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Program Book TABLE OF CONTENTS WELCOME ADDRESS ............................................................................................................................... 2 TECHNICAL PROGRAM ............................................................................................................................ 3 POSTER SESSION ..................................................................................................................................... 4 ORGANIZNG COMMITTEE ....................................................................................................................... 5 PLENARY AND INVITED SPEAKER BIOGRAPHIES ..................................................................................... 6 Plenary Speaker Biographies .............................................................................................................. 6 Invited Speaker Biographies ............................................................................................................... 8 ORAL ABSTRACTS .................................................................................................................................. 10 POSTER ABSTRACTS .............................................................................................................................. 21 CODE OF CONDUCT ............................................................................................................................... 27 All information contained herein is correct as of January 5, 2020. Abstracts appear as submitted by their authors. Neither the American Institute of Chemical Engineers (AIChE) and its entities, nor the employers affiliated with the authors or presenting speakers, are responsible for the content of the abstracts. 1 International Conference on Biomolecular Engineering • January 7-9, 2020 WELCOME ADDRESS Welcome! A warm welcome to the 2020 International Conference on Biomolecular Engineering (ICBE) brought to you by the Society for Biological Engineering (SBE), an AIChE Technological Community and hosted at the Copthorne Kings Hotel, Singapore. ICBE Asia 2020 brings together researchers to advance the understanding and application of molecular biology, biophysical chemistry, metabolic engineering, cellular and tissue engineering, biomaterials and synthetic biology. In this conference, engineers, scientists from academia and industry will gather to discuss the use of biology and biomolecular engineering to further research and discover new innovations in the health sector. The conference’s plenary lecture topics provide deeper understandings into the key areas, which include: protein and peptide engineering, biomolecular engineering and self-assembly, and biomolecular analytics and characterizations. The protein and peptide engineering session will focus on new tools and platforms developed to enable engineering of proteins and peptides. Technologies could include, but are not limited to, those for evolutionary design or synthesis. The biomolecular engineering and self-assembly session will focus on advances in biomolecular design rules and engineering tools across various length scales to achieve super molecular structures, leading to applications in therapeutics and bio catalysis. The biomolecular analytics and characterizations session will showcase advances in analytical tools that enable investigations at molecular level and its implications on the bulk properties which are relevant for translation into industrial scales. A lot of work has gone into making this conference a success. We extend our thanks to the contributions of our expert steering committee and the dedication of the staff here at SBE and AIChE in realizing the conference. Our distinguished speakers who made the conference an exciting one; our thanks to them. Before we close, we would like to thank each of you for attending ICBE 2020 and bringing your expertise and enthusiasm to the meeting. You have the vision, knowledge and experience to help us pave our way into the future. You are truly our greatest asset today and tomorrow, and we could not accomplish what we do without your support and leadership. Throughout this conference, we ask you to stay engaged, keep proactive, and help us shape the future of biomolecular engineering. We hope your experience is a pleasant, educational, and inspiring one. Sincerely, Conference Chairs of ICBE 2020 Sierin Lim Susanna Su Jan Leong Nanyang Technological University (NTU) Singapore Institute of Technology Singapore 2 International Conference on Biomolecular Engineering • January 7-9, 2020 TECHNICAL PROGRAM Tuesday, January 7, 2020 8:30 – 9:30 AM Registration 9:30 – 9:45 AM Opening Ceremony Plenary Lecture I: Peptide/Protein Engineering 9:45 – 10:30 AM 583624: James P. Tam, Nanyang Technological University, Singapore. Plenary Talk: Superglue from Nature 10:30 – 11:00 AM Break 11:00 AM – 12:30 PM Technical Session 1: Enzyme Engineering 591024: Mark Howarth, University of Oxford, United Kingdom. Invited Talk: Spy and Snoop Peptide 11:00 – 11:30 AM Superglues to Empower Vaccines, Biomaterials and Antibodies 588543: Daniel T. Peters, Newcastle University, United Kingdom. Engineering the Plague Capsular 11:30 – 11:50 AM Antigen (Caf1) Protein: A Thermally Reformable Protein Polymer 588649: Bunyarit Meksiriporn, King Mongkut's Institute of Technology Ladkrabang, Thailand. An 11:50 AM – 12:10 PM Engineered Survival-Selection Strategy for Synthetic Binding Scaffolds Specifically Targeting Post- Translationally Phosphorylated Proteins 588529: MengJun Fang, ZheJiang University, China. Improving the Productivity of 5-Hydroxy-L- 12:10 – 12:30 PM Tryptophan in Escherichia coli By Combinational Evolution of Several Key Enzymes and Co-Enzymes 12:30 – 2:00 PM Lunch 2:00 – 3:40 PM Technical Session 2: Protein Engineering and Formulation 588858: Alois Jungbauer, BOKU, Austria. Invited Talk: Digital Twins of Continuous Integrated 2:00 – 2:30 PM Biomanufacturing Processes 590928: Jakob Buecheler, Novartis, Switzerland. Invited Talk: A Closer Look into Freeze-Thaw Processes 2:30 – 3:00 PM for Therapeutic Protein Formulations 588845: Donald Belcher, The Ohio State University, USA. Evaluating Chemo-Sensitizing Potential of 3:00 – 3:20 PM Oxygen Delivery Facilitated By Transfused Polymerized Hemoglobins on Vascularized Solid Tumors 590838: Tae Hyeon Yoo, Ajou University, Korea, Republic of (South). Site-Specific Modification of IgG Via 3:20 – 3:40 PM a Simple Photocrosslinking Reaction 3:40 – 5:00 PM Poster Session and Reception Wednesday, January 8, 2020 9:00 – 9:30 AM Registration 9:30 – 11:00 AM Technical Session 3: Cellular Engineering 591063: Paul Freemont, Imperial College London, United Kingdom. Invited Talk: In Vitro Synthetic 9:30 – 10:00 AM Biology Using Cell Free Systems to Prototype Parts and Pathways to Enzymatic Conversion in a Test-Tube 588534: Xixian Chen, BioTrans, A*STAR Singapore, Singapore. Integrating Enzyme and Metabolic 10:00 – 10:20 AM Engineering for Apocarotenoids Production 584898: Kathakali Sarkar, Saha Institute of Nuclear Physics, Homi Bhabha National Institute, India. 10:20 – 10:40 AM Synthetic Genetic Devices for Decoding and Encoding Chemical Signals in Living Bacterial Cells 584867: Deepro Bonnerjee, Saha Institute of Nuclear Physics, Homi Bhabha National Institute, India. 10:40 – 11:00 AM Synthetic Genetic Devices for Higher Order Artificial Information Processing in Living Cells: Towards a Cellular Robotics Platform 11:00 – 11:30 AM Break 11:30 – 11:50 AM Rapid Fire Poster Presentations 589975: Muen Chung, RWTH Aachen, SeSaM-Biotech, Germany. Display of Functional Nucleic Acid 11:30 – 11:40 AM Polymerase on Escherichia coli Surface and Its Application in Directed Polymerase Evolution 583968: Young-Kee Kim, Hankyong National University, Korea, Republic of (South). Effect of Nutrient 11:40 – 11:50 AM Supplement on Syngas Fermentation With Clostridium Autoethanogenum 11:50 AM – 1:30 PM Lunch Plenary Lecture II: Biomolecular Engineering & Self-assembly 1:30 – 2:15 PM 588708: Samuel Stupp, Northwestern University, USA. Plenary Talk: "Biomimetic Structures for Regenerative Medicine" 2:15 – 3:25 PM Technical Session 4: Self-assembly 588467: Stefan Salentinig, University of Fribourg, Switzerland. Invited Talk: Lipid-Peptide Co-Assemblies 2:15 – 2:45 PM for Multifunctional Biointerfaces 583836: Andrew Care, Macquarie University, Australia. Bioengineering Prokaryotic Nanocompartments 2:45 – 3:05 PM into Photosensitizing Nanoparticles 3 International Conference on Biomolecular Engineering • January 7-9, 2020 TECHNICAL PROGRAM 588655: Rana Gamal, University of Garden City, University of Medical Sciences and Technology, Sudan. 3:05 – 3:25 PM Green Synthesis of Gold Nanoparticles from Camellia sinensis and Its Application Against UTI Bacteria 3:25 – 4:30 PM Poster Session 6:30 – 8:30 PM Ticketed Dinner Thursday, January 9, 2020 9:00 – 9:30 AM Registration Plenary Lecture III: Biomolecular Analytics and Characterizations 9:30 – 10:15 AM 591152: Daniel Fletcher, UC Berkeley, USA. Plenary Talk: Cell Surface Topography: How Protein Size can Alter Organization and Signaling at Cell-Cell Interfaces 10:15 – 10:45 AM Break 10:45 AM – 12:05 PM Technical Session 5: Analytics 591007: Shee-Mei Lok, Duke-NUS Medical School, USA. Invited Talk: Zika virus and its antibody complex 10:45 – 11:15 AM structures 588640: Masamichi Ikeguchi, Soka University, Japan. Invited Talk: Time-Resolved Small-Angle X-Ray 11:15 – 11:35 AM Scattering for Monitoring the Biomolecular Assembly Process 590379: Yu Jing, Nanyang
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