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Procedures for the Endocrinologist

Procedures for the Endocrinologist

PROCEDURES FOR THE ENDOCRINOLOGIST

A Clinical Test Compendium PROCEDURES FOR THE ENDOCRINOLOGIST: A Clinical Test Compendium

LabCorp provides the nation’s premier laboratory This compendium is intended as a resource for the services for the endocrinology specialist. Through endocrinologist and includes assays performed at the integration of regional laboratory testing and the LabCorp’s regional facilities as well as specialized expertise of Endocrine Sciences, a member of the testing from Endocrine Sciences. The procedures LabCorp Specialty Testing Group, LabCorp offers a listed are among the most commonly ordered by the full-service solution designed to enhance the care and endocrinology specialist. cost-effective treatment of patients.

Contents

Test Procedures and Ordering Information (Alphabetic List) ...... page 3

Endocrine Sciences . Specialized assays referred to Endocrine Sciences are identified in this compendium. The test numbers included here are for ordering testing through LabCorp only. Alternative test numbers are available for setting up service directly with Endocrine Sciences. Please ask your account representative for assistance.

Specimen Requirements . Additional specimen types not listed in this compendium may be available for testing. For more information, please consult the electronic Directory of Services and Interpretive Guide at https://www.labcorp.com/wps/portal/provider/testmenu, LabCorp’s comprehensive menu of clinical procedures.

Test Procedure Index by Disease State ...... page 14

Test Procedure Index by Disease State . The index was developed by LabCorp, Endocrine Sciences, and their clinical consultants. The information included here is provided for the convenience of clients. It is not comprehensive and is not intended to replace sound clinical judgment.

Multiple Sample/Timed-specimen Testing ...... page 18

Endocrinologist Services Test Request Form ...... page 19

Abbreviations ...... page 20

Note: LabCorp’s policy is to provide physicians, in each instance, with the flexibility to choose appropriate tests to assure that the con- venience of ordering test combinations/profiles does not prevent physicians who wish to order a test combination/profile from making deliberate informed decisions regarding which tests are medically necessary. All the tests offered in test combinations/profiles may be ordered individually using the LabCorp test request form.

2 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

11-Deoxycortisol, HPLC/MS-MS (specific 500550 HPLC/MS-MS [after 0.5 mL serum Red-top or gel-barrier Refrigerated compound S) (metyrapone, Metopirone®) extraction] Minimum: 0.2 mL tube (same day) or (Endocrine Sciences) frozen 11-Deoxycortisol, HPLC/MS-MS (specific 500171 HPLC/MS-MS [after 1.0 mL serum Gel-barrier tube, Refrigerated compound S) (basal) (Endocrine Sciences) extraction] Minimum: 0.2 mL lavender-top, green- (same day) or top tube frozen 17α-Hydroxypregnenolone, HPLC/MS-MS 140715 HPLC/MS-MS [after 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction] Minimum: 0.3 mL tube or frozen 17-OH Progesterone, Serum, HPLC/MS-MS 500163 HPLC/MS-MS [after 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction] Minimum: 0.1 mL tube or frozen 18-Hydroxycorticosterone, HPLC/MS-MS 500778 HPLC/MS-MS [after 3 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction] Minimum: 1 mL tube or frozen 3-Epi-Vitamin D,25-Hydroxy (Endocrine 503580 HPLC/MS-MS 0.6 mL serum Red-top or gel-barrier Refrigerated Sciences) Minimum: 0.3 mL tube or frozen 5-Hydroxyindoleacetic Acid (HIAA), 004069 HPLC/MS-MS 30 mL aliquot Urine collection Refrigerated Quantitative, 24-hour Urine 24-hour urine container (boric acid at 2°C to 8°C Minimum: 1 mL recommended) Acid Labile Subunit (Endocrine Sciences) 500120 Double antibody RIA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube (same day) or frozen Adrenal 21-Hydroxylase Autoantibodies 500092 Immunoprecipitation 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) assay Minimum: 0.1 mL tube (same day) or frozen Adrenocorticotropic Hormone (ACTH), 004440 ECLIA 0.8 mL plasma Lavender-top (EDTA) Frozen Plasma Minimum: 0.3 mL tube Aldolase 002030 Kinetic 2 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube Aldosterone, 24-hour Urine 004291 HPLC/MS-MS 10 mL aliquot Urine collection Refrigerated 24-hour urine container Minimum: 1 mL (no preservative) Aldosterone, LCMS (Endocrine Sciences) 500467 HPLC/MS-MS 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube (same day) or frozen α-Subunit, Free (Endocrine Sciences) 140269 ICMA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.25 mL tube (same day) or frozen α-Fetoprotein (AFP) 002253 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Aluminum, Plasma or Serum 071548 ICP/MS 7 mL plasma Blue-top tube Ambient (preferred) or serum Minimum: 0.6 mL Amenorrhea Profile (estradiol, FSH, LH, 501064 See individual assays 4 mL serum Red-top or gel-barrier Refrigerated prolactin) (Endocrine Sciences) Minimum: 2 mL tube (same day) or frozen Amylase 001396 Enzymatic 1 mL serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube Androstanediol Glucuronide, Serum 500881 HPLC/MS-MS 1 mL serum Red-top or gel-barrier Ambient or (Endocrine Sciences) Minimum: 0.5 mL tube Refrigerated (preferred) Androstenedione, LCMS (Endocrine 500152 HPLC/MS-MS [after 0.5 mL serum Red-top tube only Ambient Sciences) extraction] Minimum: 0.2 mL (same day) or frozen Angelman and Prader-Willi Syndromes, 511210 Methylation- 7 mL whole blood Lavender-top (EDTA) Ambient; do DNA specific PCR and gel or LabCorp buccal or yellow-top (ACD). not freeze. electrophoresis swab kit LabCorp buccal swab kit *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

3 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Angiotensin-converting Enzyme (ACE) 010116 Kinetic 2 mL serum Red-top or gel-barrier Ambient Minimum: 0.2 mL tube Antidiuretic Hormone (ADH), Plasma 010447 RIA after solid phase 2 mL plasma in Lavender-top (EDTA) Frozen extraction EDTA only tube Anti-islet Cell Antibodies (ICA-512 141531 Immunoprecipitation 0.5 mL serum Red-top or gel-barrier Refrigerated Autoantibodies) (Endocrine Sciences) assay Minimum: 0.1 mL tube (same day) or frozen Anti-Mullerian Hormone (Endocrine 500183 ELISA 1 mL serum Red-top or gel-barrier Refrigerated Sciences)† Minimum: 0.5 mL tube (same day) or frozen Antinuclear Antibodies, Direct 164855 Multiplex flow 1 mL serum Red-top or gel-barrier Ambient immunoassay Minimum: 0.5 mL tube β-Hydroxybutyrate 503610 Spectrophotometric 1 mL serum (patient Red-top or gel-barrier Frozen must fast overnight) tube Minimum: 0.5 mL Bone-specific Alkaline Phosphatase 513002 ICMA 1 mL serum Gel-barrier tube Refrigerated Minimum: 0.5 mL (same day) or frozen B-Type Natriuretic Peptide 140889 ICMA 0.8 mL EDTA only Plastic lavender-top Frozen Minimum: 0.5 mL (EDTA) only CAHDetx™, PCR 500768 PCR, multiplex mini- 3 mL whole blood Lavender-top (EDTA) Ambient; do (congenital adrenal hyperplasia; sequencing, fragment Minimum: 1 mL tube not freeze. 21-hydroxylase (CYP21) mutation) analysis (Endocrine Sciences) Calcitonin, Serum 004895 ICMA 1 mL serum Red-top or gel-barrier Frozen Minimum: 0.4 mL tube Calciferols (Vitamin D), Total and 503835 HPLC/MS-MS 1 mL serum Red-top or gel-barrier Refrigerated Fractionated, LC/MS-MS Minimum: 0.5 mL tube or frozen Calcitriol (1,25 di-OH Vitamin D) 500600 HPLC/MS-MS 2 mL serum Red-top or gel-barrier Refrigerated Fractionated D2 + D3, HPLC/MS-MS Minimum: 0.8 mL tube (same day) or (Endocrine Sciences) frozen Calcium, 24-hour Urine 003269 Colorimetry 25 mL aliquot Urine collection Ambient 24-hour urine con­­tainer with 10 mL Minimum: 1 mL 6N HCl or potassium metabisulfite tablets if HCl not unavailable. Pediatric without preservative acceptable. Calcium, Ionized, Serum 004804 Ion-selective electrode 1 mL serum Gel-barrier tube, Ambient; do unopened not freeze. 1 mL serum Red-top or gel-barrier Ambient or Calcium, Serum 001016 Colorimetry Minimum: 0.5 mL tube refrigerated Carcinoembryonic Antigen (CEA) 002139 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Catecholamines, Fractionated, Plasma 084152 HPLC with 3 mL EDTA or Lavender-top Frozen electrochemical heparinized plasma (EDTA) or green-top detection only . Use minimum (venipuncture) tube tourniquet time. Mix gently by inversion. Minimum: 2.2 mL Catecholamines, Fractionated, Urinary Free, 004176 HPLC/MS-MS 30 mL aliquot Urine collection Refrigerated 24-hour Urine 24-hour urine container­ (brown) (during Minimum: 4 mL with 30 mL 6N HCl and after preservative. collection) *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

4 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

CBC With Differential With Platelet Count 005009 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do blood tube not freeze. Minimum: 0.5 mL CBC With Differential Without Platelet Count 115907 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do blood tube not freeze. Minimum: 0.5 mL CBC Without Differential With Platelet Count 028142 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do blood tube not freeze. CBC Without Differential Without Platelet 005017 Automated cell counter Filled tube whole Lavender-top (EDTA) Ambient; do Count blood tube not freeze. Minimum: 0.5 mL Celiac Disease Comprehensive Antibody 165126 EIA; indirect 3 mL serum Red-top or gel-barrier Refrigerated Profile (antigluten antibodies; endomysial immunofluorescence Minimum: 1 mL tube antibodies; gliadin antibodies; tissue transglutaminase [tTG] antibodies) Celiac Disease Profile (antiendomysial 165142 EIA; indirect 3 mL serum Red-top or gel-barrier Ambient IgA, antigliadin IgA, total IgA, and immunofluorescence Minimum: 1 mL tube transglutaminase IgA) Chromogranin A† 140848 RIA 0.2 mL serum or Red-top/lavender-top Refrigerated plasma (EDTA)/green-top Minimum: 0.1 mL (venipuncture) Analysis, Blood 052019 Cytogenetics 5 mL blood Green-top Ambient; do (Constitutional) Neonates: 1-2 mL (venipuncture) tube not freeze. Congenital Adrenal Hyperplasia (CAH) 500175 See individual assays 3.5 mL serum Red-top tube only Refrigerated Pediatric Profile 6 – Comprehensive Screen Minimum: 2 mL (same day) or (androstenedione; specific S; cortisol; DHEA; frozen DOC; 17α-OH-pregnenolone; progesterone; 17α-OH-progesterone; testosterone) (Endocrine Sciences) Congenital Adrenal Hyperplasia 500166 See individual assays 1.5 mL serum Red-top tube only Ambient (CAH) Pediatric Profile 7 – Treatment Minimum: 0.7 mL (same day) or (androstenedione, 17α-OH-progesterone, frozen testosterone) (Endocrine Sciences) Corticosterone, HPLC/MS-MS (Endocrine 500135 HPLC/MS-MS [after 2 mL serum Red-top or gel-barrier Ambient Sciences) extraction] Minimum: 0.2 mL tube (same day) or frozen Cortisol, Free, Urinary Free, HPLC/MS- 500410 HPLC/MS-MS 50 mL aliquot Urine collection Refrigerated MS With Free Cortisol/Creatinine Ratio [after extraction], 24-hour urine container. Use boric (same day) or (Endocrine Sciences) colorimetry Minimum: 5 mL acid preservative. frozen Cortisol, Salivary (Endocrine Sciences) 500179 HPLC/MS-MS [after 1 mL freshly Saliva collection Ambient or extraction] collected saliva device refrigerated Cortisol, Serum, LCMS (Endocrine Sciences) 500154 HPLC/MS-MS 0.5 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.1 mL tube or frozen Cortisol, Serum, ICMA 004051 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube or frozen C-Peptide, Ultrasensitive (Endocrine 503830 ECL 1 mL serum or Red-top, gel-barrier, or Refrigerated Sciences) plasma lavender-top (EDTA) or frozen Minimum: 0.3 mL tube (preferred) C-Peptide, Urine 003236 ECLIA 10 mL aliquot Urine collection Frozen 24-hour urine container Minimum: 1 mL C-Reactive , Cardiac 120766 ICMA 1 mL serum or Red-top/lavender-top Refrigerated plasma (EDTA)/green-top Minimum: 0.5 mL (venipuncture) Creatine Kinase, Total, Serum 001362 Kinetic 2 mL serum Red-top or gel-barrier Ambient Minimum: 0. 4 mL tube *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

5 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Creatine, 24-hour Urine 003475 Enzymatic 2 mL aliquot Urine container, no Frozen 24-hour urine preservative Minimum: 0.2 mL Creatinine Clearance 003004 Colorimetry 1 mL serum (0.5 mL Gel-barrier tube Ambient minimum) and and urine collection 10 mL aliquot container 24-hour urine Minimum: 0.5 mL Creatinine, 24-hour Urine 003012 Kinetic 10 mL aliquot 24- Urine container, no Ambient, hour urine preservative, or 6N refrigerated, Minimum: 0.5 mL HCl or frozen Creatinine, Serum 001370 Kinetic 1 mL serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube C-Telopeptide, Serum (Endocrine Sciences) 500089 ELISA 0.5 mL serum Gel-barrier tube Refrigerated Minimum: 0.3 mL (same day) or frozen Cyclic AMP, Urine 004903 RIA 10 mL random urine Transport tube Frozen Minimum: 0.5 mL Dehydroepiandrosterone (DHEA), Serum 500156 HPLC/MS-MS [after 0.5 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction] Minimum: 0.3 mL tube (same day) or frozen Dehydroepiandrosterone Sulfate (DHEA-S) 500161 HPLC/MS-MS 0.2 mL serum Red-top or gel-barrier Ambient, (Endocrine Sciences) Minimum: 0.1 mL tube refrigerated or frozen Deoxycorticosterone (DOC), Serum 500138 HPLC/MS-MS [after 3 mL serum Red-top or gel-barrier Ambient (Endocrine Sciences) extraction] Minimum: 0.5 mL tube (same day) or frozen Deoxypyridinoline (Dpd) Crosslinks (Serial 511105 ICMA 10 mL urine Urine container, no Refrigerated Monitor) Minimum: 1 mL preservative Dexamethasone, Serum, HPLC/MS-MS 500118 HPLC/MS-MS [after 3 mL serum Red-top or gel-barrier Ambient, (Endocrine Sciences) extraction] Minimum: 1 mL tube refrigerated, or frozen Diabetes Autoimmune Profile (insulin ab; 500597 See individual assays 1 mL serum Red-top or gel-barrier Refrigerated GAD-65 ab; ICA512 ab) (Endocrine Sciences) Minimum: 0.4 mL tube (same day) or frozen Dihydrotestosterone (DHT) (Endocrine 500142 HPLC/MS-MS [after 1 mL serum Red-top or gel-barrier Ambient, Sciences) extraction] Minimum: 0.5 mL tube refrigerated, or frozen Electrolyte Panel 303754 Ion-selective electrode 2 mL serum Gel-barrier tube Refrigerated (carbon dioxide; chloride; potassium; (ISE); enzymatic Minimum: 0.8 mL sodium) Erythropoietin 140277 ICMA 0.5 mL serum Red-top or gel-barrier Ambient Minimum: 0.3 mL tube Estradiol, LCMS (Endocrine Sciences) 500108 HPLC/MS-MS [after 3 mL serum Red-top or gel-barrier Ambient extraction] Minimum: 1.5 mL tube (same day) or frozen Estradiol, ICMA 004515 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Estradiol Free, Equilibrium Dialysis, With 500649 HPLC/MS-MS [after 3 mL serum Red-top or gel-barrier Ambient Total Estradiol, HPLC/MS-MS (Endocrine extraction] and Minimum: 0.5 mL tube (same day) or Sciences) equilibrium dialysis frozen Estriol 004614 ICMA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Estrone, LCMS (Endocrine Sciences) 500634 HPLC/MS-MS 3 mL serum Red-top or gel-barrier Ambient [after extraction] Minimum: 1mL tube (same day) or frozen *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

6 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Fatty Acids, Free (Nonesterified ) 081893 Spectrophotometry­ 1mL serum Red-top or gel-barrier Frozen Minimum: 0.2 mL tube Ferritin, Serum 004598 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube FISH Microdeletion 510770 FISH Fixed-cell pellet, 3 Green-top Ambient slides, 5 mL blood (venipuncture) tube (adults), 1 mL blood (pediatrics), 1 mL bone marrow, or 5 mL amniotic fluid Folate, RBC 266015 ECLIA Whole blood (two Lavender-top (EDTA) Frozen (7 mL); tubes); Transfer tube refrigerate 7 mL from one whole second tube blood tube to a plastic transport tube and freeze. Refrigerate second whole blood tube Follicle-stimulating Hormone (FSH) 004309 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Follicle-stimulating Hormone (FSH), 502280 ECL 1 mL serum Red-top or gel-barrier Refrigerated Pediatric (Endocrine Sciences) Minimum: 0.2 mL tube or frozen Fructosamine 100800 Colorimetry 1 mL serum or Gel-barrier, transport, Ambient plasma lavender-top (EDTA), Minimum: 0.5 mL or green-top (venipuncture) tube Gastrin 004390 ICMA 0.5 mL serum Red-top or gel-barrier Frozen (Patient must fast tube ovrenight.) Minimum: 0.3 mL Glucagon, Plasma 004622 RIA 1 mL plasma with Lavender-top (EDTA) Frozen Trasylol® tube (chilled) Minimum: 0.5 mL Glucose, Plasma 001818 Enzymatic 0.5 mL plasma Gray-top tube Ambient Glutamic Acid Decarboxylase (GAD-65) 143008 RIA 0.5 mL serum Red-top or gel-barrier Refrigerated Autoantibody Minimum: 0.4 mL tube (same day) or frozen Glycohemoglobin, Total 001693 HPLC 7 mL whole blood Lavender-top (EDTA) Ambient Minimum: 0.5 mL tube GlycoMark® (Endocrine Sciences) 500115 Enzymatic, colorimetry 1 mL serum or Red-top or gel-barrier/ Ambient plasma lavender-top (EDTA) (same day) or Minimum: 0.75 mL tube refrgerate Growth Assesment Profile 501007 See individual assays 1 mL serum Red-top or gel-barrier Ambient (IGF-I, IGFBP-3) (Endocrine Sciences) Minimum: 0.2 mL tube (same day) or frozen Growth Hormone Antibodies (Endocrine 500144 Immunoprecipitation 1 mL serum Red-top or gel-barrier Refrigerated Sciences) assay Minimum: 0.5 mL tube (same day) or frozen Growth Hormone-binding Protein (GHBP) 500177 Ligand binding 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) immunoprecipitation Minimum: 0.2 mL tube (same day) or assay frozen Growth Hormone, RIA (Endocrine Sciences) 500632 Double antibody RIA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.4 mL tube (same day) or frozen Growth Hormone, Serum 004275 ICMA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

7 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Growth Hormone, 24-hour Urine (Endocrine 500330 IRMA 100 mL aliquot Urine collection Frozen Sciences) 24-hour urine container Minimum: 50 mL

Hemoglobin A1c 001453 Roche Tina Quant 7 mL whole blood Lavender-top (EDTA) Ambient tube Hepatic Function Panel (7) 322755 Automated 1 mL serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube Hereditary Hemochromatosis, DNA Analysis 511345 PCR; restriction 7 mL whole blood Lavender-top (EDTA) Ambient; do enzyme analysis; gel (3 mL minimum) tube/yellow-top (ACD) not freeze. electrophoresis or LabCorp buccal or LabCorp buccal swab kit swab kit Hirsutism Test Group I 500066 See individual assays 3 mL serum Red-top or gel-barrier Refrigerated (DHEA-S; testosterone; free testosterone; Minimum: 1.5 mL tube (same day) or percentage free testosterone, equilibrium frozen dialysis; SHBG) (Endocrine Sciences) Human Antimouse Antibodies 140657 EIA 0.4 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.2 mL tube Human Chorionic Gonadotropin (hCG), 004416 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated β-Subunit, Quantitative, Serum Minimum: 0.3 mL tube Inflammatory Bowel Disease Profile 164830 IFA, EIA 1.5 mL serum Red-top or gel-barrier Refrigerated (atypical antineutrophil cytoplasmic Minimum: 0.7 mL tube antibodies [ANCA]; Saccharomyces cerevisiae, IgA; Saccharomyces cerevisiae, IgG) Insulin-like Growth Factor Binding Protein 1 140822 RIA 0.5 mL serum Red-top or gel-barrier Refrigerated (IGFBP-1), RIA (Endocrine Sciences) Minimum: 0.1 mL tube (same day) or frozen Insulin-like Growth Factor Binding Protein 2 500133 RIA 1 mL serum Red-top or gel-barrier Refrigerated (IGFBP-2), RIA (Endocrine Sciences) Minimum: 0.1 mL tube (same day) or frozen Insulin-like Growth Factor Binding Protein 3 500644 RIA in dilute serum 0.5 mL serum Red-top or gel-barrier Ambient (IGFBP-3), RIA (Endocrine Sciences) Minimum: 0.1 mL tube (same day) or frozen Insulin-like Growth Factor 1 (IGF-1), 503660 Blocking RIA after 0.5 mL serum Red-top or gel-barrier Ambient Pediatric With Z Score (Endocrine Sciences) acid:alcohol extraction Minimum: 0.1 mL tube (same day) or frozen Insulin-like Growth Factor 1 (IGF-1), RIA 500485 Blocking RIA after 0.5 mL serum Red-top or gel-barrier Ambient After Extraction (Endocrine Sciences) acid:alcohol extraction Minimum: 0.1 mL tube (same day) or frozen Insulin-like Growth Factor 2 (IGF-2), RIA 141770 RIA after acid:alcohol 0.5 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) extraction Minimum: 0.1 mL tube (same day) or frozen Immunofixation, Serum 001685 IFE 3 mL serum Red-top or gel-barrier Ambient Minimum: 1mL tube Inhibin A, Ultrasensitive† 146803 ICMA 0.3 mL serum Red-top or gel-barrier Frozen Minimum: 0.2 mL tube Inhibin B† 146795 EIA 0.6 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Insulin Antibodies (Endocrine Sciences) 141598 Insulin-I125 binding 0.5 mL serum Red-top or gel-barrier Refrigerated capacity Minimum: 0.2 mL tube (same day) or frozen Insulin, Fasting 004333 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Iron 001339 Colorimetry 1 mL serum Gel-barrier tube Ambient Minimum: 0.5 mL *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

8 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Iron and Total Iron-binding Capacity (TIBC) 001321 Colorimetry 2 mL serum Gel-barrier tube Ambient Minimum: 0.5 mL Islet Cell Dysfunction Profile (insulin; 500757 See individual assays 1 mL plasma or Red-top or gel-barrier Frozen proinsulin; proinsulin:insulin ratio) serum tube (Endocrine Sciences) Minimum: 0.6 mL Kidney Stone Urine Test 306266 Two 100-mL Urine collection Frozen Combination With Saturation Calculations aliquots of 24-hour container urine Leptin, RIA (Endocrine Sciences) 500716 ELISA 1 mL of serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube (same day) or frozen Lipase 001404 Colorimetry 1 mL serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube Lipid Panel 303756 Automated 2 mL serum Gel-barrier tube Ambient (Cholesterol, total; HDL cholesterol; LDL Minimum: 0.5 mL cholesterol [calc]; triglycerides; VLDL cholesterol [calc]) Lipid Panel With LDL/HDL Ratio 235010 Automated 1 mL serum Gel-barrier tube Ambient Minimum: 0.5 mL Luteinizing Hormone (LH) 004283 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Luteinizing Hormone (LH), Pediatric 502286 ECL 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) Minimum: 0.2 mL tube (same day) or frozen Macroprolactin (Endocrine Sciences) 500324 ICMA, PEG precipitation 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.2 mL tube (same day) or frozen Magnesium, Serum 001537 Colorimetry 1 mL serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube Magnesium, Urine 003400 AAS or colorimetry 5 mL aliquot of Urine collection Refrigerated 24-hour urine container with 10 mL Minimum: 2.2 mL 6N HCI Melanocyte-stimulating Hormone (MSH)† 010421 RIA 2 mL plasma with Collect 6 mL blood in Frozen Trasylol® prechilled lavender- Minimum: 0.3 mL top tube. Transfer to a red-top tube containing 0.25 mL Trasylol® solution (10,000 KIU/mL). Mix well, centrifuge, transfer plasma to specially labeled transport tube and freeze . MEN2: RET Sequencing 504008 PCR of targeted RET 3 mL Whole Blood Lavender-top (EDTA) Ambient gene exons, DNA Minimum: 1 mL tube sequencing of those PCR products MEN2: RET Gene, Single Known Mutation 504009 PCR of targeted RET 3 mL Whole Blood Lavender-top (EDTA) Ambient (known familial mutation must be specified) gene exons, DNA Minimum: 1 mL tube sequencing of those PCR products Menopausal Transition Profile I 501218 See individual assays 5 mL serum Red-top or gel-barrier Ambient (Postmenopausal) (E2; FSH; LH; Minimum: 2 mL tube (same day) or progesterone) (Endocrine Sciences) frozen Metabolic Panel, Basic (8) 322758 Automated 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

9 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Metabolic Panel, Comprehensive (14) 322000 Automated 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube Metanephrines, Fractionated, Quantitative, 004234 HPLC/MS-MS 25 mL aliquot of Urine collection Refrigerated 24-hour Urine 24-hour urine container with 30 Minimum: 2.5 mL mL 6N HCl. Caution: Strong acid may cause skin burns. Metanephrines, Fractionation, Plasma Free 121806 HPLC/MS-MS 2 mL plasma Lavender-top (EDTA) Refrigerated Minimum: 1.5 mL tube Microalbumin/Creatinine Ratio, Random 140285 Turbidimetry, kinetic 10 mL random urine Urine collection Refrigerated Urine Minimum: 2 mL container Mineralocorticoid Pediatric Profile 500285 See individual assays 2.5 mL serum Red-top or gel-barrier Refrigerated (aldosterone; corticosterone; 18-OH- Minimum: 1.5 mL tube (same day) or corticosterone; deoxycorticosterone) frozen (Endocrine Sciences) NMR LipoProfile® 884247 Nuclear magnetic 2 mL plasma or NMR LipoTube® or Refrigerated resonance (NMR) serum (patient must red-top tube fast 12-14 hours) Minimum: 1 mL N-Telopeptide Cross-links, Serum 140830 EIA 0.5 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube N-Telopeptide Cross-links, Urine 141093 EIA 20 mL urine Transport tube Refrigerated Minimum: 1 mL

N-Telopeptide Cross-links, Urine (Serial 511097 EIA 20 mL urine Transport tube Refrigerated Monitor) Minimum: 1 mL N-Terminal Propeptide of Type 1 140850 RIA 0.5 mL serum Red-top or gel-barrier Refrigerated Procollagen, Intact Minimum: 0.4 mL tube Osmolality, Serum 002071 Freezing point 2 mL serum Red-top or gel-barrier Refrigerated depression Minimum: 0.2 mL tube Osmolality, Urine 003442 Freezing point 2 mL urine (random Urine collection Refrigerated depression or 24-hour) container (no Minimum: 0.2 mL preservative) Osteocalcin, Serum 010249 ELISA 0.8 mL serum Red-top or gel-barrier Frozen Minimum: 0.4 mL tube Pancreatic Polypeptide 146704 RIA 0.5 mL serum Red-top or gel-barrier Frozen Minimum: 0.3 mL tube Parathyroid Hormone (PTH), Intact 015610 ECLIA 0.8 mL plasma Lavender-top (EDTA) Refrigerated Minimum: 0.3 mL tube Parathyroid Hormone-related Peptide (PTH- 503380 ECL 1 mL plasma Lavender-top (EDTA) Frozen rp) (Endocrine Sciences) Minimum: 0.5 mL tube Phosphorus, Serum 001024 Colorimetry 1 mL serum Red-top or gel-barrier Ambient Minimum: 0.5 mL tube Phosphorus, Urine 003251 Colorimetry 10 mL aliquot of Urine container with Ambient entire collection 6N HCl preferred. Minimum: 0.5 mL Caution: Strong acid may cause skin burns. Potassium, Serum 001180 Ion-selective electrode 1 mL serum or Red-top, gel-barrier, or Ambient plasma green-top tube Minimum: 0.5 mL Pregnenolone, HPLC/MS-MS (Endocrine 140707 HPLC/MS-MS [after 2.5 mL serum Red-top or gel-barrier Refrigerated Sciences) extraction] Minimum: 1.1 mL tube (same day) or frozen Progesterone, LCMS (Endocrine Sciences) 500167 HPLC/MS-MS [after 1 mL serum Red-top or gel-barrier Ambient extraction] Minimum: 0.3 mL tube (same day) or frozen *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

10 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Proinsulin, ICMA (Endocrine Sciences) 500722 ICMA 1 mL plasma Lavender-top (EDTA) Refrigerated Minimum: 0.5 mL or green-top tube (same day) or frozen Prolactin With Dilution for Hook Effect 500557 ICMA 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) Minimum: 0.1 mL tube (same day) or frozen Prostate-specific Antigen 010322 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Protein Electrophoresis 001487 Electrophoresis 2 mL serum Red-top or gel-barrier Refrigerated Minimum: 1 mL tube Renal Panel (10) 322777 Automated 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube Renin Activity, Plasma, RIA (Endocrine 500458 RIA of angiotensin I 2 mL plasma in Lavender-top (EDTA) Frozen Sciences) generated at pH 5.5 at lavender-top tube multiple time points (EDTA) tube only . Collect 4 mL of blood in lavender- top venipuncture tube. Mix gently by inversion. Centrifuge immediately after collection. Minimum: 0.4 mL

Reverse T3, Serum 070104 HPLC/MS-MS 0.5 mL Serum Red-top tube or gel- Refrigerate Minimum: 0.3 mL barrier tube Rheumatoid Arthritis Factor 006502 Latex 1 mL serum or Red-top or gel-barrier Ambient immunoturbidimetry plasma /lavender-top (EDTA) Minimum: 0.5 mL tube Sedimentation Rate 005215 Westergren Filled tube whole Lavender-top (EDTA) Refrigerated blood tube Minimum: 2 mL Serotonin, Serum 120204 HPLC with 2 mL serum Red-top tube Frozen electrochemical Minimum: 1.5 mL detection Serotonin, Whole Blood 120089 HPLC with 10 mL whole blood Lavender-top (EDTA) Frozen electrochemical tube detection Sex Hormone-binding Globulin (SHBG) 500848 ECLIA 0.5 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) Minimum: 0.3 mL tube or frozen SHOX-DNA-Dx® (Endocrine Sciences) 500110 Mutation analysis 3 mL whole blood Lavender-top (EDTA) Ambient; do by PCR, DHPLC, and Minimum: 1 mL tube not freeze. sequencing as needed

Testosterone, Bioavailable, With SHBG and 500650 HPLC/MS-MS, 2 mL serum Red-top or gel-barrier Refrigerated Total Testosterone, HPLC/MS-MS (Endocrine ammonium sulfate Minimum: 0.6 mL tube or frozen Sciences) precipitation of SHBG- bound fraction, ECLIA Testosterone, Free With Total Testosterone, 500726 HPLC/MS-MS, 2 mL serum Red-top or gel-barrier Refrigerated Equilibrium Dialysis and HPLC/MS-MS equilibrium dialysis Minimum: 1 mL tube or frozen (Endocrine Sciences) Testosterone, Total, Women, Children, and 070001 HPLC/MS-MS 0.8 mL serum Red-top tube or gel- Refrigerated Hypogonadal Males, LC/MS-MS Minimum: 0.4 mL barrier tube Testosterone, Total, Serum 004226 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Thyroid Biopsy (Fine-needle Aspiration) 009001 Morphology Aspirated material Slide(s); coplin jar(s) Refrigerated *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

11 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Thyroglobulin, Comprehensive 500540 ICMA or double 5 mL serum Red-top or gel-barrier Refrigerated (With Anti-Tg Screen and Reflex to RIA) antibody RIA when Minimum: 2 mL tube (same day) or (Endocrine Sciences) anti-Tg antibodies are frozen Includes extended storage present Thyroglobulin With Antithyroglobulin 042100 Immunometric 3 mL serum Red-top or gel-barrier Refrigerated Antibody assay (IMA) and Minimum: 2 mL tube radioimmunoassay (RIA) Thyroid Antithyroglobulin Antibody 006692 ICMA 1 mL serum Red-top or gel-barrier Refrigerated tube Thyroid Cascade Profile 330015 ECLIA 2 mL serum Red-top or gel-barrier Refrigerated Minimum: 1 mL tube Thyroid Peroxidase (TPO) Antibodies 006676 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Thyroid-stimulating Immunoglobulin (TSI) 140749 Chinese hamster ovary 3 mL serum Red-top or gel-barrier Refrigerated cell line transfected with Minimum: 0.3 mL tube thyrotropin re­­cep­tor and luciferase reporter gene (Thyretain™)

Thyroid-stimulating Hormone (TSH) 004259 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube TSH Antibody (TRAb/TBII), RRA 500538 Binding inhibition assay 1 mL serum Red-top or gel-barrier Refrigerated (Endocrine Sciences) Minimum: 0.3 mL tube or frozen

Thyroxine (T4) 001149 CEDIA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube

Thyroxine (T4), Free, Dialysis and HPLC/MS- 501902 Direct dialysis and HPLC/ 1mL serum Red-top tube Refrigerated MS (Endocrine Sciences) MS-MS Minimum: 0.4 mL or frozen

Thyroxine (T4), Free, Direct 001974 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Thyroxine-binding Globulin (TBG), Serum 001735 ICMA 0.5 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube Tissue Transglutaminase (tTG), IgG 164988 EIA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.5 mL tube

Triiodothyronine (T3) Uptake 001156 CEDIA 1 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube

Triiodothyronine (T3), Free 010389 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube

Triiodothyronine, Free (FT3), Dialysis and 503600 HPLC/MS-MS 1.0 mL serum Red-top or gel-barrier Refrigerated LC/MS-MS Minimum: 0.3 mL tube or frozen Urinalysis, Routine 003038 Reagent strip 10 mL random urine Routine urinalysis Refrigerated Minimum: 2 mL tube Vanillylmandelic Acid, 24-hour Urine 004143 HPLC/MS-MS 30 mL 24-hour urine Urine collection Ambient Minimum: 1 mL container VAP® Cholesterol Profile 804500 Vertical density-gradient 2 mL serum Gel-barrier tube Refrigerated ultracentrifugation Minimum: 1 mL or frozen Vasoactive Intestinal Polypeptide 010397 RIA 2 mL plasma with Lavender-top (EDTA) Frozen Trasylol® tube Minimum: 0.4 mL Vitamin A 017509 HPLC with UV detection 2 mL serum Red-top or gel-barrier Refrigerated; Minimum: 0.6 mL tube; amber plastic protect transport tube with specimen amber top from light.

Vitamin B12 001503 ECLIA 0.8 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

12 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Test Name Test N° Methodology Specimen Container Storage*

Vitamin D, 25-Hydroxy by ICMA 081950 ICMA 0.5 mL serum Red-top or gel-barrier Refrigerated Minimum: 0.3 mL tube or frozen

Vitamin D, 25-Hydroxy, Frac­tionated D2 + 500116 HPLC/MS-MS 1 mL serum Red-top or gel-barrier Refrigerated D3, HPLC-MS/MS (Endocrine Sciences) Minimum: 0.5 mL tube or frozen Vitamin E, Serum 081000 HPLC with fluorometric 2 mL serum Red-top or gel-barrier Refrigerated; detection Minimum: 0.6 mL tube; amber plastic protect transport tube with specimen amber top from light. *Storage information is based on recommended temperatures while specimen is waiting to be picked up or transported to LabCorp.

†This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

13 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Index to Procedures by Disease State

ACTH Stimulation Amenorrhea – Primary 500171 11-Deoxycortisol, HPLC/MS-MS (Endocrine Sciences) 500163 17α-OH Progesterone, HPLC/MS-MS (Endocrine Sciences) 140715 17-OH Pregnenolone, HPLC/MS-MS (Endocrine Sciences) 005009 CBC With Differential With Platelet Count 500163 17-OH Progesterone, Serum, HPLC/MS-MS (Endocrine 052019 Chromosome Analysis, Blood (Constitutional) Sciences) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), 500467 Aldosterone, HPLC/MS-MS (Endocrine Sciences) HPLC/MS-MS (Endocrine Sciences) 500152 Androstenedione, HPLC/MS-MS (Endocrine Sciences) 500108 Estradiol, HPLC/MS-MS (Endocrine Sciences) 005009 CBC With Differential With Platelet Count 004309 Follicle-stimulating Hormone (FSH) 500154 Cortisol, Serum, HPLC/MS-MS (Endocrine Sciences) 004283 Luteinizing Hormone (LH) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), 322000 Metabolic Panel, Comprehensive (14) HPLC/MS-MS (Endocrine Sciences) 500557 Prolactin With Dilution for Hook Effect (Endocrine 500167 Progesterone, HPLC/MS-MS (Endocrine Sciences) Sciences) 070001 Testosterone, Total, Women, Children, and 070001 Testosterone, Total, Women, Children, and Hypogonadal Males, HPLC/MS-MS Hypogonadal Males, HPLC/MS-MS Adrenarche – Premature 004259 Thyroid-stimulating Hormone (TSH) 500163 17α-OH Progesterone, HPLC/MS-MS (Endocrine 001974 Thyroxine (T4) Free, Direct Sciences) Amenorrhea – Secondary (Without Hirsutism) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), 004416 β-hCG HPLC/MS-MS (Endocrine Sciences) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), 001818 Glucose, Fasting HPLC/MS-MS (Endocrine Sciences) 004333 Insulin, Fasting 500108 Estradiol, HPLC/MS-MS (Endocrine Sciences) 070001 Testosterone, Total, Women, Children, and 500726 Testosterone, Free With Total Testosterone, Hypogonadal Males, HPLC/MS-MS Equilibrium Dialysis and, HPLC/MS-MS (Endocrine 500726 Testosterone, Free With Total Testosterone, Sciences) Equilibrium Dialysis and, HPLC/MS-MS (Endocrine 004309 Follicle-stimulating Hormone (FSH) Sciences) 004283 Luteinizing Hormone (LH) Addison’s Disease 500557 Prolactin With Dilution for Hook Effect (Endocrine 004440 Adrenocorticotropic Hormone Sciences) 500092 Adrenal 21-Hydroxylase Autoantibodies (Endocrine 070001 Testosterone, Total, Women, Children, and Sciences) Hypogonadal Males, HPLC/MS-MS 500467 Aldosterone, HPLC/MS-MS (Endocrine Sciences) 330015 Thyroid Cascade Profile (TSH is tested first; abnormals 500154 Cortisol, Serum, HPLC/MS-MS (Endocrine Sciences) are reflexed.) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), Congential Adrenal Hyperplasia (CAH) HPLC/MS-MS (Endocrine Sciences) 500171 11-Deoxycortisol, HPLC/MS-MS (Endocrine Sciences) 081893 Free Fatty Acids (Nonesterified Free Fatty Acids) 140715 17-Hydroxypregnenolone, HPLC/MS-MS (Endocrine 322000 Metabolic Panel, Comprehensive (14) Sciences) 500548 Plasma Renin Activity (Endocrine Sciences) 500163 17α-OH Progesterone, HPLC/MS-MS (Endocrine Sciences) 500152 Androstenedione, HPLC/MS-MS (Endocrine Sciences) 500768 CAHDetx™, PCR (Endocrine Sciences) 500410 Cortisol, Free, Urinary Free, HPLC/MS-MS With Free Cortisol/Creatinine Ratio (Endocrine Sciences) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), HPLC/MS-MS (Endocrine Sciences) 500726 Testosterone, Free With Total Testosterone, Equilibrium Dialysis and, HPLC/MS-MS (Endocrine Sciences)

14 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Index to Procedures by Disease State

Cushing’s Syndrome Failure to Thrive 004440 Adrenocorticotropic Hormone 006627 C-Reactive Protein 500467 Aldosterone, HPLC/MS-MS (Endocrine Sciences) 005009 CBC With Differential With Platelet Count 500410 Cortisol, Free, Urinary Free, HPLC/MS-MS With Free 165142 Celiac Disease Profile Cortisol/Creatinine Ratio (Endocrine Sciences) 500644 Insulin-like Growth Factor Binding Protein 3 (IGFBP-3), 500179 Cortisol, Salivary (Endocrine Sciences) RIA (Endocrine Sciences) 501597 Cortisol, Salivary (Timed Specimen) (Endocrine 500485 Insulin-like Growth Factor-1 (IGF1), RIA After Sciences) Extraction (Endocrine Sciences) 500154 Cortisol, Serum, HPLC/MS-MS (Endocrine Sciences) 322000 Metabolic Panel, Comprehensive (14) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), 005199 Prothrombin Time (Proxy for Vitamin K) HPLC/MS-MS (Endocrine Sciences) 005215 Sedimentation Rate 001818 Glucose, Fasting 004259 Thyroid-stimulating Hormone (TSH) 070001 Testosterone, Total, Women, Children, and 001974 Thyroxine (T ) Free, Direct Hypogonadal Males, HPLC/MS-MS 4 003038 Urinalysis, Routine Dexamethasone Suppression Test 017509 Vitamin A 004440 Adrenocorticotropic Hormone 001503 Vitamin B12 500410 Cortisol, Free, Urinary Free, HPLC/MS-MS With Free Cortisol/Creatinine Ratio (Endocrine Sciences) 081000 Vitamin E 500179 Cortisol, Salivary (Endocrine Sciences) Gynecomastia 500154 Cortisol, Serum, HPLC/MS-MS (Endocrine Sciences) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), HPLC/MS-MS (Endocrine Sciences) 500118 Dexamethasone, HPLC/MS-MS (Endocrine Sciences) 500108 Estradiol, HPLC/MS-MS (Endocrine Sciences) 500161 Dehydroepiandrosterone Sulfate (DHEA-S), HPLC/MS-MS (Endocrine Sciences) 500634 Estrone, HPLC/MS-MS (Endocrine Sciences) 303754 Electrolytes (Baseline Only) 004309 Follicle-stimulating Hormone (FSH) 070001 Testosterone, Total, Women, Children, and 004283 Luteinizing Hormone (LH) Hypogonadal Males, HPLC/MS-MS 322000 Metabolic Panel, Comprehensive (14) Diabetes 500726 Testosterone, Free With Total Testosterone, 141531 Anti-islet Cell Antibodies (ICA-512) (Endocrine Equilibrium Dialysis and, HPLC/MS-MS (Endocrine Sciences) Sciences) 160721 Antipancreatic Islet Cell 330015 Thyroid Cascade Profile (TSH is tested first; abnormals are reflexed.) 500642 C-Peptide, ICMA (Endocrine Sciences) hCG Stimulation 500597 Diabetes Autoimmune Profile (Endocrine Sciences) 500183 Anti-Mullerian Hormone - Pretest (Endocrine 100800 Fructosamine Sciences) 143008 GAD 65 Autoantibody (Glutamic Acid Decarboxylase 500142 Dihydrotestosterone, HPLC/MS-MS - Pretest/Posttest Autoantibodies) (Endocrine Sciences) 001693 Glycohemoglobin,Total 500108 Estradiol, HPLC/MS-MS (Endocrine Sciences) 500115 GlycoMark® (Endocrine Sciences) 502280 Follicle-stimulating Hormone - Posttest Only 001453 Hemoglobin A1c (Endocrine Sciences) 140822 Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), 502286 Luteinizing Hormone - Posttest Only (Endocrine RIA (Endocrine Sciences) Sciences) 141598 Insulin Antibodies (Endocrine Sciences) 070001 Testosterone, Total, Women, Children, and Hypogonadal Males, HPLC/MS-MS 004333 Insulin, Fasting 004259 Thyroid-stimulating Hormone - Pretest 140285 Microalbumin/Creatinine Ratio 001974 Thyroxine (T ), Free, Direct - Pretest 500722 Proinsulin, ICMA (Endocrine Sciences) 4

15 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Index to Procedures by Disease State

Hirsutism Hyperthyroidism Follow-Up 500163 17α-OH Progesterone, HPLC/MS-MS (Endocrine 005009 CBC With Differential With Platelet Count Sciences) 322755 Liver Function Panel 500161 Dehydroepiandrosterone Sulfate (DHEA-S), 006676 Thyroid Peroxidase Antibodies (TPO) HPLC/MS-MS (Endocrine Sciences) 501902 Thyroxine (T ), Free, Dialysis and, HPLC/MS-MS 004465 Prolactin With Dilution (Endocrine Sciences) 4 (Endocrine Sciences) 070001 Testosterone, Total, Women, Children, and 500538 TSH Receptor Antibody (TRAb/TBII), RRA (Endocrine Hypogonadal Males, HPLC/MS-MS Sciences) 500726 Testosterone, Free With Total Testosterone, 004259 Thyroid-stimulating Hormone (TSH) Equilibrium Dialysis and, HPLC/MS-MS (Endocrine Sciences) Hypocalcemia 330015 Thyroid Cascade Profile (TSH is tested first; abnormals 001107 Alkaline Phosphatase are reflexed.) 001016 Calcium Hypercalcemia 500600 Calcitriol (1,25 di-OH Vitamin D) Fractionated D2 + D3, 001107 Alkaline Phosphatase HPLC/MS-MS (Endocrine Sciences) 001016 Calcium 322000 Metababolic Panel, Comprehensive (14) 003269 Calcium, 24-hour Urine 015610 Parathyroid Hormone (PTH), Intact 001453 Hemoglobin A1c 001024 Phosphorous 004333 Insulin, Fasting Hypothyroidism 322000 Metabolic Panel, Comprehensive (14) 006692 Thyroid Antithyroglobulin Antibody 500458 Renin Activity, Plasma, RIA (Endocrine Sciences) 006676 Thyroid Peroxidase Antibodies (TPO) 003038 Urinalysis, Routine 004259 Thyroid-stimulating Hormone (TSH)

Hypertension and Cardiovascular Risk 501902 Thyroxine (T4), Free, Dialysis and, HPLC/MS-MS (Endocrine Sciences) 500467 Aldosterone, HPLC/MS-MS (Endocrine Sciences) 500760 Aldosterone, Urine, With Aldosterone/Creatinine Ratio Obesity (Endocrine Sciences) 006627 C-Reactive Protein 140889 B-Type Natriuretic Peptide 005009 CBC With Differential With Platelet Count 084152 Catecholamines, Fractionated Plasma 001818 Glucose, Fasting 004176 Catecholamines, Fractionated, Urinary Free, 24-hour 001453 Hemoglobin A1c Urine 004333 Insulin, Fasting 140848 Chromogranin A 500716 Leptin (Endocrine Sciences) 120766 C-Reactive Peptide, Cardiac 303756 Lipid Panel (total cholesterol, HDL, LCL [calc], TG, VLDL 121806 Metanephrines, Fractionated, Plasma, Free [calc]) 004234 Metanephrines, Fractionated, 24-hour Urine 322000 Metabolic Panel, Comprehensive (14) 884247 NMR LipoProfile® 500726 Testosterone, Free With Total Testosterone, 500548 Renin Activity, Plasma, RIA (Endocrine Sciences) Equilibrium Dialysis and, HPLC/MS-MS (Endocrine Sciences) 004143 Vanillylmandelic Acid, 24-hour Urine 004259 Thyroid-stimulating Hormone (TSH) Hyperthyroidism 501902 Thyroxine (T4), Free, Dialysis and, HPLC/MS-MS 005009 CBC With Differential With Platelet Count (Endocrine Sciences) 322755 Liver Function Panel 003038 Urinalysis, Routine 140749 Thyroid-stimulating Immunoglobulin (TSI)

501902 Thyroxine (T4), Free, Dialysis and, HPLC/MS-MS (Endocrine Sciences)

001149 Thyroxine (T4), Total

002188 Triiodothyronine (T3), Total 500538 TSH Receptor Antibody (TRAb/TBII), RRA (Endocrine Sciences)

16 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Index to Procedures by Disease State

Osteoporosis Precocious Puberty 513002 Alkaline Phosphatase, Bone-specific 004416 β-hCG (Boys) 001016 Calcium, Serum 500161 Dehydroepiandrosterone Sulfate (DHEA-S), HPLC/MS-MS (Endocrine Sciences) 500089 C-Telopeptide, Serum (Endocrine Sciences) 500108 Estradiol, HPLC/MS-MS (Females) (Endocrine 511105 Deoxypyridinoline (Dpd) Crosslinks (Serial Monitor) Sciences) 140830 N-Telopeptide Cross-links, Serum 502280 Follicle-stimulating Hormone, Pediatric [basal or after 010249 Osteocalcin, Serum GnRH stimulation] (Endocrine Sciences) 001024 Phosphorous 502286 Luteinizing Hormone, Pediatric [basal or after GnRH 500116 Vitamin D, 25-Hydroxy, Fractionated D2 + D3, stimulation] (Endocrine Sciences) HPLC/MS-MS (Endocrine Sciences) 070001 Testosterone, Total, Women, Children, and Hypogonadal Males, HPLC/MS-MS Pituitary 004440 Adrenocorticotropic Hormone Short Stature 140269 α-Subunit, Free (Endocrine Sciences) 005009 CBC With Differential With Platelet Count 004309 Follicle-stimulating Hormone (FSH) 165142 Celiac Disease Profile 500632 Growth Hormone, RIA (Endocrine Sciences) 052019 Chromosome Analysis, Blood (Constitutional) 500485 Insulin-like Growth Factor-1 (IGF1), RIA After 500144 Growth Hormone Antibodies (Endocrine Sciences) Extraction (Endocrine Sciences) 500632 Growth Hormone, RIA (Endocrine Sciences) 004283 Luteinizing Hormone (LH) 500177 Growth Hormone-binding Protein (Endocrine 500324 Macroprolactin (Endocrine Sciences) Sciences) 004259 Thyroid-stimulating Hormone (TSH) 500485 Insulin-like Growth Factor-1 (IGF1), RIA After Extraction (Endocrine Sciences) Polycystic Ovarian Syndrome 500644 Insulin-like Growth Factor Binding Protein 3 (IGFBP-3), 500163 17α-OH Progesterone, HPLC/MS-MS (Endocrine RIA (Endocrine Sciences) Sciences) 164830 Inflammatory Bowel Disease (IBD) Profile 500881 Androstanediol Glucuronide, HPLC/MS-MS (Endocrine 322000 Metabolic Panel, Comprehensive (14) Sciences) 005215 Sedimentation Rate 500152 Androstenedione, HPLC/MS-MS (Endocrine Sciences) 500110 SHOX-DNA-Dx® 500161 Dehydroepiandrosterone Sulfate (DHEA-S), HPLC/MS-MS (Endocrine Sciences) 004259 Thyroid-stimulating Hormone (TSH) 004309 Follicle-stimulating Hormone (FSH) 001974 Thyroxine (T4) Free, Direct 001818 Glucose, Fasting 003038 Urinalysis, Routine 004333 Insulin, Fasting Thyroid Cancer 004283 Luteinizing Hormone (LH) 500540 Thyroglobulin, Comprehensive (With Anti-Tg Screen 303756 Lipid Panel (total cholesterol, HDL, LDL [calc], TG, and Reflex to RIA) (Endocrine Sciences) VLDL [calc]) 504008 MEN2: RET Gene Sequencing 500557 Prolactin With Dilution for Hook Effect (Endocrine 504009 RET Gene Single Known Mutation Sciences) Water Balance 070001 Testosterone, Total, Women, Children, and Hypogonadal Males, HPLC/MS-MS 010447 Antidiuretic Hormone (ADH), Plasma 004259 Thyroid-stimulating Hormone (TSH) 001016 Calcium, Serum

001974 Thyroxine (T4), Free, Direct 303754 Electrolytes 002071 Osmolality, Plasma 003442 Osmolality, Urine 001024 Phosphorous

17 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Multiple Sample/Timed-specimen Testing 2 3 4 5 6 7 8 Individual Specimens Specimens Specimens Specimens Specimens Specimens Specimens Test Name Test N° Test N° Test N° Test N° Test N° Test N° Test N° Test N° Adrenocorticotropic Hormone (ACTH), Plasma 004440 225250 038927 225268 038919 225276 038901 267708 (Timed Sepcimens) Aldosterone (Timed Specimens) 004374 237537 053272 361626 271190 015795 015796 010848 Calcitonin (Timed Specimens) 004895 048249 026781 026799 026807 026815 015797 019845 C-Peptide (Timed Specimens) 010108 143302 143333 143324 015798 319609 015801 015804 Dehydroepiandrosterone (DHEA) (Timed Specimens) 004100 231819 231821 231822 231823 231824 231825 231826 Dehydroepiandrosterone Sulfate (DHEA-S) 004020 144691 146315 146316 146317 146318 146319 146321 (Timed Specimens) Gastrin (Timed Specimens) 004390 208827 038745 039438 038752 204644 034934 211268 Insulin (Timed Specimens) 004333 146902 146993 147074 147165 147256 147397 014319 Renin (Timed Specimens) 002006 053686 038695 049510 038703 049528 091173 091181 Salivary Cortisol, MS (Endocrine Sciences) 500179 502120 502122 502124 503775 503776 503777 N/A (Timed Specimens)

Stimulation Testing (each timepoint ordered individually) Refer to LabCorp Stimulation Testing Requisition (3900) for additional information Timepoint Timepoint Timepoint Timepoint Timepoint Timepoint Timepoint Timepoint #1 #2 #3 #4 #5 #6 #7 #8 Test Name Test N° Test N° Test N° Test N° Test N° Test N° Test N° Test N° 11-Desoxycortisol, HPLC/MS-MS (Endocrine Sciences) 502841 502842 502843 502854 502835 502836 502847 502848 17a-Hydroxypregnenolone, HPLC/MS-MS 502799 502800 502802 502804 502805 502806 502807 502808 (Endocrine Sciences) 17-OH Progesterone, Serum, HPLC/MS-MS 502770 502772 502779 502784 502785 502795 502787 502791 (Endocrine Sciences) Adrenocorticotropic Hormone (ACTH), Plasma 503861 503862 503863 (Endocrine Sciences) Aldosterone, HPLC/MS-MS (Endocrine Sciences) 503871 503872 503873 Androstenedione, HPLC/MS-MS (Endocrine Sciences) 502851 502852 502863 502864 502865 502866 502868 502860 Cortsiol, Serum, HPLC/MS-MS (Endocrine Sciences) 503021 503022 503023 503024 503025 503026 503027 503028 Deoxycorticosterone (DOC), Serum (Endocrine Sciences) 502950 502952 502953 502954 502955 502958 502962 502965 Dehydroepiandrosterone (DHEA), Serum 502901 502902 502903 502904 502905 502906 502907 502908 (Endocrine Sciences) Dihydrotestosterone (DHT) (Endocrine Sciences) 503111 503112 503113 503114 503115 503116 503117 503118 Estradiol, HPLC/MS-MS (Endocrine Sciences) 502970 502972 502973 502974 502975 502976 502977 502978 Follicle-stimulating Hormone (FSH), Pediatric 502655 502657 502660 502694 502696 502697 502698 502699 (Endocrine Sciences) Glucose, Serum (Endocrine Sciences) 503451 503454 503457 503463 503466 503470 503472 503476 Growth Hormone, RIA (Endocrine Sciences) 503031 503032 503033 503034 503035 503036 503038 503039 Insulin-like Growth Factor Binding Protein 3 (IGFBP-3), 502881 502882 502883 502884 502885 502886 502887 502888 RIA (Endocrine Sciences) Insulin-like Growth Factor-1 (IGF1), RIA After Extraction 502700 502709 502711 502719 502715 502720 502729 502730 (Endocrine Sciences) Luteinizing Hormone (LH), Pediatric (Endocrine Sciences) 502649 502650 502653 502739 502733 502740 502741 502731 Pregnenolone, HPLC/MS-MS (Endocrine Sciences) 503071 503072 503073 503074 503075 503076 503077 503078 Progesterone, HPLC/MS-MS (Endocrine Sciences) 502760 502742 502763 502734 502735 502766 502767 502768 Testosterone, HPLC/MS-MS (Endocrine Sciences) 502643 502645 502647 502824 502825 502826 502837 502838

Glucose Tolerance Testing (GTT) Test N° Test Name Timepoint #1 Timepoint #2 Timepoint #3 Timepoint #4 Timepoint #5 102004 Gestational Glucose Tolerance Diagnostic Test Glucose, Glucose, Glucose, Glucose, N/A (3 hour, ACOG 2011 Recommendations) fasting baseline 1 hour 2 hour 3 hour 101000 Gestational Glucose Tolerance Screening and Diagnostic Test Glucose, Glucose, Glucose, N/A N/A (2 hour, ADA 2011 Standards) fasting baseline 1 hour 2 hour 101200 Glucose Tolerance Test (GTT), Two-Hour (Oral WHO Protocol) Glucose, Glucose, N/A N/A N/A fasting baseline 2 hour 090373 Glucose Tolerance Test (GTT), Blood, 5 Specimens Glucose, Glucose, Glucose, Glucose, Glucose, fasting baseline 30 minutes 1 hour 2 hour 3 hour

18 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

R Send additional copy of report to: E Fax

Endocrinologist Services 8210002648 Q () U Call Client Number/Physician’s Name Phone/Fax Number E Mail S Physician’s Address City, State, Zip 3800.18 T E D

B 1A Y 1A

1B 1B

Patient’s Legal Name (Last, First, MI) Sex Date of Birth Collection Time Fasting Collection Date Urine hrs/vol MO DAY YR AM Yes MO DAY YR 1C : 1C PM No hrs vol NPI UPIN Physician’s ID # Patient’s SS # Patient’s ID #

Physician’s Name (Last, First) Physician/Authorized Signature Hospital Patient Status: In-Patient Out-Patient Non-Patient P X L Diagnosis/Signs/Symptoms in ICD-CM format in effect at Date of Service Patient’s Address Phone E Highest Specificity A City State ZIP S REQUIRED PATIENT E PRIMARY BILLING PARTY SECONDARY BILLING PARTY Name of Policy Holder (if different from patient) Insurance Carrier * Insurance Carrier * P Address of Policy Holder APT # R ID # ID # I City State ZIP

RESP. PARTY N Group # Group # I hereby authorize the release of medical information related to the service described herein and authorize payment directly to LabCorp. T I agree to assume responsibility for payment of charges for laboratory services that are not covered by my healthcare insurer. Insurance Address Insurance Address X Name of Insured Person Name of Insured Person Patient’s Signature Date MEDICARE ADVANCE BENEFICIARY NOTICE OF NONCOVERAGE (ABN) Relationship to Patient Relationship to Patient Refer to Determining Necessity of ABN Completion on reverse. Employer Name Employer Name OTHER TESTS / INDIVIDUAL PROFILE COMPONENTS *If Medicaid State Physician’s Provider # Workers Comp TEST # TEST NAMES Yes No ITEM # 052362 FORM # 3800 LABCORP/ESOTERIX

Serial Collection Date Collection Time P Samples MO DAY YR L 1 / / E 2 / / A 3 / / S 4 / / E 5 / / P 6 / / Use Serial Sample Test Numbers Only R and Label Tubes Appropriately I

8210002648 ©2013, RR Donnelley. All rights reserved. - 0667 INDIVIDUAL COMPONENTS OF TEST COMBINATIONS / PROFILES LISTED IN THE SECTION ABOVE CAN BE ORDERED ABOVE (plus sign) = Tests Performed at Endocrine Sciences N BURLINGTON, NC 27216 + DIABETES con’t PARATHYROID, CALCIUM, AND BONE con’t THYROID con’t T *+ ROUTINE - See Reverse 500115 GlycoMark 84378 GEL 015610 Parathyroid Hormone (PTH), Intact 83970 LAV 503600 T3, Free by Dialysis & MS+ 84481 RED  *+ 83036 005009 CBC w Differential w Platelet 85025 LAV 502226 A1c+Glycomark Profile 84378 GEL+LAV 500600 Vitamin D, 1, 25-Dihydroxy+ 82652 GEL 010389 Triiodothyronine (T3), Free 84481 GEL BBF Solutions Printing 028142 CBC w/o Differential w Platelet 85027 LAV 001453 Hemoglobin A1c 83036 LAV 081950 Vitamin D, 25-OH by ICMA 82306 GEL 002188 Triiodothyronine (T3), Total 84480 GEL + 303754 Electrolyte Panel 80051 GEL 140822 IGF Binding Protein-1 83519 GEL 500116 Vitamin D, 25-OH, Frac. by MS+ 82306 GEL 006676 TPO Antibodies 86376 GEL + + 322755 Hepatic Function Panel (7) 80076 GEL 141598 Insulin Antibodies 86337 GEL REPRODUCTIVE AND SEXUAL MATURATION 500538 TSH Receptor Ab 83519 GEL OTHER 303756 Lipid Panel 80061 GEL 004333 Insulin, Fasting 83525 RED 500152 Androstenedione by MS+ 82157 RED 82043 001362 Creatine Kinase, Total, Serum 82550 GEL 235010 Lipid Panel w LDL/HDL Ratio 80061 GEL 140095 Microalbumin/Creat. Ratio, Urine Timed URN 82570 004416 β-hCG Subunit, Qnt. 84702 GEL 003012 Creatinine, 24-Hr Urine 82570 URN 82043 URN 322758 Metabolic Panel, Basic (8) 80048 GEL 140285 Microalbumin/Creatinine Ratio, Urine 82570 500142 Dihydrotestosterone (DHT) by MS+ 82651 GEL 003004 Creatinine Clearance 82575 GEL+URN 322000 Metabolic Panel, Comp. (14) 80053 GEL GROWTH 500108 Estradiol by MS+ 82670 GEL 001370 Creatinine, Serum 82565 GEL 322777 Renal Panel (10) 80069 GEL 500647 Growth Hormone, ICMA+ 83003 GEL 004515 Estradiol by ECLIA 82670 GEL 004598 Ferritin, Serum 82728 GEL 001321 Iron and TIBC 83550 GEL 005215 Sed Rate, Westergren 85652 LAV 500644 IGF Binding Protein-3+ 83519 GEL 004309 FSH 83001 GEL 83540 001537 Magnesium, Serum 83735 GEL 003038 Urinalysis, Routine 81003 URN 500485 IGF-I by blocking RIA+ 84305 GEL + 502280 FSH, Pediatric 83001 GEL 001024 Phosphorus, Serum 84100 GEL Holdings ADRENAL HYPERTENSION AND CARDIOVASCULAR 004283 LH 83002 GEL 001180 Potassium, Serum 84132 GEL  140715 17-OH Pregnenolone by MS+ 84143 GEL 500467 Aldosterone+ 82088 GEL 502286 LH, Pediatric+ 83002 GEL 010322 Prostate-Specific Antigen (PSA) 84153 GEL 001503 Vitamin B 82607 GEL 500163 17-OH Progesterone by MS+ 83498 GEL 084152 Catecholamines, Frac., Plasma 82384 LAV 500557 Prolactin, with dilution+ 84146 GEL 12 LAV PROFILES - See Reverse 004440 ACTH, Plasma 82024 004176 Catecholamines, Frac., Free, 24-Hr. 82384 URN 500848 SHBG by IRMA+ 84270 GEL + 82530 URN 501064 Amenorrhea Test Profile+ GEL 500410 Cortisol, Free, 24-Hr. Urine by MS 82570 RED + see 120766 C-Reactive Protein, Cardiac 86141 500650 Testosterone, Bio. by MS (w SHBG) reverse GEL + 500179 Cortisol, Salivary (1 specimen)+ 82533 SAL 500175 CAH Pediatric Profile 6 RED 121806 Metanephrines, Frac., Plasma Free 83835 LAV 500726 Testosterone, Free (w Total) by MS+ 84403 GEL Cortisol, Salivary Timepoints - see reverse SAL 84402 165142 Celiac Disease Test Profile GEL 004234 Metanephrines, Frac., Qnt., 24-Hr. 83835 URN 500159 Testosterone, Total by MS+ 84403 GEL 500154 Cortisol, Serum by MS+ 82533 GEL 500597 Diabetes Autoimmune Test Profile+ GEL 884247 NMR LipoProfile® 80061 NMR 004226 Testosterone, Total by ECLIA 84403 004051 Cortisol, Serum by ECLIA 82533 RED 83704 GEL 500066 Hirsutism Test Profile+ GEL + LAV 500156 DHEA by MS+ 82626 GEL 500458 Renin Activity, Plasma 84244 THYROID 500757 Islet Cell Dysfunction Test Profile+ GEL + GEL PARATHYROID, CALCIUM, AND BONE 84432 + 500161 DHEA-S by MS 82627 500540 Comp. Thyroglobulin (1 yr storage)+ 86800 GEL 501218 Menopausal Test Profile I GEL 500167 Progesterone by MS+ 84144 GEL 513002 Bone-specific Alk. Phosphatase 84080 GEL 006692 Thyroglobulin Ab (Anti-Tg) 86800 GEL 501048 Testicular Function Test Profile+ GEL DIABETES 004895 Calcitonin, Serum 82308 GEL 042100 Thyroglobulin Reflex Profile 86800 GEL 009001 Thyroid Biopsy (Fine-Needle Aspiration) FNA 503830 C-Peptide, Ultrasensitive+ 84681 GEL 003269 Calcium, 24-Hr. Urine 82340 URN 140749 Thyroid-stimulating Immunoglobulin 84445 GEL 330015 Thyroid Cascade Profile GEL

(REV 10/30/2013) 100800 Fructosamine 82985 LAV 004804 Calcium, Ionized, Serum 82330 GEL 004259 Thyroid-stimulating Hormone (TSH) 84443 GEL Clinical Information/Comments

© 2013 Laboratory Corporation of America + 500611 GAD-65 Autoantibodies 83519 GEL 001016 Calcium, Serum 82310 GEL 001149 Thyroxine (T4) 84436 GEL ORIGINAL-LABORATORY / COPY-CLIENT 8210002648 82523 001818 Glucose, Plasma 82947 GRY 141093 N-Telopeptide, Urine 82570 URN 001974 Thyroxine (T4) Free, Direct 84439 GEL GEL 001693 Glycohemoglobin (GHb), Total 83036 LAV 010249 Osteocalcin, Serum 83937 501902 Thyroxine (T4), Free by Dialysis & MS+ 84439 RED NOTE: WHEN ORDERING TESTS FOR WHICH MEDICARE OR MEDICAID REIMBURSEMENT WILL BE SOUGHT, PHYSICIANS SHOULD ONLY ORDER TESTS THAT ARE MEDICALLY NECESSARY FOR THE DIAGNOSIS OR TREATMENT OF THE PATIENT. COMPONENTS OF THE ORGAN OR DISEASE PANELS/COMBINATIONS PRINTED ABOVE ARE SHOWN ON THE REVERSE SIDE AND MAY ALSO BE ORDERED INDIVIDUALLY ABOVE. COMPONENTS MAY BE BILLED SEPARATELY PER CARRIER POLICY.

Endocrinologist Services Test Request Form

19 PROCEDURES FOR THE ENDOCRINOLOGIST: A CLINICAL TEST COMPENDIUM

Abbreviations

AAS Atomic absorption spectrometry IFE Immunofixation ACD Acid citrate dextrose IGF-I Insulin-like growth factor I ACTH Adrenocorticotropic Hormone IRMA Immunoradiometric AMH Anti-Mullerian hormone ISE Ion-selective electrode AMP Adenosine monophosphate LCMS Liquid chromatography/tandem mass spectrometry CAH Congenital adrenal hyperplasia LDL Low-density lipoprotein CBG Corticosteroid-binding globulin LH Luteinizing hormone CEA Carcinoembryonic antigen MEN Multiple endocrine neoplasia CEDIA Cloned enzyme donor immunoassay MS-MS Tandem mass spectroscopy DHEA Dehydroepiandrosterone MSH Melanocyte-stimulating Hormone DHEA-S Dehydroepiandrosterone sulfate NEFA Nonesterified free fatty acids DHT Dihydrotestosterone NMR Nuclear magnetic resonance DOC Deoxycorticosterone NTx N-Telopeptide cross-links ECL Electrochemiluminescence PEG Polyethylene glycol ECLIA Electrochemiluminescence immunoassay PRP Platelet-rich plasma EDTA Ethylenediaminetetraacetic acid PSA Prostate-specific antigen EIA Enzyme immunoassay PTH Parathyroid hormone ELISA Enzyme-linked immunosorbent assay PTH-rp Parathyroid hormone-related peptide EPO Erythropoietin RET Rearranged during transfection FISH Fluorescence in situ hybridization RIA Radioimmunoassay FSH Follicle-stimulating hormone SHBG Sex hormone-binding globulin GAD Glutamic acid decarboxylase autoantibodies SHOX Short stature GHB Glycohemoglobin TBG Thyroxine-binding globulin GHBP Growth Hormone-binding protein TBII Thyrotropin-binding inhibitory immunoglobulin GnRH Gonadotropin-releasing hormone TIBC Total iron-binding capacity hCG Human chorionic gonadotropin TPO Thyroid peroxidase antibodies HDL High-density lipoprotein TRAb Thyroid receptor antibody HIAA 5-Hydroxyindoleacetic acid TSH Thyroid-stimulating hormone HPLC High-pressure liquid chromatography TSI Thyroid-stimulating immunoglobulin IBD Inflammatory bowel disease VAP Vasoactive intestinal polypeptide ICA Islet cell antibodies VAP Vertical auto profile ICMA Immunochemiluminometric assay VLDL Very low-density lipoprotein IFA Indirect fluorescent antibody VMA Vanillylmandelic acid

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