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Generated by SRI International Pathway Tools Version 25.0, Authors S Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001664545Cyc: Rhizobium sp. N741 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari pro a dicarboxylate an amino an amino an amino an amino an amino an amino an amino an amino glycine betaine acid acid acid molybdate an amino acid acid acid acid acid an amino sulfate arsenite sn-glycerol acid an amino an amino an amino an amino acid molybdate ammonium molybdate D-xylose predicted 3-phosphate acid acid acid acid predicted predicted predicted predicted predicted predicted predicted predicted predicted ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC transporter CcoS RS32175 RS24260 RS24235 RS24230 RS24070 RS22995 RS10550 RS21135 RS28395 RS07875 TolQ RS02515 RS03820 RS19105 YajC RS09790 ArsK RS20585 RS24115 XylF RS24250 RS24325 RS25035 UgpC RS15380 RS15005 RS27235 RS20540 RS31790 transporter transporter transporter transporter transporter transporter transporter transporter RS12545 ModC RS26725 transporter of L-proline/ predicted of an of an of an of an of an of an of an of an of molybdate glycine ABC urea urea betaine amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid transporter sulfate arsenite an amino of urea molybdate ammonium D-xylose sn-glycerol an amino an amino an amino an amino an amino molybdate acid 3-phosphate acid acid acid acid acid molybdate an amino an amino an amino an amino an amino an amino an amino an amino predicted pro a dicarboxylate ABC acid acid acid acid acid acid acid acid choline choline glycine betaine transporter of choline RS24190 Amine and Polyamine Degradation Degradation/ predicted tRNA-uridine 2-thiolation Macromolecule Modification Utilization/ 4 N 6 -(3-methylbut- ditrans,octacis- a peptidoglycan with a [protein]- an O - a mature an N-terminal- an N-terminal- queuosine at a (1->4)- ABC cob(II)yrinate a,c- Cofactor, Carrier, and Vitamin Biosynthesis Fatty Acid and Lipid Biosynthesis and selenation (bacteria) Assimilation - Other a sulfurated a NifEN a NifB protein menadione NADH + a [glutamine- a ribonucleoside an L-asparaginyl- an L-cysteinyl- ectoine ectoine [2Fe-2S] iron-sulfur NADP flavin biosynthesis I (bacteria and plants) superpathway of tetrahydrofolate biosynthesis and salvage superpathway of heme b NAD de novo biosynthesis ectoine degradation 2-en-1-yl)- undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- methylthymine H peptidoglycan L-methionyl-L- L-methionyl-L- glu position 34 α-D-glucan transporter cob(II)yrinate a,c-diamide superpathway of thiamine diphosphate biosynthesis II ethanolamine utilization L-carnitine degradation I L-cysteine (n) ATP diphosphate Asn Cys dGDP diamide biosynthesis I allantoin degradation choline-O-sulfate 4-aminobutanoate allantoin degradation L-carnitine degradation II [sulfur carrier] 37 protein complex with an L-cluster synthetase]- [tRNA ] [tRNA ] Asp cluster biosynthesis biosynthesis biosynthesis from glutamate I (from aspartate) acrylonitrile adenosine N-acetyl-(N-acetyl-β-D- L-lysyl-D-alanyl-D- in DNA (meso-DAP threonyl-[protein] vitamin B12- alanyl-[protein] of a tRNA 1,4-alpha- of ectoine biosynthesis II (late degradation degradation I to glyoxylate I (early cobalt insertion) palmitate biosynthesis (type II fatty acid synthase) cys to glyoxylate III degradation I in tRNA glucosaminyl)muramoyl- alanine) pentapeptide containing) L-tyrosine vitamin B12- glucan cobalt incorporation) octanoyl-[acyl-carrier ectoine dependent + gondoate biosynthesis dependent branching + + uroporphyrinogen-III NAD GTP asp cys a [ThiS sulfur- ectoine ethanolamine L-carnitine L-carnitine L-alanyl-γ-D-glutamyl-L- bifunctional helix- NADH-quinone ribonucleotide H RS25160 H uroporphyrinogen-III L-cysteine desulfurase GTP glu protein] biosynthesis (anaerobic) cysteine (S)-(+)-allantoin choline sulfate 4-aminobutanoate (S)-(+)-allantoin nitrogenase type I methionyl aminoacyl- type I methionyl aminoacyl- tRNA uroporphyrinogen-III carrier protein] carnitine 3- acrylonitrile tRNA (N6-isopentenyl lysyl-D-alanyl-D-alanine turn-helix domain- oxidoreductase: bifunctional [glutamine ribonucleotide protein NAD kinase: glutamate-- L-aspartate (mitochondria, yeast) hydrolase hydroxyectoine iron- lytic aminopeptidase: reductase: tRNA aminopeptidase: tRNA glutamyl- uroporphyrinogen-III cysteine an acetoacetyl-[acp] desulfurase: allantoinase choline- 4-aminobutyrate- allantoinase dehydrogenase: nitrile hydratase: adenosine(37)-C2)- containing protein/ AMK03_RS08065 reductase: GlgB: glgB C-methyltransferase: cysteine AMK03_RS08295 bifunctional GTP tRNA ligase: oxidase: DoeA: doeA molybdenum transglycosylase synthetase] map AMK03_RS08825 hydrolase: map hydrolase: Q(34) C-methyltransferase: desulfurase: a malonyl-[acp] an oleoyl-[acp] AMK03_RS11275 (2S)-2-acetamido- utilization PuuE: puuE sulfatase: betC -2-oxoglutarate PuuE: puuE nthB nthA methylthiotransferase AMK03_RS08070 AMK03_RS08825 cobA desulfurase: + AMK03_RS19060 AMK03_RS27650 an acetoacetyl-[acp] AMK03_RS22855 methylated-DNA-- adenylyltransferase/ 1,4-alpha- + + cobA NADP 3,4-dihydroxy- cyclohydrolase an L-glutamyl- 3-oxoacyl-[acyl- dehydratase transaminase: monofunctional cofactor domain-containing type I methionyl class 1b arfB type I methionyl arfB synthetase H RS18310 H 2-iminosuccinate AMK03_RS11275 [+ 2 isozymes] 4-aminobutanoate allantoate choline allantoate 3-dehydrocarnitine acrylamide MiaB: miaB [protein]-cysteine S- AMK03_RS08080 [glutamine synthetase]- class 1b uroporphyrinogen-III AMK03_RS11275 2-butanone- Glu 3-oxoacyl-[acyl- biosynthetic biosynthesis protein: GluQRS: glucan I FolE: folE [tRNA ] a carboxy- carrier-protein] an [L-cysteine EutB: eutB (R)-carnitinyl-CoA AMK03_RS00480 aminopeptidase: ribonucleoside- aminoacyl-tRNA aminopeptidase: aminoacyl-tRNA C-methyltransferase: uroporphyrinogen-III 4-phosphate 7,8- [+ 2 isozymes] carrier-protein] N-alpha-acetyl succinate succinate methyltransferase: AMK03_RS08095 adenylyl-L-tyrosine ribonucleoside- branching [+ 2 isozymes] adenylated- reductase: fabG beta-ketoacyl- desulfurase]-S- crotonobetainyl- choline peptidoglycan protein AMK03_RS14865 map diphosphate hydrolase: map hydrolase: gluQRS C-methyltransferase: quinolinate an [L-cysteine diaminobutyric semialdehyde amidase: dehydrogenase, AMK03_RS19150 nuoH nuoI phosphorylase: diphosphate cobA synthase/GTP dihydroneopterin reductase: fabG sulfanyl-L-cysteine acetaldehyde CoA dehydrogenase: transglycosylase: NifN: nifN [+ 10 isozymes] reductase: AMK03_RS15625 AMK03_RS15625 protein cobA an S-sulfanyl-[L- synthase desulfurase]-S- [ThiS sulfur- beta-ketoacyl- ACP synthase acid AMK03_RS27090 AMK03_RS08110 H + FliI H + precorrin-1 cyclohydrolase II: 3'-triphosphate D-glyceraldehyde beta-ketoacyl- hydratase: caiD betA NAD-dependent hydrophobic mtgA methylated-DNA-- AMK03_RS06585 reductase: GlgB: glgB precorrin-1 cysteine desulfurase] NadA: nadA sulfanyl-L-cysteine carrier protein] ACP reductase: I: fabB deacetylase amidase: nitrogenase nuoK an N-terminal L- a 2'- nrdF nrdE an N-terminal L- glutamyl- a (1,6)-α-D- AMK03_RS24205 3-phosphate ACP reductase: queuosine biosynthesis I (de novo) succinate- membrane anchor [protein]-cysteine S- nrdF nrdE uroporphyrinogen-III (S)-4-amino-5- AMK03_RS20820 [+ 2 isozymes] DoeB: doeB alcohol (S)-ureidoglycine (S)-ureidoglycolate trimethylaminoacetone AMK03_RS01115 iron- AMK03_RS08125 a mature GlcNAc-1,6- met threonyl-[protein] deoxyribonucleoside met alanyl-[protein] queuosine at glucosyl-(1,4) 2,5-diamino-6- quinolinate AMK03_RS20820 betaine aldehyde semialdehyde protein: sdhD methyltransferase: a [glutamine GDP C-methyltransferase: uroporphyrinogen-III oxopentanoate 1-deoxy-D- cysteine a [TusA sulfur- dehydrogenase a peptidoglycan with di-trans,octa-cis molybdenum peptidoglycan anhMurNAc- asn tRNA Asn cys a tRNA Cys position 34 (5-phospho-D- a (3R)-3- nuoN (n) 5'-diphosphate -α-glucan gly (S)-ureidoglycine dehydrogenase: ureidoglycolate Asp C-methyltransferase: 7,8- xylulose-5- L-2,4- γ acrylate 6 γ AMK03_RS01495 synthetase]-O cobA desulfurase: a (3R)-3-hydroxybutanoyl-[acp] carrier protein]-S- preQ AdhP: adhP -butyrobetainyl- crotonobetainyl- betaine-aldehyde (L-alanyl- -D-glutamyl- -undecaprenyl cofactor (meso-DAP L-Ala-γ-D-Glu- of a tRNA + F0F1 ATP + ribosylamino) glutamate-1- carboxylating hydroxybutanoyl-[acp] 0 N -(3-methylbut- 4 H H cobA an S-sulfanyl-[cysteine dihydroneopterin phosphate AMK03_RS11275 an (11Z)-3-oxo- diaminobutanoate acetyl-CoA aminohydrolase: CoA CoA AMK03_RS10760 lyase: 5'-deoxyadenosine an unsulfurated diphosphate [+ 2 isozymes] -(5'-adenylyl) synthase uroporphyrinogen-III pyrimidin- semialdehyde sulfanyl-L-cysteine NADPH-dependent 7- dehydrogenase: 2-en-1-yl)-2- met L-lysyl-D-alanyl-D- biosynthesis containing) DAP-D-Ala nicotinate- glycine 3-hydroxyacyl- icos-11-enoyl-[acp] AMK03_RS27210 [+ 5 isozymes] AMK03_RS16165 -L-tyrosine uroporphyrinogen-III desulfurase]-[disordered- 3'-phosphate 2,1-aminomutase: synthase: [+ 2 isozymes] 3-hydroxyacyl- cyano-7-deazaguanine betB (methylsulfanyl) [sulfur carrier] alanine) pentapeptide a [protein]-S- protein C-methyltransferase:
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