Blood and Lymph Vascular Systems
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Chapter 20 *Lecture Powerpoint the Circulatory System: Blood Vessels and Circulation
Chapter 20 *Lecture PowerPoint The Circulatory System: Blood Vessels and Circulation *See separate FlexArt PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Introduction • The route taken by the blood after it leaves the heart was a point of much confusion for many centuries – Chinese emperor Huang Ti (2697–2597 BC) believed that blood flowed in a complete circuit around the body and back to the heart – Roman physician Galen (129–c. 199) thought blood flowed back and forth like air; the liver created blood out of nutrients and organs consumed it – English physician William Harvey (1578–1657) did experimentation on circulation in snakes; birth of experimental physiology – After microscope was invented, blood and capillaries were discovered by van Leeuwenhoek and Malpighi 20-2 General Anatomy of the Blood Vessels • Expected Learning Outcomes – Describe the structure of a blood vessel. – Describe the different types of arteries, capillaries, and veins. – Trace the general route usually taken by the blood from the heart and back again. – Describe some variations on this route. 20-3 General Anatomy of the Blood Vessels Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Capillaries Artery: Tunica interna Tunica media Tunica externa Nerve Vein Figure 20.1a (a) 1 mm © The McGraw-Hill Companies, Inc./Dennis Strete, photographer • Arteries carry blood away from heart • Veins -
The Circulatory System
Lec. 3 General Histology Instructor: Assist. Prof. Rasha A. Azeez The circulatory system The circulatory system provides a means of conveying nutrients and oxygen to and wastes out of the internal cells that make-up our bodies. There are two major components of the circulatory system. A. The cardiovascular system 1. Arteries, 2. Arterioles, 3. Capillaries, 4. Veins 5.Venules 6. Heart. B. The lymph vascular system 1. Blind ended lymphatic capillaries that collect lymph fluid from tissues. 2. Larger lymphatic vessels that connect with one and other and finally empty collected lymph into large veins in the neck where the lymphatic and cardiovascular systems merge. The cardiovascular system 1. Arterial system: There are three main types of arteries: o Elastic arteries o Muscular arteries o Arterioles o Elastic arteries These arteries that receive blood directly from the heart; includes the Aorta and the pulmonary artery; they need to be elastic because when the heart contracts, and ejects blood into these arteries, the walls need to stretch to accommodate the blood surge. The walls of these arteries have lots of elastin. a- Tunica intima is made up of an epithelium, which is a single layer of flattened epithelial cells, together with a supporting layer of elastin rich collagen. This layer also has fibroblasts and 'myointimal cells' that accumulate lipid with ageing, and the intima layer thickens, one of the first signs of atherosclerosis. a- Tunica media is broad and elastic with concentric fenestrated sheets of elastin, and collagen and only relatively few smooth muscle fibers. b- Tunica adventitia - has small vasa vasorum "a network of small blood vessels is present in the adventitia" as the large arteries need their own blood supply. -
Cardiovascular System 9
Chapter Cardiovascular System 9 Learning Outcomes On completion of this chapter, you will be able to: 1. State the description and primary functions of the organs/structures of the car- diovascular system. 2. Explain the circulation of blood through the chambers of the heart. 3. Identify and locate the commonly used sites for taking a pulse. 4. Explain blood pressure. 5. Recognize terminology included in the ICD-10-CM. 6. Analyze, build, spell, and pronounce medical words. 7. Comprehend the drugs highlighted in this chapter. 8. Describe diagnostic and laboratory tests related to the cardiovascular system. 9. Identify and define selected abbreviations. 10. Apply your acquired knowledge of medical terms by successfully completing the Practical Application exercise. 255 Anatomy and Physiology The cardiovascular (CV) system, also called the circulatory system, circulates blood to all parts of the body by the action of the heart. This process provides the body’s cells with oxygen and nutritive ele- ments and removes waste materials and carbon dioxide. The heart, a muscular pump, is the central organ of the system. It beats approximately 100,000 times each day, pumping roughly 8,000 liters of blood, enough to fill about 8,500 quart-sized milk cartons. Arteries, veins, and capillaries comprise the network of vessels that transport blood (fluid consisting of blood cells and plasma) throughout the body. Blood flows through the heart, to the lungs, back to the heart, and on to the various body parts. Table 9.1 provides an at-a-glance look at the cardiovascular system. Figure 9.1 shows a schematic overview of the cardiovascular system. -
The Circulatory System
TheThe CirculatoryCirculatory SystemSystem Xue Hui DepartmentDepartment ofof HistologyHistology && EmbryologyEmbryology TheThe CirculatoryCirculatory SystemSystem Cardiovascular system (blood vascular system) Heart Artery Capillary Vein Lymphatic vascular system Lymphatic capillary Lymphatic vessel Lymphatic duct II GeneralGeneral structurestructure ofof thethe bloodblood vesselsvessels Tunica intima Tunica media Tunica adventitia Drawing of a medium-sized muscular artery, showing its layers. II GeneralGeneral structurestructure ofof thethe bloodblood vesselsvessels IIII ArteryArtery Large artery Medium-sized artery Small artery Arteriole II Artery LargeLarge arteryartery Structure Tunica intima Tunica media 40-70 layers of elastic lamina Smooth muscle cells, collagenous fibers Tunica adventitia Function Carry the blood from the heart to the middle arteries Tunica Tunica intima intima Tunica Tunica media media Tunica Tunica adventitia adventitia Transverse sections showing part of a large elastic artery showing a well developed tunica media containing several elastic laminas. II Artery MediumMedium--sizedsized arteryartery Structure Tunica intima: clear internal elastic membrane Tunica media: 10-40 layers of smooth muscle cells Tunica adventitia: external elastic membrane Function Regulate the distribution of the blood to various parts of the body Tunica Internal intima elastic membrane Tunica media External elastic membrane Tunica adventitia II Artery SmallSmall arteryartery Structure characteristic Diameter:0.3-1mm Tunica intima: clear -
Infliximab, a TNF-Α Inhibitor, Reduces 24-H Ambulatory
Journal of Human Hypertension (2014) 28, 165–169 & 2014 Macmillan Publishers Limited All rights reserved 0950-9240/14 www.nature.com/jhh ORIGINAL ARTICLE Infliximab, a TNF-a inhibitor, reduces 24-h ambulatory blood pressure in rheumatoid arthritis patients S Yoshida1, T Takeuchi1, T Kotani1, N Yamamoto1, K Hata1, K Nagai1, T Shoda1,STakai2, S Makino1 and T Hanafusa1 Tumour necrosis factor-alpha (TNF-a) is an important mediator in the pathogenesis of rheumatoid arthritis (RA) and hypertension. TNF-a inhibitors improve clinical symptoms and inhibit joint destruction in RA, but their effect on blood pressure (BP) has not been fully investigated. We measured 24-h BP using an ambulatory BP monitor in 16 RA patients treated with a TNF-a inhibitor, infliximab, to investigate its influence on BP and its association with the regulatory factors of BP and renin-angiotensin-aldosterone and sympathetic nervous systems. Infliximab significantly reduced the 24-h systolic BP (SBP) from 127.4±21.8 to 120.1±23.4 mm Hg (Po0.0001). Particularly, morning BP (0600–0800 h) decreased from 129.7±19.7 to 116.9±13.4 mm Hg (Po0.0001), and daytime BP decreased from 131.8±15.1 to 122.5±13.7 mm Hg (Po0.0001). Infliximab significantly reduced the plasma level of norepinephrine and plasma renin activity (PRA) (from 347.5±180.7 to 283.0±181.8 pg ml À 1 and 2.6±2.7 to 2.1±2.9 ng ml À 1 h À 1, respectively) but did not significantly reduce the plasma levels of dopamine and epinephrine. -
Histological Study of the Elastic Artery, Muscular Artery, and Their Junction in Neonate Dog
Winter & Spring 2016, Volume 13, Number 1 Histological Study of the Elastic Artery, Muscular Artery, and Their Junction in Neonate Dog Fatemeh Ramezani Nowrozani1* 1. Department of Anatomical Sciences, School of Veterinary Medicine, Kazerun Branch, Islamic Azad Univercity, Kazerun, Iran. Citation: Ramezani Nowrozani F. Histological study of the elastic artery, muscular artery, and their junction in neonate dog. Anatomical Sciences. 2016; 13(1):33-38. Dr. Fatemeh Ramezani Nowrozani is the assistant professor of anatomy, histology and embryology in the department of anatomical science at Kazerun Branch, Islamic Azad Univercity, Kazerun, Iran. She was graduated with a DVM and PhD from the College of Veterinary Medicine at Shiraz University. Since 2008, she has advised DVM students at Kazerun Branch, Islamic Azad Univercity anatomy, histology and embryology. Article info: A B S T R A C T Received: 12 Jan. 2015 Accepted: 02 Oct. 2015 Introduction: We did this study because there were a few studies about aorto-branch junction. Available Online: 01 Jan 2016 Methods: Four light microscope and electron microscope study, the abdominal aorta, renal artery, and the adjoining right and left renal arteries were dissected out from 4 neonate dogs. Results: Based on the results, there is only one cell type in the tunica intima of endothelium in both arteries. In abdominal aorta, there were open connective tissue spaces, containing elastic fibers between the internal elastic membrane and endothelium. In renal artery, endothelial cells were attached directly to the internal elastic membrane. In the abdominal aorta tunica media, layers of smooth muscle cells alternating with elastic lamellae were observed, but in renal artery, the smooth muscle cells were close to each other and a small quantity of collagen and elastic fibers were found between them. -
Anatomy Review: Blood Vessel Structure & Function
Anatomy Review: Blood Vessel Structure & Function Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction • The blood vessels of the body form a closed delivery system that begins and ends at the heart. Page 2. Goals • To describe the general structure of blood vessel walls. • To compare and contrast the types of blood vessels. • To relate the blood pressure in the various parts of the vascular system to differences in blood vessel structure. Page 3. General Structure of Blood Vessel Walls • All blood vessels, except the very smallest, have three distinct layers or tunics. The tunics surround the central blood-containing space - the lumen. 1. Tunica Intima (Tunica Interna) - The innermost tunic. It is in intimate contact with the blood in the lumen. It includes the endothelium that lines the lumen of all vessels, forming a smooth, friction reducing lining. 2. Tunica Media - The middle layer. Consists mostly of circularly-arranged smooth muscle cells and sheets of elastin. The muscle cells contract and relax, whereas the elastin allows vessels to stretch and recoil. 3. Tunica Adventitia (Tunica Externa) - The outermost layer. Composed of loosely woven collagen fibers that protect the blood vessel and anchor it to surrounding structures. Page 4. Comparison of Arteries, Capillaries, and Veins • Let's compare and contrast the three types of blood vessels: arteries, capillaries, and veins. • Label the artery, capillary and vein. Also label the layers of each. • Arteries are vessels that transport blood away from the heart. Because they are exposed to the highest pressures of any vessels, they have the thickest tunica media. -
Blood Vessels: Part A
Chapter 19 The Cardiovascular System: Blood Vessels: Part A Blood Vessels • Delivery system of dynamic structures that begins and ends at heart – Arteries: carry blood away from heart; oxygenated except for pulmonary circulation and umbilical vessels of fetus – Capillaries: contact tissue cells; directly serve cellular needs – Veins: carry blood toward heart Structure of Blood Vessel Walls • Lumen – Central blood-containing space • Three wall layers in arteries and veins – Tunica intima, tunica media, and tunica externa • Capillaries – Endothelium with sparse basal lamina Tunics • Tunica intima – Endothelium lines lumen of all vessels • Continuous with endocardium • Slick surface reduces friction – Subendothelial layer in vessels larger than 1 mm; connective tissue basement membrane Tunics • Tunica media – Smooth muscle and sheets of elastin – Sympathetic vasomotor nerve fibers control vasoconstriction and vasodilation of vessels • Influence blood flow and blood pressure Tunics • Tunica externa (tunica adventitia) – Collagen fibers protect and reinforce; anchor to surrounding structures – Contains nerve fibers, lymphatic vessels – Vasa vasorum of larger vessels nourishes external layer Blood Vessels • Vessels vary in length, diameter, wall thickness, tissue makeup • See figure 19.2 for interaction with lymphatic vessels Arterial System: Elastic Arteries • Large thick-walled arteries with elastin in all three tunics • Aorta and its major branches • Large lumen offers low resistance • Inactive in vasoconstriction • Act as pressure reservoirs—expand -
BIO 2402 Resource 8
BIO 2402 — Human Anatomy & Physiology Week 8: March 7-13 This week we will be covering the last chapter of the cardiovascular system about blood vessels. You should be able to know the different types of blood vessels, the factors that influence blood pressure, and the difference between baroreceptors and chemoreceptors. Remember that the Tutoring Center offers free individual and group tutoring for this class. Our Group Tutoring sessions will be every Wednesday from 6:00-7:00 PM CST. You can reserve a spot at https://baylor.edu/tutoring. KEY TERM: Vasoconstrictor, Vasodilator, Elastic Artery, Fenestrated Capillary, Vasomotor Center Blood vessel tunics & tissues Arteries Elastic/conducting: large diameter, thick walls, elastic tissue Aorta, brachiocephalic, common carotids, subclavian, common iliac Muscular/distributing: trans. blood to arterioles, thickest tunica media, less elastic tissue Brachials, mesenterics, femorals, tibials Arterioles: only smooth muscle & endothelium Metarterioles: smaller arterioles, precapillary sphincters regulate blood flow into the capillaries. Capillaries Fenestrated: small pores that material can pass through Sinusoids: type of fenestrated capillary in the liver, spleen, pancreas, and bone marrow Continuous: more common, lacks fenestrations All of these arteries and veins can be visualized using the diagram above. Blood pressures For blood pressure we will focus on capillary dynamics and factors affecting vessel diameter. All images are taken from Dr. Taylor’s textbook Vasoconstrictors & vasodilators are factors -
Vocabulario De Morfoloxía, Anatomía E Citoloxía Veterinaria
Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) Servizo de Normalización Lingüística Universidade de Santiago de Compostela COLECCIÓN VOCABULARIOS TEMÁTICOS N.º 4 SERVIZO DE NORMALIZACIÓN LINGÜÍSTICA Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) 2008 UNIVERSIDADE DE SANTIAGO DE COMPOSTELA VOCABULARIO de morfoloxía, anatomía e citoloxía veterinaria : (galego-español- inglés) / coordinador Xusto A. Rodríguez Río, Servizo de Normalización Lingüística ; autores Matilde Lombardero Fernández ... [et al.]. – Santiago de Compostela : Universidade de Santiago de Compostela, Servizo de Publicacións e Intercambio Científico, 2008. – 369 p. ; 21 cm. – (Vocabularios temáticos ; 4). - D.L. C 2458-2008. – ISBN 978-84-9887-018-3 1.Medicina �������������������������������������������������������������������������veterinaria-Diccionarios�������������������������������������������������. 2.Galego (Lingua)-Glosarios, vocabularios, etc. políglotas. I.Lombardero Fernández, Matilde. II.Rodríguez Rio, Xusto A. coord. III. Universidade de Santiago de Compostela. Servizo de Normalización Lingüística, coord. IV.Universidade de Santiago de Compostela. Servizo de Publicacións e Intercambio Científico, ed. V.Serie. 591.4(038)=699=60=20 Coordinador Xusto A. Rodríguez Río (Área de Terminoloxía. Servizo de Normalización Lingüística. Universidade de Santiago de Compostela) Autoras/res Matilde Lombardero Fernández (doutora en Veterinaria e profesora do Departamento de Anatomía e Produción Animal. -
In Sickness and in Health: the Immunological Roles of the Lymphatic System
International Journal of Molecular Sciences Review In Sickness and in Health: The Immunological Roles of the Lymphatic System Louise A. Johnson MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK; [email protected] Abstract: The lymphatic system plays crucial roles in immunity far beyond those of simply providing conduits for leukocytes and antigens in lymph fluid. Endothelial cells within this vasculature are dis- tinct and highly specialized to perform roles based upon their location. Afferent lymphatic capillaries have unique intercellular junctions for efficient uptake of fluid and macromolecules, while expressing chemotactic and adhesion molecules that permit selective trafficking of specific immune cell subsets. Moreover, in response to events within peripheral tissue such as inflammation or infection, soluble factors from lymphatic endothelial cells exert “remote control” to modulate leukocyte migration across high endothelial venules from the blood to lymph nodes draining the tissue. These immune hubs are highly organized and perfectly arrayed to survey antigens from peripheral tissue while optimizing encounters between antigen-presenting cells and cognate lymphocytes. Furthermore, subsets of lymphatic endothelial cells exhibit differences in gene expression relating to specific func- tions and locality within the lymph node, facilitating both innate and acquired immune responses through antigen presentation, lymph node remodeling and regulation of leukocyte entry and exit. This review details the immune cell subsets in afferent and efferent lymph, and explores the mech- anisms by which endothelial cells of the lymphatic system regulate such trafficking, for immune surveillance and tolerance during steady-state conditions, and in response to infection, acute and Citation: Johnson, L.A. -
Arterial System Lecture Block 10 Vascular Structure/Function
Arterial System Lecture Block 10 Arterial System Bioengineering 6000 CV Physiology Vascular Structure/Function Arterial System Bioengineering 6000 CV Physiology Functional Overview Arterial System Bioengineering 6000 CV Physiology Vessel Structure Aorta Artery Vein Vena Cava Arteriole Capillary Venule Diameter 25 mm 4 mm 5 mm 30 mm 30 µm 8 µm 20 µm Wall 2 mm 1 mm 0.5 mm 1.5 mm 6 µm 0.5 µm 1 µm thickness Endothelium Elastic tissue Smooth Muscle Fibrous Tissue Arterial System Bioengineering 6000 CV Physiology Aortic Compliance • Factors: – age 20--24 yrs – athersclerosis 300 • Effects – more pulsatile flow 200 dV 30--40 yrs C = – more cardiac work dP 50-60 yrs – not hypertension Laplace’s Law 100 70--75 yrs (thin-walled cylinder): [%] Volume Blood T = wall tension P = pressure T = Pr r = radius For thick wall cylinder 100 150 200 P = pressure Pr Pressure [mm Hg] σ = wall stress r = radius σ = Tension Wall Stress w = wall thickness w [dyne/cm] [dyne/cm2] Aorta 2 x 105 10 x 105 Capillary 15-70 1.5 x 105 Arterial System Bioengineering 6000 CV Physiology Arterial Hydraulic Filter Arterial System Bioengineering 6000 CV Physiology Arterial System as Hydraulic Filter Arterial Cardiac Pressure • Pulsatile --> Output t Physiological smooth flow t Ideal • Cardiac energy conversion Cardiac • Reduces total Output Arterial cardiac work Pressure t Pulsatile t Challenge Cardiac Output Arterial Pressure t Filtered t Reality Arterial System Bioengineering 6000 CV Physiology Elastic Recoil in Arteries Arterial System Bioengineering 6000 CV Physiology Effects of Vascular Resistance and Compliance Arterial System Bioengineering 6000 CV Physiology Cardiac Output vs.