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Procedures for the Endocrinologist PROCEDURES FOR THE ENDOCRINOLOGIST A Clinical Test Compendium PROCEDURES FOR THE ENDOCRINOLOGIST: A Clinical Test Compendium LabCorp provides the nation’s premier laboratory This compendium is intended as a resource for the services for the endocrinology specialist. Through endocrinologist and includes assays performed at the integration of regional laboratory testing and the LabCorp’s regional facilities as well as specialized expertise of Endocrine Sciences, a member of the testing from Endocrine Sciences. The procedures LabCorp Specialty Testing Group, LabCorp offers a listed are among the most commonly ordered by the full-service solution designed to enhance the care and endocrinology specialist. cost-effective treatment of patients. Contents Test Procedures and Ordering Information (Alphabetic List) . page 3 Endocrine Sciences . Specialized assays referred to Endocrine Sciences are identified in this compendium. The test numbers included here are for ordering testing through LabCorp only. Alternative test numbers are available for setting up service directly with Endocrine Sciences. Please ask your account representative for assistance. Specimen Requirements . Additional specimen types not listed in this compendium may be available for testing. For more information, please consult the electronic Directory of Services and Interpretive Guide at https://www.labcorp.com/wps/portal/provider/testmenu, LabCorp’s comprehensive menu of clinical procedures. Test Procedure Index by Disease State . page 14 Test Procedure Index by Disease State . The index was developed by LabCorp, Endocrine Sciences, and their clinical consultants. The information included here is provided for the convenience of clients. It is not comprehensive and is not intended to replace sound clinical judgment. Multiple Sample/Timed-specimen Testing . page 18 Endocrinologist Services Test Request Form . page 19 Abbreviations . page 20 Note: LabCorp’s policy is to provide physicians, in each instance, with the flexibility to choose appropriate tests to assure that the con- venience of ordering test combinations/profiles does not prevent physicians who wish to order a test combination/profile from making deliberate informed decisions regarding which tests are medically necessary. All the tests offered in test combinations/profiles may be ordered individually using the LabCorp test request form. 2 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM Test Name Test N° Methodology Specimen Container Storage* 11-Deoxycortisol, HPLC/MS-MS (specific 500550 HPLC/MS-MS [after 0.5 mL serum Red-top or gel-barrier Refrigerated compound S) (metyrapone, Metopirone®) extraction] Minimum: 0.2 mL tube (same day) or (Endocrine Sciences) frozen 11-Deoxycortisol, HPLC/MS-MS (specific 500171 HPLC/MS-MS [after 1.0 mL serum Gel-barrier tube, Refrigerated compound S) (basal) (Endocrine Sciences) extraction] Minimum: 0.2 mL lavender-top, green- (same day) or top tube frozen 17α-Hydroxypregnenolone, HPLC/MS-MS 140715 HPLC/MS-MS [after 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction] Minimum: 0.3 mL tube or frozen 17-OH Progesterone, Serum, HPLC/MS-MS 500163 HPLC/MS-MS [after 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction] Minimum: 0.1 mL tube or frozen 18-Hydroxycorticosterone, HPLC/MS-MS 500778 HPLC/MS-MS [after 3 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction] Minimum: 1 mL tube or frozen 3-Epi-Vitamin D,25-Hydroxy (Endocrine 503580 HPLC/MS-MS 0.6 mL serum Red-top or gel-barrier Refrigerated Sciences) Minimum: 0.3 mL tube or frozen 5-Hydroxyindoleacetic Acid (HIAA), 004069 HPLC/MS-MS 30 mL aliquot Urine collection Refrigerated Quantitative, 24-hour Urine 24-hour urine container (boric acid at 2°C to 8°C Minimum: 1 mL recommended) Acid Labile Subunit (Endocrine Sciences) 500120 Double antibody RIA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube (same day) or frozen Adrenal 21-Hydroxylase Autoantibodies 500092 Immunoprecipitation 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) assay Minimum: 0.1 mL tube (same day) or frozen Adrenocorticotropic Hormone (ACTH), 004440 ECLIA 0.8 mL plasma Lavender-top (EDTA) Frozen Plasma Minimum: 0.3 mL tube Aldolase 002030 Kinetic 2 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube Aldosterone, 24-hour Urine 004291 HPLC/MS-MS 10 mL aliquot Urine collection Refrigerated 24-hour urine container Minimum: 1 mL (no preservative) Aldosterone, LCMS (Endocrine Sciences) 500467 HPLC/MS-MS 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube (same day) or frozen α-Subunit, Free (Endocrine Sciences) 140269 ICMA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.25 mL tube (same day) or frozen α-Fetoprotein (AFP) 002253 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Aluminum, Plasma or Serum 071548 ICP/MS 7 mL plasma Blue-top tube Ambient (preferred) or serum Minimum: 0.6 mL Amenorrhea Profile (estradiol, FSH, LH, 501064 See individual assays 4 mL serum Red-top or gel-barrier Refrigerated prolactin) (Endocrine Sciences) Minimum: 2 mL tube (same day) or frozen Amylase 001396 Enzymatic 1 mL serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube Androstanediol Glucuronide, Serum 500881 HPLC/MS-MS 1 mL serum Red-top or gel-barrier Ambient or (Endocrine Sciences) Minimum: 0.5 mL tube Refrigerated (preferred) Androstenedione, LCMS (Endocrine 500152 HPLC/MS-MS [after 0.5 mL serum Red-top tube only Ambient Sciences) extraction] Minimum: 0.2 mL (same day) or frozen Angelman and Prader-Willi Syndromes, 511210 Methylation- 7 mL whole blood Lavender-top (EDTA) Ambient; do DNA specific PCR and gel or LabCorp buccal or yellow-top (ACD). not freeze. electrophoresis swab kit LabCorp buccal swab kit *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp. †This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients. 3 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM Test Name Test N° Methodology Specimen Container Storage* Angiotensin-converting Enzyme (ACE) 010116 Kinetic 2 mL serum Red-top or gel-barrier Ambient Minimum: 0.2 mL tube Antidiuretic Hormone (ADH), Plasma 010447 RIA after solid phase 2 mL plasma in Lavender-top (EDTA) Frozen extraction EDTA only tube Anti-islet Cell Antibodies (ICA-512 141531 Immunoprecipitation 0.5 mL serum Red-top or gel-barrier Refrigerated Autoantibodies) (Endocrine Sciences) assay Minimum: 0.1 mL tube (same day) or frozen Anti-Mullerian Hormone (Endocrine 500183 ELISA 1 mL serum Red-top or gel-barrier Refrigerated Sciences)† Minimum: 0.5 mL tube (same day) or frozen Antinuclear Antibodies, Direct 164855 Multiplex flow 1 mL serum Red-top or gel-barrier Ambient immunoassay Minimum: 0.5 mL tube β-Hydroxybutyrate 503610 Spectrophotometric 1 mL serum (patient Red-top or gel-barrier Frozen must fast overnight) tube Minimum: 0.5 mL Bone-specific Alkaline Phosphatase 513002 ICMA 1 mL serum Gel-barrier tube Refrigerated Minimum: 0.5 mL (same day) or frozen B-Type Natriuretic Peptide 140889 ICMA 0.8 mL EDTA only Plastic lavender-top Frozen Minimum: 0.5 mL (EDTA) only CAHDetx™, PCR 500768 PCR, multiplex mini- 3 mL whole blood Lavender-top (EDTA) Ambient; do (congenital adrenal hyperplasia; sequencing, fragment Minimum: 1 mL tube not freeze. 21-hydroxylase (CYP21) mutation) analysis (Endocrine Sciences) Calcitonin, Serum 004895 ICMA 1 mL serum Red-top or gel-barrier Frozen Minimum: 0.4 mL tube Calciferols (Vitamin D), Total and 503835 HPLC/MS-MS 1 mL serum Red-top or gel-barrier Refrigerated Fractionated, LC/MS-MS Minimum: 0.5 mL tube or frozen Calcitriol (1,25 di-OH Vitamin D) 500600 HPLC/MS-MS 2 mL serum Red-top or gel-barrier Refrigerated Fractionated D2 + D3, HPLC/MS-MS Minimum: 0.8 mL tube (same day) or (Endocrine Sciences) frozen Calcium, 24-hour Urine 003269 Colorimetry 25 mL aliquot Urine collection Ambient 24-hour urine con­­tainer with 10 mL Minimum: 1 mL 6N HCl or potassium metabisulfite tablets if HCl not unavailable. Pediatric without preservative acceptable. Calcium, Ionized, Serum 004804 Ion-selective electrode 1 mL serum Gel-barrier tube, Ambient; do unopened not freeze. 1 mL serum Red-top or gel-barrier Ambient or Calcium, Serum 001016 Colorimetry Minimum: 0.5 mL tube refrigerated Carcinoembryonic Antigen (CEA) 002139 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Catecholamines, Fractionated, Plasma 084152 HPLC with 3 mL EDTA or Lavender-top Frozen electrochemical heparinized plasma (EDTA) or green-top detection only . Use minimum (venipuncture) tube tourniquet time. Mix gently by inversion. Minimum: 2.2 mL Catecholamines, Fractionated, Urinary Free, 004176 HPLC/MS-MS 30 mL aliquot Urine collection Refrigerated 24-hour Urine 24-hour urine con tainer (brown) (during Minimum: 4 mL with 30 mL 6N HCl and after preservative. collection) *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp. †This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients. 4 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM Test Name Test N° Methodology Specimen Container Storage* CBC With Differential With Platelet Count 005009 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do blood tube not freeze. Minimum: 0.5 mL CBC With Differential Without Platelet Count 115907 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do blood tube not freeze. Minimum: 0.5 mL CBC Without Differential With Platelet Count 028142 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do blood tube not freeze. CBC Without Differential Without Platelet 005017 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do Count blood tube not freeze.
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