MOLECULAR PHARMACOLOGY 26:605-609
AUTHOR INDEX FOR VOLUME 26
A berg, Aaron, Watanabe, Kyoichi A., Fox, Jack J., and Philips, Frederick S. Metabolic Competition Studies of 2’-Fluoro-S-iodo-l- Albengres, Edith. See Urien, Riant, Brioude, and Tillement, 322 f3-D-arabinofuranosylcytosine in Vero Cells and Herpes Simplex Albuquerque, E. X. See Aracava, Ikeda, Daly, and Brooks, 304 Type 1-Infected Vero Cells, 587 See Ikeda, Aronstam, Daly, and Aracava, 293 Christie, Nelwyn T. See Cantoni, Swann, Drath, and Costa, 360 Ambler, S. Kelly, Brown, R. Dale, and Taylor, Palmer. The Chrivia, John. See Bolger, Dionne, Johnson, and Taylor, 57 Relationship between Phosphatidylinositol Metabolism and Mobili- Colacino, Joseph M. See Chou, Lopez, Feinberg, Watanabe, Fox, and zation of Intracellular Calcium Elicited by Alpha,-Adrenergic Recep- Philips, 587 tar Stimulation in BC3H-1 Muscle Cells, 405 Collins, Sheila, and Marletta, Michael A. Carcinogen-Binding Aracava, Y. Ikeda, S. R., Daly, J. W., Brookes, N., and Albu- Proteins: High-Affinity Binding Sites for Benzo[ajpyrene in Mouse querque, E. X. Interactions of Bupivacaine with Ionic Channels of Liver Distinct from the Ah Receptor, 353 the Nicotonic Receptor: Analysis of Single-Channel Currents, 304 Cooper, Dermot M. F. See Sadler and Mailer, 526 See Ikeda, Aronstam, Daly, and Albuquerque, 293 Corbett, Michael D. See Doerge, 348 Aronstam, R. S. See Ikeda, S. R. , Daly, J. W., Aracava, Y. , and Cormier, Ethel. See Jordan, Lieberman, Koch, Bagley, and Ruenitz, Albuquerque, E. X. , 293 272 Aub, Debra L. See Putney, McKinney, and Leslie, 261 Costa, Erminio. See Quach, Tang, Kageyama, Mocchetti, Guidotti, Meek, and Schwartz, 255 B Costa, Max. See Cantoni, Christie, Swann, and Drath, 360 Bachur, Nicholas R. See Gutierrez, Fox, and Mossoba, 582 Cuatrecasas, P. See Chang and Blanchard, 484 Bagley, Jerome R. See Jordan, Lieberman, Cormier, Koch, and Ruenitz, 272 D
Baker, James. A. See Jaques, Tobes, Sisson, and Wiekznd, 539 Dahlbom, Richard. See Ringdahl, Resul, Ehiert, and Jensen, 170 Banker, K. M. See Sultatos, Shao, and Murphy, 99 Daly, J. W. See Aracava, Ikeda, Brookes, and Albuquerque, 304 Beaujouan, J. C., Torrens, Y., Viger, A., and Glowinski, J. A See Ikeda, Aronstam, Aracava, and Albuquerque, 293 New Type ofTachykinin Binding Site in the Rat Brain Characterized Dna, Mukul. See Marnett, Siedlik, Ochs, Pagels, Honn, Warnock, by Specific Binding of a Labeled Eledoisin Derivative, 248 Tamer, and Eling, 328 Belinsky, Steven A., Kauffman, Frederick C., and Thurman, DeBernardis, John F. See Dickinson, Leeb-Lundberg, Heald, Wik- Ronald G. Reducing Equivalents for Mixed Function Oxidation in berg, Caron, and Lefkowitz, 187 Periportal and Pericentral Regions of the Liver Lobule in Perfused De Clercq, Erik. See Yokota, Konno, arid Shigeta, 376 Livers from Normal and Phenobarbital-Treated Rats, 574 De Lean, Andr#{233},Ong, Huy, Gutkowska, Jolanta, Schiller, Peter Beuzard, Y. See Garel, Domenget, Galacteros, and Martin-Caburi, 559 w., and McNicoll, Normand. Evidence for Agonist-Induced In- Blanchard, S. G. See Chang Cuatrecasas, 484 and teraction of Angiotensin Receptor with a Guanine Nucleotide-Bind- Javitch and Snyder, 35 Blaustein, Robert 0. See ing Protein in Bovine Adrenal Zona Glomerulosa, 498 Bockaert, Joel, Cantau, Bernard, and Sebben-Perez, Mich#{232}le. See Wreggett, 214 Hormonal Inhibition of Adenylate Cyclase: a Crucial Role for Dickinson, Kenneth E. J., Leeb-Lundberg, L. M. Fredrik, 180 Heald, Sarah L., Wikberg, Jarl E. S., DeBernardis, John F., Bolger, Michael B., Dionne, Vincent, Chrivia, John, Johnson, Caron, Marc G., and Lefkowitz, Robert J. Photoaffinity Cross- David A., and Taylor, Palmer. Interaction of a Fluorescent Linking of a Radioiodinated Probe, ‘251-A55453, into Alpha,-Adre- Acyldicholine with the Nicotinic Acetylcholine Receptor and Acetyl- nergic Receptors, 187 cholinesterase, 57 Dionne, Vincent. See Bolger, Chrivia, Johnson, and Taylor, 57 Brioude, Robert. See Urien, Riant, Albengres, and Tillement, 322 Doerge, Daniel R., and Corbett, Michael D. Hydroperoxyflavin- Brookes, N. See Aracava, Ikeda, Daly, and Albuquerque, 304 Mediated Oxidations of Organosulfur Compounds: Model Studies for Brown, Joan Heller. See Masters and Harden, 149 the Flavin Monooxygenase, 348 Brown, R. Dale. See Ambler and Taylor, 405 Domenget, C. See Garel, Galacteros, Martin-Caburi, and Beuzard, 559 Burk, Raymond F. See Krieter, Ziegler, and Hill, 122 Doss, Robert C. See Waldo, Perkins, and Harden, 424 Butlen, Daniel. See Guillon and Rajerison, 241 Drath, David B. See Cantoni, Christie, Swann, and Costa, 360 Duax, W. L., Swenson, D. C., Strong, P. D., Korach, K. S., C McLachlan, J., and Metzler, M. Molecular Structures of Metab- olites and Analogues of Diethylstilbestrol and Their Relationship to Cantau, Bernard. See Bockaert and Sebben-Perez, 180 Receptor Binding and Biological Activity, 520 Cantoni, Orazio, Christie, Nelwyn T., Swann, Allan, Drath, David B., and Costa, Max. Mechanism of HgCl2 Cytotoxicity in E Cultured Mammalian Cells, 360 Caron, Marc G. See Dickinson, Leeb-Lundberg, Heald, Wikberg, Eaton, David L. See Woods and Lukens, 336 DeBernardis, and Lefkowitz, 187 Eddy, Barbara. See Venter, Home, Greguski, and Fraser, 196 Chang, K.-J., Blanchard, S. G., and Cuatrecasas, P. Benzomor- Egan, E. See Kufe, Munroe, Egan, and Spriggs, 128 phan Sites Are Ligand Recognition Sites of Putative -Receptors, Ehlert, Frederick J. See Ringdahl, Resul, Jenden, and Dahlbom, 170 484 Eling, Thomas E. See Marnett, Siedlik, Ochs, Pagels, Dos, Honn, Chao, Sheng-Hao, Suzuki, Yasuhiro, Zysk, John R., and Warnock, and Tamer, 328 Cheung, Wai Yiu. Activation of Calmodulin by Various Metal Evans, Tony, Smith, McHardy M., Tanner, Laura I., and Cations as a Function of Ionic Radius, 75 Harden, T. Kendall. Muscarinic Cholinergic Receptors of Two Cell Cheung, Wai Yiu. See Chao, Suzuki, and Zysk, 75 Lines That Regulate Cyclic AMP Metabolism by Different Molecular Chou, Ting-Chao, Lopez, Carlos, Colacino, Joseph M., Fein- Mechanisms, 395 605 606 AUTHOR INDEX
F Holy, Antonin. See Schanche, Schanche, Ueland, and Votruba, 553 Feinberg, Aaron See Chou, Lopez, Colacino, Watanabe, Fox, and Honn, Kenneth V. See Marnett, Siedlik, Ochs, Pagels, Das, Warnock, Philips, 587 Tamer, and Eling, 328 Home, Peter. See Venter, Eddy, Greguski, and Fraser, 196 Fishman, Peter H. See Zaremba, 206 Fleming, Richard M. See Howlett, 532 Howlett, Allyn C., and Fleming, Richard M. Cannabinoid Inhi- Fox, Bonnie M. See Gutierrez, Mossoba, and Bachur, 582 bition of Adenylate Cyclase: Pharmacology of the Response in Neuro- Fox, Jack J. See Chou, Lopez, Colacino, Feinberg, Watanabe, and blastoma Cell Membranes, 532 Hughes, Helen. See Smith and Mitchell, 112 Philips, 587 Fox, Richard M., Tripp, Edith H., and Taylor, Ian W. Analytical I DNA Flow Cytometric Analysis of Deoxyadenosine Toxicity in Cul- tured Human Leukemic Lymphoblasts, 388 Ikeda, S. R., Aronstam, R. S., Daly, J. W., Aracava, Y., and Fraser, Claire M. See Venter, Home, Eddy, and Greguski, 196 Albuquerque, E. X. Interactions of Bupivacaine with Ionic Chan- Frazer, Alan. See Sills and Wolfe, 10 nels of the Nicotinic Receptor: Electrophysiological and Biochemical Frelin, Christian, Vigne, Paul, Schweitz, Hugues, and Lazdun- Studies, 293 ski, Michel. The Interaction of Sea Anemone and Scorpion Neu- See Aracava, Daly, Brookes, and Albuquerque, 304 rotoxins with Tetrodotoxin-Resistant Na Channels in Other Excit- Iwata, Kumiko. See Nakajima, 430 able and Non-excitable Cells, 70 J G Jaques, Sandford, Jr., Tobes, Michael C., Sisson, James C., Galacteros, F. See Garel, Domenget, Martin-Caburi, and Beuzard, 559 Baker, James A., and Wieland, Donald M. Comparison of the Garel, M. C., Domenget, C., Galacteros, F., Martin-Caburi, J., Sodium Dependency of Uptake of meta-Iodobenzylguanidine and and Beuzard, Y. Inhibition of Erythrocyte Sickling by Thiol Re- Norepinephrine into Cultured Bovine Adrenomedullary Cells, 539 agents, 559 Javitch, Jonathan A., Blaustein, Robert 0., and Snyder, Solo- Gasiewicz, Thomas A., and Rucci, George. Cytosolic Receptor for mon H. [3H]Mazindol Binding Associated with Neuronal Dopamine 2,3,7-8-Tetrachlorodibenzo-p-dioxin: Evidence for a Homologous and Norepinephrine Uptake Sites, 35 Nature among Various Mammalian Species, 90 Jenden, Donald J. See Ringdahl, Resul, Ehlert, and Dahlbom, 170 Glazer, Robert I., and Knode, Marian C. 1-f3-D-Arabinosyl-5- Johnson, David A. See Bolger, Dionne, Chrivia, and Taylor, 57 azacytosine: Cytocidal Activity and Effects on the Synthesis and Johnson, Nicole, and Pasternak, Gavril W. Binding of [3H]Nalox- Methylation of DNA in Human Colon Carcinoma Cells, 381 onazine to Rat Brain Membranes, 477 Glowinski, J. See Beaujouan, Torrens, and Viger, 248 Jordan, V. Craig Goldstein, Dora B. See Perlman, 83 Lieberman, Mama E. Estrogen-Stimulated Prolactin Synthesis in See Perlman, 547 Vitro. Classification of Agonist, Partial Agonist, and Antagonist Gonzalez, Frank J., Tukey, Robert H., and Nebert, Daniel W. Actions Based on Structure, 279 Structural Gene Products of the Ah Locus: Transcriptional Regula- Lieberman, Mara E., Cormier, Ethel, Koch, Rick, Bagley, tion of Cytochrome P1-450 and P,-450 mRNA Levels by 3-Methyl- Jerome R., and Ruenitz, Peter C. Structural Requirements for cholanthrene, 117 the Pharmacological Activity of Nonsteroidal Antiestrogens in Vitro, Greguski, Roger. See Venter, Home, Eddy, and Fraser, 196 272 Guidotti, Alessandro. See Quach, Tang, Kageyama, Mocchetti, Meek, Costa, and Schwartz, 255 K Guillon, Gilles, Butlen, Daniel, and Rajerison, Rabary. Evidence Kadlubar, F. F. See Mulder, Mays, and Hinson, 342 for Two Molecular Forms of Solubilized Vasopressin Receptors in Kageyama, Hiroyasu. See Quach, Tang, Mocchetti, Guidotti, Meek, Rat Kidney Membranes: Regulation by Guanyl Nucleotides, 241 Costa, and Schwartz, 255 Gutierrez, Peter L., Fox, Bonnie M., Mossoba, Magdi M., and Kauffman, Frederick C. See Belinsky and Thurman, 574 Bachur, Nicholas R. Free Radicals in Quinone-Containing Anti- Kelusky, Eric C., and Smith, Ian C. P. The Influence of Local tumor Agents: Electrochemical Reduction of Diaziquone (2,5-Diazir- Anesthetics on Molecular Organization in Phosphatidylethanolam- idine-3,6-bis(carboethoxyamino)- 1 ,4-benzoquinone) and Two Ana- me Membranes, 314 logues, 582 Knode, Marian C. See Glazer, 381 Gutkowska, Jolanta. See De Lean, Ong, Schiller, and McNicoll, 498 Koch, Rick. See Jordan, Lieberman, Cormier, Bagley, and Ruenitz, 272 H Konno, Kenji. See Yokota, Shigeta, and De Clercq, 376 Hancock, Arthur A. , and Marsh, Catherine L. Distinctions be- Korach, K. S. See Duax, Swenson, Strong, McLachlan, and Metzler, tween Ligand-Binding Sites for [3H]Dopamine and D2 Dopaminergic 520 Receptors Characterized with [3H]Spiroperidol, 439 Krieter, Philip A., Ziegler, D. M., Hill, Kristina E., and Burk, Harden, T. Kendall. See Evans, Smith, and Tanner, 395 Raymond E. Increased Biliary GSSG Efflux from Rat Livers Per- See Masters and Brown, 149 fused with Thiocarbamide Substrates for the Flavin-Containing See Waldo, Doss, and Perkins, 424 Monooxygenase, 122 Haynes, Laurence W., Smith, Margaret E., and Li, Choh Hao. Kufe, Donald W., Munroe, D., Herrick, D., Egan, E., and Structural Requirements and Species Specificity of the Inhibition by Spriggs, D. Effects of 1-f3-D-Arabinofuranosylcytosine Incorpora- 13-Endorphin of Heavy Acetylcholinesterase from Vertebrate Skeletal tion on Eukaryotic DNA Template Function, 128 Muscle, 45 See Herrick, 135 Heald, Sarah L. See Dickinson, Leeb-Lundberg, Wikberg, De- L Bernardis, Caron, and Lefkowitz, 187 Herrick, David, and Kufe, Donald W. Lethality Associated with Lazdunski, Michel. See Frelin, Vigne, and Schweitz, 70 Incorporation of 5-Fluorouracil into Preribosomal RNA, 135 Leeb-Lundberg, L. M. Fredrik. See Dickinson, Heald, Wikberg, See Kufe, Munroe, Egan, and Spriggs, 128 DeBernardis, Caron, and Lefkowitz, 187 Hill, Kristina E. See Krieter, Ziegler, and Burk, 122 Lefkowitz, Robert J. See Dickinson, Leeb-Lundberg, Heald, Wikberg, Hinson, J. A. See Mulder, Kadlubar, and Mays, 342 DeBernardis, and Caron, 187 AUTHOR INDEX 607
Lenschow, Volker. See Lohse and Schwabe, 1 N Leslie, Barbara A. See Putney, McKinney, and Aub, 261 Nakajima, Tohru, and Iwata, Kumiko. [3H]Ro 22-1319 (Piquin- Li, Choh Hao. See Haynes and Smith, 45 done) Binds to the D2 Dopaminergic Receptor Subtype in a Sodium- Liarakos, Charles D. See Zytkovicz, 369 Dependent Manner, 430 Lieberman, Mara E. See Jordan, 279 Nebert, Daniel W. See Gonzalez and Tukey, 117 See Jordan, Cormier, Koch, Bagley, and Ruenitz, 272 Nienow, John R. See Loeu and Poulsen, 19 Liepe, Barbara. See McGee, 51 North, R. A. See Williams, 489 Linden, Joel. Purification and Characterization of (_)[1251J Hydroxyphenylisopropyladenosine, an Adenosine R-Site Agonist Ra- 0 dioligand and Theoretical Analysis of Mixed Stereoisomer Radioli- gand Binding, 414 Ochs, Rudy C. See Marnett, Siedlik, Pagels, Dos, Honn, Warnock, Lo, Mathew, M. S. See Trifiletti and Snyder, 228 Tamer, and Eling, 328 Loew, Gilda H., Nienow, John R., and Poulsen, Michael. Theo- Ong, Huy. See De L an, Gutkowska, Schiller, and McNicoll, 498 retical Structure-Activity Studies of Benzodiazepine Analogues: Re- quirements for Receptor Affinity and Activity, 19 P Lohse, Martin J., Lenschow, Volker, and Schwabe, Ulrich. Two Pace, Caroline S. Influence of a Tumor-Promoting Phorbol Ester on Affinity States of R Adenosine Receptors in Brain Membranes: the Electrical Response of B-cells to Glucose and Glyburide, 267 Analysis of Guanine Nucleotide and Temperature Effects on Radi- Pagels, William R. See Marnett, Siedlik, Ochs, Dos, Honn, Warnock, oligand Binding, 1 Tamer, and Eling, 328 Lopez, Carlos. See Chou, Colacino, Feinberg, Watanabe, Fox, and Pasternak, Gavril W. See Johnson, 477 Philips, 587 Perkins, John P. See Waldo, Doss, and Harden, 424 Lu, Lee-Jane Wang, and Randerath, Kurt. Long Term Instability Perlman, Barry J. and Molecular Mechanism of 5-Azacytidine-Induced DNA Hypo- Goldstein, Dora B. Membrane-Disordering Potency and Anticon- methylation in Normal and Neoplastic Tissues in Vivo, 594 vulsant Action of Valproic Acid and Other Short-Chain Fatty Acids, Lukens, Carl B. See Woods and Eaton, 336 83 Luthin, Gary R., and Wolfe, Barry B. [3H]Pirenzepine and [3HJ Goldstein, Dora B. Genetic Influences on the Central Nervous Quinuclidinyl Benzilate Binding to Brain Muscarinic Cholinergic System Depressant and Membrane-Disordering Actions of Ethanol Receptors. Differences in Measured Receptor Density Are Not Ex- and Sodium Valproate, 547 plained by Differences in Receptor Isomerization, 164 Philips, Frederick S. See Chou, Lopez, Colacino, Feinberg, Watanabe, M and Fox, 587 Poulsen, Michael. See Loeu and Nienow, 19 Maller, James L. See Sadler and Cooper, 526 Prough, Russell A. See Spearman and Moloney, 566 Markstein, R. See Seiler, 452 Putney, James W., Jr., McKinney, Jerry S., Aub, Debra L., Marletta, Michael A. See Collins, 353 and Leslie, Barbara A. Phorbol Ester-Induced Protein Secretion Marnett, Lawrence J., Siedlik, Paul H., Ochs, Rudy C., Pagels, in Rat Parotid Gland: Relationship to the Role of Inositol Lipid William R., Dan, Mukul, Honn, Kenneth V., Warnock, Robert Breakdown and Protein Kinase C Activation in Stimulus-Secretion H., Tamer, Beth E., and Eling, Thomas E. Mechanism of the Coupling, 261 Stimulation of Prostaglandin H Synthase and Prostacyclin Synthase by the Antithrombotic and Antimetastatic Agent, Nafazatrom, 328 Q Marsh, Catherine L. See Hancock, 439 Quach, Tam Thanh, Tang, Fai, Kageyama, Hiroyasu, Moe- Martin-Caburi, J. See Garel, Domenget, Galacteros, and Beuzard, 559 chetti, Italo, Guidotti, Alessandro, Meek, James L., Costa, Masters, Susan Brown, Harden, T. Kendall, and Brown, Joan Heller. Relationships between Phosphoinositide and Calcium Re- Erminio, and Schwartz, Joan P. Enkephalin Biosynthesis in Adrenal Medulla: Modulation of Proenkephalin mRNA Content of sponses to Muscarinic Agonists in Astrocytoma Cells, 149 Cultured Chromaffin Cells by 8-Bromo-Adenosine 3’,S’ -Monophos- Mays, F. F. See Mulder, Kadlubar, and Hinson, 342 phate, 255 McGee, Richard, Jr., and Liepe, Barbara. Acute Elevation of Cyclic AMP Does Not Alter the Ion-Conducting Properties of the R Neuronal Nicotinic Acetylcholine Receptor of PC12 Cells, 51 McKinney, Jerry S. See Putney, Aub, and Leslie, 261 Rajerison, Rabary. See Guillon and Butlen, 241 McKinney, Michael, Stenstrom, Scott, and Richelson, Elliott. Randerath, Kurt. See Lu, 594 Muscarinic Responses and Binding in a Murine Neuroblastoma Resul, Bahram. See Ringdahl, Ehlert, Jenden, and Dahlbom, 170 Clone (N1E-11S): Selective Loss with Subculturing of the Low- Riant, Pascale. See Urien, Albengres, Brioude, and Tillement, 322 Affinity Agonist Site Mediating Cyclic GMP Formation, 156 Richelson, Elliott. See McKinney and Stenstrom, 156 McLachlan, J. See Duax, Swenson, Strong, Korach, and Metzler, 520 Ringdahl, Bj#{243}rn,Resul, Bahram, Ehlert, Frederick J., Jenden, McNicoll, Normand. See De Lean, Ong, Gutkowska, and Schiller, 498 Donald J., and Dahlbom, Richard. The Conversion of 2-Chlo- Meek, James L. See Quach, Tang, Kageyama, Mocchetti, Guidotti, roalkylamine Analogues of Oxotremorine to Aziridinium Ions and Costa, and Schwartz, 255 Their Interactions with Muscarinic Receptors in the Guinea Pig Metzler, M. See Duax, Swenson, Strong, Korach, and McLachlan, 520 Ileum, 170 Mitchell, Jerry R. See Smith and Hughes, 112 Rucci, George. See Gasiewicz, 90 Mocchetti, Italo. See Quach, Tang, Kageyama, Guidotti, Meek, Costa, Ruenitz, Peter C. See Jordan, Lieberman, Cormier, Koch, and Bagley, and Schu’artz, 255 272 Moloney, Stephen J. See Spearman and Prough, 566 S Mossoba, Magdi M. See Gutierrez, Fox, and Bachur, 582 Mulder, G. J., Kadlubar, F. F., Mays, J. B., and Hinson, J. A. Sadler, Susan E., Mailer, James L., and Cooper, Dermot M. F. Reaction of Mutagenic Phenacetin Metabolites with Glutathione Progesterone Inhibition ofXenopus Oocyte Adenylate Cyclase Is Not and DNA: Possible Implications for Toxicity, 342 Mediated via the Bordetella pertus-sts Toxin Substrate, 526 Munroe, D. See Kufe, Herrick, Egan, and Spriggs, 128 Schanche, Jon-Sverre, Schanche, Tone, Ueland, Per Magne, Murphy, S. D. See Sultatos, Basker, and Shao, 99 Holy, Antonin, and Votruba, Ivan. The Effect of Aliphatic Ad- 608 AUTHOR INDEX
enine Analogues on S-Adenosylhomocysteine and S-Adenosylhom- Tobes, Michael C. See Jaques, Sisson, Baker, and Wieland, 539 ocysteine Hydrolase in Intact Rate Hepatocytes, 553 Torrens, Y. See Beaujouan, Viger, and Glowinski, 248 Schanche, Tone. See Schanche, Ueland, Hol ?, and Votruba, 553 Trifiletti, Rosario R. Schiller, Peter W. See De Lean, Ong, Gutkowska, and McNicoll, 498 Lo, Mathew M. S., Snyder, Solomon H. Kinetic Differences Schwabe, Ulrich. See Lohse and Lenschow, 1 between Type I and Type II Benzodiazepine Receptors, 228 Schwartz, Alan. See Simmons, 509 Snowman, Adele M., and Snyder, Solomon H. Anxiolytic Cy- Schwartz, Joan P. See Quach, Tang, Kagevama, Mocchetti, Guidotti, clopyrrolone Drugs Allosterically Modulate the Binding of [ S]t- Meek, Costa, and Schu’artz, 255 Butylbicyclophosphorothionate to the Benzodiazepine/’y-Aminobu- Schweitz, Hugues. See Frelin, Vigne, and Lazdunski, 70 tyric Acid-A Receptor/Chloride Anionophore Complex, 470 Sebben-Perez, Mich#{232}le. See Bockaert and Cantau, 180 Snyder, Solomon H. Anxiolytic Cyclopyrrolones Zopiclone and Seiler, M. P., and Markstein, R. Further Characterization of Struc- Suriclone Bind to a Novel Site Linked Allosterically to Benzodiaze- tural Requirements for Agonists at the Striatal Dopamine D2 Recep- pine Receptors, 458 tor and a Comparison with Those at the Striatal Dopamine D, Tripp, Edith H. See Fox and Taylor, 388 Receptor: Studies with a Series of Monohydroxyaminotetralins on Tukey, Robert H. See Gonzalez and Nebert, 117 Acetylcholine Release from Rat Striatum, 452 Shao, M. See Sultatos, Basker, and Murphy, 99 U Shigeta, Shiro. See Yokota, Konno, and De Clercq, 376 Ueland, Per Magne. See Schanche, Schanche, Hol.9, and Votruba, Siedlik, Paul H. See Marnett, Ochs, Pagels, Das, Honn, Warnock, 553 Tamer, and Eling, 328 Urien, Salk, Riante, Pascale, Albengres, Edith, Brioude, Rob- Sills, Matthew A., Wolfe, Barry B., and Frazer, Alan. Multiple ert, and Tillement, Jean-Paul. In Vitro Studies on the Distribu- States of the 5-Hydroxytryptamine, Receptor as Indicated by the tion of Probucol among Human Plasma Lipoproteins, 322 Effects ofGTP on [3HJ5-Hydroxytryptamine Binding in Rat Frontal Cortex, 10 V Simmons, Charles F., Jr., and Schwartz, Alan L. Cellular Path- Venter, J. Craig, Home, Peter, Eddy, Barbara, Greguski, ways of Galactose-Terminal Ligand Movement in a Cloned Human Roger, and Fraser, Claire M. Alpha1-Adrenergic Receptor Struc- Hepatoma Cell Line, 509 ture, 196 Sisson, James C. See Jaques, Tobes, Baker, and Wiekind, 539 Viger, A. See Beaujouan, Torrens, and Glowinski, 248 Smart, Robert C., and Zannoni, Vincent G. DT-Diaphorase and Vigne, Paul. See Frelin, Schweitz, and Lazdunski, 70 Peroxidase Influence the Covalent Binding of the Metabolites of Votruba, Ivan. See Schanche, Schancbe, Ueland, and Hol. ?, 553 Phenol, the Major Metabolite of Benzene, 105 Smith, Charles V., Hughes, Helen, and Mitchell, Jerry R. Free W Radicals in Vivo: Covalent Binding to Lipids, 112 Smith, Ian C. P. See Keluskv, 314 Waldo, Gary L., Doss, Robert C., Perkins, John P., and Harden, Smith, Margaret E. See Haynes and Li, 45 T. Kendall. Use of a Density Shift Method to Assess Beta-Adrener- Smith, McHardy M. See Evans, Tanner, and Harden, 395 gic Receptor Synthesis during Recovery from Catecholamine-In- Snowman, Adele M. See Trifiletti and Snyder, 470 duced Down-Regulation in Human Astrocytoma Cells, 424 Snyder, Solomon H. See Javitch and Blaustein, 35 Warnock, Robert H. See Marnett, Siedlik, Ochs, Pagels, Das, Honn, See Trifiletti, 458 Tamer, and Eling, 328 See Trifiletti and IA), 228 Watanabe, Kyoichi A. See Ciwu, Lopez, Colacino, Feinberg, Fox, and See Trifiletti and Snowman, 470 Philips, 587 Spearman, Marshall E., Moloney, Stephen J., and Prough, Weiner, Norman. See Yanagihara and Weiner, 141 Russell A. Effect of Cytosolic Components on the Metabolism of Wieland, Donald M. See Jaques, Tobes, Sisson, and Baker, 539 the Hydrazide Iproniazid, 566 Wikberg, Jan E. S. See Dickinson, Leeb-Lundberg, Heald, Dc- Spriggs, D. See Kufe, Munroe, Herrick, and Egan, 128 Bernardis, Caron, and Lefkowitz, 187 Stenstrom, Scott. See McKinney and Richelson, 156 Williams, J. T., and North, R. A. Opiate-Receptor Interactions on Strong, P. D. See Duax, Swenson, Korach, McLachlon, and Metzler, Single Locus Coeruleus Neurones, 489 520 Wolberg, Gerald, and Zimmerman, Thomas P. Effects of Calmo- Sultatos, L. G., Basker, K. M., Shao, M., and Murphy, S. D. The dulin Antagonists on Immune Mouse Lymphocytes, 286 Interaction of the Phosphorothioate Insecticides Chlorpyrifos and Wolfe, Barry B. See Luthin, 164 Parathion and Their Oxygen Analogues with Bovine Serum Albumin, See SilLs and Frazer, 10 99 Woods, James S. , Eaton, David L., and Lukens, Carl B. Studies Swann, Allan. See Cantoni, Christie, Drath, and Costa, 360 on Porphyrin Metabolism in the Kidney: Effects of Trace Metals Swenson, D. C. See Duax, Strong, Korach, McLachlan, and Metzler, and Glutathione on Renal Uroporphyrinogen Decarboxylase, 336 520 Wreggett, Keith A., and DeL#{233}an, Andr#{233}.The Ternary Complex Suzuki, Yasuhiro. See Chao, Zysk, and Ciwung, 75 Model: Its Properties and Application to Ligand Interactions with the D2-Dopamine Receptor of the Anterior Pituitary Gland, 214 T Y Tamer, Beth E. See Marnett, Siedlik, Och,s, Pagels, Das, Honn, Warnock, and Eling, 328 Yanagihara, Nobuyuki, Tank, A. William, and Weiner, Nor- Tang, Fai. See Quach, Kagevama, Mocchetti, Guidotti, Meek, Costa, man. Relationship between Activation and Phosphorylation of Ty- and Schwartz, 255 rosine Hydroxylase by 56 mM K in PC12 Cells in Culture, 141 Tank, A. William. See Yanagihara and Weiner, 141 Yokota, Tomoyuki, Konno, Kenji, Shigeta, Shiro, and De Tanner, Laura I. See Evans, Smith, and Harden, 395 Clercq, Erik. Comparative Inhibition of DNA Polymerases from Taylor, Ian W. See Fox and Tripp, 388 Varicella Zoster Virus (TK and TK) Strains by (E)-S-(2-Bronio- Taylor, Palmer. See Ambler and Brown, 405 vinyl)-2’-deoxyuridine 5’-Triphosphate, 376 See Bolger, I)ionne, Chrivia, and Johnson, 57 Z Thurman, Ronald G. See Belinsky and Kauffman, 574 Tillement, Jean-Paul. See Urien, Riant, Albengres, and Brioude, 322 Zannoni, Vincent G. See Smart, 105 AUTHOR INDEX 609
Zaremba, Terrye G., and Fishman, Peter H. Desensitization of Zimmerman, Thomas P. See Wolberg, 286 Catecholamine-Stimulated Adenylate Cyclase and Down-Regulation Zysk, John R. See Chao, Suzuki, and Cheung, 75 of Beta-Adrenergic Receptors in Rat Glioma C6 Cells: Role of Cyclic Zytkovicz, Thomas H., and Liarakos, Charles D. Factors Influ- AMP and Protein Synthesis, 206 encing the Covalent Binding of (±)-7f3,8a-Dihydroxy-9a,lOn-epoxy- Ziegler, D. M. See Krieter, Hill, and Burk, 122 7,8,9,10-tetrahydrobenzo[a]pyrene to Ribonucleic Acids, 369 MOLECULAR PHARMACOLOGY 26:610-619
CUMULATIVE SUBJECT INDEX FOR VOLUMES 25 AND 26
A beta desensitization and down-regulation, 26, 206 A23187 on intact S49 lymphoma cells, 25, 209 effect on [3H]inositol metabolism in GH3 pituitary tumor cells, 25, stimulation, phosphatidylinositol turnover (hamster), 25, 64 201 Adrenocorticotropin, suppression of benz[a]pyrene metabolism (bo- Acetaminophen vine), 25, 476 benzoquinone reduction, 25, 151 Affinity labeling, 26, 187 covalent binding, 26, 112 Agonist Acetylcholine alpha,-adrenergic receptors in vas deferens (rat), 25, 56 -activated ionic channels, 26, 304 affinity inhibitors, 26, 57 3-adrenergic receptors, on intact S49 lymphoma cells, 25, 209 noise analysis, 25, 384 states in brain (calf), 25, 10 receptor effect on beta-adrenergic receptors in S49 lymphoma cells, 25, 209 -ionic channel complex, 25, 384, 395, 26, 293 muscarinic, 26, 149 nicotinic, 25, 384, 26, 51 nicotinic acetylcholine receptor-ionic channel complex, pyridostig- phencyclidine binding (ray), 25, 360 mine action, 25, 92 sensitivity, junctional and extrajunctional regions, 25, 395 Ah locus in mice, 26, 117 Acetylcholinesterase Albumin A,2, beta-endorphin inhibition, 26, 45 binding molecular forms, 26, 45 anti-inflammatory drugs, 25, 137 Action potential nonsteroidal, 25, 137 anticonvulsants, 25, 228 co-binding of two drugs, 25, 137 inhibition by verapamil (crayfish), 25, 369 Alcohol local anesthetics, 25, 219 allyl, metabolism in liver (rat), 25, 158 Activation, dCMP deaminase, by S-aza-dCTP, 25, 436 inhibition of delta subclass of opioid binding sites, 25, 249 Activity Aldose reductase antineoplastic, 3’-amino-3’-deoxythymidine, 25, 441 inhibition (human), 25, 425 biological, 16t , 17a-acetal-substituted glucocorticoids, 25, 70 placenta (human), 25, 425 Adenosine dialdehyde Alkylation, site-directed, opioid receptors, 25, 337, 343 S-adenosylhomocysteine hydrolase and transmethylation, L929 cells Allyl alcohol metabolism, in liver (rat), 25, 158 (mouse), 25, 418 Allylisopropylacetamide inhibition (mouse), 25, 418 cytochrome P-450 destruction (rat), 25, 310 Adenosine receptors, brain, 26, 1 prosthetic heme adducts (rat), 25, 310 S-Adenosylhomocysteine Alrestatin, inhibition of placenta aldose reductase (human), 25, 425 effect of aliphatic adenine analogues (rat), 26, 553 Amiloride hydrolase, L929 cells, effects of adenosine dialdehyde (mouse), 25, effect on skeletal muscle (chick), 25, 131 418 structure-activity relationships, 25, 131 S-Adenosylmethionine-dependent transmethylations, adenosine di- Amine, tertiary muscarinic receptor binding, 25, 46 aldehyde (mouse), 25, 418 Adenylate cyclase Amino acid analysis, hepatic isozyme (rabbit), 25, 494 -y-aminobutyric acid (rat), 25, 24 Aminotetralins, dopamine D2 receptor characterization (rat), 26, 452 cannabinoid inhibition, 26, 532 y-Aminobutyric acid desensitization and down-regulation, glioma cells (rat), 26, 206 binding dopamine-sensitive (carp, rat), 25, 18 in brain (rat), 25, 352 inhibitory (rat), 25, 24 modulation by calcium (rat), 25, 352 oocyte, progesterone inhibition, 26, 526 receptors, inhibitory cyclase (rat), 25, 24 stimulation, 26, 180 -y-Aminobutyric acid A Adrenal recognition sites, -y-aminobutyric acid binding to (rat), 25, 352 chromaffin cells -y-Aminobutyric acid B effect of bungarotoxin polypeptide, 25, 327 receptors, in brain (rat), 25, 24 nicotinic receptor function, 25, 327 recognition sites, -y-aminobutyric acid binding to (rat), 25, 352 cortical cells 3’-Amino-3’-deoxythymidine, antineoplastic activity, 25, 441 polycyclic aromatic hydrocarbon metabolism (bovine), 25, 476 3’-Aminothymidine primary culture (bovine), 25, 476 diphosphate, metabolites, 25, 441 medulla inhibitor, 25, 441 enkephalin, 26, 255 mechanism of action, 25, 441 opiate receptors (bovine), 25, 38 monophosphate, metabolites, 25, 441 Adrenergic receptor triphosphate alpha, DNA polymerase inhibition, 25, 441 agonists in vas deferens (rat), 25, 56 metabolites, 25, 441 probe, high affinity, high specific activity, 26, 187 Ammonium, quaternary analogues of tertiary amines, muscarinic re- receptor structure, 26, 196 ceptor binding, 25, 46
610 SUBJECT INDEX 611
Analogue BE 2254, I-labeled, binding in vas deferens (rat), 25, 56 amiloride, structure-activity relationships, 25, 131 Benzene dimethylated, N-acetyl-p-benzoquinone imine, 25, 151 metabolites, 26, 105 thymidine toxicity, 26, 105 antineoplastic activity, 25, 441 Benzodiazepine phosphorylation, 25, 446 binding Anesthesia, theory, 25, 123 sites, peripheral, 25, 349 Anesthetic structural requirements, 25, 349 inhalation, membrane expansion and, 25, 123 1,4-Benzodiazepines, conformational and electronic properties, 26, 19 local Benzomorphan sites, binding characteristics, 26, 484 bupivacaine, 26, 293 Benzo[ajpyrene effect on sodium channels, 25, 219 diolepoxide, 26, 369 open channel blockade, 26, 304 saturable, high affinity site(s), 26, 353 membrane action, 26, 314 Berenil, nonintercalative binding, 25, 452 Angiotensin Binding -converting enzyme albumin, nonsteroidal, 25, 137 pulmonary (rabbit), 25, 287 ‘y-aminobutyric acid modulation by calcium (rat), 25, 352 substance P as substrate, hydrolysis, (rabbit), 25, 287 anti-inflammatory drugs, by albumin, 25, 137 -induced receptor-effector coupling (bovine), 26, 498 benzodiazepine Antagonism, feedback inhibition, 25, 446 peripheral sites, 25, 349 Antagonist structural requirements, 25, 349 calcium channel bisantrene, to DNA, 25, 178 binding sites, 25, 235 calcium channel antagonist, tissue heterogeneity, 25, 235 sensitivity of phencyclidine (crayfish), 25, 369 competitive, a-bungarotoxin, 25, 395 calcium, in secretion (rat), 25, 51 constants, stoichiometric, 25, 137 N-methyl phenomenon (carp, rat), 25, 18 diarylamidines, nonintercalative, 25, 452 thymidine kinase, 25, 446 dihydrotetrabenazine, comparison with reserpine binding (bovine), Antibiotic 25, 113 avoparcin, nuclear magnetic resonance studies, 25, 275 DNA, by HgCl2, 26, 360 glycopeptide inhibition, [3H]batrachotoxin in A 20-a-benzoate, 25, 219 nuclear magnetic resonance studies, 25, 275 mitoxantrone, to DNA, 25, 178 nuclear magnetic resonance study, 25, 281 muscarinic receptor, tertiary amines, 25, 46 Anticonvulsant nicotinic acetylcholine receptor-ionic channel complex, pyridostig- carbamazepine, 25, 228 mine action, 25, 92 diphenylhydantoin, 25, 228 [3H]nitrendipine, heterogeneity of sites, 25, 235 valproic acid, other short-chain fatty acids, 26, 83 noncompetitive, gephyrotoxin interaction, 25, 395 Antiestrogens, nonsteroidal, structural requirements for pharmacolog- nonintercalative ical activity, 26, 272 berenil, 25, 452 Aphidicolin, 26, 128 diarylamidines, 25, 452 Apomorphine, enantiomers, interactions with dopamine receptors stilbamidine, 25, 452 (carp, rat), 25, 18 opioid 1 -fl-D-Arabinofuranosylcytosine brain (guinea pig), 25, 337 effects on DNA during UV repair, 25, 322 discrimination of sites in brain (rat), 25, 242 incorporation into DNA, 25, 322 selective inhibition of delta subclass, 25, 249 1-fl-D-Arabinosyl-S-azacytosine effects on DNA, human colon cancer, mu, sites, 25, 29 26, 381 3H-opioid, high-affinity, biochemical characterization, 25, 29, ARA-C incorporation, into DNA, 26, 128 pBR322, plasma, by drugs, 25, 178 Ascorbate, covalent binding, 26, 105 perhydrohistrionicotoxin, inhibition, 25, 395 ATP, energy metabolism, 26, 286 phencyclidine Avoparcin inhibition by Ca2 antagonists (crayfish), 25, 369 conformation, nuclear magnetic resonance study, 25, 275, 281 to acetylcholine receptor (ray), 25, 360 -peptide complexes, structure, 25, 275 plasma protein, 26, 322 receptor, bacterial cell wall, 25, 281 PM2, circular DNA, by drugs, 25, 178 5-Azacytidine polynucleotide, in intestinal cytosol (chicken), 25, 86 -induced unstable DNA hypomethylation, 26, 594 radioligand synthesis and methylation of DNA, human colon carcinoma, 26, 381 in vas deferens (rat), 25, 56 5-Azadeoxycytidine-S’ -monophosphate, substrate for dCMP deami- prediction, 25, 1 nase, 25, 436 thermodynamics, 26, 1 S-Azadeoxycytidine-S’-triphosphate, activator for dCMP deaminase, receptor, 16a, 17a-acetal-substituted glucocorticoids, 25, 70 25, 436 Binding 5-Azadeoxycytidine, nucleotides, kinetic studies with dCMP deami- reserpine nase, 25, 436 comparison with dihydrotetrabenazine binding (bovine), 25, 113 to chromaffin granule membranes (bovine), 25, 113 B site, analysis, versus stoichiometric analysis, 25, 137 stoichiometry, 25, 137 Bacteria, cell wall, avoparcin receptor, 25, 281 structure-activity relations with tamoxifen series, 26, 272 Batrachotoxinin A 20-a-benzoate, 3H-labeled, inhibition of binding, Torpedo electroplax, 26, 293 25, 219 Biochemistry, high-affinity 3H-opioid binding, 25, 29 612 SUBJECT INDEX
Bioassay to phosgene (rat), 25, 318 opioid receptors in brain (guinea pig), 25, 343 reductive oxygenation (rat), 25, 318 Biosynthesis, purine, glycinamide transformylase, 25, 294 Carboxyl-terminal, tripeptidyl hydrolysis of substance P, 25, 287 Bisantrene Carboxymethylation, protein (mouse), 25, 418 antitumor activity, 25, 178 N-(1-(S)-Carboxy-3-phenylpropyl)-L-alanyl L proline, potentiation of binding to DNA, 25, 178 substance P activity (rabbit), 25, 287 Bordetella pertussis, toxin substrate, and progesterone inhibition, 26, Catecholamine 526 alpha1 in brown fat cells (hamster), 25, 64 Brain carrier, in chromaffin granule membranes (bovine), 25, 113 -y-aminobutyric acid binding (rat), 25, 352 uptake, chromaffin granule membranes (bovine), 25, 113 cholesterol, ethanol effects (mouse), 25, 401 Caudate nucleus, D2-dopamine receptors (calf), 25, 10 D2-dopamine receptors (calf), 25, 10 Cell gangliosides adrenal chromaffin ethanol effects (mouse), 25, 401 nicotinic receptor function, 25, 327 membrane effects, 25, 410 primary culture, 25, 327 Brain Cell membrane adrenal cortical effect of ethanol and pentobarbital, 25, 410 metabolism of polycyclic aromatic hydrocarbon (bovine), 25, 476 lipid composition, physical properties (mouse), 25, 401 primary culture (bovine), 25, 476 new type of tachykinin-binding site (rat), 26, 248 bacterial, avoparcin receptor of cell wall, 25, 281 phospholipids, ethanol effects (mouse), 25, 401 C6-2B, effect of forskolin on cyclic AMP accumulation and hormone Bromobenzene, 26, 112 responses (rat), 25, 256 (E)-S-(2-Bromovinyl)-2’-deoxyuridine 5’-triphosphate, effect on van- fat cella zoster virus, 26, 376 metabolism (hamster), 25, 64 a-Bungarotoxin phosphatidylinositol turnover (hamster), 25, 64 competitive binding, 25, 395 respiration (hamster), 25, 64 polypeptide granule, cerebellar, ‘y-aminobutyric acid B receptors (rat), 25, 24 adrenal chromaffin cells, 25, 327 HKSV28, inhibition of growth by 5,11-methenyltetrahydrohomofol- purification and characterization, 25, 327 ate, 25, 294 Bupivacaine intact, receptors, 25, 209 noncompetitive antagonists, 26, 293, 304 L929, S-adenosylmethionine-dependent transmethylations (mouse), displacement by histrionicotoxin, 26, 293 25, 418 [ S]t-Butylbicyclophosphorothionate lethality, 25, 322 binding modulation by cyclopyrrolone drugs, 26, 470 leukemic, lethality of 5-methyl-2’-deoxycytidine (human), 25, 431 549 lymphoma, beta-adrenergic receptors, 25, 209 C neuroblastoma, voltage-sensitive sodium channels, 25, 228 Ca2 , see also Calcium pheochromocytoma, [3H]norepinephnine release (rat), 25, 379 alpha,-adnenergic receptors and phosphatidylinositol, 26, 405 GH3 pituitary tumor, effect of thyrotropin-releasing hormone, 25, channel (crayfish), 25, 369 193 conductance, 26, 267 thymidylate synthetase levels, effect of 5-fluorouracil, 25, 171 dependency, [3H]norepinephrine release (rat), 25, 379 Central nervous system depressants, ethanol and sodium valproate -dependent phosphodiesterase, 26, 75 (mice), 26, 547 respiration in brown fat cells (hamster), 25, 64 Cerebellum Calcium, see also Ca2 -y-aminobutyric acid B receptors (rat), 25, 24 channel granule cells (rat), 25, 24 antagonists, 25, 235 Chain termination, relative, 26, 128 in secretion (rat), 25, 51 Channel conductance, 26, 304 sensitivity of phencyclidine (crayfish), 25, 369 Characterization, bungarotoxin polypeptide, 25, 327 efflux, 26, 149 2-Chloroalkylamine oxotremorine derivative, 26, 170 interaction with protein kinase C, 26, 261 $-Chlornaltrexamine, selective protection, 25, 337 mobilization, 26, 149 Cholesterol, brain, ethanol effects (mouse), 25, 401 modulation of -y-aminobutynic acid binding (rat), 25, 352 Chromaffin receptor regulation (rat), 25, 51 cell cultures, 8-Bromo-cyclic AMP treatment, 26, 255 role as second messenger (rat), 25, 51 granule membranes, reserpine binding (bovine), 25, 113 Calmodulin Chromatography, affinity, dye-ligands (chicken), 25, 79 activation by metals, 26, 75 Conductance, Ca2 and K , 26, 267 antagonists, 26, 286 Conjugation, glutathionone, N-acetyl-p-benzoquinone imine, 25, 151 effect on -y-aminobutyric acid binding in brain (rat), 25, 352 Conformation Cannabinoid drugs, inhibition of adenylate cyclase, 26, 532 avoparcin Captopril, potentiation, substance P activity in vivo (rabbit), 25, 287 nuclear magnetic resonance study, 25, 275, 281 Carbachol, phosphorylation of myosin light chain and phosphorylase Cross-linking, photoaffinity, 26, 187 (dog), 25, 267 Cyclic AMP Carbamazepine, effect on sodium channels, neuroblastoma cells and accumulation in thyroid, effects of alkylated xanthines (dog), 25, synaptosomes, 25, 228 261 Carbamylcholine, effect on thyroid (dog), 25, 261 forskolin-stimulated, in C6-2B cells (rat), 25, 256 Carbon tetrachloride metabolism, regulation by different molecular mechanisms, 26, 395 metabolism neuronal nicotinic receptors, 26, 51 oxygen dependency (rat), 25, 318 receptor down-regulation, 26, 206 SUBJECT INDEX 613
receptor modulation, 26, 156 mitoxantrene binding, 25, 178 Cyclic GMP receptor stimulation, 26, 156 polymerase Cyclopyrrolone inhibition by 3’-aminothymidine triphosphate, 25, 441 binding, benzodiazepine receptors, 26, 458 viral, 26, 376 -TBPS interactions, 26, 470 synthesis and methylation, human colon cancer, 26, 381 Cytidine deaminase activity, malignant hematopoietic cells (human), Dopamine 25, 431 receptor Cytochrome D2, in brain (calf), 25, 10 P-450 multiple (carp, rat), 25, 18 allylisopropylacetamide destruction (rat), 25, 310 -sensitive adenylate cyclase (carp, rat), 25, 18 extrahepatic, 25, 185 uptake inactivation (rat), 25, 310 inhibition of, 25, 35 isozymes, 25, 185 sodium and chloride dependency, 26, 35 liver microsomal, isozymes 3a and 6 (rabbit), 25, 494 Drug metabolism of carbon tetrachloride to phosgene (rat), 25, 318 antiepileptic, inhibitory action, 25, 228 microsomal, metabolism of carbon tetrachloride (rat), 25, 318 anti-inflammatory, albumin binding, 25, 137 -reductase, hemoglobin coupling, 25, 467 -dependent glutathione oxidation, 26, 122 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible, 25, 185 -induced folate deficiency (mouse), 25, 459 Culture metabolism, extrahepatic, 25, 185 primary DT-diaphorase, detoxification, 26, 105 adrenal chromaffin cells, 25, 327 dUMP, relationship to inhibition of thymidylate synthase by 5-fluo- adrenal cortical cells (bovine), 25, 476 rouracil, 25, 303 Cytolysis, lymphocyte-mediated, 26, 286 Dye Cytosol, intestinal, 1,25-dihydroxyvitamin D3 complexes (chicken), 25, -ligand 86 affinity chromatography (chicken), 25, 79 Cytotoxicity, thymidine analogues, 25, 446 interaction specificity, 25, 86 interactions with 1,25-dihydroxyvitamin D3-receptor complexes D (chicken), 25, 79 polyribonucleotide interaction (chicken), 25, 86 dCMP deaminase Dynorphin, pharmacological selectivity, 25, 343 activation by S-aza-2’-deoxycytidine, 25, 436 inhibition by dTTP, 25, 436 E Density shift method, assessment of beta-adrenergic receptor synthesis, 26, 424 Electrochemical gradient, W in chromaffin granule membranes (ho- Deoxyadenosine, lymphotoxicity of, 26, 388 vine), 25, 113 2’-Deoxy-S-azacytidine, synthesis and methylation of DNA colon car- Electrode, 02, miniature, 25, 158 cinoma (human), 26, 381 Electron microscopy, evidence for drug-DNA binding, 25, 178 Desensitization Electrophorus electric organ, 26, 45 extrajunctional, junctional, acetylcholine, 25, 395 Electroplaque, acetylcholine receptor (rat), 25, 360 neuromuscular synapse, 25, 92, 102 Eledoisin, high-affinity binding, 26, 248 nicotinic acetylcholine receptor-ionic channel complex, pyridostig- Empirical energy calculations, 26, 19 mine action, 25, 92 Enantiomer, apomorphine, interactions with dopamine receptors (carp, Deuterium NMR and anesthetics, 26, 314 rat), 25, 18 Diacylglycerol, 26, 267 Endoreduplication, 26, 128 1,2-Diacylglycerol, accumulation in GH3 pituitary tumor cells, 25, 193 f3-Endorphin Diarylamidines, nonintercalative binding, 25, 452 analogues, 26, 45 Diazepam, effect on ‘y-aminobutyric binding in brain (rat), 25, 352 pharmacological selectivity, 25, 343 Diaziquone, electrochemical reduction, 26, 582 species differences, 26, 45 Diethylstilbestrol, structure, binding, and activity, 26, 520 End-plate current Dihydrotetrabenazine binding, comparison, reserpine binding (bovine), alteration by pyridostigmine, 25, 92 25, 113 amplitude depression shortening, 25, 384 1,25-Dihydroxyvitamin D3 miniature, 26, 293 -receptor complexes “rundown” induced by gephyrotoxin, 25, 384 dye-ligand interactions (chicken), 25, 79, 86 biosynthesis in adrenal medulla, 26, 255 in intestinal cytosol (chicken), 25, 86 mu, binding sites, 25, 29 Dimethylation, N-acetyl-p-benzoquinone analogues, 25, 151 pharmacological selectivity, 25, 343 Dimethylnitrosamine, 26, 112 synthesis, 8-Bromo-cyclic AMP stimulation, 26, 255 Diphenylhexatriene, 26, 83 Enzyme Diphenylhydantoin, effect on sodium channels in neuroblastoma cells pulmonary and synaptosomes, 25, 228 angiotensin-converting (rabbit), 25, 287 Diprenorphine, in vivo receptor binding (rat), 25, 242 substance P hydrolysis (rabbit), 25, 287 Dipyridamole, prostacyclin stimulation, 26, 328 Epilepsy, inhibitory action of anticonvulsants, 25, 228 DNA Erythrocyt.e sickling, inhibition, by thiol reagents, 26, 559 analytical flow cytometry, 26, 388 Erythroleukemia cells, murine, 26, 135 bisantrene binding, 25, 178 Estrogen-stimulated prolactin synthesis, 26, 279 damage by HgCl2, 26, 360 Ethanol effects of 1-f!-D-arabinofuranosylcytosine during UV repair, 25, 322 cell-membrane disordering potency, 26, 83 hypomethylation, unstable, 5-azacytidine-induced, 26, 594 comparison, sodium valproate (mice), 26, 547 614 SUBJECT INDEX
Ethanol-Continued receptor effect on membrane fluidity, 25, 410 ligand structural specificity requirements, 25, 70 induction of liver microsomal cytochrome P-450 isozyme 3a (rabbit), skeletal muscle (rat), 25, 70 25, 494 Glucuronidation, 7-hydroxycoumarin in liver lobule (rat), 25, 487 membrane action, effect of gangliosides, 25, 410 Glucuronosyltransferase activity in liver lobule (rat), 25, 487 peptide mapping (rabbit), 25, 494 Glutathione tolerance, effect on physical properties and lipid composition, brain conjugation, N-acetyl-p-benzoquinoneimine, 25, 151 membranes (mouse), 25, 401 oxidation, drug-dependent, 26, 122 Etorphine, in vivo receptor binding (rat), 25, 242 reaction of mutagenic phenacetin metabolites, 26, 342 Glycinamide transformylase, de novo purine biosynthesis, 25, 294 F Glycopeptide, antibiotics and nuclear magnetic resonance studies, 25, 275, 281 Fat cell, metabolism, phosphatidylinositol turnover, and respiration Glycoproteins, galactose-terminal, cellular pathways (human), 26, (hamster), 25, 64 509 Fatty acids, anticonvulsant and sedative action, 26, 83 Glycoproteins, galactose-terminal, cellular pathways (human), 26, FdUMP, see 5-Fluorodeoxyuridine-5’-monophosphate Granule cell, -y-aminobutyric acid B receptors (rat), 25, 24 Fibroblast, effect of amiloride (chick), 25, 131 Guanine Flavin-containing monooxygenase, 26, 122 nucleotides Flavin monooxygenase, mechanistic studies of, 26, 348 effects on D2-dopamine receptors in brain (calf), 25, 10 Fluctuation analysis, shortening of channel lifetime, 26, 293 receptor affinity changes, 26, 1 Fluidity membrane effect of ethanol tolerance (mouse), 25, 401 H ethanol effects, 25, 401 H fluorescent probes (mouse), 25, 401 electrochemical gradient, chromaffin granule membranes (bovine), Fluorescence polarization, 26, 83 25, 113 Fluorescent acyldicholines, 26, 57 /H exchange system, 25, 131 Fluorescent energy transfer, 26, 57 Heavy metal toxicity, 26, 75 Fluorescent probe, membrane fluidity (mouse), 25, 401 Heme 5-Fluoro-2’-deoxyuridine-5’-monophosphate binding to thymidylate adducts, structure (rat), 25, 310 synthetase, 25, 171 prosthetic adducts, inactivated cytochrome P-450 (rat), 25, 310 effect of5-fluorouracil, 25, 171 Hemoglobin relationship to inhibition of thymidylate synthase by 5-fluorouracil, autooxidation, 25, 467 25, 303 catalytic activity, 25, 467 2 ‘ -Fluoro-5-iodo- 1 -f3-D-arabinofuranosylcytosine, metabolic effect, vi- cytochrome P-450-like activity, 25, 467 rus-infected cells, 26, 587 monooxygenase activity, 25, 467 5-Fluorouracil substrate specificity, 25, 467 effect on cellular thymidylate synthetase levels, 25, 171 Hepatoma incorporation into preribosomal RNA, 26, 135 Hep G2, galactose-terminal ligand movement, 26, 509 inhibition of thymidylate synthase, 25, 303 Hepatotoxicity Folate lobular, allyl alcohol (rat), 25, 158 biochemistry, effect ofphenytoin (mouse), 25, 459 Heterogeneity deficiency, drug-induced (mouse), 25, 459 tissue, calcium channel antagonist binding sites, 25, 235 distribution in liver (mouse), 25, 459 HKSV28 cell Forskolin inhibition of growth by 5,11-methenyltetrahydrohomofolate, 25, 294 -potentiated hormone responses in C6-2B cells (rat), 25, 256 Hoechst 33342 fluorescence, bromodeoxyuridine quenching, 26, 388 -stimulated cyclic AMP accumulation in C6-2B cells (rat), 25, 256 Homofolic acid 2-Furamide, 26, 112 inhibition of de novo purine biosynthesis, 25, 294 Furosemide, 26, 112 Hormone action, models for, 26, 214 G forskolin-potentiated responses in C6-2B cells (rat), 25, 256 G, block, 26, 388 gonadotropin-releasing actions (rat), 25, 51 Ganglioside luteinizing, release (rat), 25, 51 brain thyrotropin-releasing effect on membrane actions of ethanol and phenobarbital, 25, 410 effect on GH3 pituitary tumor cells, 25, 193 ethanol effects (mouse), 25, 401 -stimulated [3HJinositol metabolism in GH3 pituitary tumor cells, membrane effects, 25, 410 25, 201 Gene activation, 26, 117 Hybridization, RNA-DNA, 26, 117 Genetics (mouse), 26, 117 Hydrocarbons Gephyrotoxin polycyclic aromatic effect on neuromuscular transmission, 25, 395 competitive binding, 26, 353 interaction metabolism, adrenal cortical cells (bovine), 25, 476 noncompetitive binding, 25, 395 steroidogenesis, adrenal cortical cells (bovine), 25, 476 with acetylcholine receptor-ionic channel complex, 25, 384 Hydrolysis Glucocorticoid tripeptidyl, substance P, 25, 287 16a, 1 7cs-acetal-substituted action, 25, 70 Hydroperoxyflavin potency in vivo and in vitro, 25, 70 model for FMO, 26, 348 SUBJECT INDEX 615
7-Hydroxycoumarin K glucuronidation in liver lobule (rat), 25, 487 K N-Hydroxy-p-phenetidine channel (crayfish), 25, 369 carcinogenic activity, 26, 342 conductance, 26, 267 (-)[‘251]Hydroxyphenylisopropyladenosine phosphorylation by, 26, 141 purification, characterization, and radioligand binding, 26, 414 KC1 3H-5-Hydroxytryptamine depolarization, effect in tracheal smooth muscle (dog), 25, 267 binding, and effects of GTP, 26, 10 Kidney porphyrin metabolism, 26, 336 I uroporphyrinogen decarboxylase (rat), 26, 336 Kinetics ICRF-159, cell cycle analysis, 26, 388 competitive radioligand binding, 25, 1 Ileum, opioid receptors (guinea pig), 25, 343 dual product formation, 25, 467 Imidazole, induction of liver microsomal cytochrome P-450 isozymes ionic channels, 25, 102 3a and 6 (rabbit), 25, 494 radioligand binding, prediction, 25, 1 Inhalation anesthetics, and membrane expansion, 25, 123 sequential model, 26, 293 Inhibition action potential, verapamil (crayfish), 25, 369 L adenosine dialdehyde (mouse), 25, 418 L1210 clonogenic survival, 26, 128 aldose reductase, by alrestatin (human), 25, 425 Leukemia cells, lethality of 5-methyl-2’ -deoxycytidine (human), 25, binding, [3Hlbatrachotoxinin A 20-a-benzoate, 25, 219 431 dCMP deaminase, by dTTP, 25, 436 Ligand-dye DNA polymerase, by 3’-aminothymidine triphosphate, 25, 441 interactions with 1 ,25-dihydroxyvitamin D:,-receptor complexes feedback, dThd kinase activity, 25, 446 (chicken), 25, 79 HKSV28 cell growth, by 5,11-methenyltetrahydrohomofolate, 25, polyribonucleotide interaction (chicken), 25, 86 294 Ligand selectivity, 25, 343 selective, delta subclass of opioid binding sites, 25, 249 Lipid methylation (mouse), 25, 418 thymidylate synthase, by 5-fluorouracil, 25, 303 Lipoproteins, human plasma, and distribution of probucol, 26, 322 voltage-sensitive sodium channels in neuroblastoma cells and syn- Lithium, effect on [3Hjinositol metabolism, GH pituitary tumor cells, aptosomes, 25, 228 25, 201 Inhibitory potency, amino acid sequence requirements, 26, 45 Liver alpha,-adrenergic receptors and Ca2 , 26, 405 allyl alcohol metabolism (rat), 25, 158 bi, mono-, triphosphate, metabolism in GH3 pituitary tumor cells, cytochrome P-450, isozymes 3a and 6 (rabbit), 25, 494 25, 201 distribution of folate (mouse), 25, 459 3H-labeled, metabolism in GH3 pituitary tumor cells, 25, 201 lobule, glucuronidation of 7-hydroxycoumarin (rat), 25, 487 Interfacial phenomenon, 25, 123 5, 10-methylenetetrahydrofolate reductase, effect of phenytoin treat- Intermolecular interactions, theoretical computations, 25, 452 ment (mouse), 25, 459 Intestine peptide mapping (rabbit), 25, 494 cytosol, 1,25-dihydroxyvitamin D3 complexes (chicken), 25, 86 periportal and pericentral zones (rat), 25, 487 1,25-dihydroxyvitamin D3-receptor complexes (chicken), 25, 79 Lung, angiotensin-converting enzyme (rabbit), 25, 287 m-Iodobenzylguanidine, sodium-dependent uptake (bovine), 26, 539 Luteinizing hormone release (rat), 25, 51 Iododeoxyuridine Lymphoma, S49 cells, beta-adrenergic receptors, 25, 209 thymidine kinase-stimulated phosphorylation, 25, 446 5-Iodo-5’-amino-2’,5’-dideoxyuridine, stimulation of phosphorylation M of thymidine, 5-iodo-2’-deoxyuridine, 25, 446 Mass action law, prediction of radioligand binding kinetics, 25, 1 Ion conduction [3HjMazindol, dopamine and norepinephrine uptake sites, 26, 35 cyclic AMP effects, 26, 51 Membrane nicotinic receptors, 26, 51 brain Ion transport, effect of local anesthetics, 25, 219 effect ofethanol, 25, 410 Ionic channel effect of pentobarbital, 25, 410 -acetylcholine receptor complex, 25, 360, 384, 395 lipid composition (mouse), 25, 401 alteration of kinetics, 25, 92 physical properties (mouse), 25, 401 blockade, 25, 384 chromaffin granule, reserpine binding (bovine), 25, 113 kinetics, 25, 102 effect of local anesthetics, 26, 314 -nicotinic acetylcholine receptor complex interactions with pyridos- expansion, and inhalation anesthetics, 25, 123 tigmine, 25, 92, 102 fluidity Insecticides effect of ethanol tolerance (mouse), 25, 401 hydrolysis, 26, 99 ethanol effects, 25, 410 protein binding, 26, 99 fluorescent probes (mouse), 25, 401, 26, 83 Insulin release, 26, 267 muscle, interactions with phencyclidine (crayfish), 25, 369 Iproniazid metabolism, cytosolic effects, 26, 566 phospholipid vesicle, 25, 123 Isoproterenol, forskolin-potentiated hormone response in C6-2B cells stabilization, 25, 123 (rat), 25, 256 volume, and anesthesia, 25, 123 Isozyme Metabolism 3a, cytochrome P-450, ethanol- and imidazole-induced (rabbit), 25, brown fat cell (hamster), 25, 64 494 carbon tetrachloride, reductive-oxygenation mechanism ( rat ), 25, 6, cytochrome P-450, imidazol-induced (rabbit), 25, 494 318 616 SUBJECT INDEX
Metabolism-Contined Naloxone, in vivo receptor binding (rat), 25, 242 drug, extrahepatic, 25, 185 Neonate myoballs (rat), 25, 102 hepatic, allyl alcohol (rat), 25, 158 Neuroblastoma cells inositol, in GH3 pituitary tumor cells, 25, 201 culturing, 26, 156 5-methyl-2’-deoxycytidine, in leukemic cells (human), 25, 431 voltage-sensitive sodium channels, 25, 228 polycyclic aromatic hydrocarbon, in adrenal cortical cells (bovine), Neurological mutant (mouse), 25, 24 25, 476 Neuromuscular transmission, effect of gephyrotoxin, 25, 395 Metabolites, radical, binding to lipid, 26, 112 Neurones, locus coeruleus, opiate-receptor interactions, 26, 489 Methylation, lipid (mouse), 25, 418 Neurotoxin 3-Methylcholanthrene, 26, 117 effect on sodium channels, 25, 219, 228 5-Methyl-2’-deoxycytidine sea anemone and scorpion, interaction with tetrodotoxin-resistant deamination (human), 25, 431 Na channels (rat), 26, 70 DNA exclusion (human), 25, 431 Nicotinic receptor cyclic AMP effects, 26, 51 effects on lethality in leukemic cells in vitro (human), 25, 431 Nitrendipine, 3H-labeled, heterogeneity of binding sites, 25, 235 metabolism, in leukemic cells (human), 25, 431 p-Nitrosophenetole, reaction with glutathione, 26, 342 5,10-Methylenetetrahydrofolate reductase, hepatic, effect of phenytoin NMR, deuterium of anesthetics, 26, 314 treatment (mouse), 25, 459 Noise analysis, acetylcholine, 25, 384 5,1 1-Methenyltetrahydrohomofolate, inhibition of HKSV28 cell Norepinephrine growth, 25, 294 binding in vas deferens (rat), 25, 56 Mg ,Na , 26, 180 palytoxin-induced (rat), 25, 379 Microaggregation, gonadotropin-releasing hormone (rat), 25, 51 3H-labeled, release Micro-light guide, NADH, 25, 158 Ca2 and Na dependency (rat), 25, 379 Microsome, hepatic, cytochrome P-450 isozymes 3a and 6 (rabbit), 25, uptake 494 inhibition, 26, 35 Minor groove, (dA-dT),, oligomers, 25, 452 sodium and chloride dependency, 26, 35 Mitochondria, monoamine oxidase topography, 25, 165 sodium-dependent (bovine), 26, 539 Mitoxantrone Novonal antitumor activity, 25, 178 cytochrome P-450 destruction (rat), 25, 310 binding to DNA, 25, 178 prosthetic heme adducts (rat), 25, 310 Molecular electrostatic potential maps, 26, 19 Nuclear magnetic resonance Molecular modulators, receptor affinity, activity, 26, 19 interaction of avoparcin with receptor of cell wall, 25, 281 Monoamine oxidase studies on antibiotic, avoparcin, 25, 275 multiple forms, 25, 165 guanine, effect on D2-dopamine receptors in brain (calf), 25, 10 topography, 25, 165 guanyl, regulation, solubilized vasopressin receptors (rat), 26, 241 Monooxygenase activity of hemoglobin, substrate specificity, 25, 467 0 N- and 0-demethylation, 25, 467 p-hydroxylation, 25, 467 02, miniature electrode, 25, 158 regioselective metabolism, 25, 467 Oligomer, double-stranded (dA-dT) nonintercalative binding of her- Morphine, mu, binding sites, 25, 29 enil and stilbamidine, 25, 452 Muscarinic agonists, 26, 149 Oocyte adenylate cyclase, progesterone inhibition, 26, 526 Muscarinic receptors, regulation, 26, 156 Opiate, mu, binding sites, 25, 29 Muscle Opiate receptor interosseal (frog), 25, 102 adrenal medullary (bovine), 25, 38 membranes, interactions with phencyclidine (crayfish), 25, 369 high-affinity binding, 25, 29 skeletal in pheochromocytoma (human), 25, 38 effect of amiloride (chick), 25, 131 interactions, single locus coeruleus neurones, 26, 489 glucocorticoid receptor (rat), 25, 70 Opioid vertebrate, 26, 45 binding sites twitch biochemical characterization, by [3H]naloxonazine (rat), 26, 477 alteration by pyridostigmine, 25, 92 brain (guinea pig), 25, 337 blockade by gephyrotoxin, 25, 384 brain (rat), 25, 242 Mutant, neurological (mouse), 25, 24 delta subclass, selective inhibition, 25, 249 Myoball, neonatal (rat), 25, 102 mu,, 25, 29 Myosin light chain, phosphorylation in tracheal smooth muscle (bo- 3H-labeled, high-affinity binding, biochemical characterization, 25, vine), 25, 267 29 receptor N binding in vivo (rat), 25, 242 binding selectivity, 25, 337 Na characterization, 25, 38 dependency, [3H]norepinephrine release (rat), 25, 379 ileum (guinea pig), 25, 343 channels, tetrodotoxin-resistant interaction, polypeptide neurotox- multiple (guinea pig), 25, 343 ins (rat), 26, 70 multiplicity (rat), 25, 242 /H exchange system, 25, 131 pharmacological selectivity, 25, 343 NADH, micro-light guide, 25, 158 selective ligands, 25, 337 NADPH supply, perioportal and pericentral regions (rat), 26, 574 site-directed alkylation, 25, 337, 343 Nafazatrom, prostacyclin stimulation, 26, 328 vas deferens (mouse), 25, 343 [3H]Naloxonazine binding, rat brain membranes, 26, 477 Organophosphate pesticide disposition, 26, 99 SUBJECT INDEX 617
Oxidation vesicle membrane, 25, 123 mixed function, liver, normal and phenobarbital-treated (rat), 26, Phosphorylase phosphorylation in tracheal smooth muscle (dog), 25, 574 267 organosulfur compounds, 26, 348 Phosphorylation Oxotremorine derivative, 2-chloroalkylamine, 26, 170 by 46 mM K , 26, 141 Oxygen dependency, carbon tetrachloride metabolism (rat), 25, 318 myosin light chain and phosphorylase in tracheal smooth muscle Oxygen radicals, 26, 360 (bovine), 25, 267 Oxygenation Photoaffinity cross-linking, 26, 187 reductive, carbon tetrachloride (rat), 25, 318 [3H]Pirenzepine, 26, 164 trichioromethyl radical (rat), 25, 318 Pituitary anterior, 26, 214 P platelet, adipocytes, liver membranes, GTP, 26, 180 Palytoxin GH3 tumor cells 45Ca flux (rat), 25, 379 effect of thyrotropin-releasing hormone, 25, 193 Na influx (rat), 25, 379 [3H]inositol metabolism, 25, 201 [3H]norepinephrine release (rat), 25, 379 phosphaidyiinositol 4-phosphate, 25, 193 pheochromocytoma cell line (rat), 25, 379 phosphatidylinositol 4,5-bisphosphate, 25, 193 Pancreatic islets, 26, 267 intermediate lobe, multiple dopamine receptors (rat), 25, 18 Patch clamp Placenta, aldose reductase (human), 25, 425 cultured muscle cells (rat), 26, 304 PM2, circular DNA, drug binding to , 25, 178 single channels, 25, 102 Polycyclic aromatic hydrocarbon pBR322, plasma, drug binding to, 25, 178 metabolism in adrenal cortical cells (bovine), 25, 476 PC12 cells, 26, 51, 141 steroidogenesis in adrenal cortical cells (bovine), 25, 476 Pentobarbital, membrane action, effect of gangliosides, 25, 410 Poly(G), dye-ligand interactions, 25, 79 Pentylenetetrazol, 26, 83 Poly(I), dye-ligand interactions, 25, 79 Peptide Polyphosphoinosotide, breakdown in GH3 pituitary tumor cells, 25, -avoparcin complexes, structure, 25, 275 201 maps, hepatic isozyme (rabbit), 25, 494 Polynucleotide binding in intestinal cytosol (chicken), 25, 86 secretion, apomorphine enantiomers (carp, rat), 25, 18 Potentiation Perhydrohistrionicotoxin, binding inhibition, 25, 395 hormone response in C6-2B cells (rat), 25, 256 Peroxidase, covalent binding, 26, 105 substance P activity in vivo by captopril and MK-422 (rabbit), 25, Phenacetin metabolites, reaction with glutathione and DNA, 26, 342 287 Phencyclidine Prazosin binding effect on phosphatidylinositol metabolism (hamster), 25, 64 to acetylcholine receptor (ray), 25, 360 3H-labeled binding, 26, 196 inhibition by Ca2 antagonists (crayfish), 25, 369 Probe, radioiodinated high affinity, 26, 187 to muscle (crayfish), 25, 369 Probucol, in human plasma lipoproteins, 26, 322 interactions with muscle membranes (crayfish), 25, 369 Proenkephalin MRNA, modulaton, 26, 255 p-Phenetidine, reaction with glutathione, 26, 342 Progesterone, inhibition, Xenopus oocyte adenylate cyclase, 26, 526 Phenol, hydroquinone, 26, 105 Prolactin synthesis, estrogen-stimulated, 26, 279 [3H]Phenoxybenzamine binding, 26, 196 Prostacyclin synthase, protection, 26, 328 Phenytoin Prostaglandin H synthase, stimulation by nafazatrom, 26, 328 chronic treatment, effect on hepatic 5,10-methylenetetrahydro- Protease folate reductase activity (mouse), 25, 459 effect on -y-aminobutyric acid binding in brain (rat), 25, 352 folate biochemistry (mouse), 25, 459 probe of mitochondrial monoamine oxidase topography in situ, 25, Pheochromocytoma 165 [3H]norepinephrine release (rat), 25, 379 Protein opiate receptors (human), 25, 38 carboxylmethylation (mouse), 25, 418 Phorbol (di)esters, 26, 261 carcinogen-binding, 26, 353 Phosgene, derivation from carbon tetrachloride in liver microsomes islet-activating, Bordetelkzpertu.ssis, and progesterone inhibition, 26, (rat), 25, 318 526 Phosphatidic acid, accumulation in GH3 pituitary tumor cells, 25, 193 regulatory for hormone receptors, 26, 214 Phosphatidylinositol Protein kinase C a pha1-adrenergic receptors and Ca2 , 26, 405 and phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, 26, 267 turnover, 26, 149, 267 role in secretion, 26, 261 in brown fat cells (hamster), 25, 64 Proteolysis, receptor, 25, 79 Phosphatidylinositol 4-phosphate in GH3 pituitary tumor cells, effect Pseudocholinesterase molecular forms, 26, 45 of thyrotropin-releasing hormone, 25, 193, 201 Purification Phosphatidylinositol 4,5-bi8phosphate effect of thyrotropin-releasing bungarotoxin polypeptide, 25, 327 hormone, 25, 193 liver microsomal cytochrome P-450 isozymes 3a and 6 (rabbit), 25, in GH3 pituitary tumor cells, effect of thyrotropin-releasing hormone, 494 25, 193, 201 Purine Phosphodiesterase, inhibition in thyroid (dog), 25, 261 biosynthesis Phospholipase C glycinamide transformylase, 25, 294 role in thyrotropin-releasing hormone action in pituitary tumor cells, inhibition of homofolic acid derivatives, 25, 294 25, 193, 201 nucleotide specificity, 26, 369 Phospholipid Pyridostigmine brain, ethanol effects (mouse), 25, 401 agonist properties, 25, 92 618 S) BJECT INDEX
Pyridostigmine-Continued guinea pig ileum, 26, 170 alteration of end-plate currents, 25, 92 irreversible binding, 26, 170 anticholinesterase agent, 25, 92 regulation, 26, 156 interactions with the nicotinic acetylcholine receptor-ionic channel molecular weights, 26, 196 complex, 25, 92 nicotinic acetylcholine in adrenal chromaffin cells, 25, 327 Q -ionic channel complex, 25, 92, 102 (3H]Quinuclidinyl benzilate, 26, 164 phencyclidine binding (ray), 25, 360 Quinone-containing antitumor agents, 26, 582 nueromuscular junction, 26, 293 nonequilibrium studies, 25, 209 R opiate adrenal medullary (bovine), 25, 38 Radiation high-affinity binding, 25, 29 inactivation, 26, 196 in pheochromocytoma (human), 25, 38 Radical metaholites, bindng to lipid, 26, 112 opioid Radioligand binding in vivo (rat), 25, 242 binding binding selectivity, 25, 337 kinetics, 25, 1 ileum (guinea pig), 25, 343 mixed stereoisomer, 26, 414 multiplicity (rat), 25, 242 prediction, 25, 1 pharmacological selectivity, 25, 343 thermodynamics, 26, 1 selective ligands, 25, 337 Receptor site-directed alkylation, 25, 337, 343 acetylcholine vas deferens (mouse), 25, 343 -ionic channel complex, 25, 384, 395 peripheral nicotinic, myoballs, 26, 304 nicotinic, 26, 51 proteolysis, 25, 79 phencyclidine binding (ray), 25, 360 purification, 26, 196 adenosine, brain, 26, 1 -receptor interactions (rat), 25, 51 adrenergic, see Adrenergic receptor regulation of gonadotropin release (rat), 25, 51 agonist alpha, splenic (rat), 26, 187 -induced changes, 25, 209 subtypes, 26, 164 states in brain (calf), 25, 10 topology, 26, 196 alpha, -adrenergic up-regulation (rat), 25, 51 Ca and phosphatidylinositol, 26, 405 vasopressin, solubilized, two molecular forms (rat), 26, 241 structure, 26, 196 Receptor-effector coupling, angiotensin-induced (bovine), 26, 498 beta-adrenergic, synthesis, human astrocytoma cells, 26, 424 Reduction, N-acetyl-p-benzoquinone imine, 25, 151 ‘y-aminobutyric acid inhibitory cyclase (rat), 25, 24 Reductive oxygenation, carbon tetrachloride, by cytochrome P-450 aryl hydrocarbon, 26, 353 (rat), 25, 318 avoparcin, bacterial cell wall, 25, 281 Reserpine benzodiazepine, 26, 228 binding interactions, zopiclone and suriclone, 26, 458 to chromaffin granule membranes (bovine), 25, 113 binding, 26, 156, 484 comparison with dihydrotetrabenazine binding (bovine), 25, 113 1 6a, 1 7a-acetal-substituted glucocorticoids, 25, 70 RNA cholinergic, phencyclidine binding (ray), 25, 360 covalent binding, 26, 369 for cytochrome P.450 induction, 26, 117 processing, 26, 135 cytosolic, for 2,3,7,8-tetrachlorodibenzo-p-dioxin, 26, 90 ribosomal, 26, 135 -1,25-dihydroxvitamin D3 complexes dye-ligand interactions mRNA induction, turnover, 26, 117 (chicken), 25, 79, 86 RNase III, 26, 135 -1,25-dihydroxyvitamin D3 complexes in intestinal cytosol (chicken), [3HJRo 22-1319 (piquindone) binding to D2 receptor subtype (rat), 26, 86 25, 430 dimers, 26, 196 S dopamine, 26, 214 D2, in brain (calf), 25, 10 Secretion D2, characterization with aminotetralins, 26, 452 peptide, apomorphine enantiomers (carp, rat), 25, 18 multiple (carp, rat), 25, 18 role of protein kinase C in, 26, 261 dopaminergic, and [1H]dopamine sites, distinctions, 26, 439 Semiempirical molecular orbital methods, 26, 19 down-regulation (rat), 25, 51, 26, 206 Sensitivity -effector coupling, 26, 214 acetylcholine estrogen, 26, 279 extrajunctional region, 25, 395 glucocorticoid, ligand structure, skeletal muscle (rat), 25, 70 junctional region, 25, 395 alpha, hepatic (rat), 26, 187 phencyclidine, to calcium channel antagonists (crayfish), 25, 369 heterogeneity, 26, 228 Skeletal muscle, vertebrate, 26, 45 hormone, regulatory proteins for, 26, 214 Smooth muscle, a!pha,-adrenergic receptors (rat), 25, 56 isomerization, 26, 164 Sodium limited proteolysis of, 26, 196 channels, [3H]batrachotoxinin A 20-a-benzoate binding, 25, 219 muscarinic -dependent uptake, m-iodobenzylguanidine and norepinephrine, 26, binding of tertiary amines, 25, 46 539 cholinergic, 26, 149, 164 [‘H]Ro 22-1319 (piquindone) binding to D2 receptor subtype, 26, cyclic AMP metabolism, 26, 395 430 SUBJECT INDEX 619
voltage-sensitive channels, inhibition in neuroblastoma cells and and glutathione, 26, 342 synaptosomes, 25, 228 phenytoin (mouse), 25, 459 Sodium dodecyl sulfate gel electrophoresis, 26, 196 Transcriptional activation, 26, 117 Sodium valproate, comparison, ethanol (mice), 26, 547 Transmethylation, S-adenosylmethionine-dependent effects of adeno- Sorbinil, inhibition of placenta aldose reductase (human), 25, 425 sine dialdehyde (mouse), 25, 418 Spiroperidol Transport ion, effect of local anesthetics, 25, 219 binding Trichloromethylperoxyl radical decomposition to phosgene (rat), 25, in brain (calf), 25, 10 318 to D2 dopaminergic receptors (rat), 26, 439 Trichloromethyl radical oxygenation (rat), 25, 318 Steroidogenesis, polycyclic aromatic hydrocarbon in adrenal cortical Tripeptidyl hydrolysis, substance P, 25, 287 cells (bovine), 25, 476 Tumor Stilbamidine, nonintercalative binding, 25, 452 pituitary GH3 Stimulus-secretion coupling, 26, 261 effect of thyrotropin-releasing hormone, 25, 193 Stoichiometry [3H]inositol metabolism, 25, 201 binding Tyrosine hydroxylase, activation, 26, 141 theory, 25, 137 versus site-oriented analysis, 25, 137 U Structure-activity relationship, amiloride, 25, 131 Structure, 16a,17a-acetyl-substituted glucocorticoids, 25, 70 Ultraviolet, DNA damage, 25, 322 Uptake Substance P carboxyl-terminal tripeptidyl hydrolysis, 25, 287 catecholamine degradation by angiotensin-converting enzyme (rabbit), 25, 287 in chromaffin granule membranes (bovine), 25, 113 dopamine and norepinephrine potentiation in vivo by captopril and NK-422 (rabbit), 25, 287 substrate for angiotensin-converting enzyme (rabbit), 25, 287 inhibition, 26, 35 sodium and chloride dependency, 26, 35 Sufentanil, in vivo receptor binding (rat), 25, 242 Uroporphyrinogen decarboxylase Sulfonylurea, 26, 267 metal inhibition, mercury, 26, 336 Suriclone and zopiclone binding, benzodiazepine receptors, 26, 458 GSH stimulation, 26, 336 Synaptosome, voltage-sensitive sodium channels, 25, 228
T V
Tachykinin binding sites, 26, 248 Valproic acid, 26, 83 Tamoxifen, effect on estrogen receptor binding activity, 26, 272 Varicella zoster virus, 26, 376 Target size analysis, 26, 96 Vasopressin receptors, two molecular forms, rat kidney membranes, Ternary complex, agonist binding, 26, 10 26, 241 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 26, 90, 117 Vero cells, Herpes simplex-infected, metabolic effect of FIAC, 26, 587 12-O-Tetradecanoylphorbol-13 acetate, 26, 267 Voltage-sensitive sodium channels in neuroblastoma cells and synap- Thiol reagents, inhibition of erythrocyte sickling, 26, 559 tosomes, 25, 228 Thiourea metabolism, 26, 122 Verapamil inhibition of [ HJphencycIidine binding (crayfish), 25, 369 Thymidine Volume analogue mean excess, anesthesia hypothesis, 25, 123 antineoplastic activity, 25, 441 molal, partial, 25, 123 cytotoxicity, 25, 446 Vas deferens phosphorylation, 25, 446 alpha,-adrenergic receptors (rat), 25, 56 kinase ‘251BE 2254 binding (rat), 25, 56 -stimulated phosphorylation of iododeoxyuridine, 25, 446 norepinephrine binding (rat), 25, 56 -stimulated phosphorylation of thymidine, 25, 446 radioligand binding (rat), 25, 56 viral, 26, 376 Thymidylate synthase x inhibition by 5-fluorouracil, 25, 303 levels in cells exposed to 5-fluorouracil, 25, 171 Xanthine alkylated, effects on cyclic AMP accumulation in thyroid (dog), 25, Thyroid, cyclic AMP accumulation, effects of xanthines (dog), 25, 261 Thyrotropin-releasing hormone 261 effect on GH3 pituitary tumor cells, 25, 193 derivatives, effects on thyroid (dog), 25, 256 -stimulated 13H]inositol metabolism in GH3 pituitary tumor cells, 25, 201 Y Tetrabenazine binding in chromaffin granule membranes (bovine), 25, Yohimbine, effect on phosphatidylinositol metabolism (hamster), 25, 113 64 2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of cytochrome P-450, 25, 185 Z Toxicity, see also Hepatoxicity allyl alcohol (rat), 25, 158 Zopiclone and suriclone binding, benzodiazepine receptors, 26, 458 STATEMENT OF OWNERSHIP MANAGEMENT AND CIRCULATION Req.w.Jb,J U zcJ6i5) flT OF PU$UCA110N lB. PUSUCA110P4 NO. 2. DATE OF L NG
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