Authors 1st Author

Dominique Piché, Isabella Tavernaro, Jana Fleddermann, Materials Department, University Juan G. Lozano, Aakash Varambhia, Mahon L. Maguire, of Oxford, Parks Road, Oxford Marcus Koch, Tomofumi Ukai, Armando J. Hernández OX1 3PH, England Rodríguez, Lewys Jones, Frank Dillon, Israel Reyes Molina, Mai Mitzutani, Evelio R. González Dalmau, Toru Maekawa, Peter D. Nellist, Annette Kraegeloh, Nicole Grobert Louise V. Webb, Alessandro Barbarulo, Jelle Huysentruyt, Division of Infection and Tom Vanden Berghe, Nozomi Takahashi, Steven Ley, Immunity, UCL Institute of Peter Vandenabeele, Benedict Seddon Immunity and Transplantation, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK

Didac Carmona-Gutierrez, Andreas Zimmermann, Institute of Molecular Katharina Kainz, Federico Pietrocola, Guo Chen, Silvia Biosciences, NAWI Graz, Maglioni, Alfonso Schiavi, Jihoon Nah, Sara Mertel, University of Graz, Graz, 8010 Christine B. Beuschel, Francesca Castoldi, Valentina Austria Sica, Gert Trausinger, Reingard Raml, Cornelia Sommer, Sabrina Schroeder, Sebastian J. Hofer, Maria A. Bauer, Tobias Pendl, Jelena Tadic, Christopher Dammbrueck, Zehan Hu, Christoph Ruckenstuhl, Tobias Eisenberg, Sylvere Durand, Noélie Bossut, Fanny Aprahamian, Mahmoud Abdellatif, Simon Sedej, David P. Enot, Heimo Wolinski, Jörn Dengjel, Oliver Kepp, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Junichi Sadoshima, Natascia Ventura, Stephan J. Sigrist, Guido Kroemer, Frank Madeo

Andreas Körner, Martin Schlegel, Torsten Kaussen, Verena Department of Anesthesiology Gudernatsch, Georg Hansmann, Timo Schumacher, Martin and Intensive Care Medicine, Giera, Valbona Mirakaj Molecular Intensive Care Medicine, University Hospital Tübingen, Eberhard-Karls University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany Greg Crawford, Mark David Hayes, Rocio Castro Seoane, Department of Medicine, Imperial Sophie Ward, Tim Dalessandri, Chester Lai, Eugene Healy, College London, London, UK David Kipling, Charlotte Proby, Colin Moyes, Kile Green, Katie Best, Muzlifah Haniffa, Marina Botto, Deborah Dunn-Walters, Jessica Strid Mylène Tajan, Andreas K. Hock, Julianna Blagih, Neil A. The Francis Crick Institute, 1 Robertson, Christiaan F. Labuschagne, Flore Kruiswijk, Midland Road, London NW1 1AT, Timothy J. Humpton, Peter D. Adams, Karen H. Vousden UK

Harveer Dev, Ting-Wei Will Chiang, Chloe Lescale, Inge de The Wellcome Trust/Cancer Krijger, Alistair G. Martin, Domenic Pilger, Julia Coates, Research UK Gurdon Institute and Matylda Sczaniecka-Clift, Wenming Wei, Matthias Department of Biochemistry, Ostermaier, Mareike Herzog, Jonathan Lam, Abigail Shea, University of Cambridge, Mukerrem Demir, Qian Wu, Fengtang Yang, Beiyuan Fu, Cambridge CB2 1QN, UK Zhongwu Lai, Gabriel Balmus, Rimma Belotserkovskaya, Violeta Serra, Mark J. O’Connor, Alejandra Bruna, Petra Beli, Luca Pellegrini, Carlos Caldas, Ludovic Deriano, Jacqueline J.L. Jacobs, Yaron Galanty, Stephen P. Jackson

Curson ARJ, Williams BT, Pinchbeck BJ, Sims LP, Martínez AB, School of Biological Sciences, Rivera PPL, Kumaresan D, Mercadé E, Spurgin LG, Carrión O, University of East Anglia, Moxon S, Cattolico RA, Kuzhiumparambil U, Guagliardo P, Norwich, UK. Clode PL, Raina JB, Todd JD

Xueqing Zou, Michel Owusu, Rebecca Harris, Stephen P. Wellcome Trust Sanger Institute, Jackson, Joanna I. Loizou, Serena Nik-Zainal Wellcome Genome Campus, Hinxton, CB10 1SA, UK.

Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Laboratory of Lymphocyte Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Signalling and Development, Sriskantharajah, Glyn Bradley, Alex G. Richter, Edward Babraham Institute, Cambridge, Banham-Hall, Menna R. Clatworthy, Sergey Nejentsev, J. CB21 3AT UK Nicole Hamblin, Edith M. Hessel, Alison M. Condliffe, Klaus Okkenhaug Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Institute for Cardiovascular Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Physiology, Goethe University, Schürmann, Andrea Estefania Vasconez, James A. Oo, Frankfurt am Main, 60590, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Germany Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike CeMM Research Center for Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Molecular Medicine of the Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Austrian Academy of Sciences, Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Vienna, 1090, Austria. Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien

Ryosuke Kojima, Daniel Bojar, Giorgio Rizzi, Ghislaine Charpin- ETH Zürich, Department of El Hamri, Marie Daoud El-Baba, Pratik Saxena, Simon Biosystems Science and Ausländer, Kelly R. Tan, Martin Fussenegge Engineering, Mattenstrasse 26, 4058, Basel, Switzerland. Ferdinand Sedlmayer, Dennis Hell, Marius Müller, David Department of Biosystems Ausländer, Martin Fussenegger Science and Engineering, ETH Zürich, Mattenstrasse 26,, CH- 4058, Basel, Switzerland. Daniel Bojar, Leo Scheller, Ghislaine Charpin-El Hamri, Mingqi Department of Biosystems Xie, Martin Fussenegger Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland Martina Roilo, Michael K Kullmann, Ludger Hengst Division of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck 6020, Austria.

Ying Liu, Ghislaine Charpin-El Hamri, Haifeng Ye, Martin Department of Biosystems Fussenegger Science and Engineering, ETH Zurich, Mattenstrasse 26, CH- 4058 Basel, Switzerland. Jie Yang, Ferry Cornelissen, Natalie Papazian, Rogier M. Institute of Immunity and Reijmers, Miriam Llorian, Tom Cupedo, Mark Coles, Benedict Transplantation, Division of Seddon Infection and Immunity, University College London, Royal Free Hospital, London, England, UK. Francesca Tuorto, Carine Legrand, Cansu Cirzi, Giuseppina Division of Epigenetics, DKFZ- Federico, Reinhard Liebers, Martin Müller, Ann E ZMBH Alliance, German Cancer Ehrenhofer‐Murray, Gunnar Dittmar, Hermann‐Josef Gröne, Research Center, Heidelberg, Frank Lyko Germany [email protected]. Beatrice Freya Lucy Edwards, Richard John Wheeler, Amy Sir William Dunn School of Rachel Barker, Flávia Fernandes Moreira-Leite, Keith Gull, Jack Pathology, University of Oxford, Daniel Sunter OX1 3RE Oxford, United Kingdom. Nicola Rath, June Munro, Marie Francene Cutiongco, Alicja Cancer Research UK Beatson Jagiełło, Nikolaj Gadegaard, Lynn McGarry, Mathieu Institute, Glasgow, United Unbekandt, Evdokia Michalopoulou, Jurre J Kamphorst, David Kingdom. Sumpton, Gillian Mackay, Claire Vennin, Marina Pajic, Paul Timpson, Michael F Olson Esther Heideveld, Lea A. Hampton‐O’Neil, Stephen J. Cross, Sanquin Research, Department of Floris P.J. van Alphen, Maartje van den Biggelaar, Ashley M. Hematopoiesis, Amsterdam and Toye, Emile van den Akker Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, the Netherlands

Andrew J. Davidson, Clelia Amato, Peter A. Thomason, Robert Cancer Research UK Beatson H. Insall Institute, Glasgow, Scotland, UK.

Aida Llauró, Hanako Hayashi, Megan E. Bailey, Alex Wilson, Department of Physiology and Patryk Ludzia, Charles L. Asbury, Bungo Akiyoshi Biophysics, University of Washington, Seattle, WA Year Titel Journal

2019 Targeted T1 Magnetic Resonance Imaging Contrast ACS Applied Materials & Enhancement with Extraordinarily Small CoFe2O4 Interfaces Nanoparticles

2019 Survival of Single Positive Thymocytes Depends upon Immunity Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

2019 The flavonoid 4,4′-dimethoxychalcone promotes Nature Communications autophagy-dependent longevity across species

2019 Sympathetic nervous system controls resolution of Nature Communications inflammation via regulation of repulsive guidance molecule A

2018 Epithelial damage and tissue γδ T cells promote a unique Nature Immunology tumor-protective IgE response 2018 A Role for p53 in the Adaptation to Glutamine Starvation Cell Metabolism through the Expression of SLC1A3

2018 Shieldin complex promotes DNA end-joining and counters Nature Cell Biology homologous recombination in BRCA1-null cells

2018 DSYB catalyses the key step of dimethylsulfoniopropionate Nature Microbiology biosynthesis in many phytoplankton

2018 Validating the concept of mutational signatures with Nature Communications isogenic cell models

2018 PI3Kδ hyper-activation promotes development of B cells Nature Communications that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

2018 Oxidized phospholipids regulate amino acid metabolism Nature Communications through MTHFD2 to facilitate nucleotide release in endothelial cells 2018 MLL-fusion-driven leukemia requires SETD2 to safeguard Nature Communications genomic integrity

2018 Designer exosomes produced by implanted cells Nature Communications intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

2018 Designer cells programming quorum-sensing interference Nature Communications with microbes

2018 Caffeine-inducible gene switches controlling experimental Nature Communications diabetes

2018 Cold-inducible RNA-binding protein (CIRP) induces Nucleic Acids Research translation of the cell-cycle inhibitor p27Kip1

2018 A synthetic free fatty acid-regulated transgene switch in Nucleic Acids Research mammalian cells and mice

2018 IL-7–dependent maintenance of ILC3s is required for Journal Of Experimental normal entry of lymphocytes into lymph nodes Medicine

2018 Queuosine-modified tRNAs confer nutritional control of The EMBO Journal protein translation

2018 Direction of flagellum beat propagation is controlled by Proceedings of the National proximal/distal outer dynein arm asymmetry Academy of Sciences of The United States Of America (PNAS) 2018 Rho kinase inhibitor AT13148 blocks pancreatic ductal Cancer Research adenocarinoma invasion and tumor growth

2018 Glucocorticoids induce differentiation of monocytes Haematologica towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages

2018 WASP family proteins and formins compete in pseudopod- Journal Of Cell Biology and bleb-based migration

2018 The kinetoplastid kinetochore protein KKT4 is an Journal Of Cell Biology unconventional microtubule tip–coupling protein Impact Link 1 Link 2 Key Words Factor 8,097 10.1021/acsami.8 https://www.ncb toxicity of the nanoparticles, b17162 i.nlm.nih.gov/pm HepG2, Nanoparticle-induced c/articles/PMC6 oxidative stress, 385080/

19,734 10.1016/j.immuni. https://www.ncb Cell concentrations of 2019.01.004 i.nlm.nih.gov/pm thymocytes, lymph node and c/articles/PMC6 spleen cell 382466/

12,353 10.1038/s41467- https://www.ncb clonogenic survival plating, cell 019-08555-w i.nlm.nih.gov/pm death markers in yeast c/articles/PMC6 381180/

12,353 Nat Commun. https://www.ncbi. PBMC, macrophage, 2019; 10: 633. nlm.nih.gov/pmc/ chemokinesis articles/PMC6367 413/

21,809 Nat Immunol. https://www.ncb Immunology, Tissue Processing, 2018 Aug; 19(8): i.nlm.nih.gov/pm Cell suspension from tissue 859–870. c/articles/PMC6 071860/ 20,565 Cell Metab. 2018 https://www.ncb Growth curves, cell counting, Nov 6; 28(5): i.nlm.nih.gov/pm HCT116, OVCAR-4, OVCAR-5, 721–736.e6. c/articles/PMC6 RT4, A2780, A375, SiHa, MDA- 224545/ MB-468, U2OS, RKO, A549, HEK293T, Phoenix-ECO 19,064 Nat Cell Biol. https://www.ncb CH12, viability, cell proliferation 2018 Aug; 20(8): i.nlm.nih.gov/pm assay, HEK293T 954–965. c/articles/PMC6 145444/

14,174 Nat Microbiol. https://www.ncb Phytoplankton 2019 Jan 30. doi: i.nlm.nih.gov/pu 10.1038/s41564- bmed/30700867 019-0386-9

12,353 Nat Commun. https://www.ncbi. Knockout cell lines, Knockout cell 2018; 9: 1744. nlm.nih.gov/pmc/ lines articles/PMC5931 590/ 12,353 Nat Commun. https://www.ncbi. Splenocytes, Streptococcus 2018; 9: 3174. nlm.nih.gov/pmc/ pneumoniae articles/PMC6085 315/

12,353 Nat Commun. https://www.ncb SiRNA transfection, proliferation 2018; 9: 2292. i.nlm.nih.gov/pm assay, endothelial cells c/articles/PMC5 997752/ 12,353 Nat Commun. https://www.ncb MOLM13, MV4-11, HEL, HL-60, 2018; 9: 1983. i.nlm.nih.gov/pm KYO-1, proliferation curves c/articles/PMC5 959866/

12,353 Nat Commun. https://www.ncbi. HEK-293T, hMSC-TERT, HeLa, 2018; 9: 1305. nlm.nih.gov/pmc/ human mesenchymal stem cells, articles/PMC5880 Neuro2A cells, 805/ 12,353 Nat Commun. https://www.ncb Caco-2, A549, cell number and 2018; 9: 1822. i.nlm.nih.gov/pm viability, Polysciences, Eppelheim c/articles/PMC5 940823/ 12,353 Nat Commun. https://www.ncb Cell Viabilty, HEK-293T, human 2018; 9: 2318. i.nlm.nih.gov/pm mesenchymal stem cells (ATCC: c/articles/PMC6 SCRC4000, hMSC-hTERT) 008335/ 11,561 Nucleic Acids https://www.ncb Wild-type (wt) MEFs and p27 Res. 2018 Apr 6; i.nlm.nih.gov/pm knockout, nalyzed in triplicate 46(6): c/articles/PMC5 3198–3210. 888589/

11,561 Nucleic Acids https://www.ncbi. BHK-21, CHO-K1, HeLa, HT-1080, Res. 2018 Oct nlm.nih.gov/pmc/ Cell number and viabilit 12; 46(18): articles/PMC6182 9864–9874. 168/ 10,790 J Exp Med. 2018 https://www.ncb thymus, spleen, and mesenteric Apr 2; 215(4): i.nlm.nih.gov/pm and peripheral lymph nodes, cell 1069–1077. c/articles/PMC5 concentration 881462/

9,792 EMBO J. 2018 https://www.ncbi. HeLa, HCT116, viability Sep 14; 37(18): nlm.nih.gov/pmc/ e99777. articles/PMC6138 434/ 9,504 Proc Natl Acad https://www.ncbi. Trypanosoma brucei, Leishmania Sci U S A. 2018 nlm.nih.gov/pmc/ mexican, blood parasite Jul 31; 115(31): articles/PMC6077 E7341–E7350. 732/ 9,130 Cancer Res. 2018 https://www.ncbi. TKCC5, HEK293, lentivirus Jun 15; 78(12): nlm.nih.gov/pmc/ production, 3321–3336. articles/PMC6005 347/

9,090 Haematologica. https://www.ncb CD14+ monocytes 2018 Mar; i.nlm.nih.gov/pm 103(3): 395–405. c/articles/PMC5 830394/

8,784 J Cell Biol. 2018 https://www.ncbi. Dictyostelium discoideum, Feb 5; 217(2): nlm.nih.gov/pmc/ 701–714. articles/PMC5800 805/ 8,784 J Cell Biol. 2018 https://www.ncbi. Trypanosome brucei, Cell growth Nov 5; 217(11): nlm.nih.gov/pmc/ 3886–3900. articles/PMC6219 724/