Stress Fractures of the Foot and Ankle
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Severe Septicaemia in a Patient with Polychondritis and Sweet's
81 LETTERS Ann Rheum Dis: first published as 10.1136/ard.62.1.88 on 1 January 2003. Downloaded from Severe septicaemia in a patient with polychondritis and Sweet’s syndrome after initiation of treatment with infliximab F G Matzkies, B Manger, M Schmitt-Haendle, T Nagel, H-G Kraetsch, J R Kalden, H Schulze-Koops ............................................................................................................................. Ann Rheum Dis 2003;62:81–82 D Sweet first described an acute febrile neutrophilic dermatosis in 1964 characterised by acute onset, fever, Rleucocytosis, and erythematous plaques.1 Skin biopsy specimens show infiltrates consisting of mononuclear cells and neutrophils with leucocytoclasis, but without signs of vasculi- tis. Sweet’s syndrome is frequently associated with solid malig- nancies or haemoproliferative disorders, but associations with chronic autoimmune connective tissue disorders have also been reported.2 The aetiology of Sweet’s syndrome is unknown, but evidence suggests that an immunological reaction of unknown specificity is the underlying mechanism. CASE REPORT A 51 year old white man with relapsing polychondritis (first diagnosed in 1997) was admitted to our hospital in June 2001 with a five week history of general malaise, fever, recurrent arthritis, and complaints of morning stiffness. Besides Figure 1 autoimmune polychondritis, he had insulin dependent Manifestation of Sweet’s syndrome in a patient with relapsing polychondritis. diabetes mellitus that was diagnosed in 1989. On admission, he presented with multiple small to medium, sharply demarked, raised erythematous plaques on both fore- dose of glucocorticoids (80 mg) and a second application of http://ard.bmj.com/ arms and lower legs, multiple acne-like pustules on the face, infliximab (3 mg/kg body weight) were given. -
Hypophosphatasia Could Explain Some Atypical Femur Fractures
Hypophosphatasia Could Explain Some Atypical Femur Fractures What we know Hypophosphatasia (HPP) is a rare genetic disease that affects the development of bones and teeth in children (Whyte 1985). HPP is caused by the absence or reduced amount of an enzyme called tissue-nonspecific alkaline phosphatase (TAP), also called bone-specific alkaline phosphatase (BSAP). The absence of TAP raises the level of inorganic pyrophosphate (Pi), which prevents calcium and phosphate from creating strong, mineralized bone. Without TAP, bones can become weak. In its severe form, HPP is fatal and happens in 1/100,000 births. Because HPP is genetic, it can appear in adults as well. A recent study has identified a milder, more common form of HPP that occurs in 4 of 1000 adults (Dahir 2018). This form of HPP is usually seen in early middle aged adults who have low bone density and sometimes have stress fractures in the feet or thigh bone. Sometimes these patients lose their baby teeth early, but not always. HPP is diagnosed by measuring blood levels of TAP and vitamin B6. An elevated vitamin B6 level [serum pyridoxal 5-phosphate (PLP)] (Whyte 1985) in a patient with a TAP level ≤40 or in the low end of normal can be diagnosed with HPP. Almost half of the adult patients with HPP in the large study had TAP >40, but in the lower end of the normal range (Dahir 2018). The connection between hypophosphatasia and osteoporosis Some people who have stress fractures get a bone density test and are treated with an osteoporosis medicine if their bone density results are low. -
Osteomalacia and Osteoporosis D
Postgrad. med.J. (August 1968) 44, 621-625. Postgrad Med J: first published as 10.1136/pgmj.44.514.621 on 1 August 1968. Downloaded from Osteomalacia and osteoporosis D. B. MORGAN Department of Clinical Investigation, University ofLeeds OSTEOMALACIA and osteoporosis are still some- in osteomalacia is an increase in the alkaline times confused because both diseases lead to a phosphatase activity in the blood (SAP); there deficiency of calcium which can be detected on may also be a low serum phosphorus or a low radiographs of the skeleton. serum calcium. This lack of calcium is the only feature Our experience with the biopsy of bone is that common to the two diseases which are in all a large excess of uncalcified bone tissue (osteoid), other ways easily distinguishable. which is the classic histological feature of osteo- malacia, is only found in patients with the other Osteomalacia typical features of the disease, in particular the Osteomalacia will be discussed first, because it clinical ones (Morgan et al., 1967a). Whether or is a clearly defined disease which can be cured. not more subtle histological techniques will detect Osteomalacia is the result of an imbalance be- earlier stages of the disease remains to be seen. tween the supply of and the demand for vitamin Bone pains, muscle weakness, Looser's zones, D. The the following description of disease is raised SAP and low serum phosphate are the Protected by copyright. based on our experience of twenty-two patients most reliable aids to the diagnosis of osteomalacia, with osteomalacia after gastrectomy; there is no and approximately in that order. -
5Th Metatarsal Fracture
FIFTH METATARSAL FRACTURES Todd Gothelf MD (USA), FRACS, FAAOS, Dip. ABOS Foot, Ankle, Shoulder Surgeon Orthopaedic You have been diagnosed with a fracture of the fifth metatarsal bone. Surgeons This tyPe of fracture usually occurs when the ankle suddenly rolls inward. When the ankle rolls, a tendon that is attached to the fifth metatarsal bone is J. Goldberg stretched. Because the bone is weaker than the tendon, the bone cracks first. A. Turnbull R. Pattinson A. Loefler All bones heal in a different way when they break. This is esPecially true J. Negrine of the fifth metatarsal bone. In addition, the blood suPPly varies to different I. PoPoff areas, making it a lot harder for some fractures to heal without helP. Below are D. Sher descriPtions of the main Patterns of fractures of the fifth metatarsal fractures T. Gothelf and treatments for each. Sports Physicians FIFTH METATARSAL AVULSION FRACTURE J. Best This fracture Pattern occurs at the tiP of the bone (figure 1). These M. Cusi fractures have a very high rate of healing and require little Protection. Weight P. Annett on the foot is allowed as soon as the Patient is comfortable. While crutches may helP initially, walking without them is allowed. I Prefer to Place Patients in a walking boot, as it allows for more comfortable walking and Protects the foot from further injury. RICE treatment is initiated. Pain should be exPected to diminish over the first four weeks, but may not comPletely go away for several months. Follow-uP radiographs are not necessary if the Pain resolves as exPected. -
ASSESSMENT of FIFTH METATARSAL ETIOLOGY Daniel Reed Clemson University, [email protected]
Clemson University TigerPrints All Theses Theses 7-2008 ASSESSMENT OF FIFTH METATARSAL ETIOLOGY Daniel Reed Clemson University, [email protected] Follow this and additional works at: https://tigerprints.clemson.edu/all_theses Part of the Biomedical Engineering and Bioengineering Commons Recommended Citation Reed, Daniel, "ASSESSMENT OF FIFTH METATARSAL ETIOLOGY" (2008). All Theses. 428. https://tigerprints.clemson.edu/all_theses/428 This Thesis is brought to you for free and open access by the Theses at TigerPrints. It has been accepted for inclusion in All Theses by an authorized administrator of TigerPrints. For more information, please contact [email protected]. ASSESSMENT OF FIFTH METATARSAL FRACTURE ETIOLOGY A Thesis Presented to the Graduate School of Clemson University In Partial Fulfillment of the Requirement for the Degree Master of Science Bioengineering by Daniel Reed August 2008 Accepted by: Dr. Martine Laberge, Committee Chair Dr. Lisa Benson Dr. Larry Bowman MD ABSTRACT The fifth metatarsal “Jones Fracture” is a fracture that occurs 3.5cm distal to the tuberosity. It is an injury that is common in athletes, especially those who participate in sports with a lot of lateral movement. The Jones Fracture is known for its difficulty to heal due to non-union and re-fracture. There has been much research recently regarding in-shoe pressure distributions and their relation to shoe type, movement, and shoe surface interaction. However, only the forces along the bottom of the foot have been investigated. Literature and the direction of fracture seem to implicate a force on the lateral portion of the foot is the cause of the fracture though the exact causal forces are still largely unknown. -
An Unusual Cause of Back Pain in Osteoporosis: Lessons from a Spinal Lesion
Ann Rheum Dis 1999;58:327–331 327 MASTERCLASS Series editor: John Axford Ann Rheum Dis: first published as 10.1136/ard.58.6.327 on 1 June 1999. Downloaded from An unusual cause of back pain in osteoporosis: lessons from a spinal lesion S Venkatachalam, Elaine Dennison, Madeleine Sampson, Peter Hockey, MIDCawley, Cyrus Cooper Case report A 77 year old woman was admitted with a three month history of worsening back pain, malaise, and anorexia. On direct questioning, she reported that she had suVered from back pain for four years. The thoracolumbar radiograph four years earlier showed T6/7 vertebral collapse, mild scoliosis, and degenerative change of the lumbar spine (fig 1); but other investigations at that time including the eryth- rocyte sedimentation rate (ESR) and protein electophoresis were normal. Bone mineral density then was 0.914 g/cm2 (T score = −2.4) at the lumbar spine, 0.776 g/cm2 (T score = −1.8) at the right femoral neck and 0.738 g/cm2 (T score = −1.7) at the left femoral neck. She was given cyclical etidronate after this vertebral collapse as she had suVered a previous fragility fracture of the left wrist. On admission, she was afebrile, but general examination was remarkable for pallor, dental http://ard.bmj.com/ caries, and cellulitis of the left leg. A pansysto- lic murmur was heard at the cardiac apex on auscultation; there were no other signs of bac- terial endocarditis. She had kyphoscoliosis and there was diVuse tenderness of the thoraco- lumbar spine. Her neurological examination was unremarkable. on September 29, 2021 by guest. -
Distinguishing Transient Osteoporosis of the Hip from Avascular Necrosis
Original Article Article original Distinguishing transient osteoporosis of the hip from avascular necrosis Anita Balakrishnan, BMedSci;* Emil H. Schemitsch, MD;* Dawn Pearce, MD;† Michael D. McKee, MD* Introduction: To review the circumstances surrounding the misdiagnosis of transient osteoporosis of the hip (TOH) as avascular necrosis (AVN) and to increase physician awareness of the prevalence and diagnosis of this condition in young men, we reviewed a series of cases seen in the orthopedic unit at St. Michael’s Hospital, University of Toronto. Methods: We studied the charts of patients with TOH referred between 1998 and 2001 with a diagnosis of AVN for demographic data, risk factors, imaging results and outcomes. Results: Twelve hips in 10 young men (mean age 41 yr, range from 32–55 yr) were identified. Nine men underwent magnetic resonance imaging (MRI) before referral, which showed characteristic changes of TOH. All 10 patients were referred for surgical intervention for a diagnosis of AVN. The correct diagnosis was made after reviewing patients’ charts and the scans and was confirmed by spontaneous resolution of both symptoms and MRI findings an average of 5.5 months and 7.5 months, respectively, after consultation. Conclusions: Despite recent publications, the prevalence of TOH among young men is still overlooked and the distinctive MRI appearance still misinterpreted. Symptoms may be severe but resolve over time with reduced weight bearing. The absence of focal changes on MRI is highly suggestive of a transient lesion. A greater level of awareness of this condition is needed to differentiate TOH from AVN, avoiding unnecessary surgery and ensuring appropriate treatment. -
Hematological Diseases and Osteoporosis
International Journal of Molecular Sciences Review Hematological Diseases and Osteoporosis , Agostino Gaudio * y , Anastasia Xourafa, Rosario Rapisarda, Luca Zanoli , Salvatore Santo Signorelli and Pietro Castellino Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy; [email protected] (A.X.); [email protected] (R.R.); [email protected] (L.Z.); [email protected] (S.S.S.); [email protected] (P.C.) * Correspondence: [email protected]; Tel.: +39-095-3781842; Fax: +39-095-378-2376 Current address: UO di Medicina Interna, Policlinico “G. Rodolico”, Via S. Sofia 78, 95123 Catania, Italy. y Received: 29 April 2020; Accepted: 14 May 2020; Published: 16 May 2020 Abstract: Secondary osteoporosis is a common clinical problem faced by bone specialists, with a higher frequency in men than in women. One of several causes of secondary osteoporosis is hematological disease. There are numerous hematological diseases that can have a deleterious impact on bone health. In the literature, there is an abundance of evidence of bone involvement in patients affected by multiple myeloma, systemic mastocytosis, thalassemia, and hemophilia; some skeletal disorders are also reported in sickle cell disease. Recently, monoclonal gammopathy of undetermined significance appears to increase fracture risk, predominantly in male subjects. The pathogenetic mechanisms responsible for these bone loss effects have not yet been completely clarified. Many soluble factors, in particular cytokines that regulate bone metabolism, appear to play an important role. An integrated approach to these hematological diseases, with the help of a bone specialist, could reduce the bone fracture rate and improve the quality of life of these patients. -
Case Report: Atypical Metatarsal Fracture in a Patient on Long- Term Bisphosphonate Therapy
November 2019. Volume 6. Number 4 Case Report: ATypical Metatarsal Fracture in a Patient on Long- Term Bisphosphonate Therapy Bijan Valiollahi1 , Mostafa Salehpour1 , Hamidreza Bashari1 , Shoeib Majdi1 , Mehdi Mohammadpour1 * 1. Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran. Use your device to scan and read the article online Citation Valiollahi B, Salehpour M, Bashari H, Majdi Sh, Mohammadpour M. ATypical Metatarsal Fracture in a Patient on Long-Term Bisphosphonate Therapy. Journal of Research in Orthopedic Science. 2019; 6(4):25-30. http://dx.doi.org/10.32598/ JROSJ.6.4.67 : http://dx.doi.org/10.32598/JROSJ.6.4.67 A B S T R A C T Bisphosphonates, more particularly alendronate, are a popular category of drugs in the treatment Article info: of postmenopausal and corticosteroid-induced osteoporosis. The present study contends that the Received: 13 May 2019 long-term consumption of bisphosphonates causes not only subtrochanteric and femoral shaft Revised: 27 May 2019 fractures but also pathological fractures at other musculoskeletal sites. This report presents a Accepted: 16 Sep 2019 rare case of alendronate-induced pathological metatarsal fracture in a 59-year-old female with a Available Online: 01 Nov 2019 history of cuboid fracture following a twisting with abnormal Bone Mineral Density (BMD) (T score: −3.5; lumbar spine and −2.6; proximal femur). Keywords: Alendronate, Pathologic Fracture, Metatarsal 1. Introduction ally, drugs such as bisphosphonates contribute to devel- oping bone fractures. tress fractures occur as a result of repetitive loading and unloading of a bone [1]. In- Bisphosphonates are preferred drugs in postmenopaus- creased strain or frequency of compression al and corticosteroid-induced osteoporosis [6]. -
Hypophosphatasia: Canadian Update on Diagnosis and Management
Osteoporosis International (2019) 30:1713–1722 https://doi.org/10.1007/s00198-019-04921-y CONSENSUS STATEMENT Hypophosphatasia: Canadian update on diagnosis and management A.A. Khan1 & R. Josse2 & P. Kannu3 & J. Villeneuve4 & T. Paul5 & S. Van Uum6 & C.R. Greenberg7 Received: 17 September 2018 /Accepted: 27 February 2019 /Published online: 26 March 2019 # International Osteoporosis Foundation and National Osteoporosis Foundation 2019, corrected publication 2019 Abstract Summary Hypophosphatasia (HPP) is a rare inherited disorder of bone and mineral metabolism caused by loss of function mutations in the ALPL gene. The presentation in children and adults can be extremely variable and natural history is poorly understood particularly in adults. Careful patient evaluation is required with consideration of pharmacologic intervention in individuals meeting criteria for therapy. Introduction The purposes of this review are to present current evidence regarding the diagnosis and management of hypophosphatasia in children and adults and provide evidence-based recommendations for management. Method A MEDLINE, EMBASE, and Cochrane database search and literature review was completed. The following consensus recommendations were developed based on the highest level of evidence as well as expert opinion. Results Hypophosphatasia is a rare inherited disorder of bone and mineral metabolism due to loss of function mutations in the tissue non-specific alkaline phosphatase (ALPL) gene causing reductions in the activity of the tissue non-specific isoenzyme of alkaline phosphatase (TNSALP). Deficient levels of alkaline phosphatase result in elevation of inhibitors of mineralization of the skeleton and teeth, principally inorganic pyrophosphate. The impaired skeletal mineralization may result in elevations in serum calcium and phosphate. Clinical features include premature loss of teeth, metatarsal and subtrochanteric fractures as well as fragility fractures. -
Mineralization of Bones in Osteoporosis and Osteomalacia Walaa Fikry Elbossaty*
Review Article iMedPub Journals Annals of Clinical and Laboratory Research 2017 www.imedpub.com Vol.5 No.4:201 ISSN 2386-5180 DOI: 10.21767/2386-5180.1000201 Mineralization of Bones in Osteoporosis and Osteomalacia Walaa Fikry Elbossaty* Department of Chemistry, Biochemistry Division, Faculty of Science, Damietta University, Damietta, Egypt *Corresponding author: Walaa Fikry Elbossaty, Department of Chemistry, Biochemistry Division, Faculty of Science, Damietta University, Damietta, Egypt, Tel: + 020573761683; E-mail: [email protected] Received: September 01, 2017; Accepted: November 20, 2017; Published: November 27, 2017 Citation: Elbossaty WF (2017) Mineralization of Bones in Osteoporosis and Osteomalacia. Ann Clin Lab Res Vol.5: No.4: 201. more well-known than osteomalacia [2]. Abstract Literature Review All vital process in human life as walking, jumping, working, and enjoy with good life apply healthy bone. The normal bone formation required significant amount of some minerals as calcium and phosphorous, also vitamin D which play important role in movement of calcium in to bone which responsible for bone healthy. There are different causes include life style, genetics, hormonal, and insufficient amount take from calcium and vitamin D which responsible for defect in bone formation process, and appear abnormal bone structure. The most bone diseases are osteoporosis, and osteomalacia in this work we discuss the definition, causes sign, diagnosis, pathophysiology, and treatment of both osteoporosis, and osteomalacia. Keywords: Osteoporosis; Vitamin D; Osteomalacia; Figure 1 Structure of bone Calcium Osteoporosis Introduction Definition of osteoporosis: Osteoporosis is a bone disease which characterized by low bone mass as result of body loses Bone too much bone and makes too little bone. -
Metatarsal Fracti]Res
METATARSAL FRACTI]RES Bradley D. Castellano, DPM Stepben V. Corey, DPM TbomasJ. Merrill, DPM John A. Rucb, DPM As with many common disorders of the foot, the displaced fractures, stress fractures, joint disloca- area of metatarsal fractures has received only tions, intra-articular fractures, severely comminut- superficial attention in historical and current med- ed and even compound fractures. The sllrgeon ical and surgical discr-rssions. General principles must have a thorough working knowledge of of fracture management have been sparingly these injuries in the specific region and unique applied to the topic in most ofihopedic and podi- anatomy of the forefoot. The full scope of poten- atric texts. The fifth metatarsal, however, has tial injury must be appreciated to avoid misdiag- received some degree of attention uncler the nosis and inappropriate treatment. eponym of the Jones' fracture. The eponym how- The variety of injuries to the metatarsal ever is often misapplied to the common avulsion region can be systematically classified. This type fracture of the fifth metatarsal base. Most refer- of classification can serve the same purpose as ences ciealing with the subject are interesting per- the Lauge-Hansen system in ankle fractures. A sonal experiences with metatarsal fractures and working knowledge of the mechanism of injury is an attempt to introduce a new or re-visited tech- also the key to successful management of many nique for the management of a unique or bizarre of the common injuries through conservative injury. Figura presents a iogical and rather com- methods or closed reduction techniques. plete classification of metatarsal fractures and dis- Complete clinical and radiographic evalua- cusses treatment.l tion are essential stepping stones in the success- State of the art has yet to be described in the ful management of metatarsal fractures.