Fenticonazole: an Effective Topical Treatment for Superficial Mycoses As the First-Step of Antifungal Stewardship Program
European Review for Medical and Pharmacological Sciences 2017; 21: 2749-2756 Fenticonazole: an effective topical treatment for superficial mycoses as the first-step of antifungal stewardship program F. TUMIETTO1, L. GIACOMELLI2 1Infectious Diseases Unit Teaching Hospital S. Orsola-Malpighi, Alma Mater Studiorum University of Bologna, Bologna, Italy 2Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy Abstract. – The resistance of microorgan- infections are defined as infections in which the isms to antimicrobial drugs is a major issue for pathogen is confined to the superficial layer, with public health, with important consequences in minimal or no histological signs1. terms of morbidity, mortality and resource use. The dermatophyte or ringworm infections, su- The phenomenon is so serious that in some ar- eas of the world resistant strains to all available perficial candidosis of the mouth, skin or genital drugs have been selected. tract and infections due to Malassezia, such as Many conditions may result in the development Pityriasis versicolor, are the main conditions. Tin- of resistance: they include the indiscriminate or ea affects external areas of the body. Candidiasis is inappropriate (e.g., for viral infection or coloniza- caused most often by the yeast Candida albicans, tion) use of antibiotics, the excessive duration of although in recent years, cases due to non-albicans the prescribed treatment regimens, as well as in- adequate dosing or administration routes. strains are increasing significantly. Candidiasis of- Resistance is well-known, but less studied, al- ten affects the genitals or inside of the mouth. so for infections caused by fungi. All these infections are usually diagnosed clin- In the last decade, an impressive outbreak ically.
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