GG11CH04-Winkler ARI 4 August 2010 16:2 ANNUAL REVIEWS Further Admixture Mapping Click here for quick links to ∗ Annual Reviews content online, including: Comes of Age • Other articles in this volume • Top cited articles 1 1 • Top downloaded articles Cheryl A. Winkler, George W. Nelson, • Our comprehensive search and Michael W. Smith2 1Basic Science Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, NCI Frederick, Frederick, MD 21702 2Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702; email:
[email protected] Annu. Rev. Genomics Hum. Genet. 2010. 11:65–89 Key Words First published online as a Review in Advance on mapping by admixture linkage disequilibrium, risk loci, genetic July 1, 2010 mapping, hidden Markov chain, health disparities The Annual Review of Genomics and Human Genetics is online at genom.annualreviews.org Abstract This article’s doi: Admixture mapping is based on the hypothesis that differences in disease 10.1146/annurev-genom-082509-141523 by Fordham University on 01/13/13. For personal use only. rates between populations are due in part to frequency differences in Copyright c 2010 by Annual Reviews. disease-causing genetic variants. In admixed populations, these genetic All rights reserved variants occur more often on chromosome segments inherited from 1527-8204/10/0922-0065$20.00 the ancestral population with the higher disease variant frequency. A ∗This is a work of the U.S. Government and is not genome scan for disease association requires only enough markers to Annu. Rev. Genom. Human Genet. 2010.11:65-89. Downloaded from www.annualreviews.org subject to copyright protection in the United identify the ancestral chromosome segments; for recently admixed pop- States.