DOCSLIB.ORG

WO 2020/212952 A1 22 October 2020 (22.10.2020)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
WO 2020/212952 A1 22 October 2020 (22.10.2020) (12) INTERNATIONAL APPLICATION PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization iii iiiii min linn ill II Minim mill ill m International Bureau (10) International Publication Number (43) International Publication Date WO 2020/212952 A1 22 October 2020 (22.10.2020) (51) International Patent Classification: 62/946, 159 10 December 2019 (10. 12.2019) U S A61K 31/675 (2006.01) A61P 25/30 (2006.01) (71) Applicant: COMPASS PATHFINDER LIMITED A61K 31/4045 (2006.01) A61P 25/00 (2006.01) [GB/GB]; 3rd Floor, 1 Ashley Road, Altrincham, Cheshire A61P1/00 (2006.01) A61P 25/06 (2006.01) WA14 2DT (GB). A61P 25/16 (2006.01) A61P25/22 (2006.01) (72) Inventors: LONDESBROUGH, Derek John; 37 Linden (21) International Application Number: Grove, Hartlepool, Durham TS26 9QA (GB). BROWN, PCT/IB2020/053688 Christopher; 30 Cherrytree Gardens, Gateshead, Tyne and (22) International Filing Date: Wear NE9 6TY (GB). NORTHEN, Julian Scott; 36 Hep- 17 April 2020 (17.04.2020) scott Terrace, South Shields, Tyne and Wear NE33 4TH (GB). MOORE, Gillian; 22 Matfen Court, Sedgefield, (25) Filing Language: English Durham TS21 2JB (GB). PATIL, Hemant Kashinath; (26) Publication Language: English 137C Kingston Road, Leatherhead, Surrey KT22 7NT (GB). NICHOLS, David E.; 56702 Nash, Chapel Hill, N C (30) Priority Data: 27517 (US). CROAL, Megan; c/o COMPASS Pathways 62/835,449 17 April 2019 (17.04.2019) U S Limited, 3rd Floor, 1 Ashley Road, Altrincham Cheshire 62/835,450 17 April 2019 (17.04.2019) U S WA14 2DT (GB). ERIKSSON, Hans Ake; c/o COM¬ 62/835,458 17 April 2019 (17.04.2019) U S PASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrin¬ 62/835,460 17 April 2019 (17.04.2019) U S cham Cheshire WA14 2DT (GB). GOLDSMITH, George; 62/835,464 17 April 2019 (17.04.2019) U S c/o COMPASS Pathways Limited, 3rd Floor, 1 Ashley 62/835,465 17 April 2019 (17.04.2019) U S Road, Altrinch am Cheshire WA14 2DT (GB). HICKEY, 62/835,472 17 April 2019 (17.04.2019) U S Molly Tabitha; c/o COMPASS Pathways Limited, 3rd 62/835,474 17 April 2019 (17.04.2019) U S Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT 62/835,476 17 April 2019 (17.04.2019) U S (GB). HURLEY, Shaun; c/o COMPASS Pathways Limit¬ 62/835,477 17 April 2019 (17.04.2019) U S ed, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 62/835,478 17 April 2019 (17.04.2019) U S 2DT (GB). MALIEVSKAIA, Ekaterina; c/o COMPASS 62/835,479 17 April 2019 (17.04.2019) U S Pathways Limited, 3rd Floor, 1 Ashley Road, Altrincham 62/835,480 17 April 2019 (17.04.2019) U S Cheshire WA14 2DT (GB). MARWOOD, Lindsey; c/o 62/835,481 17 April 2019 (17.04.2019) U S COMPASS Pathways Limited, 3rd Floor, 1 Ashley Road, 62/835,482 17 April 2019 (17.04.2019) U S Altrinch am Cheshire WA14 2DT (GB). MCCULLOCH, 62/835,484 17 April 2019 (17.04.2019) U S Drummond E-Wen Joe; c/o COMPASS Pathways Limit¬ 62/835,485 17 April 2019 (17.04.2019) U S ed, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 62/893,1 10 2 8 August 2019 (28.08.2019) U S 2DT (GB). MEDHURST, Laurie Emma; c/o COMPASS 62/893,61 1 2 9 August 2019 (29.08.2019) U S Pathways Limited, 3rd Floor, 1 Ashley Road, Altrin- (54) Title: TREATMENT OF DEPRESSION AND OTHER VARIOUS DISORDERS WITH PSILOCYBIN Exact 2 4 0 Mol W : 284 25 (57) Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a ther¬ apeutically -effective dose of psilocybin. The methods described herein may b e used to treat a variety of diseases, disorders, and con¬ ditions. For example, the methods may b e used to treat depression, neurocognitive disorders, autism spectrum disorder, and/or atten¬ tion-deficit/hyperactivity disorder. [Continued on nextpage] chant Cheshire WA14 2DT (GB). POULSEN, Nathan; c/o COMPASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT (GB). SELIMBE- YOGLU, Aslihan; c/o COMPASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT (GB). SOULA, Ana'is: c/o COMPASS Pathways Limit¬ ed, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT (GB). SHUXIANG, Amanda Tan; c/o COMPASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT (GB). VERAART, Manon Cecile Elisabeth; c/o COMPASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT (GB). WHELAN, Tobias Patrick; c/o COMPASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT (GB). WILDE, Lars Christian; c/o COM¬ PASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrin¬ cham Cheshire WA14 2DT (GB). WRIGHT, Stephen; c/ o COMPASS Pathways Limited, 3rd Floor, 1 Ashley Road, Altrincham Cheshire WA14 2DT (GB). (74) Agent: COOLEY (UK) LLP; Dashwood, 69 Old Broad Street, London EC2M IQS (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available) : AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, WS, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available) : ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, Cl, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE TREATMENT OF DEPRESSION AND OTHER VARIOUS DISORDERS WITH PSILOCYBIN RELATED APPLICATIONS This application claims priority to U.S. Application Serial Nos. 62/835,449; 62/835,450; 62/835,458; 62/835,460; 62/835,464; 62/835,465; 62/835,472; 62/835,474; 62/835,476; 62/835,477; 62/835,478; 62/835,479; 62/835,480; 62/835,481 ; 62/835,482; 62/835,484; and 62/835,485, all filed April 17 , 2019; U.S. Application Serial No. 62/893, 110 , filed August 28, 201 9 , U.S. Application Serial No. 62/893,61 1, filed August 29, 2019, and U.S. Application Serial No. 62/946,159, filed December 10, 2019, each of which is incorporated herein by reference in its entirety. BACKGROUND Depression is one of the most common mental illnesses, affecting more than 264 million people worldwide. It is characterized by depressed mood and markedly diminished interest or pleasure in activities. Other symptoms include significant weight loss or weight gain, decrease or increase in appetite, insomnia or hypersomnia, psychomotor agitation or retardation, fatigue or loss of energy, feelings of worthlessness or excessive or inappropriate guilt, diminished ability to think or concentrate or indecisiveness, recurrent thoughts of death, suicidal ideation or suicidal attempts. Current treatments for depression often consist of a combination of psychotherapy and one or more daily medications that regulate neurotransmitters such as dopamine, serotonin, and norepinephrine. These medications often take weeks to months to achieve their full effects and in the meantime, individuals continue to suffer from their symptoms and be at risk of self-harm, as well as harm to their personal and professional lives. There remains a need in the art for an effective treatment for depression that provides a rapid onset of antidepressant effects within hours or a few days and is sustained long-term. SUMMARY Psilocybin may provide numerous clinical benefits, such as benefits in neural plasticity and cognitive function (as measured using e.g., Cambridge Neuropsychological Test Automated Battery (CANTAB) tests) with improvements in, for example, working memory and executive function, sustained attention, and episodic memory. These benefits have implications for psilocybin’s use in the treatment of various diseases, disorders, and conditions, including both psychiatric and neurological aspects thereof. In some embodiments, the disclosure provides a method of treating depression in a subject in need thereof, the method comprising administering an effective amount of psilocybin or an active metabolite thereof to the subject. In some embodiments, the subject has a major depressive disorder, atypical depression, bipolar disorder, catatonic depression, a depressive disorder due to a medical condition, postpartum depression, premenstrual dysphoric disorder, or seasonal affective disorder. In some embodiments, the subject has a depressive disorder that is resistant to treatment.
Load more

Recommended publications
  • 4F ONLINE SHOP TERMS and CONDITIONS DEFINITIONS: 1. Seller
    4F ONLINE SHOP TERMS AND CONDITIONS DEFINITIONS: 1. Seller - company operating under the company name OTCF S.A. having its registered address in Wieliczka (ul. Grottgera 30, Wieliczka 32-020), registered by the District Court for Kraków - Śródmieście, XII Commercial Division of the National Court Register, under KRS number 0000555276, NIP tax identification number 9451978451, REGON state statistical number 356630870, share capital of PLN 7,384,500 (fully paid up), 4F Online Shop Customer Service Office telephone number +48 12 384 80 45 (fees charged as per the operator's rates), e-mail address: [email protected]. 2. Shop - 4F online shop available at https://4fstore.com, operated by the Seller being a sales platform, through which the Seller: 1. provides Shop functionality and services to Users; 2. solicits conclusion of distance contracts of sale of Goods; enables Users to become acquainted with the Goods offered by the Shop. Through the Shop, the Seller makes available adequate system, ICT and technological tools to provide the foregoing services. 3. Shop Website the website available at https://4fstore.com. 4. Terms and Conditions - these Terms and Conditions, setting out rules for the use of the Shop, in particular the rules for the conclusion of contracts of sale of the Goods offered by the Shop, the rules for performance thereof, and the rules of the complaint procedure. 5. User - a natural or a legal person, or an organisational unit without legal personality, who uses Shop functionalities. 6. Client - a User who has entered into contract of sale with the Seller. 7. Consumer - – a User being a natural person and performing a legal action with the Seller that is not directly related to the business or professional activity thereof, in particular entering into a contract of sale through the Shop.
    [Show full text]
  • 04-06-04 (The Liberty Champion, Volume 21, Issue 19)
    Scholars Crossing 2003 -- 2004 Liberty University School Newspaper Spring 4-6-2004 04-06-04 (The Liberty Champion, Volume 21, Issue 19) Follow this and additional works at: https://digitalcommons.liberty.edu/paper_03_04 Recommended Citation "04-06-04 (The Liberty Champion, Volume 21, Issue 19)" (2004). 2003 -- 2004. 15. https://digitalcommons.liberty.edu/paper_03_04/15 This Article is brought to you for free and open access by the Liberty University School Newspaper at Scholars Crossing. It has been accepted for inclusion in 2003 -- 2004 by an authorized administrator of Scholars Crossing. For more information, please contact [email protected]. Heed the Price advice Bush: Loyal leader or liar? ROTC: pushing potential Price gives the do's and Opinion gives reasons for Bush's plan for Iraq Liberty's ROTC program prepares don'ts of dating. and reminds us why we're there cadets to be future leaders in the first place. in the Army See page 2 See page 6 See page 2 The Liberty SERVING LIBERTY UNIVERSITY FOR TWENTY YEARS VOL. 21, NO. 19 ioAPRInL 6, 200 4 Speaker for graduation ORATION ON TOUR announced ByJakeBelue NEWS EDITOR On Monday morning, the Chancellor's Office at Liberty received a call confirming that Karl Rove would be giving the commencement address. "I wanted either President Bush or the Senior Advisor to the President," Dr. Jerry Falwell said with a laugh. "I wanted number one or number two." Karl Rove has been the president's chief political strategist for the past 15 years. Rove oversees the strategic planning, political affairs, public liaison, and intergovernmental affairs efforts of the White House.
    [Show full text]
  • Guaiana, G., Barbui, C., Caldwell, DM, Davies, SJC, Furukawa, TA
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Explore Bristol Research Guaiana, G., Barbui, C., Caldwell, D. M., Davies, S. J. C., Furukawa, T. A., Imai, H., ... Cipriani, A. (2017). Antidepressants, benzodiazepines and azapirones for panic disorder in adults: a network meta-analysis. Cochrane Database of Systematic Reviews, 2017(7), [CD012729]. https://doi.org/10.1002/14651858.CD012729 Publisher's PDF, also known as Version of record Link to published version (if available): 10.1002/14651858.CD012729 Link to publication record in Explore Bristol Research PDF-document This is the final published version of the article (version of record). It first appeared online via Cochrane Library at https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012729/full . Please refer to any applicable terms of use of the publisher. University of Bristol - Explore Bristol Research General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Cochrane Database of Systematic Reviews Antidepressants, benzodiazepines and azapirones for panic disorder in adults: a network meta-analysis (Protocol) Guaiana G, Barbui C, Caldwell DM, Davies SJC, Furukawa TA, Imai H, Koesters M, Tajika A, Bighelli I, Pompoli A, Cipriani A Guaiana G, Barbui C, Caldwell DM, Davies SJC, Furukawa TA, Imai H, Koesters M, Tajika A, Bighelli I, Pompoli A, Cipriani A. Antidepressants, benzodiazepines and azapirones for panic disorder in adults: a network meta-analysis. Cochrane Database of Systematic Reviews 2017, Issue 7.
    [Show full text]
  • Final Program
    IPA-0716-539 Final Program #IPASanFran2016 ABOUT IPA Founded in 1982, the International Psychogeriatric Association (IPA) is a unique and diverse professional healthcare community promoting better geriatric mental health – across disciplines, across borders, and across geriatric issues. Psychiatrists, Scientists, Neurologists, Geriatricians, Primary Care Physicians, Epidemiologists, Nurses, Psychologists, Occupational Therapists, Social Workers and many other healthcare profession- als come to the IPA community from all over the world to discuss, learn, share and research information about behavioral and biological aspects of geriatric mental health. IPA Member Benefits • Subscription to International Psychogeriatrics, IPA’s multidisciplinary peer-reviewed journal published monthly • Subscription to the IPA Bulletin, IPA’s membership newsletter • Reduced rates and access to IPA congress and meetings • IPA Online – the IPA website – including the IPA Member Area with special features including access to fellow members and The IPA Complete Guide to Behavioral and Psychological Symptoms of Dementia (BPSD) • Participation in IPA Member Forums, IPA’s in-person and online groups which enable members to meet, communicate, and collaborate with IPA colleagues around the world. Groups include: Regional Initiative Forums (groups by geographic areas); Professional Discipline Forums (groups such as nurses, psychologists, primary care physicians, social workers, and occupational therapists); and Shared Interest Forums (interest groups including long term care, young onset dementia, testamentary capacity and others) IPA Board of Directors OFFICERS DIRECTORS EX OFFICIO Raimundo Mateos, President, Spain Sabine Bährer-Kohler, Switzerland Manabu Ikeda, Japan Mary Sano, President-Elect, United States David Conn, Canada IPA SECRETARIAT Huali Wang, Secretary, PR China Brian Draper, Australia Kate Filipiak, CAE, Executive Director Constantine G.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
    US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8.598,119 B2 Mates Et Al
    US008598119B2 (12) United States Patent (10) Patent No.: US 8.598,119 B2 Mates et al. (45) Date of Patent: Dec. 3, 2013 (54) METHODS AND COMPOSITIONS FOR AOIN 43/00 (2006.01) SLEEP DSORDERS AND OTHER AOIN 43/46 (2006.01) DSORDERS AOIN 43/62 (2006.01) AOIN 43/58 (2006.01) (75) Inventors: Sharon Mates, New York, NY (US); AOIN 43/60 (2006.01) Allen Fienberg, New York, NY (US); (52) U.S. Cl. Lawrence Wennogle, New York, NY USPC .......... 514/114: 514/171; 514/217: 514/220; (US) 514/229.5: 514/250 (58) Field of Classification Search (73) Assignee: Intra-Cellular Therapies, Inc. NY (US) None See application file for complete search history. (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 (56) References Cited U.S.C. 154(b) by 215 days. U.S. PATENT DOCUMENTS (21) Appl. No.: 12/994,560 6,552,017 B1 4/2003 Robichaud et al. 2007/0203120 A1 8, 2007 McDevitt et al. (22) PCT Filed: May 27, 2009 FOREIGN PATENT DOCUMENTS (86). PCT No.: PCT/US2O09/OO3261 S371 (c)(1), WO WOOOf77OO2 * 6, 2000 (2), (4) Date: Nov. 24, 2010 OTHER PUBLICATIONS (87) PCT Pub. No.: WO2009/145900 Rye (Sleep Disorders and Parkinson's Disease, 2000, accessed online http://www.waparkinsons.org/edu research/articles/Sleep PCT Pub. Date: Dec. 3, 2009 Disorders.html), 2 pages.* Alvir et al. Clozapine-Induced Agranulocytosis. The New England (65) Prior Publication Data Journal of Medicine, 1993, vol. 329, No. 3, pp. 162-167.* US 2011/0071080 A1 Mar.
    [Show full text]
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • Dementia: Types, Stages and Sleep Disturbances
    DEMENTIA: TYPES, STAGES AND SLEEP DISTURBANCES Ericka L. Crouse, PharmD, BCPP, BCGP Associate Professor VCU School of Pharmacy Disclosures Dr. Crouse has nothing to disclose Objectives 1. Compare and contrast different types of dementia 2. Differentiate between stages of dementia and role of pharmacotherapy in each stage 3. List pros and cons of medications to treat sleep disturbances in dementia Pre-Assessment Question Which type of dementia is characterized by visual hallucinations especially of small animals and objects? A. Alzheimer’s B. Vascular C. Lewy-body D. Fronto-temporal Pre-Assessment Question Memantine is FDA indicated for which stage of Alzheimer’s disease? A. Mild cognitive impairment B. Mild/moderate C. Moderate/severe D. Only in combination with donepezil for mild/moderate Pre-Assessment Question Rapid-eye movement (REM) sleep behavior disorder is associated with which type of dementia? A. Alzheimer’s B. Vascular C. Lewy-body D. Fronto-temporal Pre-Assessment Question Which of the following is a risk associated with use of zolpidem in elderly patients? A. Falls with injury B. Decreased appetite C. Cognitive Impairment D. Anticholinergic effects Title TYPES OF DEMENTIA Change in Terminology DSM-IV DSM-5 • Dementia • Neurocognitive Disorder DSM = Diagnostic and Statistical Manual of Mental Disorders DSM-5 Am Psychiatric Assoc 2013 DSM-5 Criteria Evidence of a significant decline in cognitive function from previous level in ≥ 1 cognitive domain - Complex attention, executive function, learning and memory, language, perceptual-motor
    [Show full text]
  • Download Final Program
    September 20 – 23 2016 FINAL PROGRAM Bringing the Parkinson’s Community Together! Welcome Letters ................................................... 1-3 Committee Members ................................................ 4 General Information ............................................... 5-8 Wellness Way ...................................................11-14 WPC Theater .........................................................15 WPC Art Walk ........................................................17 TABLE OF WPC Awards .........................................................18 CONTENTS Social Program and Special Events ............................... 20 Travel Grants and Travel Grants Supporters ............22-23 Continuing Education ............................................... 24 Program-at-a-Glance .......................................... 26-27 Congress Program .............................................29-56 Posters and Poster Tours .................................... 57-95 Exhibition ........................................................ 96-115 PD Glossary .................................................. 118-126 Faculty List ......................................................... 127 Oregon Convention Center ....................................... 128 Portland Map .......................................................129 Organizational Partners ......................................... 130 Acknowledgements ...............................................131 The purpose of the World Parkinson Congresses is to create
    [Show full text]
  • WO 2015/072852 Al 21 May 2015 (21.05.2015) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2015/072852 Al 21 May 2015 (21.05.2015) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 36/84 (2006.01) A61K 31/5513 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/045 (2006.01) A61P 31/22 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/522 (2006.01) A61K 45/06 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/NL20 14/050780 KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (22) International Filing Date: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 13 November 2014 (13.1 1.2014) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (25) Filing Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 61/903,430 13 November 2013 (13. 11.2013) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: RJG DEVELOPMENTS B.V.
    [Show full text]
  • A Phase 3, Multicenter, Randomized, Double-Blind
    Official Title: A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment NCT Number: NCT03999918 Document Date: 21 Jun 2020 CLINICAL STUDY PROTOCOL UNMASKED PROTOCOL A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment Protocol Number: ACP-103-054 Amendment 4 EudraCT Number: 2018-003251-37 Original Protocol Date: 30 August 2018 Protocol Amendment 1 Date: 05 December 2018 Protocol Amendment 2 Date: 18 March 2019 Protocol Amendment 3 Date: 29 October 2019 Protocol Amendment 4 Date: 21 June 2020 Confidentiality Statement This protocol is the confidential information of ACADIA Pharmaceuticals Inc. and is intended solely for the guidance of the clinical investigation. This protocol may not be disclosed to parties not associated with the clinical investigation or used for any purpose without the prior written consent of ACADIA Pharmaceuticals Inc. Confidential and Proprietary Information of ACADIA Pharmaceuticals Inc. Page 1 of 81 Study: ACP-103-054 Final Version: 1.0 Clinical Study Protocol Amendment 4 UNMASKED VERSION Date: 21 June 2020 SPONSOR SIGNATURE PAGE Title: A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment ACADIA President: President ACADIA Pharmaceuticals Inc. See appended electronic signature page Signature Date ACADIA Study Lead: Executive Director, Clinical Research ACADIA Pharmaceuticals Inc.
    [Show full text]
  • The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances
    WHO/PSM/QSM/2006.3 The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2006 Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Medicines Policy and Standards The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 © World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]