recen~ Literature):

National Cancer Institute Workshop. The Revised Bethesda System for Reporting Cervical/Vaginal Cytologic Diagnoses. Report of the 1991 Bethesda Workshop. Acta Cytol 36: 273-276. Bottles K, Reiter RC, Steiner AL, Zaleski S, et a). Problems Encountered with the Bethesda System. The UniversitY, oflowa &perience. Obstet Gynccol 1991;78: 410-414. Barth A, Brenner RJ, and Giuliano AE. Current Management of Ductal Carcinoma In-Situ. West J ofMed 1995; 163(4): 360-366

California Tum9rTissue Registry c/o: Department of Pathology and Human Anatomy Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350 (909) 824-4788 FAX: (909) 478-4188 CASE NO. 1, ACCESSION NO. 27748 NOVEMBER 1995

INLAND fRIVBRSTDE!SAN BERNARPINOl - Tuberculosis (3). LONG BEACH - Atypical mycobaelcrial splenitis (10). SAN DfEGO

ADDITIONAL SPECIAL STAINS: Acid fast positive ++++

DIAGNOSIS:

MYCOBACTERIUM A V1UM- INTRACELLULARE, SPLEEN T07000/E20 17

REFERENCES:

Suster S, Moran CA, Blanco M. Mycobacterial Spindle-Cell ~udotuma< of the Spleen. Am 1. Oin Pathol1994; 101: 539· 542. Zalewski P, Fligiel S, Berlin GW, etal. Disseminated Mycobacterium Avium·lntracellulare Infection In Homosexual Men Dying of Acquired Immunodeficiency Syndrome. JAMA 1982; 248: 2980. Green JB, Sidhu GS, Lewin S, et al. Myeoba<:lcrium Avium-lntraccllulare. A CaliSe of Disseminated Ufe-Threatening lofeelion in HOCDOseJ

C'TTR, November 1995 "Minutes'' pagel CASE NO. z, ACCESSION NO. 27760 NOVEMBER 1995

INLAND lRNER$IDEISAN BERNARDINO) • Sclerosing (3). LONG BEACH - Sclerosing hemangioma (10). SAN DIEGO (Naval Medical Center) - Sclerosing hemangioma (10); Epithelioid (5). SAN DIEGO (Qrossmont Hospital) - Epithelioid hemangioendothelioma (:5). SANIABARBARA - Sclerosing hemangioma (3). SANIA ROSA - TVSBAT vs pulmonary (1); So.ealled sclerosing hemangioma (1); Sclerosing hemangioma (1). OAKlAND (Naval Hospital) - Sclerosing hemangioma (4). BAY AREA - Sclerosing hemangioma, lung (3). • PLEASANTON/FREMONT - Sclerosing hemangioma (4); Histiocytoid hemangioma (2). SACRAMENTO CUC Davis) - Sclerosing hemangioma. fLORIDA ITALLAHASSEE)·- - Sclerosing hemangioma (5). NEW JERSEY (SUMM!TI - Sclerosing hemangioma (2); (1). MARYLAND

DIAGNOSIS:

SCLEROSING HEMANGIOMA, LUNG T07000/M88320

FOLLOW-UP: Two years later the patient had no further lung problems.

REFERENCFS: Katzenstein AL. Gmellcb JT, Carrington CB. Sclerosing Hemangioma of the Lung. A Clinicopalho logic Study of51 Cases. Am J Surg Pathol l9SO; 4: 343·356. Wojcik EM, Sneigc N, Lawrence DD, Ordonez NG. Fine Needle Aspiration Cytology ofSclerosing Hemangioma of the Lung. Case Report wilh lmmunobisiOchemical Study. Diagn Cytopatbol1993; 9(3): 304-309. Sugio K, Yol!oyemo H, KaneoS, et al. Scleroo~ing Hemangioma oftbe Lung. IUdiographicand Palhological Study. Aen Thotac Surg 1992; 53(2): 295-300. Anderson C. Ludwig ME. O'Donnell M, Garcia N. Fine Needle Aspiration cytology of Pulmonary Carcinoid Tumors. Acta Cytologica (United States) 1990; 34{4): 505-510. Shimosato Y. Lung Tumors o[ Uncertain Histogenesis. Sem in Diag Pathol1995; 12{2); 185-192.

C1TR. November 199' "Minu.~'"' pagc3 CASE NO. 3, ACCESSION NO. 27778 NOVEMBER 1995

INLAND

DIAGNOSIS:

BRENNER TIJMOR, OVARY T87000/M90000

REFERENCES:

Teilum G. Special Tumors of the Ovary and Testis and Related Extra Gonadal Lesions. Comparative Pathology and Histological Classitication. J.B. Lippincott Company. Philadelphia and Toronto pp 236-245. Roth LM. Fine Structure of the B'renner Tumors. Cancer 1971; 27: 1482-1488. Silverberg SG. Brenner Tumor of the Ovary. A Clinicopathologic Study of60 Tumors in 54 Women. C.ncer 1971; 28: 588- 596.

CTTR. November 1995 "Mioules .. CASE NO. 4, ACCESSION NO. 17781 NOVDffiER 1995

INlAND CRJYERSIDEISAN BERNARDINO\ • Atypical polypoid (3). LQNG B8ACH - Atypical polypoid adenomyoma of endometrium (10). SAN DIEGO (Naval Medical Cencer\ • Atypical polypoid adenomyolllJI (IS). SAN DIEGO (Grossmont HospjtaO • Adenomyoma witb squamous metaplasia (5). SANIA BARBARA • Ade.no!ibroma (3). SANTA ROSA - Endometrial polyp with uDutra" bodies (1); Atypical polypoid adenomyoma (I); Endometrial polyp, polypoid adenomyoma (I). OAK[ANQ (Naval HospitaD - Adenomyoma (4). BAY AREA - Hyperplastic polypoid adenomyoma wit!J focal atypia, endometrial polyp (3). PLEASANTON/FREMONT • Atypical polypoid adenomyoma (6). SACRAMENTO CUC Davis) • Atypical adenomyoma.

FLORJPA IT~ EEl - Atypical polypoid adenomyoma (5). NEW .JERSEY (SUMMJJ) - Polypoid adenomyoma (3). MARYLAND {Bethesda Naval Medical Cuter) • Atypical polypoid adenomyoma (15). TEXAS TECH CEL PASO) • Atypical polypoid adenomyom• (3). TENNJ!SSEE C!

DIAGNOSIS:

ATYPICAL POLYPOID ADENOMYOMA, ENDOMETRIAL POLYP T76800/M89320

FOLLOW-UP:

Seven months after surgery the patient bad no reoccuning symptoms.

REFERENCES: Longaac T, Chung M, RouseR, and Hendrickson M. Atypical Polypoid Adcnomyofibromas (Atypical Polypoid Adenomyomas) of the Uterus. A Clinicopathologic Study or 55 Cases. Am 1 Surg Pathol!996; 20(1): 1·20. Young RH, Treger T, Scully BE. Atypical Polypoid Adenomyoma. Am J Clin Patboll986; 86: 139·165. Oobashi Y, Fiedle.r PN, ~cangiu MI.. Polypoid Cystic Adenomyosl. or the Uterus. A Report or a ca... lnt J Qynecol Fatbol 1992; 11{3): 240-243. Minai KR, Pcng XC, Wallach RC, Demopoulos Rl. Coexistent Atypical Polypoid Ade00<11yoma aod Endometrial Adenocarcinoma. Hum-Patbo1!99S; 26{5): 574-576. Lee KR. Al}'pical Polypoid Adeoomyo

CTI'R, Novcmbe.t 1995 "Mlnuaes" paa:e.5 '

CASE NO. 5, ACCESSION NO. 27783 NOVEJI.IDER 1995

INlAND CRTVERSIDEJ§AN BERNARDINO) • €horioangioma (3). LONG BEACH • Chorangioma (10). SAN DIEGO (Naval Medical Center) • Chorioangioma (15).

SAN DIEGO (Grossmont Hospit~J) • Chorangioma (5). SANTA BARBARA • Cborangioma (3). SANTA ROSA • Chorangioma/angioma (1); Chorangioma '(2). OAKlAND (Naval Hospital) · Chorangioma (4). BAY AREA • Chorangioma, placenta (3). PLEASANTON/fREMONT • Cborangioma (hemangioma) (6). SACRAMENTO (UC Davis) · Chorangioma. FLORIDA CTALLAHASSEEl - Hemangioma/cborangioma (5). NEW JERSEY CSUMMIJ) • Chorangioma (3). MARYLAND (Bethesda Naval Medical Center) · Cborangioma (15). TEXAS TECH CEL PASO) · Mature angioma ( chorangioma) (3). TENNESSEE (Knoxville) • Cborangioma WASHINGTON (Duwamnrish Valley) • Cborangioma (2). MASSACHUSETTS (Berkshire Medical Center) • Cho'rangioma (10). NEW HAMPSHIRE (Manchester) • eborangioma (2). JAPAN (Sbimada·Kyoto) • Chorioangioma.

Additional Special Stains: Factor Vlii/CD-34 positive

DIAGNOSIS:

MATURE CHORANGIOMA, PUCENTA T88100/M91200

REFERENCES:

Majlessi HF, Wagner KM, Brooks JJ. Atypical Cellular Cborangioma.ofthe Placenta. lnt J Gynecol Patbol1983; 1: 403·408.. Omoy A. Crone K, Altshuler G. Pathological Features of the Placenta in Fetal Deaths. Arch Pathol Lab Med 1976; 100: 367- 371. BemiJSchke K. Examination of the Placenta. Obstet Gynecol196; 18: 309-333. Wallenburg HCS. Chorioangioma of the Placenta. Obstet Gyneool Surv 1971; 26: 411-425.

CT'fR. Novc.mbu 199S *'Minutes" page6 CASE NO. 6, ACCESSION NO. 1:1185 NOVEMBER 1995

INlAND CRJyERSIDE/SAN BERNARDINO) - Neurilemmoma (3). LONG BEACH - Scbwannoma (10). SAN DIEQQ

MASSACHUSETTS CBcrk~hire Medical Genter) • Schwannoma (10). NEW HAMPSHIRE (Manchester) • Myxoma (1); Benign, favor ganglioneuroma (1). JAPAN (Sbimada-Kyoto) - Ganglioneuroma.

DIAGNOSIS:

SCHWANNOMA WITH DEGENERATIVE CHANGES, LEFT CHEST (Note: Some sUdes show presence ofganglion cells) TY21001M95600

REFERENCES:

Rovioro G, Montossi M, Varoli F, ct al. Primary Pulmonary Tumours orNeurogcnic.Origin. Thorax 1983; 38: 94Z·94S. Mubrer KH, Fisher HP. Primary Pulmonary Neurilemmoma, Thorae Catdiova.~ Surg 1983; 31: 313-316. lmaizum_i M. Talcah&Shi T, Niimi T. eta!. A CUe oC Primary Intrapulmonary Neur-ilemmom-a. A Review o!thc Literarure. JapnJ Surg 1989; 740-746.

C'rffi. Novembter 1905 "Minutes'' CASE NO. 7, ACCESSION NO. Z778Z NOVEMBER 1995

1NlAND (RfVERSrDEISAN BERNARDINO) - Melanosis roli and megacolo11 (3). LONG BEACH - Mucosal hyperplasia with melanosis roli (10). SAN DIEGO CNaval Medical Center) - Severe melanosis coli (15). SAN DIEGO CGrossmont Hospital) - Melanosis coli (laxative abuse) (5). SANTA BARBARA - Melanosis coli (3). SANTA ROSA - Melanosis coli (3). OA!CLANQ (Naval Hospital) - Melanosis coli (4). BAY AREA - Melanosis, coli, (laxative abuse?) and ganglionic cel.ls, colon/terminal ileum (3).

PLEASANTON/FREMONT - Melanosis coli (c~thartic colon) (6). SACRAMENTO NC Davis) - Melanosis coli. FLORIDA (TATI A!fA$SEEl - Melanosis coli (5). NEW IERSEX CSUMM!J) - Melanosis coli (3). MARYLAND CBetbesda Naval Medical Center) -Melanosis coli (15). TEXAS IECH IEL PASO) - Melanosis coli (3). TENNESSEE (J(noxvjlle) - Melanosis coli. WASffiNGTON CDuwammisb Valley) - Melanosis coli (2). MASSACHQSEJTS

Additional Spednl Stains: PAS positive Iron/Acid Fast negative

DIAGNOSIS:

MElANOSIS COLI T67000/M57740

REFERENCES:

Winoesch JH, Jackman RJ, McDonald JR. Melanasis Coli. Generol Review and Sludy of 887 Cases. Dis Coloo Rec1um 1958; 1: 172. Smirh B. Parhologie O>anges in Colon Produced by Anthraquinone Putgatives. Dis Colon Reclllm 1973; 16: 45S.

C1TR. Novc.mbc:r 199$ "Minulu'' page a CASE NO. 8, ACCESSION NO. 2.78i:l NOVElvtBER 199.5

INLAND ffiiVE.RSIDEJSAN BERNARDINO) • Wilm's tumor (3). LONG BEACH - Metanephric adenoma (10). SAN DIEGO (Nav.al Medical Center) · Adult Wilm's tumor (5); Benign tubular adenoina (1); Metanephric adenoma (8). SAN DIEGO (Grossmont) - Metanephric adenoma (5). SANTA BARBARA - Cortical adenoma (3). SANTA ROSA - Nephroblastoma (adult) (1); .Embryonal adenoma (1); Thbular nephroblastoma (1). OAKLAND (Naval Hospital) • Adult Wilm's tumor (4). BAY AREA • Adult Wilm's tumor, right kidney (3} PLEASANTON/FREMONT • Metanephric adenoma (renal cortical adenoma) (5); ?Wilm's (1). SACRAMENTO (UC Davis) • Metanephric adenoma. FLORIDA (TALLAHASSEE> · A!Jult Wilm's tumor (5). NEW JERSEY CSUMMID·- · Wilm's·tumor (3). MARYLAND (Bethesda Naval Medical Center) • Metanephric adenoma (15).

TEXAS TECH (EL PASb) • Adult nephroblastoma (3}. TENNESSEE (Knoxville) - Renal cell carcinoma. WASHINGTON CDuwammisb Valley) · Adult Wilm's tumor (2). MASSACHUSEITS (Berkshire Medical Center) (10) • Mesonephric adenoma (10). NEW HAMPSHIRE (Manchester) • Favor well-differentiated adenocarcinoma (1}; Well-differentiated tubuiM variant of renal cell carcinoma. JAPAN (Shimada-Kyoto) - Carcinoid tumor.

DIAGNOSIS:

METANEPHRIC ADENOMA, KIDNEY T71000/M81400

CONSULTATION: Edward C. Jones, M.D. of Vancouver Hospital, Vancouver, British Columbia diagnosed case as "Metanephric Adenoma". (Article in American JoumaJ ofSurgical Pathology. See reference below.)

R£FERENCFS: Jones EC, Pins M. Dickersin GR, and Young RH. Metanephric Adenoma of the Kidney. A Clinicopathological, lmmunobistochemical, Plow Cytometric, Cytogenetic, and Electron Microscopic Study ofSeven Cases. Am J Surg Pathol 1995; 19(6): 615-626. . Brisigotti M, Cozzuno C,·Fabbretti G, Sergi C, et al. Metanephric Adenoma. Histol Histopatboll992 7(4): 689-692. 'Nonomura A, Mizukami Y, Hasegawa T, Ohkawa M, e1 al. Metanephric Adenoma of the Kidney. Pathollnt 1995; 45(2); 160-164.

C'ITR. November 199$ .. Mioutes'" page9 CASE NO. 9, ACCESSION NO. 27790 NOVDffiER 1995

INlAND

TEXAS TECH (EL PASO} - Epi t b~lioid ~~rwma (3). TENNESSEE (Knoxville) - Sarcomatoid carcinoma vs malignant mesothelioma vs transitional cell carcinoma. WASHINGTON (Duwammish Vallev)- High-grade non-small cell malignant tumor. ICC in favor of epithelial origin (2). MASSACHYSEJTS !Berkshire Medical Center) - Malignant extrarenal rhabdoid tumor (10) NEW JiAMPSHIRE (Manchester) - Malignant tumor, favor undifferentiated carcinoma (1); Poorly-differentiated carcinoma (1). JAPAN (Sbimada-Kvoto) - Malignant fi brous histiocytoma.

DIAGNOSlS:

POORLY DIFFERENTIATED CARCINOMA Wl'fB RHABDOID FEATURES, SMALL DOWEL T64000/M80103

RgFERENGfS: Wicl: MR. Riner JH, Dehner LP. Malignant Rhabdoid Tumors. A Oinicopathologie Review aod Cooceptual Dis<:owion. Scm Diog P•thol 199S; 12(3): 233-243. Oletty Rand Bhathal PS. Cecal Adenocarciooma with Rhabdoid Phenotype. Vuc!tows Arch Patbol Anal Histopathol1993; 422.: 179-182. Perez-Atoyde AR. Newbury R. Fletcher JA, et al Coogenitol "Neurovascular Hamartoma" of the Skin. A Passiblc Marker of Malignant Rhabdoid Tumor. Am 1 Surg Pathol1994; 18: 1030-1038. Uejatlla T, Nagi E, YavT, etal. Vimentin-Positive Gastric Carcinomas with Rhabdoid Features. A Oinicopatbologicand lmmunoltistochemical Study. Am J Surg Pathol 1993; 17: 813-819. Weela DA. Beckwith JB, Mie,rau GW, et al. Rhabdoid Tumor of IGdncy. A Report of Ill Cases from the Notional Wiltll 's' Tumor Study Pathology Ceoter. Am J Surg Pothol1989; 13: 439-458.

pnaelO CASE NO. 10, ACCESSION NO. 17766 NOVEMBER199S

INlAND

OAKLAND (Naval Ho~pi tall • Hlbemoma (4). BAY AREA • ffibemoma, left shoulder (3). PLEASANJONJFREMONT · Lipoma (4); Traumatized hibemoma (2). SACRAMENTO fUC Davis) • Hibemoma. FLORIDA • Hibemoma (3). TENNESSEE O

DIAGNOSIS:

BIBERNO~SHOULDER TY1220/M88800

RI'.FERENCES:

Mertens F, Rydbohn A. Brosjo 0, Willen H, et 11. Hibemomas Aze Cbllllctalzed by RearrangemenlS of Ouomooome Bands. lnt 1 Cancer(U.S.) 1994; 58(4): 503-SOS. Roos SR, Cboy L. Graves RA, Fox N, et al. Hibemoma Formation in Transgenic Mice and Isolation of a Brown Adipocyte Cell Expressing lbe Uncoupling Protein Gene. Proc Natl Acad Sei US A 1992; 89(16): 7561· 7565. Hashimoto CHand Cobb CJ. Cylodi1gnoois ofHibemoma. A Case Report. Oiagn Cytopathol (U.S.) !987; 3(4):326·329. Allen PW. Tumor$ and Proliferatioos of Adipose Tassue. A Oinioopothologic Approach. MI50D Monographs of Diagnostic Palbology, pp 8!-88. Enterline tiT, Lowery LD and Richman AV. Does Malignant Hibernoma Exist? Am J Surg Pocholl979; (3(3): 265-271 .

~ Novtmber 199S .'Minutes'' pogoll