antioxidants Review Salvadora persica: Nature’s Gift for Periodontal Health Mohamed Mekhemar 1,* , Mathias Geib 2 , Manoj Kumar 3 , Radha 4, Yasmine Hassan 1 and Christof Dörfer 1 1 Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrecht’s University, 24105 Kiel, Germany;
[email protected] (Y.H.);
[email protected] (C.D.) 2 Dr. Geib Private Dental Clinic, Frankfurter Landstraße 79, 61352 Bad Homburg, Germany;
[email protected] 3 Chemical and Biochemical Processing Division, ICAR—Central Institute for Research on Cotton Technology, Mumbai 400019, India;
[email protected] 4 School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India;
[email protected] * Correspondence:
[email protected]; Tel.: +49-431-500-26251 Abstract: Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy. Citation: Mekhemar, M.; Geib, M.; Kumar, M.; Radha; Hassan, Y.; Dörfer, Keywords: Salvadora persica; periodontal disease; periodontitis; anti-inflammatory agents; antioxidants; C.