bioRxiv preprint doi: https://doi.org/10.1101/2020.03.02.973065; this version posted March 3, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein Dominik Vogel1#, Sigurdur Rafn Thorkelsson2#, Emmanuelle R. J. Quemin2, Kristina Meier1, Tomas Kouba3, Nadja Gogrefe1, Carola Busch1, Sophia Reindl1, Stephan Günther1,4, Stephen Cusack3, Kay Grünewald2, Maria Rosenthal1,* 1 Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Hamburg, 20359, Germany 2 Centre for Structural Systems Biology, Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, University of Hamburg, Hamburg, Germany 3 European Molecular Biology Laboratory, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France 4 German Center for Infection Research (DZIF), Partner site Hamburg – Lübeck – Borstel – Riems, Hamburg, 20359, Germany # These authors contributed equally to this work. * To whom correspondence should be addressed: Maria Rosenthal; Tel: +49 40 42818 942; Fax: +49 40 42818 931; Email:
[email protected]. 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.03.02.973065; this version posted March 3, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. ABSTRACT The Bunyavirales order contains several emerging viruses with high epidemic potential, including Severe fever with thrombocytopenia syndrome virus (SFTSV).