BIBE 2019, June 20-22, 2019, Hangzhou, China

Contents

Biomedical Signal Processing and Medical Information

001 A modified basic scale entropy computing method for one-dimensional signal complexity analysis in real time ...... 1 Huijie Shao1, Yongxin Chou1,3, Liguo Wang2, Ya Gu1, Jicheng Liu1 1School of Electrical and Automatic Engineering, Changshu Institute of Technology, Suzhou, China 2Department of Orthopaedics Gansu Provincial Hospital, Lanzhou, China 3The East China Science and Technology Research Institute of Changshu Co., Ltd., Suzhou, China

002 The dominant T wave cluster and One-Class SVM based analysis of multilead ECG for classification of myocardial infarction ...... 7 Yue Zhang, Jie Li The Division of Information Science and Technology Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

003 Serum metabolite signatures are associated with types and locations of gastrointestinal tract cancers ...... 14 Yitao Li, Shouli Wang, Dandan Liang, Chao Sang, Aihua Zhao, Tianlu Chen Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

004 A wearable wireless bio-medical front-end circuit for monitoring elec-trophysiological signals ...... 18 Zheng Yang1, Jingmin Wang2 1Key Laboratory of Microelectronic Devices and Circuits Institute of Microelectronics, Peking University, Beijing, China 2College of Career Technology, Hebei Normal University, Shijiazhuang, China

005 Analysis of pulse wave simulation in cun, guan and chi based on wave propagation model ...... 23 Jian-jun Yan1, Yu-chen Sun1, Rui Guo2,3, Yi-qin Wang2, Hai-xia Yan2 1Institute of Mechanical and Power Engineering, East China University of Technology, Shanghai, China 2Laboratory of Information Access and Synthesis of Traditional Chinese Medicine Four Diagnosis， Shanghai University of Traditional Chinese Medicine, Shanghai, China 3Institute of Interdisciplinary Research Complex, Shanghai University of Traditional Chinese Medicine, Shanghai, China

006 Multiple combinations of time-frequency distributions and classifiers for detecting epileptic EEG signal ...... 29 Renjie Zhang, Xian Zhao, Wei Chen Center for Intelligent Medical Electronics, School of Information Science and Technology, Fudan University, Shanghai, China

007 Portable image-based detection system for Upconverting phosphor immune lateral flow assay ...... 35 Chao Li, Meng Chen, Zhi Cheng, Feng Chen, Taihu Wu, Yaohua Du Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin, China

III BIBE 2019, June 20-22, 2019, Hangzhou, China

008 Dysmenorrhea on blood pressure and radial pulse spectrum in women ...... 42 Chih-Yu Chen1, Chi-Wei Chang2, Sheng-Hung Wang2, Gin-Chung Wang3 1Renai Branch of Taipei City Hospital, Taipei, Taiwan 2MiiAnn Medical Research Center, Taipei, Taiwan 3JinMu Health Technology, Taipei, Taiwan

009 Antenna miniaturization design for wireless capsule endoscopy systems ...... 46 Ximin Yu1, Junming Ren2, Jingjing Wang1, Jun Du1, Jun Ma1, Yong Ren1 1Department of Electronic Engineering Tsinghua University, Beijing, China 2Department of Electronic Engineering, City University of Hongkong, Hongkong, China

010 Method of detecting neonatal jaundice based on dual optical path ...... 51 Zhe Zhou1, Shu-Jun Wu2, Yue-fang Dong1, Wei-wei Fu1 1Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China 2School of optoelectronic engineering, Changchun University of science and Technology, Changchun, China

011 MiBRP: a predictor using Laplacian support vector machine and se-quence information to identify microRNA-binding residues ...... 56 Xin Ma, School of Statistics and mathematics, Nanjing Audit University, Nanjing, China

012 The effects of polycystic ovary syndrome on cardiovascular system in women of childbearing age ...... 62 Chih-Yu Chen1, Chi-Wei Chang2, Sheng-Hung Wang2, Gin-Chung Wang3 1Renai Branch of Taipei City Hospital, Taipei, Taiwan 2MiiAnn Medical Research Center, Taipei, Taiwan 3JinMu Health Technology, Taipei, Taiwan

013 Design and fabrication of graphene-based biosensors for saliva bi-omarkers of Chronic Obstructive Pulmonary Disease ...... 66 Lan Huang1, Zhaochu Yang1, Rui Carvalho1, Tao Dong1, Nuno M. M. Pires1, Anders Wilhelmsen2 1Institute of Applied Micro-Nano Science and Technology – IAMNST, Chongqing Key Laboratory of Colleges and Universities on Micro-Nano Systems Technology and Smart Transducing, Chongqing Key Laboratory of Micro-nano Systems and Intelligent Sensing, National Research Base of Intelligent Manufacturing Service, Chongqing Technology and Business University, Nanan District, Chongqing, China 2Department of Microsystems – IMS, Faculty of Technology, Natural Sciences and Maritime Sciences, University of South-Eastern Norway, Kongsberg, Norway

014 Principal component analysis for normalized one beat PPG waveform ...... 70 Daisuke Fujita1, Arata Suzuki1, Kazuteru Ryu2 1Wakayama University, Wakayama, Japan 2Kanai Hospital, Kyoto, Japan

015 Automatic denoising and artifact removal from neonatal EEG ...... 74 Saadullah Farooq Abbasi, Mohammad Awais, Xian Zhao, Wei Chen Department of Biomedical Engineering Fudan University Shanghai, China

016 Selective analysis of neuron orientation based on phase and amplitude coupling ...... 79 Zhaohui Li, Yue Du Yanshan University, Qinhuangdao City, Hebei Province, China

IV BIBE 2019, June 20-22, 2019, Hangzhou, China

017 Research on the recognition method of blood circulation system based on pulse wave ...... 83 Zimei Su, Junyi Yao, Bin Deng, Zhanqiu Shen Institute of Sensor and Reliability Engineering, Harbin University of Science and Technology, Harbin, China

018 Cross recurrence quantification analysis of ECG and EPCG in patients with coronary artery disease and healthy old subjects ...... 92 Liping Li1, Kuixing Zhang1, Na Zhang2 1Department of Biomedical Engineering, School of Science and Engineering, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China 2Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong Univer- sity, Jinan, Shandong, China

019 A PCG classification method using xgboost ...... 96 Ting Li, Xing-rong Chen, Lin Zhou, Fu-ming Sun School of Information and Communication Engineering, Dalian Minzu University, Dalian, China

020 Recognition algorithm of Parkinson's disease based on weighted local discriminant preservation projection embedded ensemble algorithm ...... 100 Yuchuan Liu1, Xiaoheng Tan1, Pin Wang1, Yanling Zhang2 and Yongming Li1 1School of Microelectronics and Communication Engineering, Chongqing University, Chongqing, China 2First Affiliated Hospital of Army Medical University, Chongqing, China

021 Facial pain intensity estimation for ICU patient with partial occlusion coming from treat- ment ...... 106 Jiann-Shu Lee, Chuan-Wei Wang Department of Computer Science and Information Engineering, National University of Tainan, Tainan, Taiwan

022 Obstructive sleep apnea detection based on unsupervised feature learning and hidden markov model ...... 110 Kaicheng Feng and Guanzheng Liu School of Biomedical Engineering, Sun Yat-Sen University, China

023 ECG-based biometrics using convolutional neural networks and ensemble empirical mode decomposition ...... 114 Runxin Huang1, Zhidong Zhao1,2, Yanjun Deng1 and Chunwei Guo2 1College of Electronic and Communication Engineering, Hangzhou Dianzi University, Hangzhou, China 2Hangdian Smart City Research Center of Zhejiang Province, Hangzhou Dianzi University, Hangzhou, China

024 Analysis of TCM hypertension syndrome types and core prescriptions based on SVD dimension reduction algorithms and association rules ...... 119 Gaole Lu, Dong Cao, Hui Ye School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Panyu, Guangzhou, China

025 Heart sound segmentation based on SMGU-RNN ...... 126 Chundong Xu1, Jing Zhou1, Lan Li1, Jing Wang2, Dongwen Ying1,3, Qinglin Li1 1Faculty of Information Engineering, Jiangxi University of Science and Technology, Ganzhou, China 2School of Information and Electronics, Beijing Institute of Technology, Beijing, China 3Key Laboratory of Speech Acoustics and Content Understanding, Institute of Acoustics, Chinese Academy of Sciences, Beijing, China

V BIBE 2019, June 20-22, 2019, Hangzhou, China

026 Avoiding subject-specific model selection via highway networks in EEG signals ...... 133 Yangang Li1,2, Yu Qi2 and Yueming Wang1,2 1Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China 2Department of Computer Science, Zhejiang University, Hangzhou, China

027 A preliminary result on sleep posture identification with BCG signals ...... 138 Yichao Zhang1, Weize Song2, Zhenming Yuan2, Xiaoyan Sun3 1Engineering Research Center of Mobile Health Management System, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, China 2School of Information Science and Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, China 3Engineering Research Center of Mobile Health Management System, Ministry of Education, School of Information Science and Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, China

028 Prediction of pregnancy diabetes based on machine learning ...... 142 Fan Du1, Weiyang Zhong1, Wei Wu2, Danhong Peng3, Tian Xu, Jun Wang1, Gongdao Wang3, Fengzhen Hou4 1Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing, China 2Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China 3Department of Obstetrics and Gynecology, Zhongda Hospital, Southeast University, Nanjing, China 4School of Science, China Pharmaceutical University, Nanjing, China

029 The Chinese pharmacopoeia and standards of the ministry of Traditional Chinese Medicine contain Arisaematis rhizoma for external use analysis of medication law ...... 148 Ting Gao, Ming Bai, Mingsan Miao Henan University of Chinese Medicine, Zhengzhou, China

030 Classification of hypertension in pregnancy based on random forest and Xgboost fusion model ...... 151 Xinke Lan1, Wei Wu2, Danhong Peng3, Tian Xu3, Jun Wang1, Gongdao Wang3, Fengzhen Hou4 1Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing, China 2Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China 3Department of Obstetrics and Gynecology, Zhongda Hospital, Southeast University, Nanjing, China 4School of Science, China Pharmaceutical University, Nanjing, China

031 Structural alignment of long, highly structured RNAs based on ordered tree method ...... 156 Longjian Gao1, Chengzhen Xu1, Xueqin Sun1, Wangan Song1, Feng Xiao1, Dongbing Zhang1,2 1School of Computer Science and Technology, Huaibei Normal University, Huaibei, Anhui, China 2Information College, Huaibei Normal University, Huaibei, China

032 Analysis of medication rule of Chinese medicine for allergic dermatitis based on association rules ...... 161 Pengfei Lu, Ting Zuo, Ming Bai, Mingsan Miao Henan University of Chinese Medicine, Zhengzhou, China

033 Study on the Correlation of Microstate Sequences of MEG ...... 165 Yafei Zhang1, Wei Yan2, Jun Wang1, Jin Li3, Fengzhen Hou4 1Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications,Nanjing, China 2Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China 3College of Physics and Information Technology, Shaanxi Normal University, Xi’an, China 4School of Science, China Pharmaceutical University, Nanjing, China

VI BIBE 2019, June 20-22, 2019, Hangzhou, China

034 Change of Lactobacillus and Bifidobacteria genera from breast milk to elders and their potential for preserving human health ...... 170 Na Li, Xixi Zhao, Haobin Zhao, Muhammad Shahid Riaz Rajokaa, Junling Shi Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi Province, China

035 Real world study on Chinese Medicine rehabilitation for stroke based on electronic medical record data ...... 176 Lin Zhang1, Houwu Gong2, Heng Chen3, Liang Ou1, Hui Yang1, Xiaofang He4 1Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China 2DHC SOFTWARE Co. Ltd., Beijing, China 3Hunan Provincial TCM Hospital, Changsha, China 4Guizhou Provincial People's Hospital, Guiyang, China

036 Integrated care for pregnant women with Type one diabetes using wearable technology ...... 182 Dawn Adams1, Huiru Zheng1, Marlene Sinclair2, Marie Murphy3, Julie McCullough2 1Computer Science and Informatics, Ulster University, Jordanstown Campus, Northern Ireland, England 2Maternal, Foetal and Infant Research Centre, Faculty of Life and Health Sciences, Ulster University, England 3Sport & Exercise Sciences Research Institute, Ulster University, England

037 Intelligent home design for elderly health monitoring and rating based wireless passive sensor network ...... 187 Da Liu, Long Meng, Xinyi Qiu, Hui Feng, Hemant Ghayvat, Wei Chen School of Information Science and Technology, Fudan University, Shanghai, China

038 Feasibility study of a smart insole based AI Gait Assistant system ...... 192 Geng An1, Graham McCalmont2, Philip Morrow2, Mingjing Yang1, Haiying Wang2, Sally McClean2, Huiru Zheng2 1College of Physics and Information Engineering, Fuzhou University, Fujian, China 2School of Computing, Ulster University, Jordanstown Campus, Northern Ireland

Medical Imaging Technology and Image Processing

039 A novel method for detection of hard exudates from fundus images based on RBF and improved FCM ...... 197 Weiwei Gao1, Jianxin Shen2 and Jing Zuo3 1College of Mechanical Engineering, Shanghai University of Engineering Science, Shanghai, China 2College of Mechanical & Electrical Engineering, Nanjing University of Aeronautics and Astronau- tics, Nanjing, China 3Department of Ophthalmology, Jiangsu province hospital of TCM, Nanjing 210029, China

040 Automatic detection of cerebral micro-bleed in SWI images based on 3D CNN ...... 203 Zhenfeng Cheng1,2, Yueyan Bian2, Shengyu Fan1,2, Yu Luo4, Yan Kang1,2,3 1School of Sino-Dutch Biomedical and Information Engineering, Northeastern University, Shenyang, China 2Neusoft Institue of Intelligent Healthcare Technology, Co. Ltd., Shenyang, China 3Engineering Research Center for Medical Imaging and Intelligent Analysis, National Education Ministry, China 4Radiology Department, Translational Research Institute of Brain and Brain-Like Intelligence, Shang- hai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China

VII BIBE 2019, June 20-22, 2019, Hangzhou, China

041 Hand gesture based control with multi-modality data – towards surgical applications ...... 209 Yu Sun1, Lijie Miao1, Zhenming Yuan1, Xiaoyan Sun1,2 1School of Information Science and Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, China 2Engineering Research Center of Mobile Health Management System, Ministry of Education, Hangz- hou, Zhejiang, China

042 Analysis of bivariate time series of magnetoencephalography for depression Based on Granger Kernel Method ...... 213 Jialin Hu1, Wei Yan2, Jun Wang1, Jin Li3, Fengzhen Hou4 1Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing, China 2Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China 3College of Physics and Information Technology, Shaanxi Normal University, Xi’an, China 4School of Science, China Pharmaceutical University, Nanjing, China

043 Amplitudes and frequencies cross modulation of epileptic EEG between 16 leads ...... 219 Yujie Cai1, Jiafei Dai2, Jin Li3, Jun Wang1, Fengzhen Hou4 1Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province Nanjing University of Posts and Telecommunications, Nanjing, China 2Nanjing General Hospital of Nanjing Military Command, Nanjing, China 3College of Physics and Information Technology Shaanxi Normal University, Xi’an, China 4Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing, China

044 Metal artifact reduction in kVCT images via L1 sparse regularization of MVCBCT prior images ...... 223 Hongxing Qin1,2, Shasha Hou1,2, Hongfei Sun3,4, Liugang Gao3,4, Xinye Ni3,4 1Chongqing Key Laboratory of Computational Intelligence, Chongqing, China 2Chongqing University of Posts and Telecommunications, Chongqing, China 3The Affiliated of Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, China 4The center for medical physics of Nanjing Medical University, Changzhou, China

045 Modeling three-dimensional segmentation uncertainties for cone beam CT-based image- guided adaptive radiotherapy for prostate cancer ...... 232 Jian Wu1, Elisabeth Weiss2, Jeffrey F. Williamson3, Nitai Mukhopadhyay2, William C. Sleeman IV2 and Martin J. Murphy2 1University of Florida, Gainesville, Florida, USA 2Virginia Commonwealth University, Richmond, Virginia, USA 3Washington University, St. Louis, Missouri, USA

046 Design of transverse gradient coil for human finger blood glucose NMR detection apparatus ...... 238 Lang Chen, Rongsheng Lu, Zhu Hu, Zhonghua Ni School of Mechanical Engineering, Southeast University, Nanjing, China

047 Color doppler ultrasound monitoring of radial artery stealing in patients with autologous arteriovenous fistula ...... 243 Yang Bai1, Guanghong Han2 and Ying Xu3 1Department of Ultrasound, the First Hospital of Jilin University, Changchun, China 2Department of Oral Geriatrics, School and Hospital of Stomatology, Jilin University, Changchun 3Department of Nephrology, the First Hospital of Jilin University, Changchun, China

VIII BIBE 2019, June 20-22, 2019, Hangzhou, China

048 Radiomics analysis for prostate cancer classification in multiparametric magnetic resonance images ...... 247 Chen Yan1, Yahui Peng1, Xinchun Li2 1School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing, China 2Department of Radiology, First Affiliated Hospital of Guangzhou Medical University, Guanzhou, China

049 A novel triple-angle method for rapid B1+ mapping ...... 251 Hongyu Guo1,2, Gaochao Ma1,2, Zhongnan Yu1 1Institute of biomedical electromagnetic engineering, Shenyang University of Technology, Shenyang, China 2Neusoft Medical Systems, China

050 Continuous monitoring of in vivo human brown adipose tissue in response to cold stimulation by photoacoustic tomography ...... 256 Guang Zhang1,2, Jinge Yang1,2, Teng Pan1,2 and Huabei Jiang1,2,3 1School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China 2Center for Information in Biomedicine, University of Electronic Science and Technology, Chengdu, Sichuan, China 3Department of Medical Engineering, University of South Florida, Tampa, FL, USA

051 A miniature fluorescence molecular tomography endoscope ...... 260 Hao Yang1, Dingkang Wang2, Tianqi Shan2, Xianjin Dai2, Huikai Xie2, Lily Yang3, Huabei Jiang1 1University of South Florida, Tampa, USA 2University of Florida, Gainesville, USA 3Emory University, Atlanta, USA

052 Thermoacoustic imaging of tibia fracture in rats ...... 264 Xue Wang1,2, Yuan Zhao1,2, Lin Huang1,2, Huabei Jiang1,2,3 1School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China 2Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China 3Department of Medical Engineering, University of South Florida, Tampa, USA

053 Study on back projection iteration reconstruction method based on sensitivity matrix for Magnetic Induction Tomography ...... 268 Li Ke, Lili Yin, Qiang Du and Wanni Zu Institute of Biomedical and Electromagnetic Engineering, Shenyang University of Technology, Shenyang, China

054 An investigation into the impact of partial volume correction on detection rate of epilepsy using 18F-FDG PET ...... 273 Xinyi Li1, Miao Zhang2, Peng Huang3, Wei Liu3 and Qiu Huang1,2 1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China 2Department of Nuclear Medicine, Ruijin Hospital, Shanghai, China 3Department of Functional Neurosurgery, Ruijin Hospital, Shanghai, China

055 Microwave-induced thermoacoustic tomography for whole-body neonatal mouse imaging .... 278 Yuan Zhao1,3, Tianqi Shan2, Zihui Chi1,3, Lin Huang1,3 and Huabei Jiang1,3,4 1School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China 2Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA 3Center for Information in Medicine, University of Electronic Science and Technology of China Chengdu, China 4Department of Medical Engineering, University of South Florida, Tampa, Florida, USA

IX BIBE 2019, June 20-22, 2019, Hangzhou, China

056 Capsule wireless image receiving device integrating storage and display ...... 283 Deyu Kong1,2, Linfei Ye1,2, Xuan Zhao1,2 and Jiansheng Xu1 1Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China 2University of Chinese Academy of Sciences, Beijing, China

Molecular Biology

057 Construction and expression of a recombinant plasmid containing the porcine epidemic diarrhea virus S1 gene delivered by Lactobacillus ...... 288 Yichao Deng, Ziyi Jiang, Yi Fan, Xi-yu Mao, Wen-ting Lv, Ling Zhu Sichuan Provincial Key Laboratory of animal diseases and human health, Sichuan Agricultural University, Chengdu, Sichuan, China

058 AMPrimer: An R package for anchored multiplex PCR primer design...... 293 Yiqing Wang1, Xin Liu2, Xiangyu Wu1, Xuye Yuan1, Jia Meng1 and Yujiao Tang1 1Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, Suzhou, China 2Department of Hematology, People's Hospital of Tangshan City, Tangshan, China

059 Understanding the relationships between rumen microbiome genes and metabolites to be used for prediction of cattle phenotypes ...... 297 Mengyuan Wang1, Huiru Zheng1, Haiying Wang1, Richard J. Dewhurst2, Rainer Roehe2 1School of Computing, Ulster University, United Kingdom 2Future Farming Systems, Scotland’s Rural College, Edinburgh, United Kingdom

060 UGT1A1 gene mutation and hyperthyroidism combined with hepatic failure: case report and literature review ...... 302 Qianyu Yan, Jingyun Fu Department of Endocrinology and Metabolism, First Affiliated Hospital of Kunming Medical University, Kunming, China

061 Sequencing and analysis of gut microbiota in forest musk deer from Qinghai and Sichuan ..... 306 Xu Liu1, Dan-Qin Li1, Wei Zhao1, Dong Yu1, Jian-Guo Cheng2, Yan Luo1, Yin Wang1, Ze-Xiao Yang1, Xue-Ping Yao1, Shao-Shuai Wu1, Wu-You Wang1, Wei Yang1 1College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Sichuan, China 2Sichuan Institute of Musk Deer Breeding, Dujiangyan, Sichuan, China

062 Effect of heat treatment on the functional characteristics of spirulina protein ...... 313 Chunxia Wang, Li Zhang, Jinjie Liu, Linde Liu School of Life Sciences, Ludong University, Yantai, China

063 Bioinformatics analysis of differentially expressed genes and identifycation of AGER as a key gene in lung cancer ...... 317 Jianzhi Deng1, Yuehan Zhou2 and Xiaohui Cheng1 1Guangxi key Laboratory of Embedded Technology and Intelligent System, Guilin University of Technology, Guilin, China 2College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China

064 Construction and functional analysis of luciferase reporter plasmid containing CXCL12 Gene 3’UTR ...... 321 Feng Huang, Jia-Peng Li, Xing-Hua Liao Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Hubei, China

X BIBE 2019, June 20-22, 2019, Hangzhou, China

065 Analysis the genetic diversity of Lonicera japonica from different regions of Jiaodong Peninsular (Shandong Province, China) by SSR and TrnL-trnF spacer ...... 326 Ranran Wu, Li Zhang, Yifei Wang, Yihe Ge and Linde Liu School of Life Sciences, Ludong University, Yantai, China

066 Dynamics of p53 network and Eag1 channel regulated by Nutlin-3 ...... 330 Xuzhao Wang1,2,3, Yafei Chen3, Hui Liu3, Yufeng Hu3, Yong Zhan1,2,3, Hailong An1,2,3 1State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, China; 2Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin, China; 3Key Laboratory of Molecular Biophysics of Hebei Province, School of Science, Hebei University of Technology, Tianjin, China

067 Development of a real-time RT-PCR for Rabbit Hemorrhagic Disease Virus detection according to VP10 gene ...... 334 Yi-lin Luo, Li-jun Zhou, Xiang Wang, Yan Li, Zhi-dan Luo, Yin Wang, Xue-ping Yao, Yan Luo, Yi Geng, Ze-xiao Yang Sichuan Agricultural University, Chengdu, China

068 The positive effect of metformin on reproduction is through its action on AMPK in GT1-7 cells to regulate KISS1R, and GNRH1 expression ...... 339 Jingyun Fu, Xuan Qu, Jun Zhong and Ping Zhang Division of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

069 Derivatization modification research of butanol at Pueraria Root ...... 343 Xiaohan Zhang, Jianlong Zhang, Li Zhang, Linde Liu School of Life Sciences, Ludong University, Yantai, China

070 Study on segmented bioimpedance detection and calculation method of intracellular and extracellular fluid volumes in human cells ...... 347 Li Ke, Jiawei Xu, Yunan Zhao, Qiang Du, Haiming Lv Institute of Biomedical and Electromagnetic Engineering, Shenyang University of Technology, Shenyang, China

071 Gene association analysis via the method of local polynomial regression ...... 352 Jinli He, Yixing Guo, Qingqing Li and Xiaohan Zhao Department of Statistic, School of Mathematical Sciences, Heilongjiang University and Heilongjiang Provincial Key Laboratory of the Theory and Computation of Complex Systems, Harbin, China

072 Effect of miR223 on production of IL-1β and IL-6 in gingival epithelial cells ...... 357 Ying Wen, Binjie Liu Department of Periodontology, Xiangya stomatology hospital, Central South University, Changsha, China

073 Effects of extrusion and enzyme co-extrusion on structure of pea protein ...... 363 Meng Wang1,2, Lui Li1,2, Guihua Sheng1,2, Wanting Sun1,2, Sai Wang1,2, Xuanhong Chen1,2, Leichao Dong1,2, Quancheng Zhou1,2 1Department of Food Science, School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, China 2Key Laboratory of Shandong Provincial Universities for Technologies Agricultural Products, Zibo, China

XI BIBE 2019, June 20-22, 2019, Hangzhou, China

074 Research on intelligent auto-generating test paper algorithm based on gene expression programming ...... 369 Bo Bi1, Xiao Han1, Jinping Tang2, Yang Lu1 1School of Mathematics and Statistics, Northeast Petroleum University, Daqing, China 2School of Data Science and Technology, Heilongjiang University, Haerbin, China

075 Purification of peanut allergen protein Ara h 3 ...... 374 Minjia Wang, Bing Niu, Zhirui Deng, Qin Chen Shanghai University, Shanghai, China

076 Mechanisms for cells responding to mechanical stresses via the cell membrane ...... 378 Dan Guo, Zhenzhu Li, Chunmei Jiang, Xiaoguang Xu, Dongyan Shao, ShuZhen Lei, Junling Shi Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi Province, China

077 Phylogenetic analysis of tomato varieties based on combined DNA markers ...... 384 Jun Luo, Yu-Jing Liu, Han-Wen Deng, Lin-De Liu, Yan-Lin Sun School of Life Sciences, Ludong University, Yantai, China

078 MKL-1 enhances luciferase activity of a reporter gene containing the miR-142 promoter in MDA-MB-231 cells ...... 388 Han-Han Li, Jia-Peng Li, Xing-Hua Liao Institute of Biology Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Hubei, China

079 Estimate the proportion of non-specific binding in MeRIP-Seq data ...... 392 Jingxuan Bao1, Zhen Wei2, Jia Meng2, Jionglong Su1 1Department of Mathematical Sciences, Xi’an Jiaotong-Liverpool University, Suzhou, Jiangsu, China 2Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, Suzhou, Jiangsu, China

080 Prediction of drug-protein interaction network based on preferential attachment ...... 397 Wei Wang, Hehe Lv, Yuan Zhao Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, Henan Province, China

081 Production of lipopeptides by Bacillus subtilis in solid status fermentation and their application in antifungal and heavy metal remove ...... 401 Pengpeng Zhao1, Yan Wang2, Shuzhen Lei1, Xixi Zhao1, Danni Zhu3, Chunmei Jiang1, Dongyan Shao1, Junling Shi1 1Key Laboratory of Space Biological Experiment Simulation Technology, College of Life Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China 2Microbiology Institute of Shaanxi, Xi'an, Shaanxi, China 3College of Life Sciences and Food Engineering, Shaanxi Xueqian Normal University, Xi'an, China

082 Bioinformatic analysis of WSSV envelope proteins ...... 409 Yongzhong Lu, Qian Qiu, Linyue Cheng, Jie Liu Shandong Provincial Key Laboratory of Biochemical Engineering, Qingdao University of Science and Technology, Qingdao, China

083 Effects of NaCl and pH on the functional properties of Spirulina protein ...... 414 Xia Meng, Li Zhang, Jinjie Liu, Xiaohan Zhang, Chunxia Wang, Linde Liu School of Life Sciences, Ludong University, Yantai, China

XII BIBE 2019, June 20-22, 2019, Hangzhou, China

084 Predict disease-related RNA methylation sites from the methylation-expression association by using hypergeometric test ...... 418 Yujiao Tang, Kunqi Chen, Zhen Wei, Xiangyu Wu and Jia Meng Department of Biological Sciences, Research Center for Precision Medicine, Xi’an Jiaotong-Liverpool University, Suzhou, China

085 Preliminary study on pollination ecology of Vitex negundo in Yantai, China ...... 425 Huinan Lv, Linde Liu, Li Zhang and Lijuan Wang School of Life Sciences, Ludong University, Yantai, China

Chemistry, Pharmacology and Toxicology

086 Efficacy and safety of Qi-Boosting Toxin-Resolving formulae for breast cancer: a meta-analysis...... 429 Liang Zhou1, Lixin Liang2, Zhijun Zeng3, Houwu Gong4 1Department of Breast Surgery, The First Hospital of Hunan University of Chinese Medicine ChangSha ,China 2Departement of Health management, The First Hospital of Hunan University of Chinese Medicine, ChangSha, China 3Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha, China 4DHC SOFTWARE Co., Ltd., Beijing, China

087 The effect of the application of desflurane combined with dexme-detomidine to postoperative cognitive dysfunction in the aged rats ...... 435 Shanshan Yu, Dongmei Li and Jinlan Wang Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China

088 Network pharmacology study on anti-depressant mechanism of Shuyu Capsule ...... 441 Liting Li1, Haiyan Qiu4, Mimi Liu1, Yongming Cai1,2,3 1Guangdong Pharmaceutical University, Guangdong Guangzhou, China 2Guangdong Provincial TCM Precision Medicine Big Data Engineering Technology Research Center, Guangdong Guangzhou, China 3Guangdong University College of Precision Medicine Big Data Engineering Research Center Based on Cloud Computing, Guangdong Guangzhou, China 4Guangdong Huangcun Sports Training Center (Rehabilitation Center), Guangdong Guangzhou, China

089 Analysis on the law of Chinese medicine in the treatment of food allergy ...... 453 Rui Wu, Mingshan Miao, Xiumin Li Henan University of Chinese Medicine, Zhengzhou, China

090 An electrophysiological research of anti-tumor drug targeting TMEM16A ...... 457 Shuai Guo1,2,3, Yafei Chen3, Yong Zhan1,2,3, Hailong An1,2,3 1State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin, China 2Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin, China 3Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, China

091 Molecular mechanism of coix seed with anti-diabetes activity based on network pharmacology ...... 461 Huaqiong Wu, Tingting Cheng, Huanhuan Wang, Mei Zhang, Xulong Huang and Feng Xu Guizhou University of Traditional Chinese Medicine, Guiyang, China

XIII BIBE 2019, June 20-22, 2019, Hangzhou, China

Biomechanics and Biomechanical Engineering

092 Biomechanical analysis of thermal-plasty treatment for atherosclerosis with coupled thermal-electrical-structural model ...... 465 Xiaoning Lou, Shiqing Zhao, Jianqi Sun and Aili Zhang School of Biomedical Engineering, Shanghai Jiao Tong University, China

093 Ultrasound evaluation of the efficacy of angioplasty for renal artery stenosis ...... 471 Yang Bai1, Guanghong Han2, Xiadong Du1, Ying Xu3 1Department of Ultrasound, the First Hospital of Jilin University, Changchun, China 2Department of Oral Geriatrics, School and Hospital of Stomatology, Jilin University, Changchun 3Department of Nephrology, the First Hospital of Jilin University, Changchun, China

094 Effectiveness of a new constant workload cycle ergometer for assessing cardiopulmonary fitness ...... 474 Junhong Wang1,2, Yining Sun1, Xianjun Yang1, Shaoming Sun1, Likui Zhan1 1Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, China 2University of Science and Technology of China, Hefei, China

Other Topics

095 Prediction algorithm and experimental verification of phase change temperature field in cryotherapy ...... 479 Yuxiao Yang, Kuining Li, Bin Liu, Chuxiao Xu School of eEnergy and Power Engineering, Chongqing University, Chongqing, China

096 Colonoscope size influence to the deformation of colon ...... 486 Zhitao Xiao1, Xuehuan He2, Jing Bai2*, Debao Zhou2 1School of Electronics and Information Engineering, Tianjin Polytechnic University, Tianjin China 2Department of Mech. and Industrial Engineering, *Department of Electrical Engineering, University of Minnesota, Duluth, MN, USA

097 Pattern corneal cross-linking with eyeball tracking...... 490 Yiming Zhou1,2, Yingbing Hu1,3, Yun Chen1,3, Shengli Mi1,2,3 1Graduate School at Shenzhen, Tsinghua University, Shenzhen, China 2Department of Mechanical Engineering, Tsinghua University, Beijing, China 3Open Faculty for Innovation, Education, Science, Technology and Art, Tsinghua University, Shenzhen, China

098 Analysis of risk factors for arteriovenous fistula-related ischemic diseases in long-term dialysis patients ...... 497 Yang Bai1, Guanghong Han2, Xiadong Du1, Ying Xu3 1Department of Ultrasound, the First Hospital of Jilin University, Changchun, China 2Department of Oral Geriatrics, School and Hospital of Stomatology, Jilin University, Changchun, China 3Department of Nephrology, the First Hospital of Jilin University, Changchun, China

099 Perioperative care for the reduction of pressure ulcer incidence for patients undergoing femur fracture surgery: an effectiveness study ...... 501 Jianmei Bai, Hospital of Zhuahai Campus, Jinan University, Zhuhai, Guangdong, China

XIV BIBE 2019, June 20-22, 2019, Hangzhou, China

100 Research and application of design algorithm for facial skull restoration ...... 504 Yongsheng Pei1,2, Yuanchao Yang1,2, Tianfang Sheng1,2 and Dawei Yang3 1Research Institute of Health Industry Technology, Yanshan University, Qinhuangdao,China 2Hebei Key Laboratory of Special Delivery Equipment, Yanshan University, Qinhuangdao, China 3Department of Neurosurgery, the First Hospital of Qinhuangdao City, Qinhuangdao, China

101 Study of synthesized multi-frequency excitation signal and magnetic induction detection method based on Walsh function ...... 508 Li Ke, Kehao Zhang, Qiang Du and Chenyang Wang Institute of Biomedical and Electromagnetic Engineering, Shenyang University of Technology, Shenyang, China

102 Analysis of the influence of PM 2.5 on skin based on big-data of microenvironment ...... 512 Hua Sun1, Yanwen Jiang1, Jiaping Chen1, Xuesheng Qian2 1China-Norm Management Consulting Co., Ltd., Shanghai, China 2School of Management, Fudan University, Shanghai, China

103 Characteristic analysis of eczema treated with external Chinese medicine ...... 517 Ming Bai, Tianyuan Liu and Mingsan Miao Henan University of Chinese Medicine, China

104 Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis ...... 521 Lu Yan1, Guanwen Liu1, Xinglong Wang2, Chunmei Jiang1, Dongyan Shao1, Junling Shi1 1Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi Province, China 2College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

105 The mechanism of quercetin anti-breast cancer and nano-modification enhancing the anti-tumor effect of quercetin ...... 525 Hui Sun1,2, Han Jin1, Bing Pang1, Haobing Zhao1, Rongrong Yang1, Yao Lu1, Dongyan Shao1, Chunmei Jiang1, Junling Shi1 1Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi Province, China 2School of Recreation and Health, Guilin Tourism University, Guilin, Guangxi Province, China

106 Antibacterial effect and wound healing ability of silver nanoparticles green synthesized by iturin ...... 530 Xixi Zhao, Liangfu Zhou, Chongyang Ai, Kai Wang, Lu Yan, Xiaoguang Xu, Chunmei Jiang, Junling Shi Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi Province, China

107 Progress in biological application of rare earth upconversion luminescent nanomaterials ...... 534 Shuang Zhou1, Peng Zou1, Fan Li2, Beilong Zhang1, Jiaxin Tong1, Jinhua Li1 1International Joint Research Center for Nanophotonics and Biophotonics, Nanophotonics and Biophotonics Key Laboratory of Jilin Province, School of Science, Changchun University of Science and Technology, Changchun, China 2Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China

108 Water-soluble CuInS2/ZnS quantum dots for reactive oxygen species production ...... 538 Beilong Zhang1, Peng Zou1, Jinhua Li1, Xiaojun Wang2, Xinyue Zhang1, Li Ma2 1International Joint Research Center for Nanophotonics and Biophotonics, Nanophotonics and Biophotonics Key Laboratory of Jilin Province, School of Science, Changchun University of Science and Technology, Changchun, China 2Georgia Southern University, USA

XV BIBE 2019, June 20-22, 2019, Hangzhou, China

109 Flowering information of wine grape affects its flower visitors ...... 542 Ting Zhang1, Lin-de Liu1, Li-ying Luan1, Li Zhang1, Lijiao Meng1, Guang-ren Pei2, Jiming Li2 1School of Life Sciences, Ludong University, Yantai, China 2Changyu Castel Chateau Co., Ltd., Yantai, China

XVI