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2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page i PocketDavis’s Clinical Drug Reference 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page ii 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page iii PocketDavis’s Clinical Drug Reference Shamim Tejani, PharmD Pediatric Clinical Pharmacist St. Joseph’s Hospital and Medical Center Phoenix, Arizona Cynthia A. Sanoski, B.S., PharmD, FCCP, BCPS Chair, Department of Pharmacy Practice Jefferson School of Pharmacy Thomas Jefferson University Philadelphia, Pennsylvania 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page iv F. A. Davis Company 1915 Arch Street Philadelphia, PA 19103 www.fadavis.com Copyright © 2009 by F. A. Davis Company Copyright © 2009 by F. A. Davis Company. All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without written permission from the publisher. Printed in the United States of America Last digit indicates print number 10 9 8 7 6 5 4 3 2 1 Director of Content Development: Darlene D. Pedersen Senior Acquisitions Editor: Thomas A. Ciavarella Project Editor: Meghan K. Ziegler Design and Illustration Manager: Carolyn O’Brien As new scientific information becomes available through basic and clinical research, recommended treatments and drug therapies undergo changes. The author(s) and publisher have done everything possible to make this book accurate, up to date, and in accord with accepted standards at the time of publication. The author(s), editors, and publisher are not responsible for errors or omissions or for consequences from application of the book, and make no warranty, expressed or implied, in regard to the contents of the book. Any practice described in this book should be applied by the reader in accordance with professional standards of care used in regard to the unique circumstances that may apply in each situation. The reader is advised always to check product information (package inserts) for changes and new information regarding dose and contraindications before administering any drug. Caution is especially urged when using new or infrequently ordered drugs. ISBN-13: 978-0-8036-2078-0 ISBN-10: 0-8036-2078-0 Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by F. A. Davis Company for users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the fee of $.25 per copy is paid directly to CCC, 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license by CCC, a separate system of payment has been arranged. The fee code for users of the Transactional Reporting Service is: 8036-2078-0/09 0 + $.25. 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page v To my son, Cameron, the “transformer” who has changed my life forever. To my daughter, Sierra, the “big star” without whom I could not navigate. Your patience made this book possible. Shamim Tejani To my mother, Geraldine, whose continual love, support and guidance are present in all that I do. Thank you for your patience and under- standing as I worked on this important project. Cynthia Sanoski 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page vi 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page vii Table of Contents Preface ix Reviewers xi List of Abbreviations xiii Drug Monographs in Alphabetical Order by Generic Name 1 Appendices 280 Appendix A. Commonly Used Antidotes for Drug Overdoses 280 Appendix B. Controlled Substances Schedules 282 Appendix C. Critical Care Drug Infusions 283 Appendix D. Cytochrome P450 Substrates/Inducers/ Inhibitors 285 Appendix E. Formulas Helpful for Calculating Doses 289 Appendix F. Equianalgesic Dosing Guidelines 290 Appendix G. Insulins and Insulin Therapy 292 Appendix H. Measurement Conversion Table 295 Appendix I. Pediatric Intravenous Medication Quick Reference Chart 296 Appendix J. Pregnancy Categories 298 Appendix K. Routine Pediatric and Adult Immunizations 299 Comprehensive Generic/Trade Index 301 vii 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page viii 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page ix Preface Davis’s Pocket Clinical Drug Reference is a quick resource for the most commonly used drugs in clinical practice. The monographs are designed to highlight pertinent information; specifically, each mono- graph includes a drug’s generic name, brand name, therapeutic indication, pharmacologic class, pregnancy class, contraindications, adverse drug reactions, drug interactions, dose, availability, and mon- itoring parameters. To incorporate as many drugs as possible into a pocket drug guide format, only the most common adverse drug reactions and drug interactions are presented within each monograph. The table entitled Cytochrome P450 Substrates/Inhibitors/Inducers (page 285) pro- vides more specific information regarding the drugs that may be involved in certain drug interactions. Additionally, within each monograph, a Notes section is included to highlight miscellaneous information that users should consider when initiating or monitor- ing drug therapy in their patients. In the Appendix, a number of useful tables and charts, covering topics such as immunization guidelines, intravenous drugs, and nar- cotic equianalgesic dosing guidelines, provide additional information that is relevant to clinical practice. To obtain detailed drug informa- tion beyond what is supplied in the monographs of this pocket drug guide, the user should refer to the medical literature or the complete product information supplied by the manufacturer. ix 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page x 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page xi Reviewers Naveed Ahmed, MPAS, PA-C Ellen Wruble Hakim, PT, DScPT, Drexel University MS, CWS, FACCWS Hahnemann Physician Assistant Vice Chair for Professional Program Programs Director for Philadelphia, Pennsylvania Entry-Level DPT Program University of Maryland School Carole Berube, BSN, MSN, MA of Medicine (Psychology), RN Department of Physical Therapy Professor Emerita in Nursing, and Rehabilitation Instructor in Health Sciences Baltimore, Maryland Bristol Community College Fall River, Massachusetts Ken Harbert, PhD, CHES, PA-C Dean and Program Director Mary Anne Crandall, RN, BS, South College MS, PhD, CLT, CCT Knoxville, Tennessee Doctor Therapeutic Laser and Thermal Imaging Center Kris Hardy, CMA, RHE, CDF Medford, Oregon Medical Assistant Program Director/Instructor Dori Gilman, MA Brevard Community College LPN Coordinator, LPN & RN Cocoa, Florida Instructor North Country Community Marsha Hemby, ADN, CMA College Department Chair, Medical Saranac Lake, New York Assisting Pitt Community College Cheryl Gilton, RN, BSN, Med Greenville, North Carolina Director, Pharmacy Technician Program Mary Ann Laxen, PA-C, MAB Allegany College of Maryland Director, Physician Assistant Special Health Initiatives Program Cumberland, Maryland University of North Dakota, School of Medicine and Health Catherine C. Goodman, PT, MBA Sciences Faculty Affiliate, Medical Writer Grand Forks, North Dakota (Medical Multimedia Group) University of Montana Kathy Makkar, PharmD School of Pharmacy and Allied Clinical Pharmacy Specialist, Health Cardiology Missoula, Montana Lancaster General Hospital Lancaster, Pennsylvania xi 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page xii Allison A. Morgan, MPA, PA-C Daniel Thibodeau, MHP, PA-C Instructor Assistant Professor, Physician Duquesne University Assistant Program John H. Rangos, Sr. Eastern Virginia Medical School School of Health Sciences Norfolk, Virginia Pittsburgh, Pennsylvania Marilyn M. Turner, RN, CMA Patti Pagels, MPAS, PA-C Medical Assisting Program Assistant Professor/Vice-Chair, Director Clinical Service Ogeechee Technical College University of North Texas Health Statesboro, Georgia Science Center Fort Worth, Texas Karen Snipe, CPhT, Med Pharmacy Technician Program Coordinator Department Head, Diagnostic & Imaging Services Trident Technical College Charleston, South Carolina xii 2078_FM_i-xviii.qxd 2/5/09 1:27 PM Page xiii List of Abbreviations → → increase, increased ATP adenosine triphosphate decrease, decreased AV atrioventricular A1C glycosylated hemoglobin Availability (G): ABG arterial blood gas generic availability ABW actual body weight AVM arteriovenous ac before meals malformation ACE angiotensin-converting BG blood glucose enzyme bid two times a day ACEI angiotensin-converting BMD bone mineral density enzyme inhibitor BMI body mass index ACLS advanced cardiac life BMT bone marrow support transplantation ACS acute coronary syndrome BP blood pressure ACT activated clotting time BPH benign prostatic AD Alzheimer’s disease hyperplasia ADH antidiuretic hormone bpm beats per minute ADHD attention-deficit hyper- BSA body surface area activity disorder BUN blood urea nitrogen ADR adverse drug reaction BZ benzodiazepine AF atrial fibrillation Ca calcium AFl atrial flutter CA cancer AIDS acquired immune CABG coronary artery bypass deficiency syndrome graft alk phos alkaline phosphatase CAD coronary artery disease ALL acute lymphocytic leukemia cap capsule ALT alanine aminotransferase CAP community-acquired AML acute myelogenous pneumonia leukemia CBC complete blood count ANA antinuclear antibodies CCB calcium channel blocker ANC absolute neutrophil count CEL chronic eosinophilic ANLL acute nonlymphocytic leukemia leukemia CK creatine kinase aPTT activated partial thrombo- CKD chronic kidney disease plastin time CI contraindication ARB angiotensin receptor CML chronic myelogenous blocker
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