DOCSLIB.ORG

Supreme Court of the United States

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Supreme Court of the United States No. 19- In THE Supreme Court of tljr United Staten KANEKA CORPORATION, Petitioner, v. XIAMEN KINGDOMWAY GROUP COMPANY, PACIFIC RAINBOW INTERNATIONAL INC., Respondent. On Petition for Writ of Certiorari to the United States Court of Appeals for the Federal Circuit SUPPLEMENTAL APPENDIX Keith D. Nowak Counsel of Record William F. Sondericker Gerald W. Griffin Carter Ledyard & Milburn LLP Two Wall Street New York, New York 10005 (212) 732-3200 [email protected] Counsel for Petitioner fV/ED 291472 $ COUNSEL PRESS mlVSS& (800)274-3321 • (800)359-6859 I TABLE OF CONTENTS Page U.S. PATENT NO. 7,910,340 (’340 PATENT), WITH ATTACHED CERTIFICATE OF CORRECTION............................................ SA1 USPTO RESTRICTION REQUIREMENT & APPLICANT ELECTION IN RESPONSE TO RESTRICTION REQUIREMENT........................................................................ SA20 The Director of the United States Patent and Trademark Office Has received an applicationfor a patentfor a new and useful invention. The title and description of the invention, are enclosed. Qitiited The requirements of law have been com­ plied with, and it has been determined that a patent on the invention shall be granted States under the law. Therefore, this United States Patent Grants to the person(s) having title to this patent the right to exclude others from mak­ ing, using, offering for sale, or selling the invention throughout the United States of America or importing the invention into the United States ofAmerica, and if the invenr tion is a process, of the right to exclude oth­ ers from using, offering for sale or selling throughout the United States ofAmerica, or importing into the United States of America, products made by that process, for the term setforth in 35 U.S.C. 154(a)(2) or (c)(1), subject to the payment of mainte­ nance fees as provided by 35 U.S.C. 41(b), See the Maintenance Fee Notice on the inside of the Cover. Director of the United States Patent and Trademark Office i! I. (■ 1 of I9 SA1 KAN-CDCAL-240405 US007910340B2 (i2) United States Patent (10) Patent No.: US 7,910,340 B2 Yajima etal. (45) Date of Patent: Mar. 22,2011 (54) PROCESSES FOR PRODUCING COENZYME ■TP 55-27 A 1/1980 Q10 JP 55-28 A 1/1980 IP 55-21756 A 2/1980 JP 55-68295 A (75) Inventors: Kazuyoshi Yajima, Hyogo (IP); 5/1980 JP 55- 148084 A 11/1980 Takahisa Kato. Hyogo (JP); Akihisa JP 56- 55196 A 5/1981 Kanda, Osaka (JP); Shiro Kitaraura, JP 56- 154994 A 11/1981 JP i Hyogo (JP); Yasuyoshi Ucda, Hyogo 56-154996 A li/1981 JP 57-33599 A 2/19S2 (JP) JP 57-70834 A 5/1982 JP 60-75294: 4/1985 (73) Assignee: Kaneka Corporation, Osaka-shi (JP) JP ■60-75294 A 4/1985 IP 10-57072 A 3/1998 (*) Notice: Subject to any disclaimer, the lerm of this JP 10-109933 A 4/1998 JP patent is extended or adjusted under-35 10-330251 A 12/1998 JP 2001-61478 U.S.C. 154(b) by 588 days. 3/2001 WO WO 96/17626 6/1996 (21) Appi. No.: 11/981,181 OTHER PUBLICATIONS (22) Filed: Oct. 31,2007 Tnkada etal. Brochimicaet Biophysics Acla. 1982,679:308-314 * Yoshida el al.“Production of ubiquinone-10 using bacteria". Journal (65) Prior Publication Data of General and Applied Microbiology. 1998, 44:19-26.* Disch, Andrea ei al.. “On the Absence of the Giyceraldehyde 3-Phos- US 2008/0171373 Al Jul. 17, 2008 phate/Pynivate. Pathway for Isoprenoid Biosynthesis in Fungi and Yeasts,’’ FKMS Microbiology Ixrters, vol. 168, No. 2. 1998; pr> Related U.S. Application Data 201-208. Kockovn-Kratochvilova, A. et al., “Die Beziehungen innerhnlb der (62) Division of application No. JO/500,249,. filed as Gattung Cryptococcus (Sanfclice) Vuilicmin”, Zbi Bah. Abt. II, Bd., application No. PCT/JP02/13766 on Dec. 27, 2002. vol. 131,No. 7,1976. pp.610-,631. now abandoned. Natori, Y, et al., “Production of Coenzyme Q10 by Pseudomonas N842”. Agrtc. Biol.Chem., vol. 42, No. 9. 1978,pp. 1799-1800. (30) Foreign Application Priority Data Natori, Y. et al., “Enhancement of Coenzyme. Q,0 Accumulation by Mutation and Effects of Medium Components on the Formation of Dec. 27, 2001 (JP.) 2001-398545 Coenzyme Q Homoiogs by Pseudomonas X842 and Mutants’’. Agric. Biol. Chem.. vol. 45, No. 10.1981, pp. 2175-2182. (51) Int. Cl. Ohla. H. et at., "Agromonas oligotmphicM gen. nov.. sp. nov., a cup mo (2006.01) Nitrogen-Fixing Otigotrophic Bacterium", Antonie van CI2P 7/66 (2006,01) Leeuwenhoek. Vol. 49, Nos, 4-5, 1983, pp, 429-446. (52) U.S.CI........ ,........ 435/133: 435/41 Sakato, K. et al., ‘‘Agitation-Aeration Studies'on Coenzyme Ql0 Production Using Rhodopseudonionns spheroides,” Biotechnology (58) Field of Classification Search .... ................. None and Applied Biochemistry, vol. 16, No. lv 1992, pp. 19-28. See application file for complete search history. (Continued) (56) References Cited Primary Examiner — Vera Afremova. U.S. PATENT DOCUMENTS (74) Attorney, Agent, or Firm — Westerman. Hatton. 3.769,170 A * 10/1973 Rondo etal. 435/133 4.220,719 A 9/1980 Aida etal. Daniels & Adrian, LLP 6.156.802 A 12/2000 Mae etal. FOREIGN PATENT DOCUMENTS (57) ABSTRACT DE 236 552 Al 11/1986 The present invention relates to a process for producing EP 0 051 921 Al 5/1982 reduced coenzyme Q,0 which comprises obtaining microbial EP 0073 134 A2 3*1983 EP 0 956 854 Al 11/1999 cells containing reduced coenzyme Qlb at a ratio of not less EP 1 123 979 Al 8/2001 Ilian 70 mole % among the entire coenzymes Q1q, optionally EP 1 336 657 Al 8/2003 disrupting the cells and recovering thus-produced reduced EP 1 354 957 Al 10/2003 .coenzyme Qj 0. The present invention also relates to a process EP 1 386 905 Al 2/2004 for producing oxidized coenzyme Q10 which comprises EP 1 391 515 Al 2/2004 EP 1 408 024 Al 4/2004 either recovering oxidized coenzyme Q10 after oxidizing the EP 1415 969 Al 5/2004 above-mentioned microbial cells or disrupted product EP 1415 970 Al 5/2004 thereof, orrecovering reduced coenzyme Q, n fronrthe above- EP 1415 971 Al 52004 mentioned microbial ceils or disrupted product thereof to F.P I 415 972 Al 5*2004 oxidize thus-obtained reduced coenzyme thereafter. EP- 1 415 9 73 Al 5/2004, EP 1440 962 Al 7/2004 According to Ibe-processes of the present invention, reduced EP 1452 174 Al 9/2004 coenzyme Q10 and oxidized coenzyme Ql0 can be produced GB 930752 7/1963 simply on (lie industrial scale. JP 48-8836 B 3*1973 JP 54-110388 A 8*1979 JP 54-119090 A 9*1979 45 Claims, 1 Drawing Sheet 2 of 19 SA2 KAN-CDCAL-240406 US 7,910.340 B2 Page 2 OTHER PUBLICATIONS Waknb, N. et aL “'Acidiphilium mutih'ormsp. nov., an Acidophilic Cbemoorganolrophic Bacterium from Pyritic Acid Mine Drainage”, Urakami X, el al., “Production of Isopnenoid Compounds in the Journal of Gcncraland AppliedMtaobiohgy, vol, 40. No. 2, J 994, Facultative Mcfhylbiroph PmfoniOnds extroqucm". ,1 Ferme/it. pp: J43-159. Teehnoi, vol. 66, No. 3, 1988, pp. 325-332: Yabuuchi. E.. et ai.. "Proposals of Sphingomonaspancimobllis gen. Urakami,. T. ei ai.,. “Production pi! Ubiquinone and nov, and conib, now, Sphingpmonas parapaucimobilis sp. nov„ Sphlngompnasyanoikkiyac sp. nov., Sphlngomonas adhaeslva sp. Bacteriochiorophyll <x by Rhodobaair sphaeivhles and nov.. Sphlngomonas capsulata comb, nov., and Two Gcnospccies of Bhodobacter su/fidopiuim->', Journal of Fermentation a/td die Genus Sphingomonas,” Microbiology midlmnntnolog)\ vol. 34, Bioengineering, vol. 76. No. 3, 1993. pp. 191-194. No. 2'. 1990, pp. 99-119. Urakami, T.. et al., “Transfer oFPseudomotias amhiovbrans (den Yamada, Y. et al.;, “The Coenzyme Q System in Strains of Dooren de Jong 1926) to Aminobactcr gen; nov. as Aminobactcr Tricbosporoti Species and Related Organisms”, Journal of General andnovorans comb. nov. and Description otAminobactcr aganoensis andAppliedMicrobiology*, vol. 28, No. 4, J9S2, pp. 355-35$. sp. nov. and Aminobactcr niigataensis sp. nov,”. International Jour­ Yoshida. H. ct a).- "Production of Ubiqiunone^O-Using Bacteria”, nal of Systematic Bacteriology, vol. 42, No. 1, Jan. 1992, pp. 84-92. Journalpf General andAppliedMicrobiolog}', vol. 44. No. 1, ,1'998. Vcntiiroli el al., Blochlmica eiBipfjhj’stca Acta, 935 (198$) pp. 258- pp. 19-26. 272.'." Wakabayashi et al.t Biol. Pharni Bull, 1994, I 7(8):9?7-1002. * cited by examiner 3 of 19 SA3 KAN-CDCAL-240407 a SOLVENT/" \ m FIG.! JsOlVENT IsQlVENT^ THIRD c+ RECOVERY^. ft SECOND SERRATION TANK a FIRST ■> SEPARATION r* SEPARATION A TANK > TANK residue recovery RESIDUE -5»» RESIDUE ♦ GO > CE11-DISRUTED f<r 4^ -ISOPROPANOL SOLUTION rtf- A 1 V:U T_y £Ti 4 n-hexane 11 V o § N K) •O FIRST %% SECOND SECOND STIRRING STIRRING STIRRING TANK El TANK, TANK £ 05 z l4 ■ VO o ■G o O OJ O J ji. > ® I" ■W I Ki NJ Ai o O A o (0 00 US 7,910.340 B2 1 2 PROCESSES FOR PRODUCING COENZYME in addition lo pharmaceutical products as a pharmaceutically Q10 and physiologically effective substance for a variety of dis­ eases. RELATED APPLICATIONS On the other hand, reduced coenzyme Q10 has not so much 5 drawn attention so far: however, in these years, there has been This application si a divisional of Ser. No. 10/500.249,filed reported that reduced coenzyme Q10 is more effective in vari - on Nov. 3. 2004 and now abandoned, which is a 371 pf ous applications than oxidized coenzyme Q10. PCT/JP02/13766, filed on Dec. 27. 2002. which claims ben­ For example, Japanese Kokai Publication llei-10-330251 efits to Japanese Application No.
Load more

Recommended publications
  • Improved Procedure for the Reductive Acetylation of Acyclic Esters and a New Synthesis of Ethers
    J. Org. Chem. 2000, 65, 191-198 191 Improved Procedure for the Reductive Acetylation of Acyclic Esters and a New Synthesis of Ethers David J. Kopecky and Scott D. Rychnovsky* Department of Chemistry, University of California, Irvine, California 92717-2025 Received September 14, 1999 An optimized protocol for the DIBALH reductive acetylation of acyclic esters and diesters is described. This reductive acetylation procedure allows a wide variety of esters to be converted into the corresponding R-acetoxy ethers in good to excellent yields. It was found that, under mild acidic conditions, many R-acetoxy ethers can be further reduced to the corresponding ethers. This net two-step ester deoxygenation is an attractive alternative to the classical Williamson synthesis for certain ethers. Introduction The reduction and in situ acetylation of esters was developed in our laboratory several years ago to provide access to unusual cyclic acetal structures.1 The general strategy involved trapping of the aluminum hemiacetal intermediate found in the reduction of an ester to an aldehyde by diisobutylaluminum hydride (DIBALH). Other groups had previously trapped the same type of intermediate with a trimethylsilyl group.2 After some exploration, we found that acetic anhydride, DMAP, and pyridine led to efficient trapping to give R-acetoxy ethers 1 Figure 1. Original DIBALH reductive acetylation conditions from the cyclic esters we had been studying. We were for lactones and some acyclic esters. surprised to find that the same conditions gave satisfac- R tory yields of the -acetoxy ethers from acyclic esters. a 12 h period, an R-acetoxy ether of the general structure The R-acetoxy ethers can be activated with a variety of 3 was isolated.
    [Show full text]
  • Catalytic Effect of Ultrananocrystalline Fe3o4 on Algal Bio-Crude Production Via HTL Process
    Electronic Supplementary Material (ESI) for Nanoscale. This journal is © The Royal Society of Chemistry 2015 Catalytic Effect of Ultrananocrystalline Fe3O4 on Algal Bio-Crude Production via HTL Process Arnulfo Rojas-Péreza, Daysi Diaz-Diestraa,b, Cecilia B. Frias-Floresa, Juan Beltran-Huaraca,b, K. C. Dasc, Brad R. Weinera,b, Gerardo Morella,b and Liz M. Díaz-Vázquez*a Table 1-S: Profile of volatile and semivolatile compounds of the bio-crudes obtained from raw Ulva fasciata in absence of UNCFO (only compounds with quality identification factor higher that 70 were considered through NIST library) Library/ID Area Benzenepropanoic acid 0.1005 1H-Pyrrole 0.0114 Anthracene 0.0409 2,3,4-Trimethylpyrrole 0.0231 2,5-di-tert-Butyl-1,4-benzoquinone 0.0565 1H-Pyrrole 0.0493 Methylhydroquinon 0.1455 Pyridine 0.084 Acetophenone 0.0671 2-Pyridinamine, 4,6-dimethyl- 0.0094 Acetamide 0.08 2-Acetonylcyclopentanone 0.0097 1H-Indole, 2,6-dimethyl- 0.2334 Phenol 0.0503 1,2-Benzenediol 0.1657 Benzoic acid 0.09 Butylated Hydroxytoluene 0.2888 Benzenamine 0.0154 2-Isopropyl-10-methylphenanthrene 0.1123 2-Cyclopenten-1-one 0.147 5-Chloro-3-phenyl-1H-indazole 0.0976 2,4-Heptadiene 0.1024 1-Isopropyl-1H-indole 0.1426 Nonanoic acid 0.0385 Anthracene 0.067 7-Methylindan-1-one 0.0168 2,5-Diphenyl-2,4-hexadiene 0.0685 3-Methylcatechol 0.1156 2,3,7-Trimethylindole 0.2276 Acetophenone 0.1829 2-Methyl-5-(hexyn-1-yl)pyridine 0.0527 1H-Indole 0.1785 1-Nonadecene 0.2075 Acetamide, 0.1709 Heptadecanoic acid 0.2635 2,4-Diamino-N,N,5-trimethyl-6- 0.2219 9-Octadecenoic acid
    [Show full text]
  • University of Illinois
    UNIVERSITY OF ILLINOIS THIS IS TO CERTIFY THAT THE THESIS PREPARED UNDER MY SUPERVISION BY ENTITLED IS APPROVED BY ME AS FULFILLING THIS PART OF THE REQUIREMENTS FOR THE DEGREE OF. A pproved: *:'X T ‘ AD OF DEPARTMENT OF. O 1364 The Synthesis of Deuterium Labelled Precursors for Their Use in Mechanistic Studies of Chemical Vapor Deposition By Michael E. Smith Thesis for the Degree of Bachelor of Science in Chemistry College of Liberal Arts and Sciences University of Illinois Urbana, Illinois 1988 ACKNOWLEDGEMENTS This thesis is the culmination of three semesters of work in the Girolami group* I'd like to thank all of the members of the group for being supportive and always being there to answer my questions. I would especially like to thank the follwingt Jim Jensen for being a terrific source of advice and giving an undergraduate the chance to shoulder the load and do some real chemistry? Debbie Pollina for doing the groundwork for the chloride synthesis and pulling the magical Vielsmier reagent out of thin air (well, almost); Hans Gozum for teaching me the finer art of destructive chemistry and helping me get rid of my Austrian accent; and Dave Dempsey for making my excursions to 350B the stuff that legends are made of. Finally, my deepest thanks to Greg Girolami, who showed me what chemistry is all about, and helped put my feet firmly on the road to graduate school. TABLE OF CONTENTS Page Number Introduction 1 Results and Discussion 4 Experimental 10 Appendix* Use of AutoCAD Introduction 12 Menus 12 Display Capabilities 14 Drawing Modes 17 Editing 19 Hardcopy 20 Design Techniques 21 Conclusion 23 References 24 1 INTRODUCTION The synthesis of inorganic materials has traditionally involved high temperatures.
    [Show full text]
  • Observation of Water Dangling OH Bonds Around Dissolved Nonpolar Groups
    Observation of water dangling OH bonds around dissolved nonpolar groups P. N. Pereraa, K. R. Fegaa, C. Lawrenceb, E. J. Sundstroma, J. Tomlinson-Phillipsa, and Dor Ben-Amotza,1 aDepartment of Chemistry, Purdue University, West Lafayette, IN 47907; and bDepartment of Chemistry, Grand Valley State University, Allendale, MI 49401 Edited by Michael D. Fayer, Stanford University, Stanford, CA, and approved June 12, 2009 (received for review April 3, 2009) We report the experimental observation of water dangling OH spectra (20), and here, we employ it to uncover dangling OH bonds in the hydration shells around dissolved nonpolar (hydro- vibrational bands arising from the hydration shells around dissolved carbon) groups. The results are obtained by combining vibrational nonpolar groups. (Raman) spectroscopy and multivariate curve resolution (MCR), to The remainder of this article begins by describing the results reveal a high-frequency OH stretch peak arising from the hydration of the experiments we performed to confirm our assignment of shell around nonpolar (hydrocarbon) solute groups. The frequency the observed peak to water dangling OH bonds. Changes in the and width of the observed peak is similar to that of dangling OH intensity of the dangling OH peak are then used to estimate the bonds previously detected at macroscopic air–water and oil–water number of water dangling OH bonds around hydrocarbon chains interfaces. The area of the observed peak is used to quantify the of different size. The width of the observed dangling OH peak number of water dangling bonds around hydrocarbon chains of is used to establish a lower bound on the lifetime of the different length.
    [Show full text]
  • 215 F12-Notes-Ch 13
    Chem 215 F12-Notes – Dr. Masato Koreeda - Page 1 of 13 Date: September 10, 2012 Chapter 13. Alcohols, Diols, and Ethers Overview: Chemistry and reactions of sp3 oxygen groups, particularly oxidation of an alcohol, ether formation, and reactions of oxirane (epoxide) groups. I. What are alcohols, phenols, and ethers? IUPAC names Common names Alcohols (R-OH) Primary alcohols CH3OH methanol methyl alcohol (1°-alcohols) CH3CH2OH ethanol ethyl alcohol pKa ~16-17 CH3CH2CH2OH 1-propanol n-propyl alcohol H3C C CH2OH 2-methyl-1-propanol isobutyl alcohol H3C H H3C C CH2OH 2,2-dimethyl-1-propanol neopentyl alcohol H3C CH3 H C Secondary alcohols 3 C OH 2-propanol isopropyl alcohol (2°-alcohols) H3C H pKa ~17-18 H C-CH 3 2 C OH 2-butanol sec-butyl alcohol H3C H Tertiary alcohols H3C C OH 2-methyl-2-propanol tert-butyl alcohol (3°-alcohols) H3C CH pKa ~19 3 Phenols (Ph-OH) pKa ~10-12 diethyl ether Ethers (R-O-R') CH3CH2-O-CH2CH3 Ph-O-CH=CH2 phenyl vinyl ether RO-: alkoxy CH3O methoxy CH3CH2O ethoxy ArO-: aryloxy PhO phenoxy II. Oxidation Oxidation – historical use of the term: (1) oxide (oxyd/oxyde) – the ‘acid’ form of an element; e.g., S + air → oxide of S (acid of sulfur) (2) oxidation or oxidize – to make such an acid, to make the oxide (3) oxygen – Lavoisier: substance in the air that makes acids; “the bringer of acids” = “oxygen” (4) oxidation or oxidize – to increase the % oxygen in a substance (reduction: to reduce the % oxygen) More modern definition: oxidation or oxidize – loss of electrons (coupled with reduction as gain of electrons) Note: The loss of electrons (oxidation) by one atom or compound must be matched by the gain of electrons (reduction) by another.
    [Show full text]
  • Stereoselective Reduction of the Keto Group at 7-Position of a Bile Keto Acid
    Europaisches Patentamt J European Patent Office © Publication number: 0 230 085 Office europeen des brevets A1 © EUROPEAN PATENT APPLICATION <2j) Application number: 86202393.4S93.4 © Int. CI.4: C07J 9/00 @ Date of filing: 30.12.86 © Priority: 09.01.86 IT 1903886 © Applicant: BLASCHIM S.p.A. Via Vittor Pisani, 28 @ Date of publication of application: 1-20124 Milano(IT) 29.07.87 Bulletin 87/31 @ Inventor: Magni, Ambrogio © Designated Contracting States: Via Donizetti, 20 AT BE CH DE ES FR GB GR IT LI LU NL SE I-22058 Osnago Como(IT) Inventor: Piccolo, Oreste Via Cassa di Risparmi, 31 1-57100 Livorno(IT) Inventor: Ascheri, Antonio Via Don Sturzo, 4 I-20057 Vedano Al Lambro Mi(IT) © Representative: Marchi, Massimo et al c/o Marchi & Mittler s.r.l. Viaie Lombardia 20 1-20131 Milano(IT) © Stereoselective reduction of the keto group at 7-position of a bile keto acid. © The keto group at 7-position of a bile keto acid is stereoselectively reduced to beta-hydroxy group with hydrogen in the presence of nickel, of a base the quantity of which is of at least 0.3 mole to each mole of keto acid, and of an alcohol, having from 3 to 10 C atoms, selected from the group consisting of secondary alcohols, tertiary alcohols and beta-branched alcohols. 00 CM LU <erox Copy Centre 0 230 085 S. I tKtUSbLfcUTIVE REDUCTION OF THE KETO GROUP AT "-POSITION OF A BILE KETO ACID" i nis invention relates to a process tor reducing stereoselectiveiy the keto group at 7-position of a bile keto acid to beta hydroxy group with hydrogen in the presence of nickel, of a base the quantity of which is of at least 0.3 mole to each mole of keto acid, and of an alcohol, having from 3 to 10 C atoms, selected from the group consisting of secondary alcohols, tertiary alcohols and beta-branched alcohols.
    [Show full text]
  • Calculation of the Isobaric Heat Capacities of the Liquid and Solid Phase of Organic Compounds at and Around 298.15 K Based on Their “True” Molecular Volume
    molecules Article Calculation of the Isobaric Heat Capacities of the Liquid and Solid Phase of Organic Compounds at and around 298.15 K Based on Their “True” Molecular Volume Rudolf Naef Department of Chemistry, University of Basel, 4003 Basel, Switzerland; [email protected]; Tel.: +41-61-9119273 Received: 28 March 2019; Accepted: 20 April 2019; Published: 24 April 2019 Abstract: A universally applicable method for the prediction of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, derived from their “true” volume. The molecules’ “true” volume in A3 is calculated on the basis of their geometry-optimized structure and the Van-der-Waals radii of their constituting atoms by means of a fast numerical algorithm. Good linear correlations of the “true” volume of a large number of compounds encompassing all classes and sizes with their experimental liquid and solid heat capacities over a large range have been found, although noticeably distorted by intermolecular hydrogen-bond effects. To account for these effects, the total amount of 1303 compounds with known experimental liquid heat capacities has been subdivided into three subsets consisting of 1102 hydroxy-group-free compounds, 164 monoalcohols/monoacids, and 36 polyalcohols/polyacids. The standard deviations for Cp(liq,298) were 20.7 J/mol/K for the OH-free compunds, 22.91 J/mol/K for the monoalcohols/monoacids and 16.03 J/mol/K for the polyols/polyacids. Analogously, 797 compounds with known solid heat capacities have been separated into a subset of 555 OH-free compounds, 123 monoalcohols/monoacids and 119 polyols/polyacids.
    [Show full text]
  • Aldrich Alcohols and Phenols
    Aldrich Alcohols and Phenols Library Listing – 1,200 spectra Subset of Aldrich FT-IR Library related to alcohols and phenols. The Aldrich Material-Specific FT-IR Library collection represents a wide variety of the Aldrich Handbook of Fine Chemicals' most common chemicals divided by similar functional groups. These spectra were assembled from the Aldrich Collection of FT-IR Spectra and the data has been carefully examined and processed by Thermo. The molecular formula, CAS (Chemical Abstracts Services) registry number, when known, and the location number of the printed spectrum in The Aldrich Library of FT-IR Spectra are available. Aldrich Alcohols and Phenols Index Compound Name Index Compound Name 306 ((1S)-ENDO)-(-)-BORNEOL, 99% 310 (1S,2S,3S,5R)-(+)- 1044 (+)-(4,6-O-BENZYLIDENE)METHYL- ISOPINOCAMPHEOL, 98% ALPHA-D- GLUCOPYRANOSIDE, 351 (2-ENDO, 3-EXO)-5-NORBORNENE- 97% 2,3- DIMETHANOL 1042 (+)-2,3-O-BENZYLIDENE-D- 355 (2-ENDO,3-EXO)- THREITOL, 99% BICYCLO(2.2.2)OCT-5-ENE- 2,3- 528 (+)-ARABINOGALACTAN DIMETHANOL, 96% 305 (+)-BORNEOL, 98% 1130 (2R,3R)-(+)-2-METHYL-3- 1198 (+)-CATECHIN HYDRATE, 98% PHENYLGLYCIDOL, 97% 284 (+)-CIS-P-MENTHANE-3,8-DIOL, 1166 (2R,3R)-(+)-3-(4- 97% BROMOPHENYL)GLYCIDOL, 97% 334 (+)-ISOPULEGOL, 99% 1128 (2R,3R)-(+)-3-PHENYLGLYCIDOL, 340 (+)-LIMONEN-10-OL, 95% 97% 330 (+)-P-MENTH-1-EN-9-OL, 97%, 121 (2R,3R)-(-)-2,3-BUTANEDIOL, 97% MIXTURE OF ISOMERS 129 (2R,4R)-(-)-PENTANEDIOL, 99% 445 (+)-PERSEITOL 122 (2S,3S)-(+)-2,3-BUTANEDIOL, 99% 332 (+)-TERPINEN-4-OL, 96% 1131 (2S,3S)-(-)-2-METHYL-3- 958 (+/-)-4-FLUORO-ALPHA-(N-
    [Show full text]
  • Facile Reduction of Carboxylic Acids by Zinc Borohydride
    5314 J. Org. Chem. 1995,60, 5314-5315 Notes Facile Reduction of Carboxylic Acids by Table 1. Rate and Stoichiometry of Reduction of Zinc Borohydride Carboxylic Acids with Zn(B&)Za mmol of H- consumedmmol of acid S. Narasimhan,* S. Madhavan, and acid K. Ganeshwar Prasad 0.25 h 0.5h 1.0 h 2.0h 3.0 h 4.0 h 5.0h 6.0h Centre for Agrochemical Research, SPIC Science benzoic 1.38 1.54 1.67 1.83 1.93 2.31 2.56 2.82 Foundation, Guindy, Madras 600 032, India benzoicb 1.38 1.54 1.76 1.86 2.02 2.34 2.63 3.10 palmitic 1.06 1.96 2.21 2.53 2.63 2.76 2.83 2.95 Received February 27, 1995 palmiticb 1.83 1.96 2.53 2.99 3.10 pivalic 2.15 2.40 2.84 2.92 It is well-known that basic borohydrides do not reduce pivalicb 2.15 2.41 2.82 2.92 carboxylic acids directly and invariably need addition of undecenoif gel other reagents' such as AlC13,2 12,3etc. to effect this Ratio of H- to acid, 8.25:2.5. Catalyzed by 10 mol % of transformation. However, zinc borohydride, which is cyclohexene. [H-]:[acid] = 1L2.5. considered to be a mild reagent,4 readily reduces both aliphatic and aromatic acids to the corresponding alcohols in refluxing THF. The reaction requires only stoichio- metric quantities of hydride for this conversion. RCH;!OB=O THF,67 "C 6 8RCOOH + 3Zn(BH4), 8RCHZOH + 8H2 Faster reduction of pivalic acid could be due to the The following representative acids were chosen for the bulky tert-butyl group.
    [Show full text]
  • Copyright by Andrew Robert Waldeck 2016
    Copyright by Andrew Robert Waldeck 2016 The Dissertation Committee for Andrew Robert Waldeck Certifies that this is the approved version of the following dissertation: Development and Application of Metal Catalyzed Transfer Hydrogenative C-C Bond Forming Reactions Committee: Michael J. Krische, Supervisor Stephen F. Martin Guangbin Dong Jennifer S. Brodbelt Sean M. Kerwin Development and Application of Metal Catalyzed Transfer Hydrogenative C-C Bond Forming Reactions by Andrew Robert Waldeck, B.S.; B.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin May 2016 Dedication To my parents and to Erin: Without your love and support, none of this would have been possible. Acknowledgements The work described in this document would not have been possible without the mentorship of Professor Krische and the collaboration of a number of talented individuals. Felix, Emma, Jeff, Anne-Marie, and Abbas: Working with each of you has made me a better chemist. Thank you for all of the help and guidance each of you has provided in the context of the projects on which we worked together. Thank you to rest of the Krische group for your insightful conversations. Victoria, Zach, and Stephen: Thank you for your help reviewing and editing this document and thank you for being a source of many laughs during my time here. John Ketcham: Thank you for your advice and insight regarding all things chemistry, but thank you especially for being a friend.
    [Show full text]
  • 215-216 HH W11-Notes-Ch 13
    Chem 215-216 HH W11-Notes – Dr. Masato Koreeda - Page 1 of 13 Date: February 9, 2011 Chapter 13. Alcohols, Diols, and Ethers Overview: Chemistry and reactions of sp3 oxygen groups, particularly oxidation of an alcohol, ether formation, and reactions of oxirane (epoxide) groups. I. What are alcohols, phenols, and ethers? IUPAC names Common names Alcohols (R-OH) Primary alcohols CH3OH methanol methyl alcohol (1°-alcohols) CH3CH2OH ethanol ethyl alcohol pKa ~16-17 CH3CH2CH2OH 1-propanol n-propyl alcohol H3C C CH2OH 2-methyl-1-propanol isobutyl alcohol H3C H H3C C CH2OH 2,2-dimethyl-1-propanol neopentyl alcohol H3C CH3 H C Secondary alcohols 3 C OH 2-propanol isopropyl alcohol (2°-alcohols) H3C H pKa ~17-18 H C-CH 3 2 C OH 2-butanol sec-butyl alcohol H3C H Tertiary alcohols H3C C OH 2-methyl-2-propanol tert-butyl alcohol (3°-alcohols) H3C CH pKa ~19 3 Phenols (Ph-OH) pKa ~10-12 diethyl ether Ethers (R-O-R') CH3CH2-O-CH2CH3 Ph-O-CH=CH2 phenyl vinyl ether RO-: alkoxy CH3O methoxy CH3CH2O ethoxy ArO-: aryloxy PhO phenoxy II. Oxidation Oxidation – historical use of the term: (1) oxide (oxyd/oxyde) – the ‘acid’ form of an element; e.g., S + air → oxide of S (acid of sulfur) (2) oxidation or oxidize – to make such an acid, to make the oxide (3) oxygen – Lavoisier: substance in the air that makes acids; “the bringer of acids” = “oxygen” (4) oxidation or oxidize – to increase the % oxygen in a substance (reduction: to reduce the % oxygen) More modern definition: oxidation or oxidize – loss of electrons (coupled with reduction as gain of electrons) Note: The loss of electrons (oxidation) by one atom or compound must be matched by the gain of electrons (reduction) by another.
    [Show full text]
  • Trace Oxygenated Hydrocarbons in Liquid Hydrocarbon Streams
    SGC-ADS-0188 System Gas Chromatograph Trace Oxygenated Hydrocarbons in Liquid Hydrocarbon Streams Nexis GC-2030OAS3 188 GC-2014OAS3 This method is for determining trace oxygenated hydrocarbons in C4 liquefied petroleum gas (LPG) as described in below compound table. It requires the use of a dedicated gas chromatographic system which is configured with an automatic sampling and backflush technique in multiple columns. Analyzer Information System Configuration: Two valves two SPL injectors / two capillary columns / two FID Concentration Range: Concentration Range Concentration Range No. Name of Compound No. Name of Compound Low Conc. High Conc. Low Conc. High Conc. 1 Methyl Ether 1ppm 100,000ppm 31 2‐Ethylbutyraldehyde 1ppm 100,000ppm 2 Ethyl Methyl Ether 1ppm 100,000ppm 32 3,3‐Dimethylbutyraldehyde 1ppm 100,000ppm 3 Ethyl Ether 1ppm 100,000ppm 33 2‐Methylvaleraldehyde 1ppm 100,000ppm 4 Acetaldehyde 1ppm 100,000ppm 34 Methyl Butyrate 1ppm 100,000ppm 5 Methyl Formate 1ppm 100,000ppm 35 1,4‐Dioxane 1ppm 100,000ppm 6 tert‐Butyl Ethyl Ether 1ppm 100,000ppm 36 Hexanal 1ppm 100,000ppm 7 tert‐Butyl Methyl Ether 1ppm 100,000ppm 37 3‐Pentanone 1ppm 100,000ppm 8 Isopropyl Ether 1ppm 100,000ppm 38 3,3‐Dimethyl‐2‐butanone 1ppm 100,000ppm 9 Propylene Oxide 1ppm 100,000ppm 39 2‐Pentanone 1ppm 100,000ppm 10 sec‐Butyl Methyl Ether 1ppm 100,000ppm 40 Isopropanol 1ppm 100,000ppm 11 Propionaldehyde 1ppm 100,000ppm 41 n‐Propanol 1ppm 100,000ppm 12 Butyl Methyl Ether 1ppm 100,000ppm 42 Cyclopropyl Methyl Ketone 1ppm 100,000ppm 13 tert‐Amyl Methyl Ether 1ppm
    [Show full text]