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WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA). -
Pathological Investigation of Rosacea with Particular Regard Of
CORE Metadata, citation and similar papers at core.ac.uk Provided by White Rose E-theses Online A Clinico-Pathological Investigation of Rosacea with Particular Regard to Systemic Diseases Dr. Mustafa Hassan Marai Submitted in accordance with the requirements for the degree of Doctor of Medicine The University of Leeds School of Medicine May 2015 “I can confirm that the work submitted is my own and that appropriate credit has been given where reference has been made to the work of others” “This copy has been supplied on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement” May 2015 The University of Leeds Dr. Mustafa Hassan Marai “The right of Dr Mustafa Hassan Marai to be identified as Author of this work has been asserted by him in accordance with the Copyright, Designs and Patents Act 1988” Acknowledgement Firstly, I would like to thank all the patients who participate in my rosacea study, giving their time and providing me with all of the important information about their disease. This is helped me to collect all of my study data which resulted in my important outcome of my study. Secondly, I would like to thank my supervisor Dr Mark Goodfield, consultant Dermatologist, for his continuous support and help through out my research study. His flexibility, understanding and his quick response to my enquiries always helped me to relive my stress and give me more strength to solve the difficulties during my research. Also, I would like to thank Dr Elizabeth Hensor, Data Analyst at Leeds Institute of Molecular Medicine, Section of Musculoskeletal Medicine, University of Leeds for her understanding the purpose of my study and her help in analysing my study data. -
Approach to Elephantiasis Nostra of Unclear Etiology: a Case Report with a Brief Review
Journal of Phebology and Lymphology Approach to Elephantiasis Nostra of Unclear Etiology: A Case Report with a Brief Review Authors: Hamit Serdar BAŞBUĞ, Macit BİTARGİ, Kanat ÖZIŞIK Affiliation: Kafkas University Faculty of Medicine, Department of Cardiovascular Surgery, Kars, TURKEY Adress: 1Physiotherapist, Post Graduate Lato Sensu Course on Lymphovenous Rehabilitation of the Medical School in São José do Rio Preto‐FAMERP‐ Rua Tursa 1442 ,apto 201‐ Barroca ‐ Belo Horizonte‐Minas Gerais‐Brazil‐Cep 30431‐091 E‐mail: [email protected]*corresponding author Published: April 2015 Received: January 2015 Journal Phlebology and Lymphology 2015; 8:1‐5 Accepted: 20 March 2015 Abstract Lower extremity lymphedema is an important clinical condition causing morbidity and is frequently encountered by the phlebologists. Elephantiasis Nostra is the status characterized with the extraordinary massive swelling of one or both legs with subsequent thickening and fibrosis of the overlying skin. It is an exaggerated manifestation of a longstanding chronic lymphedema. Etiologically, secondary lymphedema is caused by an external effect such as a chronic lymphangitis, removal of the lymph nodes, trauma, mechanical obstruction, radiotherapy, venous insufficiency, obesity, heart failure, bacterial or helminthic infection (Lymphatic Filariasis), in contrary to the primary lymphedema in which an inherent malfunction of lymphatic channels exists. A morbidly obese female patient with a bilateral Elephantiasis Nostra and our effort on setting the etiological definition and the treatment approach is presented. Key words: Lymphoedema; obesity; leg ulcers Introduction Elephantiasis is the end result of lymphogranuloma Elephantiasis is a progressive enlargement of an extremity venereum, and lastly the Proteus Syndrome which is an 4 or body part accompanied by a chronic inflammatory genetic disorder widely called as "Elephant Man" . -
Pathogenesis of Rosacea Anetta E
REVIEW Pathogenesis of Rosacea Anetta E. Reszko, MD, PhD; Richard D. Granstein, MD Rosacea is a chronic, common skin disorder whose pathogenesis is incompletely understood. An inter- play of multiple factors, including genetic predisposition and environmental, neurogenic, and microbial factors, may be involved in the disease process. Rosacea subtypes, identified in the recently published standard classification system by the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea, may in fact represent different disease processes, and identifying subtypes may allow investigators to pursue more precisely focused studies. New developments in molecular biology and genetics hold promise for elucidating the interplay of the multiple factors involved in the pathogen- esis of rosacea, as well as providing the bases for potential new therapies. osacea is a common, chronic skin disorder and secondary features needed for the clinical diagnosis primarily affecting the central and con- of rosacea. Primary features include flushing (transient vex areas of COSthe face. The nose, cheeks, DERM erythema), persistent erythema, papules and pustules, chin, forehead, and glabella are the most and telangiectasias. Secondary features include burn- frequently affected sites. Less commonly ing and stinging, skin dryness, plaque formation, dry affectedR sites include the infraorbital, submental, and ret- appearance, edema, ocular symptoms, extrafacial mani- roauricular areas, the V-shaped area of the chest, and the festations, and phymatous changes. One or more of the neck, the back, and theDo scalp. Notprimary Copy features is needed for diagnosis.1 The disease has a variety of clinical manifestations, Several authors have theorized that rosacea progresses including flushing, persistent erythema, telangiecta- from one stage to another.2-4 However, recent data, sias, papules, pustules, and tissue and sebaceous gland including data on therapeutic modalities of various sub- hyperplasia. -
Elephantiasis Nostras Verrucosa in Leprosy
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861. Volume 5, Issue 4 (Mar.- Apr. 2013), PP 35-36 www.iosrjournals.org Elephantiasis Nostras Verrucosa in leprosy. Sonam Goyal1, S.N Mahajan2, Sourya Acharya3, Adarsh Lata Singh4 1. Resident, Dept of Medicine 2. Professor and HOD , Dept of Medicine 3. Professor ,Dept of Medicine 4. Professor and HOD ,Dept of Dermatology and Venereal Diseases. Abstract: We present a case of Elephantiasis Nostras Verrucosa in a patient of leprosy with peripheral neuropathy. Key Words: ENV, Leprosy, peripheral neuropathy I. Introduction: Elephantiasis nostras verrucosa (ENV) is the progressive disfiguring enlargement of a body part caused by recurrent soft tissue bacterial infections in the setting of chronic secondary lymphedema. The basic predisposing factor its development is lymphatic obstruction in any part of the body. This obstruction may be primary or secondary due to long standing non lymphatic edematous conditions that ultimately lead to secondary obstruction to lymph flow. Secondary infections due to poor vascularity, neuropathy and lymphedema further aggravates the clinical situation. II. Case Report: A 70 Years old male patient presented to us with chief complain of swelling and disfigurement, foul smelling discharge in bilateral lower limbs since 1 month. He was diagnosed case of lepromatous leprosy and was on anti leprosy treatment since 8 months .At the time of the diagnosis of leprosy his nerve conduction study had been done which revealed demyelinating -
Richtlijn Acneïforme Dermatosen
Richtlijn Acneïforme dermatosen Richtlijn: Acneïforme dermatosen Colofon Richtlijn Acneïforme dermatosen © 2010, Nederlandse Vereniging voor Dermatologie en Venereologie (NVDV) Postbus 8552, 3503 RN Utrecht Telefoon: 030-2823180 E-mail: [email protected] Alle rechten voorbehouden. Niets uit deze uitgave mag worden verveelvoudigd of openbaar worden gemaakt, in enige vorm of op enige wijze, zonder voorafgaande schriftelijke toestemming van de Nederlandse Vereniging voor Dermatologie en Venereologie. Deze richtlijn is opgesteld door een daartoe geïnstalleerde werkgroep van de Nederlandse Vereniging voor Dermatologie en Venereologie. De richtlijn is vervolgens vastgesteld in de algemene ledenvergadering. De richtlijn vertegenwoordigt de geldende professionele standaard ten tijde van de opstelling van de richtlijn. De richtlijn bevat aanbevelingen van algemene aard. Het is mogelijk dat deze aanbevelingen in een individueel geval niet van toepassing zijn. De toepasbaarheid en de toepassing van de richtlijnen in de praktijk is de verantwoordelijkheid van de behandelend arts. Er kunnen zich feiten of omstandigheden voordoen waardoor het wenselijk is dat in het belang van de patiënt van de richtlijn wordt afgeweken. 1 Versie 18-06-2010 WERKGROEP Prof. dr. P.C.M. van de Kerkhof, dermatoloog, voorzitter werkgroep Mw. J.A. Boer, huidtherapeut Drs. R.J. Borgonjen, ondersteuner werkgroep Dr .J.J.E. van Everdingen, dermatoloog Mw. M.E.M. Janssen, huidtherapeut Drs. M. Kerzman, NHG/huisarts Dr. J. de Korte, dermatopsycholoog Drs. M.F.E. Leenarts, dermatoloog i.o. Drs. M.M.D. van der Linden, dermatoloog Dr. J.R. Mekkes, dermatoloog Drs. J.E. Mooij, promovendus dermatologie Drs. L. van ’t Oost, dermatoloog i.o. Dr. V. Sigurdsson, dermatoloog Mw. C. Swinkels, hidradenitis patiënten vereniging/patiëntvertegenwoordiger Drs. -
| Oa Tai Ei Rama Telut Literatur
|OA TAI EI US009750245B2RAMA TELUT LITERATUR (12 ) United States Patent ( 10 ) Patent No. : US 9 ,750 ,245 B2 Lemire et al. ( 45 ) Date of Patent : Sep . 5 , 2017 ( 54 ) TOPICAL USE OF AN ANTIMICROBIAL 2003 /0225003 A1 * 12 / 2003 Ninkov . .. .. 514 / 23 FORMULATION 2009 /0258098 A 10 /2009 Rolling et al. 2009 /0269394 Al 10 /2009 Baker, Jr . et al . 2010 / 0034907 A1 * 2 / 2010 Daigle et al. 424 / 736 (71 ) Applicant : Laboratoire M2, Sherbrooke (CA ) 2010 /0137451 A1 * 6 / 2010 DeMarco et al. .. .. .. 514 / 705 2010 /0272818 Al 10 /2010 Franklin et al . (72 ) Inventors : Gaetan Lemire , Sherbrooke (CA ) ; 2011 / 0206790 AL 8 / 2011 Weiss Ulysse Desranleau Dandurand , 2011 /0223114 AL 9 / 2011 Chakrabortty et al . Sherbrooke (CA ) ; Sylvain Quessy , 2013 /0034618 A1 * 2 / 2013 Swenholt . .. .. 424 /665 Ste - Anne -de - Sorel (CA ) ; Ann Letellier , Massueville (CA ) FOREIGN PATENT DOCUMENTS ( 73 ) Assignee : LABORATOIRE M2, Sherbrooke, AU 2009235913 10 /2009 CA 2567333 12 / 2005 Quebec (CA ) EP 1178736 * 2 / 2004 A23K 1 / 16 WO WO0069277 11 /2000 ( * ) Notice : Subject to any disclaimer, the term of this WO WO 2009132343 10 / 2009 patent is extended or adjusted under 35 WO WO 2010010320 1 / 2010 U . S . C . 154 ( b ) by 37 days . (21 ) Appl. No. : 13 /790 ,911 OTHER PUBLICATIONS Definition of “ Subject ,” Oxford Dictionary - American English , (22 ) Filed : Mar. 8 , 2013 Accessed Dec . 6 , 2013 , pp . 1 - 2 . * Inouye et al , “ Combined Effect of Heat , Essential Oils and Salt on (65 ) Prior Publication Data the Fungicidal Activity against Trichophyton mentagrophytes in US 2014 /0256826 A1 Sep . 11, 2014 Foot Bath ,” Jpn . -
Unusual Cause of Saxophone Penis
Letters to the Editor AAddressddress fforor ccorrespondence:orrespondence: Dr. Amar Surjushe, Department of Other causes of genital elephantiasis like infections and Dermatology, Venereology, and Leprology, Grant Medical College and [3,4] Sir JJ Groups of Hospitals, Mumbai - 400 008, India. malignancies are very rare. E-mail: [email protected] A 45-year-old man, father of four, with swelling of scrotum RREFERENCESEFERENCES and penis of about 2 months duration was referred by a surgeon. Onset was sudden and within 2 weeks he developed 1. Wilson B. Necrotizing fasciitis. Am Surg 1952;18:416-31. 2. Weinberg AN, Swartz MN, Tsao H, Johnson RA. Fitzpatrick’s a large swelling of penis and scrotum. He only had a feeling dermatology in general medicine. In: Freedberg IM, Eisen of heaviness and was depressed due to the embarrassing AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Soft condition. There was no history of injury, operation, or tissue infections: Erysipelas, cellulitis, gangrenous cellulitis radiation prior to the onset. He had a large number of pus- and myonecrosis. 6th ed. New York: McGraw- Hill Publishing filled eruptions on both legs with fever, about 8 weeks prior Division; 2003. p. 1883-95. to the onset. He was treated by a doctor (non-dermatologist) 3. Melish ME, Bertuch AA. Bacterial skin infections. In: with oral and topical antibiotics. All lesions had healed in Feigin RD, Cherry JD, editors. Textbook of pediatric 10-15 days leaving behind scars. There was no history of infectious diseases. 4th ed. Philadelphia: W.B. Saunders Company; 1998. p. 741-52. extramarital sexual contact or genital ulcer disease. -
Obesity-Associated Abdominal Elephantiasis
Hindawi Publishing Corporation Case Reports in Medicine Volume 2013, Article ID 626739, 3 pages http://dx.doi.org/10.1155/2013/626739 Case Report Obesity-Associated Abdominal Elephantiasis Ritesh Kohli,1 Vivian Argento,2 and Yaw Amoateng-Adjepong3 1 Department of Internal Medicine, Bridgeport Hospital, Yale University School of Medicine, Columbia Tower, Appt. no. 308, 50 Ridgefield Avenue, Bridgeport, CT 06610, USA 2 Geriatric Fellowship, Bridgeport Hospital, Yale University School of Medicine, 267 Grant Street, CT 06610, USA 3 Department of Internal Medicine, Bridgeport Hospital, Yale University School of Medicine, 267 Grant Street, CT 06610, USA Correspondence should be addressed to Ritesh Kohli; [email protected] Received 28 November 2012; Revised 1 March 2013; Accepted 5 March 2013 Academic Editor: Jeffrey M. Weinberg Copyright © 2013 Ritesh Kohli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abdominal elephantiasis is a rare entity. Abdominal elephantiasis is an uncommon, but deformative and progressive cutaneous disease caused by chronic lymphedema and recurrent streptococcal or Staphylococcus infections of the abdominal wall. We present 3 cases of patients with morbid obesity who presented to our hospital with abdominal wall swelling, thickening, erythema, and pain. The abdominal wall and legs were edematous, with cobblestone-like, thickened, hyperpigmented, and fissured plaques on the abdomen. Two patients had localised areas of skin erythema, tenderness, and increased warmth. There was purulent drainage from the abdominal wall in one patient. They were managed with antibiotics with some initial improvement. -
Pathological Investigation of Rosacea with Particular Regard Of
A Clinico-Pathological Investigation of Rosacea with Particular Regard to Systemic Diseases Dr. Mustafa Hassan Marai Submitted in accordance with the requirements for the degree of Doctor of Medicine The University of Leeds School of Medicine May 2015 “I can confirm that the work submitted is my own and that appropriate credit has been given where reference has been made to the work of others” “This copy has been supplied on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement” May 2015 The University of Leeds Dr. Mustafa Hassan Marai “The right of Dr Mustafa Hassan Marai to be identified as Author of this work has been asserted by him in accordance with the Copyright, Designs and Patents Act 1988” Acknowledgement Firstly, I would like to thank all the patients who participate in my rosacea study, giving their time and providing me with all of the important information about their disease. This is helped me to collect all of my study data which resulted in my important outcome of my study. Secondly, I would like to thank my supervisor Dr Mark Goodfield, consultant Dermatologist, for his continuous support and help through out my research study. His flexibility, understanding and his quick response to my enquiries always helped me to relive my stress and give me more strength to solve the difficulties during my research. Also, I would like to thank Dr Elizabeth Hensor, Data Analyst at Leeds Institute of Molecular Medicine, Section of Musculoskeletal Medicine, University of Leeds for her understanding the purpose of my study and her help in analysing my study data. -
Folliculitis
Folliculitis Common Cutaneous • Inflammation of hair follicle(s) Bacterial Infections • Symptoms: Often pruritic (itchy) Pseudomonas folliculitis Eosinophilic Folliculitis (HIV) Folliculitis: Causes • Bacteria: – Gram positives (Staph): most common – Gram negatives: Pseudomonas – “hot tub” folliculitis • Fungal: Pityrosporum aka Malassezia • HIV: eosinophilic folliculitis (not bacterial) • Renal Failure: perforating folliculitis (not bacterial) Treatment of Folliculitis 21 year old female with controlled Crohn’s disease and history of • Bacterial hidradenitis suppuritiva presents stating – culture pustule she has recurrent flares of her HS – topical clindamycin or oral cephalexin / doxycycline – shower and change shirt after exercise – keep skin dry; loose clothing • Fungal: topical antifungals (e.g., ketoconazole) • Eosinophilic folliculitis – Phototherapy – Treat the HIV MRSA MRSA Eradication • Swab nares mupirocin ointment bid x 5 days • GI noted Crohn’s was controlled but increased – Swab axillae, perineum, pharynx infliximab intensity, but that was not controlling • Chlorhexidine 4% bodywash qd x 1 week recurrent “flares” • Chlorhexidine mouthwash qd x 1 week; soak toothbrush (or disposable) •I & D MRSA on three occasions • Bleach bath: 1/3 cup to tub, soak x 10 min tiw x 1 week, then prn (perhaps weekly) • THIS WAS INFLIXIMAB-RELATED • Oral antibiotics x 14 days: Bactrim, Doxycycline, depends FURUNCULOSIS FROM MRSA COLONIZATION on sensitivities – D/C infliximab • Swab partners – Anti-MRSA regimen • Hand sanitizer frequently – Patient is better • Bleach wipes to surfaces (doorknobs, faucet handles) • Towels use once then wash; paper towels when possible Pointing abscess (furuncle) --pointing requires I & D-- Acute Paronychia Furuncle Treatment Impetigo • Incise & Drain (I & D) Culture pus • Warm soaks • Antibiotics – e.g., cephalexin orally AND mupirocin topically • If recurrent, suspect nasal carriage of Staph aureus swab culture and mupirocin to nares b.i.d. -
A Dissertation on CLINICO EPIDEMIOLOGICAL STUDY of FACIAL DERMATOSES AMONG ADULTS
A Dissertation on CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS Dissertation submitted to THE TAMILNADU DR.M.G.R. MEDICAL UNIVERSITY CHENNAI-600032 With partial fulfillment of the requirements for the award of M.D.DEGREE IN DERMATOLOGY, VENEREOLOGY AND LEPROLOGY (BRANCH - XX) REG. No. 201730201 COIMBATORE MEDICAL COLLEGE AND HOSPITAL COIMBATORE MAY 2020 DECLARATION I Dr . MANIVANNAN . M solemnly declare that the dissertation entitled “CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS ” is a bonafide work done by me at Coimbatore Medical College Hospital during the year June 2018 to May 2019 under the guidance & supervision of Dr. M. KARUNAKARAN M.D., (DERM) Professor& Head of Department, Department of Dermatology, Coimbatore Medical College & Hospital. The dissertation is submitted to Dr. MGR Medical University towards partial fulfillment of requirement for the award of MD degree branch XX Dermatology, Venereology and Leprology. PLACE: Dr. MANIVANNAN .M DATE: CERTIFICATE This is to certify that the dissertation entitled “CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS” is a bonafide original work done by Dr. MANIVANNAN.M. Post graduate student in the Department of Dermatology, Venereology and Leprology, Coimbatore Medical College Hospital, Coimbatore under the guidance of Dr. M. KARUNAKARAN M.D., (DERM), Professor and HOD of Department, Department of Dermatology, Coimbatore Medical College Hospital, Coimbatore in partial fulfillment of the regulations for the Tamilnadu DR.M.G.R Medical University, Chennai towards the award of MD., degree (Branch XX.) in Dermatology, Venereology and Leprology. Date : GUIDE Dr. M. KARUNAKARAN M.D., (DERM) Professor & HOD, Department of Dermatology, Coimbatore Medical College & Hospital. Date : Dr.