Open Space’ Meeting Called on 12 November 2015
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Research Development Innovation 2013/2014 Report
Centro Nacional de Biotecnología Campus de Cantoblanco RESEARCH Darwin 3, Madrid 28049, Spain Tel.: [+ 34] 91 585 4500 / Fax: [+ 34] 91 585 4506 DEVELOPMENT www.cnb.csic.es INNOVATION 2013/2014 REPORT INDEX Welcome to the CNB ................................................................................................................................................. 9 Carmen Castresana 1 / Plant Molecular Genetics 13 Genetic and molecular basis of naturally-occurring variation in plant development .............................................. 14 Carlos Alonso-Blanco Plant immunity strategies against microbial pathogen infection .............................................................................. 15 Carmen Castresana Genetic control of shoot branching patterns in plants ............................................................................................. 16 Pilar Cubas Plant-pathogen interaction in viral infections ........................................................................................................... 17 Juan Antonio García / Carmen Simón Genes involved in root architecture and in arsenic phytoremediation .................................................................... 18 Antonio Leyva Tejada Regulation of gene activity in plants: the phosphate starvation rescue system ...................................................... 19 Javier Paz-Ares Light signalling and day length control of potato tuber formation ........................................................................... 20 Salomé -
Haemophilia: Recent History of Clinical Management
HAEMOPHILIA: RECENT HISTORY OF CLINICAL MANAGEMENT The transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 10 February 1998 Edited by D A Christie and E M Tansey HAEMOPHILIA: RECENT HISTORY OF CLINICAL MANAGEMENT Participants Dr Derek Bangham Professor Ilsley Ingram Dr Ethel Bidwell Dr Peter Jones Sir Christopher Booth Professor Christine Lee (Chair) Dr Brian Colvin Dr James Matthews Dr Angela Dike Mrs Riva Miller Mr Ross Dike Dr Charles Rizza Dr Helen Dodsworth Rev Alan Tanner Professor Stuart Douglas* Dr Tilli Tansey Professor Robert Duthie Professor Edward Tuddenham Dr David Evans Dr David Tyrrell Dr Sheila Howarth Mr Clifford Welch Others present at the meeting: Dr Trevor Barrowcliffe, Ms Jacqui Marr, Dr J K Smith, Miss Rosemary Spooner Apologies: Professor Jean-Pierre Allain, Dr Donald Bateman, Dr Rosemary Biggs, Mrs Peggy Britten,** Professor Judith Chessells, Dr Audrey Dawson, Mr Ron Hutton, Professor Ralph Kekwick, Professor Sir David Weatherall *Deceased 15 November 1998 **Deceased 1 March 1999 2 Haemophilia: Recent history Professor Christine Lee:1 I think haemophilia is one of the best areas of clinical medicine where we have seen a very rapid introduction of scientific discovery into clinical practice. All of us who work on haemophilia realize that this has gone on very much with cooperation between the patients and the scientists and the doctors. I first saw haemophilia in 1967 when I was a medical student in Oxford and we were doing our orthopaedics at the Nuffield Orthopaedic Hospital. I have a very clear memory of a ward of little boys with their legs strung up, their arms strung up, and I think there was a schoolroom nearby. -
Clinical Pharmacology in the UK, C. 1950–2000: Industry and Regulation
CLINICAL PHARMACOLOGY IN THE UK, c. 1950–2000: INDUSTRY AND REGULATION The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 25 September 2007 Edited by L A Reynolds and E M Tansey Volume 34 2008 ©The Trustee of the Wellcome Trust, London, 2008 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 085484 118 9 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Reynolds L A, Tansey E M. (eds) (2008) Clinical Pharmacology in the UK c.1950-2000: Industry and regulation. Wellcome Witnesses to Twentieth Century Medicine, vol. 34. London: Wellcome Trust Centre for the History of Medicine at UCL. CONTENTS Illustrations and credits v Abbreviations vii Witness Seminars: Meetings and publications; Acknowledgements E M Tansey and L A Reynolds ix Introduction Professor Parveen Kumar xxiii Transcript Edited by L A Reynolds and E M Tansey 1 References 73 Biographical notes 89 Glossary 103 Index 109 ILLUSTRATIONS AND CREDITS Figure 1 AstraZeneca Clinical Trials Unit, South Manchester. Reproduced by permission of AstraZeneca. 6 Figure 2 A summary of the organization of clinical trials. Adapted from www.clinicaltrials.gov/ct2/info/glossary (visited 1 May 2008). 10 Figure 3 Clinical trial certificates (CTC) and clinical trial exemption (CTX), 1972–1985. Adapted from Speirs (1983) and Speirs (1984). -
An Investigation Into the in Vitro and in Vivo Function of Murine MRP-14 (S100A9)
An Investigation into the In Vitro and In Vivo Function of Murine MRP-14 (S100A9) Josie A. R. Hobbs March 2003 Supervisors Dr. Nancy Hogg (Cancer Research UK) Prof. Peter Beverley (University College London) This thesis is submitted in part fulfilment of the requirements for the degree of Doctor of Philosophy at the University of London ProQuest Number: U643505 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest. ProQuest U643505 Published by ProQuest LLC(2016). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. Microform Edition © ProQuest LLC. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 Abstract MRP-14 and its heterodimeric partner, MRP-8 are highly expressed in neutrophils and monocytes where they constitute 40% and 1% of the total cytosolic protein respectively. They are both low molecular weight proteins that belong to the SI GO family of Ca^^-binding proteins. Using the air pouch model of inflammation it has been demonstrated that recombinant murine MRP-14 (rMRP-14) is a potent chemoattractant for myeloid cells in vivo (May, 1999). While rMRP-14 did not directly cause chemotaxis or activation of myeloid cells in vitro, it caused a rapid elevation in the levels of cytokines in air pouch exudate, suggesting that rMRP-14 causes leukocyte influx via an indirect mechanism. -
Harper, Peter: Transcript of a Video Interview (06-Jun-2015)
History of Modern Biomedicine Research Group School of History, Queen Mary University of London Mile End Road, London E1 4NS website: www.histmodbiomed.org VIDEO INTERVIEW TRANSCRIPT Harper, Peter: transcript of a video interview (06-Jun-2015) Interviewer: Tilli Tansey Transcriber: Debra Gee Editors: Tilli Tansey, Alan Yabsley Date of publication: 20-Mar-2017 Date and place of interview: 06-Jun-2015; Glasgow Publisher: Queen Mary University of London Collection: History of Modern Biomedicine Interviews (Digital Collection) Reference: e2017093 Number of pages: 4 DOI: 10.17636/01021439 Acknowledgments: The project management of Mr Adam Wilkinson is gratefully acknowledged. The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity (no. 210183). The current interview has been funded by the Wellcome Trust Strategic Award entitled “Makers of modern biomedicine: testimonies and legacy” (2012-2017; awarded to Professor Tilli Tansey). Citation: Tansey E M (intvr); Tansey E M, Yabsley A (eds) (2017) Harper, Peter: transcript of a video interview (06-Jun- 2015). History of Modern Biomedicine Interviews (Digital Collection), item e2017093. London: Queen Mary University of London. Related resources: items 2017094 - 2017099, History of Modern Biomedicine Interviews (Digital Collection) Note: Video interviews are conducted following standard oral history methodology, and have received ethical approval (reference QMREC 0642). Video interview transcripts are edited only for clarity and factual accuracy. Related material has been deposited in the Wellcome Library. © The Trustee of the Wellcome Trust, London, 2017 History of Modern Biomedicine Interviews (Digital Collection) - Harper, P e2017093 | 2 Harper, Peter: transcript of a video interview (06-Jun-2015)* Biography: Professor Peter Harper (b. -
EMBO Facts & Figures
excellence in life sciences Reykjavik Helsinki Oslo Stockholm Tallinn EMBO facts & figures & EMBO facts Copenhagen Dublin Amsterdam Berlin Warsaw London Brussels Prague Luxembourg Paris Vienna Bratislava Budapest Bern Ljubljana Zagreb Rome Madrid Ankara Lisbon Athens Jerusalem EMBO facts & figures HIGHLIGHTS CONTACT EMBO & EMBC EMBO Long-Term Fellowships Five Advanced Fellows are selected (page ). Long-Term and Short-Term Fellowships are awarded. The Fellows’ EMBO Young Investigators Meeting is held in Heidelberg in June . EMBO Installation Grants New EMBO Members & EMBO elects new members (page ), selects Young EMBO Women in Science Young Investigators Investigators (page ) and eight Installation Grantees Gerlind Wallon EMBO Scientific Publications (page ). Programme Manager Bernd Pulverer S Maria Leptin Deputy Director Head A EMBO Science Policy Issues report on quotas in academia to assure gender balance. R EMBO Director + + A Conducts workshops on emerging biotechnologies and on H T cognitive genomics. Gives invited talks at US National Academy E IC of Sciences, International Summit on Human Genome Editing, I H 5 D MAN 201 O N Washington, DC.; World Congress on Research Integrity, Rio de A M Janeiro; International Scienti c Advisory Board for the Centre for Eilish Craddock IT 2 015 Mammalian Synthetic Biology, Edinburgh. Personal Assistant to EMBO Fellowships EMBO Scientific Publications EMBO Gold Medal Sarah Teichmann and Ido Amit receive the EMBO Gold the EMBO Director David del Álamo Thomas Lemberger Medal (page ). + Programme Manager Deputy Head EMBO Global Activities India and Singapore sign agreements to become EMBC Associate + + Member States. EMBO Courses & Workshops More than , participants from countries attend 6th scienti c events (page ); participants attend EMBO Laboratory Management Courses (page ); rst online course EMBO Courses & Workshops recorded in collaboration with iBiology. -
Brigitte M. Jockusch Editor the Actin Cytoskeleton Handbook of Experimental Pharmacology
Handbook of Experimental Pharmacology 235 Brigitte M. Jockusch Editor The Actin Cytoskeleton Handbook of Experimental Pharmacology Volume 235 Editor-in-Chief James E. Barrett, Philadelphia Editorial Board V. Flockerzi, Homburg M.A. Frohman, Stony Brook, NY P. Geppetti, Florence F.B. Hofmann, Mu¨nchen M.C. Michel, Mainz C.P. Page, London W. Rosenthal, Berlin K. Wang, Beijing More information about this series at http://www.springer.com/series/164 Brigitte M. Jockusch Editor The Actin Cytoskeleton Editor Brigitte M. Jockusch Cell Biology, Life Sciences BRICS, TU Braunschweig Braunschweig, Germany ISSN 0171-2004 ISSN 1865-0325 (electronic) Handbook of Experimental Pharmacology ISBN 978-3-319-46369-8 ISBN 978-3-319-46371-1 (eBook) DOI 10.1007/978-3-319-46371-1 Library of Congress Control Number: 2016963070 # Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
Non-Cleavable Talin Rescues Defect in the T-Cell Conjugation of T-Cells
Immunology Letters 172 (2016) 40–46 Contents lists available at ScienceDirect Immunology Letters j ournal homepage: www.elsevier.com/locate/immlet Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1 a,b a,b a,b,∗ Daina Lim , Yuning Lu , Christopher E. Rudd a Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK b Cambridge Institute of Medical Research, Hills Road, CB2 OXY Cambridge, UK a r a t i b s c t l e i n f o r a c t Article history: While the cytoskeletal protein talin binds to the -chain of LFA-1, the immune cell adaptor SKAP1 (SKAP- Received 13 October 2015 55) binds to the ␣-chain of the same integrin via RapL. Whereas calpain protease cleavage of talin is Received in revised form 2 February 2016 important for LFA-1 activation, it has been unclear whether SKAP1 can alter the function of talin or its Accepted 5 February 2016 associated adaptor RIAM in T-cells. In this paper, we report that Skap1−/− T-cells showed a reduction in Available online 19 February 2016 the translocation of talin and RIAM to the contact interface of T-cells with antigenic beads or dendritic cells (DCs) presenting OVA peptide to OT-1 T-cells. In addition, Skap1−/− T-cells show an altered pattern Keywords: of talin cleavage, while the expression of a cleavage resistant form of talin (L432G) restored the impaired T-cells − − Talin adhesion of OT1 transgenic Skap1 / T-cells with DCs. -
In Memoriam – Alan Hall Keith Burridge*
© 2015. Published by The Company of Biologists Ltd | Journal of Cell Science (2015) 128, 3167-3170 doi:10.1242/jcs.177154 OBITUARY In memoriam – Alan Hall Keith Burridge* ABSTRACT On May 3 of this year, cell biology lost a giant with the untimely passing of Alan Hall (Fig. 1). Alan didn’t discover the Rho family of GTPases but, more than anyone else, he and his laboratory brought these key regulatory proteins to the prominent position that they now occupy. I first met Alan in the early 1990s shortly after his landmark papers with Anne Ridley were published (Ridley and Hall, 1992; Ridley et al., 1992). Over the years our interests frequently overlapped, we met often at conferences and became friends. Ultimately, we became collaborators, each of us directing projects within a Program Project Grant that is headed by Klaus Hahn, and that also includes Gaudenz Danuser and John Sondek. Shortly before his death we had been in conversation about this grant and were discussing when we would next get together as a group. I was looking forward to seeing him again, not only because I enjoyed his company but because I always learned something new from every interaction. Other obituaries have covered Alan Hall’s career, research accomplishments and service to the research community, such as being Chair of Cell Biology at the Memorial Sloan Kettering Cancer Center and Editor-in-Chief of the Journal of Cell Biology. Here, I wish to share my perspective on his enormous contribution to the Rho GTPase field, particularly focusing on the decade of the 1990s when he and his laboratory thrust Rho GTPases to the forefront of cell biology. -
Women Physiologists
Women physiologists: Centenary celebrations and beyond physiologists: celebrations Centenary Women Hodgkin Huxley House 30 Farringdon Lane London EC1R 3AW T +44 (0)20 7269 5718 www.physoc.org • journals.physoc.org Women physiologists: Centenary celebrations and beyond Edited by Susan Wray and Tilli Tansey Forewords by Dame Julia Higgins DBE FRS FREng and Baroness Susan Greenfield CBE HonFRCP Published in 2015 by The Physiological Society At Hodgkin Huxley House, 30 Farringdon Lane, London EC1R 3AW Copyright © 2015 The Physiological Society Foreword copyright © 2015 by Dame Julia Higgins Foreword copyright © 2015 by Baroness Susan Greenfield All rights reserved ISBN 978-0-9933410-0-7 Contents Foreword 6 Centenary celebrations Women in physiology: Centenary celebrations and beyond 8 The landscape for women 25 years on 12 "To dine with ladies smelling of dog"? A brief history of women and The Physiological Society 16 Obituaries Alison Brading (1939-2011) 34 Gertrude Falk (1925-2008) 37 Marianne Fillenz (1924-2012) 39 Olga Hudlická (1926-2014) 42 Shelagh Morrissey (1916-1990) 46 Anne Warner (1940–2012) 48 Maureen Young (1915-2013) 51 Women physiologists Frances Mary Ashcroft 56 Heidi de Wet 58 Susan D Brain 60 Aisah A Aubdool 62 Andrea H. Brand 64 Irene Miguel-Aliaga 66 Barbara Casadei 68 Svetlana Reilly 70 Shamshad Cockcroft 72 Kathryn Garner 74 Dame Kay Davies 76 Lisa Heather 78 Annette Dolphin 80 Claudia Bauer 82 Kim Dora 84 Pooneh Bagher 86 Maria Fitzgerald 88 Stephanie Koch 90 Abigail L. Fowden 92 Amanda Sferruzzi-Perri 94 Christine Holt 96 Paloma T. Gonzalez-Bellido 98 Anne King 100 Ilona Obara 102 Bridget Lumb 104 Emma C Hart 106 Margaret (Mandy) R MacLean 108 Kirsty Mair 110 Eleanor A. -
Wellcome Witnesses to Twentieth Century Medicine: Volume 2 Tansey, EM; Christie, DA; Reynolds, LA
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Queen Mary Research Online Wellcome Witnesses to Twentieth Century Medicine: Volume 2 Tansey, EM; Christie, DA; Reynolds, LA For additional information about this publication click this link. http://qmro.qmul.ac.uk/jspui/handle/123456789/2746 Information about this research object was correct at the time of download; we occasionally make corrections to records, please therefore check the published record when citing. For more information contact [email protected] WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online following the links to Publications/Wellcome Witnesses at www.ucl.ac.uk/histmed Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to