CORRESPONDENCE Colour*Biind Drivers of Motor Vehicles, J.D.H
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CORRESPONDENCE Colour*biind drivers of motor vehicles, J.D.H. lies 1566 Screening for ovarian cancer, B. Dixon-Warren; D.R. Popkin 1566 A foundling hospital anthem for the International Year of the Child, A.J. Macnab, 1567 H.i. Macnab Use of choline In the treatment of ataxia associated with multiple sclerosis, R.A. Blattel 1568 Planning for psychiatric emergencies, A.J.R. Finlayson; M.R. Eastwood, S. Stiasny, 1568 F. Cashman, S.K. Littmann, G. Voineskos Skateboard injuries, V. Marchessault 1570 Nephrolithiasis in rural practice, R.J. Woistenholme 1570 Clinical pharmacology and therapeutics of benzodiazepines, D.P. Zarowny 1571 The Canada Health Survey - who will pay for it? W.A. McLeish 1571 Tuberculous cervical lymphadenitis, RN. Rivington 1572 Vietnamese refugees, M.L. Schwartz; A. Chan 1572 Psychiatric illness in physicians, G.A. Bailey 1572 Books 1579 Book Reviews 1597 Therapeutic Section and index 1600 Personal File 1624 Classified AdvertisIng 1626 Advertisers' Index 1634 CMA JOURNAL/DECEMBER 22, 1979/VOL. 121 1559 ing the role of neuraminidase in the 5. DowNn JC, LAyER WG: Isolation of the 2nd international Congress control of influenza. We think that of a type A influenza virus from an for Virology, MELNICK JL (ed), Australian pelagic bird. Virology 51: Karger, Basel, 1972, p 121 a vaccine containing only pure 259, 1973 23. COUCH RB, KASEL JA, GERIN JL, neuraminidase may prove to be 6. SCHULMAN JL: Immunology of in- et al: Induction of partial immunity ideal. On the basis of Kilbourne fluenza, in influenza Viruses and to influenza by a neuraminidase- and colleagues' hypothesis, natural influenza, KILBOURNE ED (ed), specific vaccine. J infect Dis 129: infection after immunization with Acad Pr, New York, 1975, p 373 411, 1974 neuraminidase would 7. BURNET FM: Principles of Animal 24. KILBOURNE ED: Comparative effi- result in a Virology, Acad Pr, New York, 1955, cacy of neuraminidase-specific and durable bispecific immunity to sub- p 380 conventional influenza virus vaccines sequent reinfection with antigen- 8. PANIKER CKJ: Serological relation- in induction of antibody to neura- ically similar influenza A viruses. ships between the neuraminidases of minidase in humans. I infect Dis The vaccine would be changed only influenza viruses. J Gen Virol 2: 134: 384, 1976 when the neuraminidase in the 385, 1968 25. OGRA PL, CHOW T, BEUTNER KR, 9. COLEMAN MT, DOWDLE WR, et al: Clinical and immunologic virus altered, and since 1934 only PEREIRA HG, et al: The Hong evaluation of neuraminidase-specific two types of neuraminidase have Kong/68 influenza A, variant. Lan- influenza A virus vaccine in humans. been detected. (N1 changed to N2 cet 2: 1384, 1968 I infect Dis 135: 499, 1977 in 1957.) In the future the immu- 10. SCHULMAN JL, KILBOURNE ED: In- 26. KENDAL AP, NOBLE GR, DOWDLE nogenic spectra of dependent variation in nature of WR: Neuraminidase content of in- neuraminidases hemagglutinin and neuraminidase fluenza vaccines and neuraminidase from the various strains may help antigens of influenza virus: distinc- antibody responses after vaccination in choosing a combination of neura- tiveness of hemagglutinin antigen of of immunologically primed and un- minidase antigens likely to provide Hong Kong-68 virus. Proc Natl primed populations. I infect Dis 136 a potent mixture to fight the un- Acad Sci USA 63: 326, 1969 (suppi): S415, 1977 predictable influenza epidemic. The 11. SCHULMAN JL: Effects of immunity 27. HENNESSY AV, MINusE E, DAvEN- on transmission of influenza: ex- PORT FM: Antineuraminidase anti- vaccine would be free of contamina- perimental studies. Prog Med Virol body response of man to influenza tion by the viral seed strain or the 12: 128, 1970 virus neuraminidase N2: results ob- substrate used for its cultivation. 12. FRANCIS T JR, DAVENPORT FM, tained with an improved hemagglu- It could be prepared in advance HENNESSY AV: Serological recapi- tination inhibition technique and an and would be available when tulation of human infection with enzyme inhibition test. I immunol needed. It would be acceptable different strains of influenza virus. 109: 213, Aug 1972 to Trans Assoc Am Physicians 66: 231, 28. MosTow SR, SCHILD GC, DOWDLE the public because there would 1953 WR, et al: Application of the single likely be no significant secondary 13. KENDAL AP, MINUSE E, MAASSAB radial diffusion test for assay of reactions. Children and pregnant HF, et al: Influenza neuraminidase antibody to influenza type A viruses. women could be vaccinated safely. antibody patterns of man. Am J I Clin Microbiol 2: 531, 1975 The proposed pure neuramini- Epidemiol 98: 96, 1973 29. DESSELBERGER U: Preparation-con- 14. STUART-HARRIS C: The influenza ditioned changes of the antigenicity dase vaccine may cost more but, problem. Med Lab Technol 32: 161, of influenza virus neuraminidases. when one looks at the benefits it 1975 Arch Virol 53: 335, 1977 offers, it becomes very appealing 15. Influenza virus. Morb Mortal Wkly 30. ARORA DJS, SCHUBERT JH, VINCENT and worth trying. Rep 26: 193, 1977 L: The presence of two neuramini- 16. ARORA DJS, PAvILANIS V, Bou- dases in an influenza virus. Can J I am grateful to Dr. G. Lussier for DREAULT A, et al: Antigenic proper- Microbiol (in press) his interest, to Drs. V. Pavilanis, A. ties of influenza virus proteins. Pre- Boudreault and J. Lecomte for read- sented at 3rd International Sympo- ing and discussing the manuscript, sium on Aerobiology, University of and to Miss Dominique D'Ascola for Sussex, Brighton, England, Sept 16- typing the paper. 18, 1969 BOOKS I This work was supported in part 17. BRANDON FB, Cox F, QUINN E, et al: Influenza immunization. Clin- under national health research and ical studies with ether-split subunit This list is an acknowledgement of development project 6605-1 359-41 of studies. Bull WHO 41: 629, 1969 books received. It does not preclude the Department of National Health 18. FENTERS JD, YAMASHIROYA HM, review at a later date. and Welfare. PETZOLD RF, et al: Enhanced im- References munogenicity in mice of a purified, tween-ether-treated influenza vac- ACUTE CARE. Based on the Proceed- 1. PEREIRA HG: Influenza: antigenic cine. Appl Microbiol 20: 544, 1970 ings of the Sixth International Sympo- spectrum. Prog Med Virol 11: 46, 19. WARBURTON MF: Desoxycholate- sium on Critical Care Medicine. Edited 1969 split influenza vaccines. Bull WHO by B.M. Tavares and R. Frey. 234 pp. 2. WEBSTER RG, PEREIRA HG: A com- 41: 639, 1969 Illust. Springer-Verlag New York, Inc., mon surface antigen in influenza 20. RUBEN FL, JACKSON GG: A new New York, 1979. $42.90, paperbound. viruses from human and avian subunit influenza vaccine: accepta- ISBN 0-387-09210-2 sources. J Gen Virol 3: 201, 1968 bility compared with standard vac- ARACHIDONIC ACID METABOLISM IN 3. WEBSTER RO: Estimation of the cines and effect of dose on anti- INFLAMMATION AND THROMBOSIS. molecular weights of the polypeptide genicity. J infect Dis 125: 656, 1972 Proceedings of the "First European chains from the isolated hemagglu- 21. WRIGHT PF, DOLIN A, LA MON- Workshop on Inflammation" held in TAGNE JR: Summary of clinical trials Basel in March 1979. Edited by K. tinin and neuraminidase subunits of Brune and M. Baggiolini. 301 pp. lIlust. influenza viruses. Virology 40: 643, of influenza vaccines - II. J infect Birkhauser Verlag, Basel; Birkhauser 1970 Dis 134: 633, 1976 Boston Inc., Cambridge, Massachusetts, 4. Idem: On the origin of pandemic 22. KILBOURNE ED, SCHULMAN JL, 1979. $38. ISBN 3-7643-1095-2 influenza viruses. Curr Top Micro- COUCH RB, et al: Orthomyxoviruses biol Immunol 59: 75, 1972 and paramyxoviruses, in Proceedings continued on page 1588 CMA JOURNAL/DECEMBER 22, 1979/VOL. 121 1579 asplenia,24 allowing a marked in- Miss Theresa W. Gyorkos, national malaria following treatment with ni- crease in the parasitemia and a reference centre for parasitology, Mc- trogen mustard. J Infect Dis 82: 5, fatal outcome, as reported by others Gill University, for their assistance 1948 and advice; and Dr. J.A. Marcoux, 19. SPIRA DT, GOLENSER J, ZUCKERMAN in protozoal infections,. especially A, et al: Multiple modes of action 10,26 head, division of infectious diseases, babesiosis, occurring after sple- Centre hospitalier universitaire of cyclophosphamide on plasmodial nectomy. de infections in rats. Trans R Soc Trop Sherbrooke, for reviewing the manu- Med Hyg 66: 921, 1972 Certain hematologic and patho- script. logical aspects of this case also de- 20. TALIAFERRO WH, TALIAFERRO LG, References SIMMONS EL: Increased parasitemia serve attention. The routine proce- in chicken malaria (Plasmodium gal- dures established to determine cell 1. DoixN A, DAMAS AF, ANDRIAMIAN- linaceum and Plasmodium lophurae) counts and differential counts and DRA A: Immunod.presseur et palu- fol!owing x-irradiation. J Infect Dis disme. A propos de deux cas de 77: 158, 1945 to examine blood smears do not leuc.mie trait.s au choraminopbene rule out the possibility of an oc- 21. BRUCE-CHWATT Li, DORRELL J, ayant r.v.l. un paludisme latent. TOPLEY E: Antilymphocyte serum casional "slip". As well, when an Bull Soc Pathol Exot 62: 867, 1969 and the course of rodent malaria in unusual pigment is detected in tis- 2. TAPPER ML, ARMSTRONG D: Mala- mice. Trans R Soc Trop Med Hyg sue sections one should determine na complicating neoplastic disease. 66: 522, 1972 Arch intern Med 136: 807, 1976 22. ARMSTRONG D, YOUNG LS, MEYER whether a method was employed 3. DOVER AS, GUINEE VF: that avoids the deposition of form- Malaria RD. et al: Infectious complications transmission by leucocyte compo- of neoplastic disease. Med C/in aim pigment by the use of neutral nent therapy. JAMA 217: 1701. Nordi Am 55: 729, 1971 buffered formalin. A selective dis- 1971 23. REMINGTON iS: The compromised tribution of such pigment within 4.