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Pharmacology
Pharmacology New for 2020-2021 Competitor orientation deleted from ILC. Event Summary Pharmacology provides HOSA members with the opportunity to gain knowledge and skills regarding the area of healthcare concerned with uses, effects, and modes of actions of drugs. This competitive event consists of a written test with a tie-breaker essay question. This event aims to inspire members to learn about how drugs work in the body, proper administration, and adaptations for different patients and conditions. Dress Code Competitors must be in official HOSA uniform or proper business attire. Bonus points will be awarded for proper dress. General Rules 1. Competitors in this event must be active members of HOSA-Future Health Professionals, in good standing. 2. Secondary and Postsecondary/Collegiate divisions are eligible to compete in this event. 3. Competitors must be familiar with and adhere to the “General Rules and Regulations of the HOSA Competitive Events Program (GRR)." 4. All competitors shall report to the site of the event at the time designated for each round of competition. At ILC, competitor’s photo ID must be presented prior to ALL competition rounds. Official References • Fulcher, Soto and Fulcher. Pharmacology: Principles and Applications. Elsevier, Latest edition. • Ford, Susan and Sally Roach. Roach’s Introductory Clinical Pharmacology. Wolters Kluwer, Latest edition. Written Test 5. Test Instructions: The written test will consist of 100 multiple choice items in a maximum of 90 minutes. 6. Time Remaining Announcements: There will be a verbal announcement when there are 60 minutes, 30 minutes, 15 minutes, 5 minutes, and 1 minute remaining to complete the test. -
Cell Biology and Fundamentals in Histology - En-Cours-2018-Liepr1004 Liepr1004 Cell Biology and Fundamentals in 2018 Histology
Université catholique de Louvain - Cell biology and fundamentals in histology - en-cours-2018-liepr1004 liepr1004 Cell biology and fundamentals in 2018 histology 5 credits 45.0 h Q2 Teacher(s) Behets Wydemans Catherine ;Henriet Patrick ; Language : French Place of the course Louvain-la-Neuve Main themes The major themes are : - Characteristics common to all living species - The human cell, its functioning and division - Classical, evolutive and molecular genetics - Cellular bases in sexual reproduction - The differents cell types and their organisation in tissues - The major steps in human embryonic development Aims By the end of the module, students should understand the bases of unicity and diversity in the living world. They will know the structure and functioning of human cell and genome as well as the mechanisms of 1 cell division and embryonic development. Moreover, they will know the structure of the major types of human tissues. - - - - The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”. Content (auteurs - titulaires actuels) : P. Henriet and Ph. van den Bosch de Aguilar 1. UNICITY IN THE LIVING WORLD 2. THE HUMAN CELL 3. DIVERSITY IN THE LIVING WORLD 4. MOLECULAR GENETICS 5. CELL DIVISION 6. GAMETOGENESIS AND FERTILIZATION 7. INTRODUCTION TO HUMAN EMBRYOLOGY Histology 1. EPITHELIAL TISSUE 2. CONNECTIVE TISSUE 3. BLOOD TISSUE 4. MUSCLE TISSUE -
Clinical Pharmacology 1: Phase 1 Studies and Early Drug Development
Clinical Pharmacology 1: Phase 1 Studies and Early Drug Development Gerlie Gieser, Ph.D. Office of Clinical Pharmacology, Div. IV Objectives • Outline the Phase 1 studies conducted to characterize the Clinical Pharmacology of a drug; describe important design elements of and the information gained from these studies. • List the Clinical Pharmacology characteristics of an Ideal Drug • Describe how the Clinical Pharmacology information from Phase 1 can help design Phase 2/3 trials • Discuss the timing of Clinical Pharmacology studies during drug development, and provide examples of how the information generated could impact the overall clinical development plan and product labeling. Phase 1 of Drug Development CLINICAL DEVELOPMENT RESEARCH PRE POST AND CLINICAL APPROVAL 1 DISCOVERY DEVELOPMENT 2 3 PHASE e e e s s s a a a h h h P P P Clinical Pharmacology Studies Initial IND (first in human) NDA/BLA SUBMISSION Phase 1 – studies designed mainly to investigate the safety/tolerability (if possible, identify MTD), pharmacokinetics and pharmacodynamics of an investigational drug in humans Clinical Pharmacology • Study of the Pharmacokinetics (PK) and Pharmacodynamics (PD) of the drug in humans – PK: what the body does to the drug (Absorption, Distribution, Metabolism, Excretion) – PD: what the drug does to the body • PK and PD profiles of the drug are influenced by physicochemical properties of the drug, product/formulation, administration route, patient’s intrinsic and extrinsic factors (e.g., organ dysfunction, diseases, concomitant medications, -
I. Antihistamines Seunghoon Han* Department of Clinical Pharmacology and Therapeutics, Seoul St
2014;22(1):13-18 TCP Translational and Clinical Pharmacology http://dx.doi.org/10.12793/tcp.2014.22.1.13 Clinical Pharmacology Review for Primary Health Care Providers: I. Antihistamines Seunghoon Han* Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul 137-701, Korea *Correspondence: S. Han; Tel: +82-2-2258-7326, Fax: +82-2-2258-7876, E-mail: [email protected] Received 31 May 2014 Primary health care providers play a critical role in maintaining public health, and the appropri- Accepted 31 May 2014 ate use of pharmaceutical products is one of the major parts of their practice. This series of articles, pISSN: 2289-0882 entitled ‘Clinical Pharmacology Review for Primary Health Care Providers,’ is intended to help pri- mary health care providers select more appropriate prescriptions for frequently used drugs based on up-to-date information. We expect that this effort will contribute to improvements in public health and diminish unnecessary drug use. Introduction tion on the H1 receptor.[8] THERAPEU Antihistamines include some of the most frequently prescribed drugs in the primary health care environment for the symp- Generations and Classes tomatic relief of allergic diseases, the common cold, urticaria, Many primary health care providers are well-informed about T and insomnia.[1-5] The importance of antihistamines has been the different ‘generations’ of antihistamines but not about the ICS TU emphasized as the prevalence of target diseases increases.[6,7] different ‘classes’ characterized according to chemical structure. However, the appropriate use, clinical effectiveness, and target [1] This discrepancy seems reasonable because ‘inter-generation’ T populations for prescription of antihistamines are still a matter differences are more prominent than ‘inter-class’ differences. -
Guidance for Reviewers Pharmacology/Toxicology Review Format
Guidance for Reviewers Pharmacology/Toxicology Review Format U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Pharmacology/Toxicology May 2001 Guidance for Reviewers Pharmacology/Toxicology Review Format Additional copies are available from: Drug Information Branch (HFD-210) Center for Drug Evaluation and Research (CDER) 5600 Fishers Lane, Rockville, MD 20857, (Tel) 301-827-4570 Internet at http://www.fda.gov/der/guidance/index.htm U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Pharmacology/Toxicology May 2001 Guidance for Reviewers Table of Contents I. INTRODUCTION ....................................................................................................1 II. BACKGROUND.......................................................................................................1 III. DISCUSSION ...........................................................................................................1 A. IND REVIEW FORMAT ....................................................................................1 B. NDA REVIEW FORMAT...................................................................................1 IV. ATTACHMENTS .....................................................................................................1 A. IND REVIEW FORMAT ....................................................................................A-i B. NDA REVIEW FORMAT...................................................................................B-i -
Department of Pharmacology (GRAD) 1
Department of Pharmacology (GRAD) 1 faculty participate fully at all levels. The department has the highest DEPARTMENT OF level of NIH funding of all pharmacology departments and a great diversity of research areas is available to trainees. These areas PHARMACOLOGY (GRAD) include cell surface receptors, G proteins, protein kinases, and signal transduction mechanisms; neuropharmacology; nucleic acids, cancer, Contact Information and antimicrobial pharmacology; and experimental therapeutics. Cell and molecular approaches are particularly strong, but systems-level research Department of Pharmacology such as behavioral pharmacology and analysis of knock-in and knock-out Visit Program Website (http://www.med.unc.edu/pharm/) mice is also well-represented. Excellent physical facilities are available for all research areas. Henrik Dohlman, Chair Students completing the training program will have acquired basic The Department of Pharmacology offers a program of study that leads knowledge of pharmacology and related fields, in-depth knowledge in to the degree of doctor of philosophy in pharmacology. The curriculum is their dissertation research area, the ability to evaluate scientific literature, individualized in recognition of the diverse backgrounds and interests of mastery of a variety of laboratory procedures, skill in planning and students and the broad scope of the discipline of pharmacology. executing an important research project in pharmacology, and the ability The department offers a variety of research areas including to communicate results, analysis, and interpretation. These skills provide a sound basis for successful scientific careers in academia, government, 1. Receptors and signal transduction or industry. 2. Ion channels To apply to BBSP, students must use The Graduate School's online 3. -
Immune Response and Histology of Humoral Rejection in Kidney
Document downloaded from http://www.elsevier.es, day 23/05/2017. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited. n e f r o l o g i a 2 0 1 6;3 6(4):354–367 Revista de la Sociedad Española de Nefrología www.revistanefrologia.com Review Immune response and histology of humoral rejection in kidney transplantation a,∗ a b a Miguel González-Molina , Pedro Ruiz-Esteban , Abelardo Caballero , Dolores Burgos , a c a a Mercedes Cabello , Miriam Leon , Laura Fuentes , Domingo Hernandez a Nephrology Department, Regional University Hospital of Malaga, Malaga University, IBIMA, REDINREN RD12/0021/0015, Malaga, Spain b Immunology Department, Regional University Hospital of Malaga, Malaga University, IBIMA, REDINREN RD12/0021/0015, Malaga, Spain c Pathology Department, Regional University Hospital of Malaga, Malaga University, IBIMA, REDINREN RD12/0021/0015, Malaga, Spain a r t i c l e i n f o a b s t r a c t Article history: The adaptive immune response forms the basis of allograft rejection. Its weapons are direct Received 4 June 2015 cellular cytotoxicity, identified from the beginning of organ transplantation, and/or anti- Accepted 26 March 2016 bodies, limited to hyperacute rejection by preformed antibodies and not as an allogenic Available online 3 June 2016 response. This resulted in allogenic response being thought for decades to have just a cellu- lar origin. But the experimental studies by Gorer demonstrating tissue damage in allografts Keywords: due to antibodies secreted by B lymphocytes activated against polymorphic molecules were Immune response disregarded. -
Satellitosis, a Crosstalk Between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour
cancers Review Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour Prospero Civita 1,2,* , Ortenzi Valerio 3 , Antonio Giuseppe Naccarato 3 , Mark Gumbleton 2 and Geoffrey J. Pilkington 1,2,4,* 1 Brain Tumour Research Centre, Institute of Biological and Biomedical Sciences (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK 2 School of Pharmacy and Pharmaceutical Sciences, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF10 3NB, UK; gumbleton@cardiff.ac.uk 3 Department of Translational Research and New Technologies in Medicine and Surgery, Pisa University Hospital, 56100 Pisa, Italy; [email protected] (O.V.); [email protected] (A.G.N.) 4 Division of Neuroscience, Department of Basic and Clinical Neuroscience, Institute of Psychiatry & Neurology, King’s College London, London SE5 9RX, UK * Correspondence: CivitaP@cardiff.ac.uk (P.C.); geoff[email protected] (G.J.P.) Received: 9 November 2020; Accepted: 4 December 2020; Published: 11 December 2020 Simple Summary: This article reviews the concept of cellular satellitosis as originally described histologically by Santiago Ramón y Cajal in 1899 and Hans Joachim Scherer, more specifically in the context of glioblastoma invasiveness, during the early part of the 20th century. With the advent of new and emerging molecular technologies in the 21st century, the significance of both vascular and neuronal satellitosis by neoplastic cells offers intriguing possibilities into further clarifying the development, pathobiology and therapy of malignant glioma through closer investigation into the nature of these histological hallmarks. -
Basic Histology (23 Questions): Oral Histology (16 Questions
Board Question Breakdown (Anatomic Sciences section) The Anatomic Sciences portion of part I of the Dental Board exams consists of 100 test items. They are broken up into the following distribution: Gross Anatomy (50 questions): Head - 28 questions broken down in this fashion: - Oral cavity - 6 questions - Extraoral structures - 12 questions - Osteology - 6 questions - TMJ and muscles of mastication - 4 questions Neck - 5 questions Upper Limb - 3 questions Thoracic cavity - 5 questions Abdominopelvic cavity - 2 questions Neuroanatomy (CNS, ANS +) - 7 questions Basic Histology (23 questions): Ultrastructure (cell organelles) - 4 questions Basic tissues - 4 questions Bone, cartilage & joints - 3 questions Lymphatic & circulatory systems - 3 questions Endocrine system - 2 questions Respiratory system - 1 question Gastrointestinal system - 3 questions Genitouirinary systems - (reproductive & urinary) 2 questions Integument - 1 question Oral Histology (16 questions): Tooth & supporting structures - 9 questions Soft oral tissues (including dentin) - 5 questions Temporomandibular joint - 2 questions Developmental Biology (11 questions): Osteogenesis (bone formation) - 2 questions Tooth development, eruption & movement - 4 questions General embryology - 2 questions 2 National Board Part 1: Review questions for histology/oral histology (Answers follow at the end) 1. Normally most of the circulating white blood cells are a. basophilic leukocytes b. monocytes c. lymphocytes d. eosinophilic leukocytes e. neutrophilic leukocytes 2. Blood platelets are products of a. osteoclasts b. basophils c. red blood cells d. plasma cells e. megakaryocytes 3. Bacteria are frequently ingested by a. neutrophilic leukocytes b. basophilic leukocytes c. mast cells d. small lymphocytes e. fibrocytes 4. It is believed that worn out red cells are normally destroyed in the spleen by a. neutrophils b. -
The Histology of the Neuromuscular Junction In
75 THE HISTOLOGY OF THE NEUROMUSCULAR JUNCTION Downloaded from https://academic.oup.com/brain/article/84/1/75/372729 by guest on 27 September 2021 IN DYSTROPHIA MYOTONICA BY VIOLET MACDERMOT Department of Neurology, St. Thomas' Hospital, London, S.E.I (1) INTRODUCTION DYSTROPJHC MYOTONICA is a familial disease affecting males and females, usually presenting in adult life, characterized by muscular wasting and weakness together with certain other features. The muscles mainly in- volved are the temporal, masseter, facial, sternomastoid and limb muscles, in the latter those mainly affected being peripheral in distribution. A widespread disorder of muscular contraction, myotonia, is also present but is noticed chiefly in the tongue and in the muscles involved in grasping. The other features of the condition are some degree of mental defect, dysphonia, cataracts, frontal baldness, sparse body hair and testicular atrophy. Any of the manifestations of the disease may be absent and the order of presentation of symptoms is variable. The myotonia may precede muscular wasting by many years or may occur independently. In those muscles which are severely wasted the myotonia tends to disappear. The interest of dystrophia myotonica lies in the peculiar distribution of muscle involvement and in the combination of a disorder of muscle function with endocrine and other dysplasic features. The results of histological examination of biopsy and post-mortem material have been described and reviewed by numerous workers, notably Steinert (1909), Adie and Greenfield (1923), Keschner and Davison (1933), Hassin and Kesert (1948), Wohlfart (1951), Adams, Denny-Brown and Pearson (1953), Greenfield, Shy, Alvord and Berg (1957). -
Pharmacology 101
Pharmacology 101 Tyler Fischback, PharmD, BCPS, DPLA Clinical Pharmacy Manager Confluence Health Wenatchee, WA Objectives • Define Pharmacology, Pharmacokinetics and Pharmacodynamics • Understand how drug interactions work • Understand how some specific drugs behave in the body (opioids, benzodiazepines, amiodarone) • Apply pharmacology principles into practice Medication Errors and Adverse Drug Events • Error: An error of commission or omission at any step along the pathway that begins when a clinician prescribes a medication and ends when the patient actually received the medication. • ADE: Harm experienced by a patient as a result of exposure to a medication. ADE does not necessarily indicate an error or poor care. However, ~1/2 of ADEs are preventable. Anyone here ever seen a medication error or adverse drug event? Anyone here ever made a medication error? How many different prescription medications are available on the U.S. market? 1,000 So, it’s no surprise why we see so many problems………………… EXCEPT……. The real number is 10,000 Adverse Drug Events • ~1/3 of U.S. adults use 5 or more medications • Annually, ADE = 700,000 ER visits and 100,000 hospitalizations • So, is pharmacology important to your work? • Additionally, 5% of hospitalized patient experience an ADE during their stay • High risk: Anticoagulants, Opioids, Insulin, Cardiac, and Transitions of Care Adverse Drug Events, cont. • Elderly are more susceptible • Pediatrics patients more susceptible (weight-based dosing), especially liquids • Caregivers and patients admittedly -
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations
International Journal of Molecular Sciences Editorial Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations Giuliano Ciarimboli Experimental Nephrology, Department of Internal Medicine D, University Hospital Münster, 48149 Münster, Germany; [email protected] This editorial summarizes the 13 scientific papers published in the Special Issue “Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations” of the International Journal of Molecular Sciences. In this Special Issue, the readers will find integrative information on transporters for organic cations. Besides reviews on physi- ology, pharmacology, and toxicology of these transporters [1–3], which offer a concise overview of the field, the readers will find original research work focusing on specific transporter aspects. Specifically, the review “Organic Cation Transporters in Human Physiology, Phar- macology, and Toxicology” by Samodelov et al. [1] summarizes well the general as- pects of physiology, pharmacology, and toxicology of transporter for organic cations. The other review “Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts” by Ali Selo et al. [2] focuses on these aspects of transporters for organic cations in the lung, an important but often ne- glected field. In the paper “Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs”, by performing a system biology analysis of SLC22 transporters, Engelhart et al. [4] suggest the existence of a transporter–metabolite network. They propose that, in this network, mono-, oligo-, and multi-specific SLC22 transporters Citation: Ciarimboli, G. Physiology, interact to regulate concentrations and fluxes of many metabolites and signaling molecules. Biochemistry, and Pharmacology of In particular, the organic cation transporters (OCT) subgroup seems to be associated with Transporters for Organic Cations.