Anti-MASTL Monoclonal Antibody, Clone SJQMZ 85D (DCABH-4990) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-MASTL monoclonal antibody, clone SJQMZ 85D (DCABH-4990) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to MASTL Antigen Description Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at Ser-62 and Ser-67, respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Immunogen Recombinant full length protein, corresponding to amino acids 1-879 of Human MASTL with a 26kDa proprietary tag. Isotype IgG1 Source/Host Mouse Species Reactivity Mouse, Human Clone SJQMZ 85D Purity Protein G purified Conjugate Unconjugated Applications WB, IHC-P Positive Control Human and Mouse MASTL-transfected HEK cell lysates; Raji, Ramos, Dana and MT2 cell lysates; 293T and HeLa transfected cell lysates; Human tonsil, testicle, bone marrow, Hodgkin and Burkitt lymphoma tissues. Format Liquid Size 100 μg Buffer pH: 7.40; Constituents: PBS, 1% BSA 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Preservative None Storage Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. GENE INFORMATION Gene Name MASTL microtubule associated serine/threonine kinase-like [ Homo sapiens ] Official Symbol MASTL Synonyms MASTL; microtubule associated serine/threonine kinase-like; serine/threonine-protein kinase greatwall; FLJ14813; THC2; greatwall protein kinase; microtubule-associated serine/threonine- protein kinase-like; GW; GWL; hGWL; MAST-L; GREATWALL; RP11-85G18.2; Entrez Gene ID 84930 Protein Refseq NP_001165774 UniProt ID Q96GX5 Chromosome Location 10p12.1 Function ATP binding; kinase activity; nucleotide binding; protein phosphatase 2A binding; protein serine/threonine kinase activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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Meta-Analysis of Nasopharyngeal Carcinoma
BMC Genomics BioMed Central Research article Open Access Meta-analysis of nasopharyngeal carcinoma microarray data explores mechanism of EBV-regulated neoplastic transformation Xia Chen†1,2, Shuang Liang†1, WenLing Zheng1,3, ZhiJun Liao1, Tao Shang1 and WenLi Ma*1 Address: 1Institute of Genetic Engineering, Southern Medical University, Guangzhou, PR China, 2Xiangya Pingkuang associated hospital, Pingxiang, Jiangxi, PR China and 3Southern Genomics Research Center, Guangzhou, Guangdong, PR China Email: Xia Chen - [email protected]; Shuang Liang - [email protected]; WenLing Zheng - [email protected]; ZhiJun Liao - [email protected]; Tao Shang - [email protected]; WenLi Ma* - [email protected] * Corresponding author †Equal contributors Published: 7 July 2008 Received: 16 February 2008 Accepted: 7 July 2008 BMC Genomics 2008, 9:322 doi:10.1186/1471-2164-9-322 This article is available from: http://www.biomedcentral.com/1471-2164/9/322 © 2008 Chen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Epstein-Barr virus (EBV) presumably plays an important role in the pathogenesis of nasopharyngeal carcinoma (NPC), but the molecular mechanism of EBV-dependent neoplastic transformation is not well understood. The combination of bioinformatics with evidences from biological experiments paved a new way to gain more insights into the molecular mechanism of cancer. Results: We profiled gene expression using a meta-analysis approach. Two sets of meta-genes were obtained. Meta-A genes were identified by finding those commonly activated/deactivated upon EBV infection/reactivation.
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