Introduction to the Peripheral Nervous System 2
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Nerve Ultrasound in Dorsal Root Ganglion Disorders: Smaller Nerves Lead to Bigger Insights
Clinical Neurophysiology 130 (2019) 550–551 Contents lists available at ScienceDirect Clinical Neurophysiology journal homepage: www.elsevier.com/locate/clinph Editorial Nerve ultrasound in dorsal root ganglion disorders: Smaller nerves lead to bigger insights See Article, pages 568–572 After decades of having to make do with electric stimulation representing the fascicles, bundled together in a large outer cable and recording (i.e. nerve conduction studies, electromyography sheath (van Alfen et al., 2018). and evoked potentials), nerve ultrasound now provides the oppor- Next, it is important to realize what the ratio between axon/ tunity to improve neurodiagnostic patient care by deploying a myelin and connective tissue in a given nerve segment is, and powerful tool to detect neuromuscular pathology in an accurate how that ratio changes from the proximal root to the distal end and patient-friendly way (Mah et al., 2018; Walker et al., 2018). branches (Schraut et al., 2016). Connective tissue elements of the Nerve ultrasound is also increasingly providing neurologists and perineurium and epineurium are relatively sparse at the very prox- clinical neurophysiologists with the opportunity to increase their imal root and plexus levels, with an average connective tissue con- insight in the pathophysiology of peripheral nervous system tent of around 25–30%. Ultrasonographically, this means that roots (PNS) pathology. In this issue of Clinical Neurophysiology, Leadbet- will always look rather black in appearance without much dis- ter and coworkers (Leadbetter et al., 2019) describe the results of cernible fascicular architecture, as the sparseness of connective tis- their study on nerve ultrasound for diagnosing sensory neuronopa- sue elements provides relatively few reflectors to create an image thy in spinocerebellar ataxia type 2 and CANVAS syndrome. -
The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’S Disease
life Review The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease Gianfranco Natale 1,2,* , Larisa Ryskalin 1 , Gabriele Morucci 1 , Gloria Lazzeri 1, Alessandro Frati 3,4 and Francesco Fornai 1,4 1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy; [email protected] (L.R.); [email protected] (G.M.); [email protected] (G.L.); [email protected] (F.F.) 2 Museum of Human Anatomy “Filippo Civinini”, University of Pisa, 56126 Pisa, Italy 3 Neurosurgery Division, Human Neurosciences Department, Sapienza University of Rome, 00135 Rome, Italy; [email protected] 4 Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.) Neuromed, 86077 Pozzilli, Italy * Correspondence: [email protected] Abstract: The gastrointestinal (GI) tract is provided with a peculiar nervous network, known as the enteric nervous system (ENS), which is dedicated to the fine control of digestive functions. This forms a complex network, which includes several types of neurons, as well as glial cells. Despite extensive studies, a comprehensive classification of these neurons is still lacking. The complexity of ENS is magnified by a multiple control of the central nervous system, and bidirectional communication between various central nervous areas and the gut occurs. This lends substance to the complexity of the microbiota–gut–brain axis, which represents the network governing homeostasis through nervous, endocrine, immune, and metabolic pathways. The present manuscript is dedicated to Citation: Natale, G.; Ryskalin, L.; identifying various neuronal cytotypes belonging to ENS in baseline conditions. -
Lecture Notes on Human Anatomy. Part One, Fourth Edition. PUB DATE Sep 89 NOTE 79P.; for Related Documents, See SE 051 219-221
DOCUMENT RESUME ED 315 320 SE 051 218 AUTHOR Conrey, Kathleen TITLE Lecture Notes on Human Anatomy. Part One, Fourth Edition. PUB DATE Sep 89 NOTE 79p.; For related documents, see SE 051 219-221. Black and white illustrations will not reproduce clearly. AVAILABLE FROM Aramaki Design and Publications, 12077 Jefferson Blvd., Culver City, CA 90506 ($7.75). PUB TYPE Guides - Classroom Use - Materials (For Learner) (051) EDRS PRICE MF01 Plus Postage. PC Not Available from EDRS. DESCRIPTORS *Anatomy; *Biological Sciences; *College Science; Higher Education; *Human Body; *Lecture Method; Science Education; Secondary Education; Secondary School Science; Teaching Guides; Teaching Methods ABSTRACT During the process of studying the specific course content of human anatomy, students are being educated to expand their vocabulary, deal successfully with complex tasks, anduse a specific way of thinking. This is the first volume in a set of notes which are designed to accompany a lecture series in human anatomy. This volume Includes discussions of anatomical planes and positions, body cavities, and architecture; studies of the skeleton including bones and joints; studies of the musculature of the body; and studiesof the nervous system including the central, autonomic, motor and sensory systems. (CW) *****1.**k07********Y*******t1.****+***********,****A*******r****** % Reproductions supplied by EDRS are the best that can be made from the original document. **************************************************************A**t***** "PERMISSION TO REPRODUCE -
Autonomic Nervous System
AUTONOMIC NERVOUS SYSTEM PAGE 1 AUTONOMIC NERVOUS SYSTEM PAGE 2 AUTONOMIC NERVOUS SYSTEM PAGE 3 AUTONOMIC NERVOUS SYSTEM PAGE 4 AUTONOMIC NERVOUS SYSTEM PAGE 5 AUTONOMIC NERVOUS SYSTEM PAGE 6 AUTONOMIC NERVOUS SYSTEM PAGE 7 AUTONOMIC NERVOUS SYSTEM PAGE 8 AUTONOMIC NERVOUS SYSTEM PAGE 9 REVIEW QUESTIONS 1. The autonomic nervous system controls the activity of _?_. (a) smooth muscle (b) cardiac muscle (c) glands (d) all of these (e) none of these 2. All preganglionic and postganglionic autonomic neurons are _?_ neurons. (a) somatic efferent (b) visceral efferent (c) somatic afferent (d) visceral afferent (e) association neurons 3. Which neurotransmitter is released at the synapses between preganglionic and postganglionic autonomic neurons ? (a) epinephrine (b) norepinephrine (c) acetylcholine (d) serotonin (e) oxytocin 4. All preganglionic sympathetic neurons are located in: (a) the lateral horn of the spinal cord of spinal cord segments T1-L2 (b) brainstem nuclei (c) intramural (terminal) ganglia (d) paravertebral ganglia of the sympathetic chains (e) prevertebral ganglia 5. All preganglionic parasympathetic neurons are located in _?_. (a) prevertebral ganglia (b) the lateral horn of spinal cord segments T1-L2 (c) sympathetic chain ganglia (d) intramural ganglia (e) brainstem nuclei and spinal cord segments S2-S4 6. Prevertebral and paravertebral ganglia contain _?_. (a) preganglionic sympathetic neurons (b) preganglionic parasympathetic neurons (c) postganglionic sympathetic neurons (d) postganglionic parasympathetic neurons (e) all of these 7. The otic, ciliary, submandibular and pterygopalatine ganglia are located in the head region and contain _?_. (a) preganglionic sympathetic neurons (b) preganglionic parasympathetic neurons (c) postganglionic sympathetic neurons (d) postganglionic parasympathetic neurons (e) none of these 8. -
The Sympathetic and the Parasympathetic Nervous System
The sympathetic and the parasympathetic nervous system Zsuzsanna Tóth, PhD Institute of Anatomy, Histology and Embryology Semmelweis University The role of the autonomic nervous system Claude Bernard • „milieu intérieur” concept; every organism lives in its internal environment that is constant and independent form the external environment Walter Bradford Cannon homeostasis; • an extension of the “milieu interieur” concept • consistence in an open system requires mechanisms that act to maintain that consistency • steady-state conditions require that any tendency toward change automatically meets with factors that resist that change • regulating systems that determine the homeostatic state : o autonomic nervous system ( sympathetic, parasympathetic, enteral) o endocrine system General structure of the autonomic nervous system craniosacral thoracolumbar Anatomy Neurotransmittersof the gut autonomic nervous system. symp. gangl pregangl. fiber pregangl. postgangl. fiber fiber (PoR) PoR enteral ganglion PoR PoR smooth muscle smooth muscle Kuratani S Development 2009;136:1585-1589 Sympathetic activation: Fight or flight reaction • energy mobilization • preparation for escape, or fight vasoconstriction • generalized Parasympathetic activation: adrenal • energy saving and restoring • „rest and digest” system • more localized vasoconstriction Paravertebral ganglia and the sympathetic chains pars cervicalis superius ganglion medium cervicale stellatum pars vertebrae • from the base of the skull to the caudal end thoracalis thoracalis of the sacrum • paravertebral ganglia (ganglia trunci sympathici) • rami interganglionares pars vertebrae • the two chains fuses at the ganglion impar abdominalis lumbalis sacrum pars pelvina foramen sacralia anteriora ganglion impar Anatomy of the cervical part of the sympathetic trunk superior cervical ganglion • behind the seath of the carotid, fusiform ggl. cervicale superius • IML T1-3 vegetative motoneurons- preganglionic fibers truncus symp. -
Spinal Nerves, Ganglia, and Nerve Plexus Spinal Nerves
Chapter 13 Spinal Nerves, Ganglia, and Nerve Plexus Spinal Nerves Posterior Spinous process of vertebra Posterior root Deep muscles of back Posterior ramus Spinal cord Transverse process of vertebra Posterior root ganglion Spinal nerve Anterior ramus Meningeal branch Communicating rami Anterior root Vertebral body Sympathetic ganglion Anterior General Anatomy of Nerves and Ganglia • Spinal cord communicates with the rest of the body by way of spinal nerves • nerve = a cordlike organ composed of numerous nerve fibers (axons) bound together by connective tissue – mixed nerves contain both afferent (sensory) and efferent (motor) fibers – composed of thousands of fibers carrying currents in opposite directions Anatomy of a Nerve Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Epineurium Perineurium Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Endoneurium Nerve Rootlets fiber Posterior root Fascicle Posterior root ganglion Anterior Blood root vessels Spinal nerve (b) Copyright by R.G. Kessel and R.H. Kardon, Tissues and Organs: A Text-Atlas of Scanning Electron Microscopy, 1979, W.H. Freeman, All rights reserved Blood vessels Fascicle Epineurium Perineurium Unmyelinated nerve fibers Myelinated nerve fibers (a) Endoneurium Myelin General Anatomy of Nerves and Ganglia • nerves of peripheral nervous system are ensheathed in Schwann cells – forms neurilemma and often a myelin sheath around the axon – external to neurilemma, each fiber is surrounded by -
The Peripheral Nervous System
The Peripheral Nervous System Dr. Ali Ebneshahidi Peripheral Nervous System (PNS) – Consists of 12 pairs of cranial nerves and 31 pairs of spinal nerves. – Serves as a critical link between the body and the central nervous system. – peripheral nerves contain an outermost layer of fibrous connective tissue called epineurium which surrounds a thinner layer of fibrous connective tissue called perineurium (surrounds the bundles of nerve or fascicles). Individual nerve fibers within the nerve are surrounded by loose connective tissue called endoneurium. Cranial Nerves Cranial nerves are direct extensions of the brain. Only Nerve I (olfactory) originates from the cerebrum, the remaining 11 pairs originate from the brain stem. Nerve I (Olfactory)- for the sense of smell (sensory). Nerve II (Optic)- for the sense of vision (sensory). Nerve III (Oculomotor)- for controlling muscles and accessory structures of the eyes ( primarily motor). Nerve IV (Trochlear)- for controlling muscles of the eyes (primarily motor). Nerve V (Trigeminal)- for controlling muscles of the eyes, upper and lower jaws and tear glands (mixed). Nerve VI (Abducens)- for controlling muscles that move the eye (primarily motor). Nerve VII (Facial) – for the sense of taste and controlling facial muscles, tear glands and salivary glands (mixed). Nerve VIII (Vestibulocochlear)- for the senses of hearing and equilibrium (sensory). Nerve IX (Glossopharyngeal)- for controlling muscles in the pharynx and to control salivary glands (mixed). Nerve X (Vagus)- for controlling muscles used in speech, swallowing, and the digestive tract, and controls cardiac and smooth muscles (mixed). Nerve XI (Accessory)- for controlling muscles of soft palate, pharynx and larynx (primarily motor). Nerve XII (Hypoglossal) for controlling muscles that move the tongue ( primarily motor). -
PN1 (Midha) Microanatomy of Peripheral Nerves-Part1.Pdf
Peripheral Nerve Basics • Consist of processes of cell bodies found in the DRG, anterior horn, and autonomic ganglia • Organized by several distinct connective tissue layers – the epineurium, perineurium, and endoneurium • Vascular supply provided by the vasa nervorum Peripheral Nerve Basics • Neuronal processes bound into fascicles by perineurium • Fascicles bound into nerves by epineurium • Endoneurium is a division of the perineurium which form thin layers of connective tissue surrounding neuronal fibers in a fascicle Sural nerve in cross-section Epineurium • Loose areolar tissue with sparse, longitudinally-oriented collagen fibers • Some elastic fibers where epineurium abuts perineurium • Able to accommodate a significant amount of nerve stretching and movement • Increases in thickness where nerves cross joints • Constitutes an increasing proportion of nerves as they increase in size • Epineurial fat helps cushion nerves from compressive injury • Decreased epineurial fat found in patients with diabetes Perineurium • Cellular component composed of laminated fibroblasts of up to 15 layers in thickness which are bounded by a basal lamina • Semi-permeable: inner lamellae have tight junctions, providing a barrier to intercellular transport of macromolecules – Tight junctions can be loosened with topical anaesthetics and with osmotic change Perineurium • Exhibits a slightly positive internal pressure – Fascicular contents herniate upon perineurial injury • Under tension longitudinally – Nerve segment shortens upon transection – may complicate surgical repair as nerve can be stretched only approximately 10% before being inhibited by collagen Endoneurium • Intrafascicular connective tissue consisting of a collagenous matrix in the interstitial space • Develops into partitions of dense connective tissue between diverging fascicles and eventually becomes perineurium when the fascicles separate • Collagen fibers are longitudinally-oriented and run along nerve fibers and capillaries. -
The Anatomic Basis of Vertebrogenic Pain and the Autonomic Syndrome Associated with Lumbar Disk Extrusion
219 The Anatomic Basis of Vertebrogenic Pain and the Autonomic Syndrome Associated with Lumbar Disk Extrusion 1 2 John R. Jinkins • Extruded lumbar intervertebral disks traditionally have been classified as posterior or Anthony R. Whittemore 1 central in location. A retrospective review of 250 MR imaging examinations of the lumbar William G. Bradley1 spine that used mid- and high-field imagers revealed 145 positive studies, which included a significant number of extrusions extending anteriorly. With the lateral margin of the neural foramen/pedicle as the boundary, 29.2% of peripheral disk extrusions were anterior and 56.4% were posterior. In addition, a prevalence of 14.4% was found for central disk extrusions, in which there was a rupture of disk material into or through the vertebral body itself. The clinical state of neurogenic spinal radiculopathy accom panying posterior disk extrusion has been well defined; however, uncomplicated anterior and central disk extrusions also may be associated with a definite clinical syndrome. The vertebrogenic symptom complex includes (1) local and referred pain and (2) autonomic reflex dysfunction within the lumbosacral zones of Head. Generalized alter ations in viscerosomatic tone potentially may also be observed. The anatomic basis for the mediation of clinical signs and symptoms generated within the disk and paradiskal structures rests with afferent sensory fibers from two primary sources: (1) posterolateral neural branches emanating from the ventral ramus of the somatic spinal root and (2) neural rami projecting directly to the paravertebral autonomic neural plexus. Thus, conscious perception and unconscious effects originating in the vertebral column, although complex, have definite pathways represented in this dual peripheral innervation associated with intimately related andfor parallel central ramifications. -
Nervous System Central Nervous System Peripheral Nervous System Brain Spinal Cord Sensory Division Motor Division Somatic Nervou
Autonomic Nervous System Organization of Nervous System: Nervous system Integration Central nervous system Peripheral nervous system (CNS) (PNS) Motor Sensory output input Brain Spinal cord Motor division Sensory division (Efferent) (Afferent) “self governing” Autonomic Nervous System Somatic Nervous System (Involuntary; smooth & (Voluntary; skeletal muscle) cardiac muscle) Stability of internal environment depends largely on this system Marieb & Hoehn – Figure 14.2 Autonomic Nervous System Ganglion: Comparison of Somatic vs. Autonomic: A group of cell bodies located in the PNS Cell body Effector location NTs organs Effect CNS Single neuron from CNS to effector organs ACh + Stimulatory Heavily myelinated axon Somatic NS Somatic Skeletal muscle ACh = Acetylcholine Two-neuron chain from CNS to effector organs CNS ACh Ganglion NE Postganglionic axon Preganglionic axon (unmyelinated) (lightly myelinated) Sympathetic + Stimulatory Autonomic NS Autonomic or inhibitory CNS Ganglion (depends ACh ACh on NT and NT receptor Smooth muscle, Type) Postganglionic glands, cardiac Preganglionic axon axon muscle Parasympathetic (lightly myelinated) (unmyelinated) NE = Norepinephrine 1 Autonomic Nervous System Organization of Nervous System: Nervous system Integration Central nervous system Peripheral nervous system (CNS) (PNS) Motor Sensory output input Brain Spinal cord Motor division Sensory division (Efferent) (Afferent) Autonomic Nervous System Somatic Nervous System (Involuntary; smooth & (Voluntary; skeletal muscle) cardiac muscle) Sympathetic division -
The Autonomic Nervous System of Selachians. by John Z
The Autonomic Nervous System of Selachians. By John Z. Young, B.A. With 28 Text-figures. CONTENTS. I. INTRODUCTION ......... 571 II. MATERIAL AND METHODS 572 III. ANATOMY AND HISTOLOGY OF THE SYMPATHETIC SYSTEM . 575 1. Nature of the Rami Communicantes .... 575 2. Anterior Eami Communicantes and Sympathetic Ganglia 581 3. Anatomy of the Sympathetic System in the Trunk . 581 4. Sympathetic System and Suprarenals in the Kidney Kegion 586 5. Sympathetic System in the Tail ..... 589 6. Autonomic Fibres in Spinal Dorsal Roots . 593 7. Cytology of the Sympathetic Ganglia .... 593 8. Relation of the Sympathetic Cells to the Suprarenal Tissue 598 9. Post-Branchial Plexus 600 IV. INNERVATION OF THE VISCERA 603 1. Nerves of the Alimentary Canal ..... 603 2. Innervation of the Urinogenital System . 609 3. Cardiac Nerves 610 V. CRANIAL AUTONOMIC SYSTEM 610 1. Autonomic Fibres in Branchial Nerves . 610 2. Profundus and Ciliary Nerves ..... 614 VI. PHYLOGENETIC HISTORY OF THE AUTONOMIC NERVOUS SYSTEM 617 VII. SUMMARY. 621 VIII. BIBLIOGRAPHY 623 I. INTRODUCTION. THE only complete account of the sympathetic nervous system of Selachians is that of Chevrel published in 1887. Since that date several papers have appeared dealing with special points of structure or function, such as those of Bottazzi (1902), Muller and Liljestrand (1918), and Lutz (1981), on the innerva- tion of the viscera; of Diamare (1901) on the histology; and of NO. 300 o o 572 JOHN Z. YOUNG Hoffmann (1900), Miiller (1920), and others, on the development. No attempt has yet been made to investigate the autonomic nervous system of these fish from the general standpoint intro- duced by Langley (1921) and Gaskell (1915); this the present study attempts to do. -
What Is the Autonomic Nervous System?
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.74.suppl_3.iii31 on 21 August 2003. Downloaded from AUTONOMIC DISEASES: CLINICAL FEATURES AND LABORATORY EVALUATION *iii31 Christopher J Mathias J Neurol Neurosurg Psychiatry 2003;74(Suppl III):iii31–iii41 he autonomic nervous system has a craniosacral parasympathetic and a thoracolumbar sym- pathetic pathway (fig 1) and supplies every organ in the body. It influences localised organ Tfunction and also integrated processes that control vital functions such as arterial blood pres- sure and body temperature. There are specific neurotransmitters in each system that influence ganglionic and post-ganglionic function (fig 2). The symptoms and signs of autonomic disease cover a wide spectrum (table 1) that vary depending upon the aetiology (tables 2 and 3). In some they are localised (table 4). Autonomic dis- ease can result in underactivity or overactivity. Sympathetic adrenergic failure causes orthostatic (postural) hypotension and in the male ejaculatory failure, while sympathetic cholinergic failure results in anhidrosis; parasympathetic failure causes dilated pupils, a fixed heart rate, a sluggish urinary bladder, an atonic large bowel and, in the male, erectile failure. With autonomic hyperac- tivity, the reverse occurs. In some disorders, particularly in neurally mediated syncope, there may be a combination of effects, with bradycardia caused by parasympathetic activity and hypotension resulting from withdrawal of sympathetic activity. The history is of particular importance in the consideration and recognition of autonomic disease, and in separating dysfunction that may result from non-autonomic disorders. CLINICAL FEATURES c copyright. General aspects Autonomic disease may present at any age group; at birth in familial dysautonomia (Riley-Day syndrome), in teenage years in vasovagal syncope, and between the ages of 30–50 years in familial amyloid polyneuropathy (FAP).