DOCSLIB.ORG

Medical Progress)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Medical Progress) Refer to: Cherry JD, Welliver RC: Mycoplasma pneumoniae in- fections of adults and children (Medical Progress). Medical West J Med 125:47-55, Jul 1976 PROGRESS Mycoplasma Pneumoniae Infections of Adults and Children JAMES D. CHERRY, MD, and ROBERT C. WELLIVER, MD, Los Angeles Although the hallmark of Mycoplasma pneumoniae infection is pneumonia, the organism is also responsible for a protean array of other symptoms. With an increased awareness of the broad clinical spectrum of M. pneumoniae disease and the ready availability of the cold agglutinin and M. pneumoniae complement-fixation tests, interested clinicians will note additional clinical- mycoplasmal associations in their patients. MYCOPLASMA PNEUMONIAE INFECTIONS are re- this, numerous other mycoplasmas were isolated sponsible for a considerable number of human from cattle and other animals.' These other my- illnesses. Although there is a vast amount of coplasmas were originally called pleuropneumo- scientific knowledge available, there is still much nia-like organisms (PPLO). Presently, the term confusion related to the spectrum and manage- PPLO has been replaced by Mycoplasma; this is ment of clinical diseases due to mycoplasmas. one genus of the family Mycoplasmataceae. My- The purpose of this article is to review M. pneu- coplasmas have been isolated from many different moniae infections of children and adults in a way animals including man. M. pneumoniae, initially that will be useful to clinicians. Particular atten- called the Eaton agent, was identified in associa- tion will be given to the less well-known mani- tion with primary atypical pneumonia in 1944.4 festations of M. pneumoniae infections. The Eaton agent was originally believed to be a virus until Marmion and Goodburn5 in 1961 Definition and History showed that it was identical to pleuropneumonia- Mycoplasmas are the smallest free-living micro- like organisms. During the same year, Chanock organisms; they lack a cell wall, they grow on and colleagues6 administered a tissue culture lifeless media but require sterol for growth, and grown Eaton agent strain to human volunteers they are resistant to penicillin but sensitive to and produced respiratory illness similar to pri- several other antibiotics." 2 Nocard and Roux3 mary atypical pneumonia. Although several dif- isolated the first mycoplasma species (now known ferent mycoplasmas have been recovered from as M. mycoides var mycoides) from cattle with humans (Table 1), the present report is only con- contagious pleuropneumonia in 1898. Following cerned with M. pneumoniae infections. It is to out at the onset that From the Department of Pediatrics, Division of Infectious Dis- important point eases, University of California, Los Angeles, Center for the Health in this report many of the clinical manifestations Sciences. Reprint requests to: James D. Cherry, MD, Department of commented on were sporadic events and therefore Pediatrics, Division of Infectious Diseases, UCLA School of Medicine, Los Angeles, CA 90024. may not necessarily have had a cause and effect THE WESTERN JOURNAL OF MEDICINE 47 MYCOPLASMA PNEUMONIAE INFECTIONS TABLE 1.-Mycoplasmas* Recovered from Humans7 The incidence of pneumonia due to M. pneu- Respiratory tract Genital tract moniae is greatest in persons between the ages of M. pneumoniae M. hominis 5 and 15 years while the percentage of all pneu- M. orale (three types) M. fermentans monia attributable to M. pneumoniae is highest M. salivarium "T" - strains in late teenage and early adult years, when pneu- *Listed by site of most common recovery. monia due to all other causes is less com- mon. -10,12 Pneumonia due to M. pneumoniae is relationship with M. pneumoniae infection. There uncommon in persons less than 4 or greater than is always the possibility of dual infection with the 60 years of age.9"10 unrecovered infectious agent being responsible Symptoms and Signs.9-14 Illness usually presents for the symptoms. It is the opinion of the authors, with the gradual onset of malaise and fever. however, that these isolated cases should be in- Headache may also be a predominant early cluded, with reservation, as they offer valuable symptom. Cough begins after three to five days points of reference for the observers. (See Figure and becomes increasingly prominent. Initially 1 for clinical associations.) nonproductive, the cough may later produce frothy, white or even blood-tinged sputum. Find- Clinical Disease ings on Gram stain of the sputum show polymor- Pneumonia phonuclear leukocytes with no predominant Incidence. The incidence of pneumonia due to bacterial type evident. Gastrointestinal symptoms M. pneumoniae in the general population is ap- of anorexia, nausea and abdominal pain may proximately one case per 1,000 persons per year. occur. A pertussis-like syndrome with paroxysms During epidemic periods, rates as high as three of coughing has been described.'5 per 1,000 have been noted.8 M. pneumoniae in- Temperatures from 1000 to 103°F (37.80 to fections account for about 10 to 20 percent of 39.4°C) are common while higher temperatures all cases of pneumonia.9-11 Since isolation rates are unusual.'9 Physical findings are generally of do not vary greatly during the year, M. pneumo- little aid in distinguishing M. pneumoniae pneu- niae causes a greater proportion of pneumonia monia from that of other causes. However, as during the summer months when pneumonia due noted in Table 2, coryza is less common and to other organisms is less common.9"2 lymphadenopathy more apparent in persons with Figure 1.-Clinical associa- tions of Mycoplasma pneu- moniae. 48 JULY 1976 * 125 * 1 MYCOPLASMA PNEUMONIAE INFECTIONS TABLE 2.-Relative Frequency of Selected Symptoms usually normal.8'1 However, Turner and col- and Signs in Patients with Mycoplasma pneumoniae Pneumonia and Patients with Pneumonias of other leagues noted that the total leukocyte count was Typesl' greater than 10,000 cells per cu mm in 13 of 22 M. Pneumoniae Pneumonias of children with M. pneumoniae infections; in 15 Findings Pneumonia Other Types children, the differential percentage showed Cough ............... ++++ ++++ greater than 60 percent polymorphonuclear cells. Headache ............... +++ +++ The sedimentation rate is frequently quite ele- Pharyngitis ............. + + + + + + Sputum ............... + + + + + + vated.25 Serologic tests for syphilis are occasion- Lymphadenopathy ........ + ++ + + ally noted to be falsely positive, serum cold Conjunctivitis ........... + + + + agglutinins are frequently observed and antibodies Temperature >40°C . .... ++ ++ Coryza ............... ++ + + + to streptococcus MG antigen are found.6"0283' Pleuritis ............... + + Serum IgM is frequently elevated while levels of IgG and IgA are normal.30 The direct Coombs' M. pneumoniae pneumonia than in patients with test occasionally gives positive findings.30 pneumonias of other causes. Respiratory Disease other than Pneumonia Dry rales are the most common finding on aus- cultation of the chest. for four General. M. pneumoniae infections account for They may persist a significant amount of respiratory illness other weeks or more even though the patient is clini- than 1013'20'31-35 cally improved. Symptoms of consolidation and pneumonia. Between 0 and 8 per- friction rub may occur, substernal pain may be cent of all upper respiratory infections are due to present but pleuritic pain is uncommon. M. pneumoniae. Pharyngitis is not uncommonly associated with M. pneumoniae infection; the M. pneumoniae pneumonia is more severe in peak incidence of M. pneumoniae pharyngitis is patients with sickle cell anemia,'6 with immuno- at 12 to 14 years old.32 Bronchitis, bronchiolitis deficiency syndromes'7 and with severe preexist- and croup have all been noted in association ing cardiorespiratory problems.'8" 9 Although rare with M. pneumoniae infection.'0"13'33-35 Symptoms deaths have occurred, recovery is usual, although in these illnesses of children are usually mild. the clinical course is variable if untreated. Cough In adults, exacerbations of chronic obstructive persists for three to four weeks in adults and pulmonary disease have been associated with M. usually for a shorter time in children,8"0 while pneumoniae infections.36'37 nonrespiratory symptoms of headache, myalgia Lung Abscess. Three patients with lung ab- and malaise may remit 7 to 10 days after their scess in association with M. pneumoniae infection onset. have been reported.38'39 All three patients were Roentgenography. Inconsistent relationships males, aged 17, 24 and 45 years. All had two to among the degree of symptoms, physical findings four week histories of productive cough and and results of chest roentgenographs are a hall- pleuritic chest pain. In one patient, who was mark of mycoplasma infection.9'10' 4"15'20 In many treated with tetracycline, there was dramatic im- persons in whom significant infiltrates are seen on provement and on a follow-up roentgenograph chest roentgenographs, there are no or minimal six weeks later only minimal lingual scarring was pulmonary findings. The radiologic pattern of M. seen. In the other two patients there was transient pneumoniae pneumonia cannot be distinguished relief of symptoms during a week of therapy with from other nonbacterial pneumonias.2' Early in tetracycline, but relapse occurred when the medi- the course of M. pneumoniae pneumonia, the pat- cation was discontinued. Both of these two pa- tern is reticular and interstitial; subsequently, tients eventually recovered although in neither
Load more

Recommended publications
  • The Mysterious Orphans of Mycoplasmataceae
    The mysterious orphans of Mycoplasmataceae Tatiana V. Tatarinova1,2*, Inna Lysnyansky3, Yuri V. Nikolsky4,5,6, and Alexander Bolshoy7* 1 Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, 90027, California, USA 2 Spatial Science Institute, University of Southern California, Los Angeles, 90089, California, USA 3 Mycoplasma Unit, Division of Avian and Aquatic Diseases, Kimron Veterinary Institute, POB 12, Beit Dagan, 50250, Israel 4 School of Systems Biology, George Mason University, 10900 University Blvd, MSN 5B3, Manassas, VA 20110, USA 5 Biomedical Cluster, Skolkovo Foundation, 4 Lugovaya str., Skolkovo Innovation Centre, Mozhajskij region, Moscow, 143026, Russian Federation 6 Vavilov Institute of General Genetics, Moscow, Russian Federation 7 Department of Evolutionary and Environmental Biology and Institute of Evolution, University of Haifa, Israel 1,2 [email protected] 3 [email protected] 4-6 [email protected] 7 [email protected] 1 Abstract Background: The length of a protein sequence is largely determined by its function, i.e. each functional group is associated with an optimal size. However, comparative genomics revealed that proteins’ length may be affected by additional factors. In 2002 it was shown that in bacterium Escherichia coli and the archaeon Archaeoglobus fulgidus, protein sequences with no homologs are, on average, shorter than those with homologs [1]. Most experts now agree that the length distributions are distinctly different between protein sequences with and without homologs in bacterial and archaeal genomes. In this study, we examine this postulate by a comprehensive analysis of all annotated prokaryotic genomes and focusing on certain exceptions.
    [Show full text]
  • A Case of Cryptogenic Organizing Pneumonia in a Seventh-Decade Woman
    Saudi Journal of Medicine ISSN 2518-3389 (Print) Scholars Middle East Publishers ISSN 2518-3397 (Online) Dubai, United Arab Emirates Website: http://scholarsmepub.com/ A case of Cryptogenic Organizing Pneumonia in a seventh-decade woman. "Yahya Al-FIFI’s Diagnostic Criteria for Cryptogenic Organizing Pneumonia (COP) Without Lung Tissues Biopsies for Histopathology". Is This the Truth of the Reality Or The Reality of the Truth? Yahya Salim Yahya AL-FIFI Consultant, Internal Medicine &Infectious Diseases, Department of Medicine, Infection Diseases Division, Prince Mohammad Bin Nasser Hospital, Jizan, Jazan, Saudi Arabia. Email: [email protected] Abstract: We describe the first and rare case report of a cryptogenic organizing *Corresponding author pneumonia (COP) in a seventh decade diabetic and hypertensive woman from low Yahya Salim Yahya highlands, Jazan, Saudi Arabia. The evidence of the clinical scenario, laboratories testing, radiological images findings followed by a significant improvement due to Article History steroid treatment are quite enough to diagnose COP, irrespective of the lung tissues Received: 19.11.2017 biopsies procedures and processing accessibility for histopathology, in a timely manner Accepted: 24.11.2017 as reveals in “Yahya Al-FIFI’s diagnostic criteria for cryptogenic organizing pneumonia Published: 30.11.2017 (COP) without lung tissues biopsies for histopathology”. We started a methylprednisolone forty milligrams intravenously every eight hourly for seven days DOI: which is showing a dramatic clinical improvement within initial twenty-four hours of 10.21276/sjm.2017.2.7.4 the first seven days and complete recovery clinically and radiologically, at the end of the following fourteen days of tapering prednisolone doses without a relapse for seven months.
    [Show full text]
  • Lansdell Vs. Georgia-Pacific Corporation Awcc# F007360
    BEFORE THE ARKANSAS WORKERS’ COMPENSATION COMMISSION CLAIM NO. F007360 ALVIN LANSDELL, EMPLOYEE CLAIMANT GEORGIA-PACIFIC CORPORATION, SELF-INSURED EMPLOYER RESPONDENT OPINION FILED SEPTEMBER 3, 2003 Upon review before the FULL COMMISSION in Little Rock, Pulaski County, Arkansas. Claimant represented by HONORABLE GREGORY R. GILES, Attorney at Law, Texarkana, Arkansas. Respondent represented by HONORABLE MARK A. PEOPLES, Attorney at Law, Little Rock, Arkansas. Decision of the Administrative Law Judge: Affirmed as modified. OPINION AND ORDER The claimant appeals an Administrative Law Judge’s opinion filed August 21, 2002. The Administrative Law Judge found that Act 1281 of 2001 made substantive law changes to the burden of proof for occupational disease and was to be applied prospectively. The Administrative Law Judge therefore found, “Claimant has failed to prove by clear and convincing evidence that he sustained an occupational disease which arose out of and in the course of his employment.” After reviewing the entire record de novo, the Lansdell - F007360 2 Full Commission finds that our recent decision in a companion case, Sikes v. Georgia-Pacific Corporation, Workers’ Compensation Commission F000657 (July 7, 2003), is controlling in this matter as to the appropriate burden of proof. We therefore find that the Legislature meant to apply Act 1281 retroactively, so that the “preponderance of the evidence” standard of Ark. Code Ann. § 11-9-601 (e)(1)(B) applies to the instant matter. The Full Commission further finds that the claimant failed to prove by a preponderance of the evidence that he sustained a compensable occupational disease. We therefore affirm, as modified, the opinion of the Administrative Law Judge.
    [Show full text]
  • Pediatric Ambulatory Community Acquired Pneumonia (CAP)
    ANMC Pediatric (≥3mo) Ambulatory Community Acquired Pneumonia (CAP) Treatment Guideline Criteria for Respiratory Distress Criteria For Outpatient Management Testing/Imaging for Outpatient Management Tachypnea, in breaths/min: Mild CAP: no signs of respiratory distress Vital Signs: Standard VS and Pulse Oximetry Age 0-2mo: >60 Able to tolerate PO Labs: No routine labs indicated Age 2-12mo: >50 No concerns for pathogen with increased virulence Influenza PCR during influenza season Age 1-5yo: >40 (ex. CA-MRSA) Blood cultures if not fully immunized OR fails to Age >5yo: >20 Family able to carefully observe child at home, comply improve/worsens after initiation of antibiotics Dyspnea with therapy plan, and attend follow up appointments Urinary antigen detection testing is not Retractions recommended in children; false-positive tests are common. Grunting If patient does not meet outpatient management criteria Radiography: No routine CXR indicated Nasal flaring refer to inpatient pneumonia guideline for initial workup Apnea and testing. AP and lateral CXR if fails initial antibiotic therapy Altered mental status AP and lateral CXR 4-6 weeks after diagnosis if Pulse oximetry <90% on room air recurrent pneumonia involving the same lobe Treatment Selection Suspected Viral Pneumonia Most Common Pathogens: Influenza A & B, Adenovirus, Respiratory Syncytial Virus, Parainfluenza No antimicrobial therapy is necessary. Most common in <5yo If influenza positive, see influenza guidelines for treatment algorithm. Suspected Bacterial
    [Show full text]
  • Correlation Between the Oral Microbiome and Brain Resting State Connectivity in Smokers
    bioRxiv preprint doi: https://doi.org/10.1101/444612; this version posted October 16, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Correlation between the oral microbiome and brain resting state connectivity in smokers Dongdong Lin1, Kent Hutchison2, Salvador Portillo3, Victor Vegara1, Jarod Ellingson2, Jingyu Liu1,3, Amanda Carroll-Portillo3,* ,Vince D. Calhoun1,3,* 1The Mind Research Network, Albuquerque, New Mexico, 87106 2University of Colorado Boulder, Boulder, CO 3University of New Mexico, Department of Electrical and Computer Engineering, Albuquerque, New Mexico, 87106 * authors contributed equally to the work. Abstract Recent studies have shown a critical role for the gastrointestinal microbiome in brain and behavior via a complex gut–microbiome–brain axis, however, the influence of the oral microbiome in neurological processes is much less studied, especially in response to the stimuli in the oral microenvironment such as smoking. Additionally, given the complex structural and functional networks in brain system, our knowledge about the relationship between microbiome and brain functions on specific brain circuits is still very limited. In this pilot work, we leverage next generation microbial sequencing with functional MRI techniques to enable the delineation of microbiome-brain network links as well as their relations to cigarette smoking. Thirty smokers and 30 age- and sex- matched non-smokers were recruited for measuring both microbial community and brain functional networks. Statistical analyses were performed to demonstrate the influence of smoking on: the taxonomy and abundance of the constituents within the oral microbial community, brain functional network connectivity, and associations between microbial shifts and the brain signaling network.
    [Show full text]
  • Secondary Pulmonary Alveolar Proteinosis in Hematologic
    review Secondary pulmonary alveolar proteinosis in hematologic malignancies Chakra P Chaulagain a,*, Monika Pilichowska b, Laurence Brinckerhoff c, Maher Tabba d, John K Erban e a Taussig Cancer Institute of Cleveland Clinic, Department of Hematology/Oncology, Cleveland Clinic in Weston, FL, USA, b Department of Pathology, Tufts Medical Center Cancer Center & Tufts University School of Medicine, Boston, MA, USA, c Department of Surgery, Tufts Medical Center Cancer Center & Tufts University School of Medicine, Boston, MA, USA, d Division of Critical Care, Pulmonary and Sleep Medicine, Tufts Medical Center Cancer Center & Tufts University School of Medicine, Boston, MA, USA, e Division of Hematology/Oncology, Tufts Medical Center Cancer Center & Tufts University School of Medicine, Boston, MA, USA * Corresponding author at: Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL 33331, USA. Tel.: +1 954 659 5840; fax: +1 954 659 5810. Æ [email protected] Æ Received for publication 29 January 2014 Æ Accepted for publication 1 September 2014 Hematol Oncol Stem Cell Ther 2014; 7(4): 127–135 ª 2014 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved. DOI: http://dx.doi.org/10.1016/j.hemonc.2014.09.003 Abstract Pulmonary alveolar proteinosis (PAP), characterized by deposition of intra-alveolar PAS positive protein and lipid rich material, is a rare cause of progressive respiratory failure first described by Rosen et al. in 1958. The intra-alveolar lipoproteinaceous material was subsequently proven to have been derived from pulmonary surfactant in 1980 by Singh et al. Levinson et al. also reported in 1958 the case of 19- year-old female with panmyelosis afflicted with a diffuse pulmonary disease characterized by filling of the alveoli with amorphous material described as ‘‘intra-alveolar coagulum’’.
    [Show full text]
  • Mental Figure 1 Color Key a -2 0 2 B Z-Score 100%
    Supplemental Figure 1 Color Key A -2 0 2 B z-score 100% 75% 50% 25% 0% KC pan 1 WT pan 3 WT KC pan 3 WT pan 2 WT pan 1 WT KC pan 2 C Color Key D a: Brevibacterium f: Chlamydiales b: Brevibacteriaceae g: Chlamydiia -3 0 3 z-score c: Sphingobacteriaceae h: Chlamydiae d: Sphingobacteriales i: Mogibacterium e: Sphingobacteriia j: Oscillospira k: Methylobacteriaceae NML Control Microb.-entrained MΦ PDA PDA Patient Population Control Microb.-entrained MΦ + Myd88i E F Ctrl Abx 350 * 300 250 200 150 40X 100 Tumor weight (mg) 50 0 x Ctrl Ab Supplemental Figure 2 A KC WT B ** * Actinobacteria * ** Bacteroidetes Cyanobacteria Deferribacteres * Firmicutes Proteobacteria % Relative abundance TM7 Others Time(wks) 3 9 13 16 20 24 28 32 36 3 9 13 16 20 24 28 32 36 Alpha Diversity Measure C E 60 KC WT 40 20 B. pseudolongum B. animalis 60 5 KC WT 0 B. adolescentis 40% Rel. abundance 3 9 13 16 20 24 28 32 36 3 9 13 16 20 24 28 32 36 20 Age (weeks) B. pseudolongum B. animalis 5 0 B. adolescentis % Rel. abundance 3 9 13 16 20 24 28 32 36 3 9 13 16 20 24 28 32 36 F Age (weeks) Week 3 Week 9 Week 13 p=0.678 p=0.02 p=0.385 Time(wks) 3 9 24 20 13 16 D 28 32 36 Week 13 KC WT Firmicutes; Ruminococcus Firmicutes; Dehalobacterium Alpha Diversity Measure Firmicutes; Oscillospira Bacteroidates; Odoribacter Axis.2 [12.7%] Actinobacteria; Bifidobacterium Axis.2 [23.8%] Axis.2 [24.7%] Week 16 Bacteroidetes; Bacteroidales Axis.1 [80.8%] Axis.1 [65.4%] Axis.1 [49.6%] Actinobacteria; Bifidobacterium Week 16 Week 20 Week 24 Week 20 p=0.339 p=0.036 p=0.021 Firmicutes; Dehalobacterium
    [Show full text]
  • Exploring the Cockatiel (Nymphicus Hollandicus) Fecal Microbiome, Bacterial Inhabitants of a Worldwide Pet
    Exploring the cockatiel (Nymphicus hollandicus) fecal microbiome, bacterial inhabitants of a worldwide pet Luis David Alcaraz1, Apolinar M. Hernández2 and Mariana Peimbert2 1 Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autonóma de México, Mexico City, Mexico 2 Departamento de Ciencias Naturales, Unidad Cuajimalpa, Universidad Autónoma Metropolitana, Mexico City, Mexico ABSTRACT Background. Cockatiels (Nymphicus hollandicus) were originally endemic to Australia; now they are popular pets with a global distribution. It is now possible to conduct detailed molecular studies on cultivable and uncultivable bacteria that are part of the intestinal microbiome of healthy animals. These studies show that bacteria are an essential part of the metabolic capacity of animals. There are few studies on bird microbiomes and, to the best of our knowledge, this is the first report on the cockatiel microbiome. Methods. In this paper, we analyzed the gut microbiome from fecal samples of three healthy adult cockatiels by massive sequencing of the 16S rRNA gene. Additionally, we compared the cockatiel fecal microbiomes with those of other bird species, including poultry and wild birds. Results. The vast majority of the bacteria found in cockatiels were Firmicutes, while Proteobacteria and Bacteroidetes were poorly represented. A total of 19,280 different OTUs were detected, of which 8,072 belonged to the Erysipelotrichaceae family. Discussion. It is relevant to study cockatiel the microbiomes of cockatiels owing to their wide geographic distribution and close human contact. This study serves as a reference for cockatiel bacterial diversity. Despite the large OTU numbers, the diversity is not even Submitted 14 July 2016 Accepted 28 November 2016 and is dominated by Firmicutes of the Erysipelotrichaceae family.
    [Show full text]
  • Prevalence of Ureaplasma Urealyticum, Mycoplasma Hominis and Chlamydia Trachomatis in Patients with Uncomplicated Recurrent Urin
    Nephrology and Renal Diseases Research Article ISSN: 2399-908X Prevalence of Ureaplasma urealyticum, Mycoplasma hominis and Chlamydia trachomatis in patients with uncomplicated recurrent urinary tract infections Jadranka Vlasic-Matas1*, Hrvoje Raos2, Marijana Vuckovic2, Stjepan Radic2 and Vesna Capkun3 1Polyclinic Nephrology Department, Split, Croatia 2School of Medicine, University of Split, Split, Croatia 3Department of Nuclear Medicine, Split University Hospital Center, Split, Croatia Abstract Aim: To assess the prevalence of Ureaplasma urealyticum, Mycoplasma hominis and Chlamydia trachomatis in patients with chronic urinary tract infections (UTIs) and its correlation with leukocyturia and symptoms. Methods: The study included 220 patients (130 women and 90 men) presenting with chronic voiding symptoms and sterile leukocyturia. Urine, urethral swabs and cervical swabs (for women patients) were taken to determine the presence of these pathogens. Patients were treated by tetracycline and followed up three and six months after initial therapy. Results: In 186 (85%) out of 220 patients, U. urealyticum was found, while C. trachomatis was present in 34 patients (15%). In majority of female patients (112 out of 130; 86%) U. urealyticum was found. In addition to ureaplasma, in eight patients M. hominis was found. C. trachomatis was identified in 18 female patients (14%). In 74 out of 90 (82%) male patients U. urealyticum was detected while in six of them M. hominis was also found. C. trachomatis was identified in 16 male patients (18%). U. urealyticum was significantly related to leukocyturia, as opposed to C. trachomatis (p<0,001). Women had more frequent symptomatology (p = 0,015) and higer leukocyturia (p<0.001). Conclusion: Leukocyturia is more common find in U.
    [Show full text]
  • Radiologically Suspected Organizing Pneumonia in a Patient Recovering from COVID-19: a Case Report
    Infect Chemother. 2021 Mar;53(1):e8 https://doi.org/10.3947/ic.2021.0013 pISSN 2093-2340·eISSN 2092-6448 Case Report Radiologically Suspected Organizing Pneumonia in a Patient Recovering from COVID-19: A Case Report Hyeonji Seo 1, Jiwon Jung 1, Min Jae Kim 1, Se Jin Jang 2, and Sung-Han Kim 1 1Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Received: Jan 28, 2021 ABSTRACT Accepted: Feb 10, 2021 Corresponding Author: We report a case of coronavirus disease 2019 (COVID-19)-associated radiologically suspected Sung-Han Kim, MD organizing pneumonia with repeated negative Severe acute respiratory syndrome coronavirus Department of Infectious Diseases, Asan 2 (SARS-CoV-2) polymerase chain reaction (PCR) results from nasopharyngeal swab Medical Center, University of Ulsan College of and sputum samples, but positive result from bronchoalveolar lavage fluid. Performing Medicine, 88, Olympic-ro, 43-gil, Songpa-gu, SARS-CoV-2 RT-PCR in upper respiratory tract samples only could fail to detect COVID-19- Seoul 05505, Korea. Tel: +82-2-3010-3305 associated pneumonia, and SARS-CoV-2 could be an etiology of radiologically suspected Fax: +82-2-3010-6970 organizing pneumonia. E-mail: [email protected] Keywords: COVID-19; SARS-CoV-2; Organizing pneumonia; Bronchoalveolar lavage; Copyright © 2021 by The Korean Society Polymerase chain reaction of Infectious Diseases, Korean Society for Antimicrobial
    [Show full text]
  • Avian Mycoplasmosis (Mycoplasma Gallisepticum)
    Avian Importance Mycoplasma gallisepticum is an economically significant pathogen that can Mycoplasmosis cause significant losses in chickens, turkeys and game birds from chronic respiratory disease, reduced feed efficiency, decreased growth and lower egg (Mycoplasma production. In addition, the carcasses of birds sent to slaughter may be downgraded. Many countries with modern poultry operations have eradicated this organism from gallisepticum) commercial chicken and turkey breeding flocks; however, it can still be an issue in other poultry operations, such as multi-age layer flocks, game bird raising facilities Pleuropneumonia–like Organism and backyard birds. Since 1994, conjunctivitis caused by one lineage of M. (PPLO) Infection, Chronic gallisepticum has become a significant disease in wild birds in North America. Respiratory Disease of Chickens, Although other wild birds can be affected, the major impact has been on house Infectious Sinusitis of Turkeys, finches (Carpodacus mexicanus), which have experienced major population House Finch Conjunctivitis declines in some areas. Etiology Last Updated: November 2018 Mycoplasma gallisepticum, a member of the family Mycoplasmataceae (class Mollicutes, order Mycoplasmatales), is one of the most important agents of mycoplasmosis in terrestrial poultry. There are multiple strains of this organism, which can differ in virulence and may also have different host preferences. The house finch lineage is a distinct lineage that has diverged significantly from poultry strains and has become established
    [Show full text]
  • Comprehensive Analysis of Risk Factors for Periodontitis Focusing on the Saliva Microbiome and Polymorphism
    International Journal of Environmental Research and Public Health Article Comprehensive Analysis of Risk Factors for Periodontitis Focusing on the Saliva Microbiome and Polymorphism Naoki Toyama 1,* , Daisuke Ekuni 1 , Daisuke Matsui 2, Teruhide Koyama 2 , Masahiro Nakatochi 3, Yukihide Momozawa 4, Michiaki Kubo 4 and Manabu Morita 1 1 Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan; [email protected] (D.E.); [email protected] (M.M.) 2 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan; [email protected] (D.M.); [email protected] (T.K.) 3 Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan; [email protected] 4 Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City 230-0045, Japan; [email protected] (Y.M.); [email protected] (M.K.) * Correspondence: [email protected]; Tel.: +81-86-235-6712 Abstract: Few studies have exhaustively assessed relationships among polymorphisms, the micro- biome, and periodontitis. The objective of the present study was to assess associations simultaneously among polymorphisms, the microbiome, and periodontitis. We used propensity score matching with a 1:1 ratio to select subjects, and then 22 individuals (mean age ± standard deviation, 60.7 ± 9.9 years) Citation: Toyama, N.; Ekuni, D.; were analyzed.
    [Show full text]