DOCSLIB.ORG

A Dissertation on CLINICO EPIDEMIOLOGICAL STUDY of FACIAL DERMATOSES AMONG ADULTS

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
A Dissertation on CLINICO EPIDEMIOLOGICAL STUDY of FACIAL DERMATOSES AMONG ADULTS A Dissertation on CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS Dissertation submitted to THE TAMILNADU DR.M.G.R. MEDICAL UNIVERSITY CHENNAI-600032 With partial fulfillment of the requirements for the award of M.D.DEGREE IN DERMATOLOGY, VENEREOLOGY AND LEPROLOGY (BRANCH - XX) REG. No. 201730201 COIMBATORE MEDICAL COLLEGE AND HOSPITAL COIMBATORE MAY 2020 DECLARATION I Dr . MANIVANNAN . M solemnly declare that the dissertation entitled “CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS ” is a bonafide work done by me at Coimbatore Medical College Hospital during the year June 2018 to May 2019 under the guidance & supervision of Dr. M. KARUNAKARAN M.D., (DERM) Professor& Head of Department, Department of Dermatology, Coimbatore Medical College & Hospital. The dissertation is submitted to Dr. MGR Medical University towards partial fulfillment of requirement for the award of MD degree branch XX Dermatology, Venereology and Leprology. PLACE: Dr. MANIVANNAN .M DATE: CERTIFICATE This is to certify that the dissertation entitled “CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS” is a bonafide original work done by Dr. MANIVANNAN.M. Post graduate student in the Department of Dermatology, Venereology and Leprology, Coimbatore Medical College Hospital, Coimbatore under the guidance of Dr. M. KARUNAKARAN M.D., (DERM), Professor and HOD of Department, Department of Dermatology, Coimbatore Medical College Hospital, Coimbatore in partial fulfillment of the regulations for the Tamilnadu DR.M.G.R Medical University, Chennai towards the award of MD., degree (Branch XX.) in Dermatology, Venereology and Leprology. Date : GUIDE Dr. M. KARUNAKARAN M.D., (DERM) Professor & HOD, Department of Dermatology, Coimbatore Medical College & Hospital. Date : Dr. M. KARUNAKARAN M.D., (DERM) Professor & HOD, Department of Dermatology, Coimbatore Medical College & Hospital. Date : Dr. B. ASOKAN, M.S., Mch., Dean, Coimbatore Medical College & Hospital, Coimbatore. COPYRIGHT DECLARATION BY THE CANDIDATE I hereby declare that The Tamilnadu DR.M.G.R Medical University, Chennai shall have the rights to preserve, use and disseminate this dissertation/thesis in print or electronic format for academic/research purpose. PLACE: COIMBATORE Dr. MANIVANNAN .M DATE: PLAGIARISM CERTIFICATE This is to certify that this dissertation work titled "CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES" of the candidate Dr. M. MANIVANNAN with Registration number for the award of M.D.DERMATOLOGY, VENEREOLOGY AND LEPROSY in the branch of XX. I personaly verfied the urkund.com website for the purpose of plagiarism check. I found that the uploaded thesis file contains from introduction to conclusion pages and results shows 1% of plagiarism in the dissertation. Signature of the Guide ACKNOWLEDGEMENT I solicit my humble thanks to the Dean Dr. B. Asokan, M.S., Mch., Coimbatore Medical College Hospital, for allowing me to conduct the study in this hospital. I am also immensely thankful to my guide Prof. Dr.M.Karunakaran M.D., (DERM) Professor Head of the Department, Dermatology and Leprology for his invaluable guidance, motivation and help throughout the study. I express my earnest gratitude to Dr. Muthukumaran M.D., Prof. and Head of the Department, Department of Venerealogy, all the Assistant Professors, Department of Dermatology Dr.B.Eswaramoorthy M.D., Dr.R.Madhavan M.D., Dr.S.Bharathi M.D., Dr.Swarnalakshmi M.D., Dr.pradeepa M.D , Dr. Ranjani M.D and Dr. Arul D.D.V.L without their help and guidance this work would not have been possible. I owe a lot to my parents and other family members who have always been my pillar of support in all stages of my life. My sincere thanks to my seniors Dr.A.Amutha, Dr.M.S.Krishnameera, Dr.Divya, Dr.Dhineshkumar and my fellow post graduate colleagues Dr.Vijayalakshmi, Dr.Neikhrielie Khro, Dr.Manipriya, Dr.Aravind and Dr.Kiruthika who have been of immense help throughout the study period. I am very grateful to all patients for their co-operation and participation in the study. TABLE OF CONTENTS S.NO CONTENTS PAGE NO. 1. INTODUCTION 1 2. REVIEW OF LITERATURE 2 3. AIM AND OBJECTIVES OF THE STUDY 51 4. MATERIALS AND METHODS 52 5. OBSERVATION AND RESULT 54 6. DISCUSSION 89 7. SUMMARY 95 8. CONCLUSION 97 9. BIBLIOGRAPHY 102 10. ANNEXURES PROFORMA CONSENT FORM KEY TO MASTER CHART MASTER CHART LIST OF TABLES S.No. TABLES PAGE NO. 1. CLASSIFICATION OF FACIAL DERMATOSES 3 2. CLINICAL GRADING SYSTEM OF ACNE 10 (PILLSBURRY’S CLASSIFICATION) 3. SUBTYPES OF ROSACEA AND THEIR CLINICAL 14 FEATURES 4. FITZPATRICK SKIN TYPES 15 5. TYPES OF MELASMA 17 6. BORDEAUX VITILIGO GLOBAL ISSUES 22 CONSENSUS CONFERENCE CLASSIFICATION 7. CLASSIFICATION OF SEGMENTAL VITILIGO OF 22 FACE 8. CLASSIFICATION OF PHOTODERMATOSES 27 9. AGE WISE DISTRIBUTION OF FACIAL 55 DERMATOSES 10. SITES OF DISTRIBUTION OF FACIAL DERMATOSES 58 11. AGE AND SEX WISE DISTRIBUTION OF ACNE 59 12. SITES OF DISTRIBUTION OF ACNE 61 13. GRADING OF ACNE 61 14. AGGREVATION FACTORS OF ACNE 62 15. AGE WISE DISTRIBUTION OF PIGMENTARY 63 DISORDERS 16. AGE WISE DISTRIBUTION OF INFECTIONS 70 17. AGE WISE DISTRIBUTION OF ECZEMATOUS 73 DISEASES 18. AGE GROUP WISE DISTRIBUTION OF SKIN 77 TUMOURS 19. INCIDENCE OF SKIN TUMOURS OF FACE 78 LIST OF CHARTS S.No. CHARTS PAGE NO. 1. SEX DISTRIBUTION IN FACIAL DERMATOSES 54 2. OCCUPATIONAL DISTRIBUTION OF FACIAL 55 DERMATOSES 3. SEASONAL VARIATIONS IN FACIAL 56 DERMATOSES 4. SYMPTOMS IN FACIAL DERMATOSES 57 5. INCIDENCE OF VARIOUS FACIAL DERMATOSES 57 6. GENDER DISTRIBUTION OF ACNE 59 7. OCCUPATIONAL DISTRIBUTION OF ACNE 60 8. OCCUPATIONAL DISTRIBUTION OF 64 PIGMENTARY DISORDERS 9. SEASONAL DISTRIBUTION OF PIGMENTARY 65 DISORDERS 10. SEX DISTRIBUTION OF MELASMA 66 11. OCCUPATIONAL DISTRIBUTION OF MELASMA 67 12. DISTRIBUTION PATTERN OF MELASMA 68 13. OCCUPATIONAL DISTRIBUTION OF INFECTIONS 70 14. INCIDENCE WISE DISTRIBUTION OF 71 INFECTIONS 15. OCCUPATIONAL DISTRIBUTION OF ECZEMAS 74 AFFECTING FACE 16. OCCUPATIONAL DISTRIBUTION OF SKIN 77 TUMOURS COLOUR PLATES S.No COLOUR PLATES PAGE NO. 1. ACNE VULGARIS 80 2. NODULO CYSTIC ACNE 80 3. MELASMA 81 4. HERPES LABIALIS 81 5. ACNE SCARS 82 6. PERIORAL DERMATITIS 82 7. TINEA FACIEI 83 8. VITILIGO 83 9. MOLLUSCUM CONTAGIOSUM 84 10. PHOTO SENSITIVE ECZEMA 84 11. DERMATOSIS PAPULOSA NIGRA 85 12. HERPES SIMPLEX 85 13. ROSACEA 86 14. HANSEN’S DISEASE 86 15. XANTHELASMA 87 16. SYRINGOMA 87 17. TRICHOEPITHELIOMA 88 18. TUBEROUS SCLEROSIS 88 LIST OF ABBREVIATIONS DPN : Dermatosis Papulosa Nigra SCC : Squamous Cell Carcinoma BCC : Basal Cell Carcinoma SLE : Systemic Lupus Erythematosus PMLE : Polymorphic Light Eruption. TLR : Toll Like Receptors PAMPs : Pathogen Associated Molecular Patterns. MITF : Melanocyte Inducing Transcription Factor. ABSTRACT TITLE : CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS BACKGROUND AND PURPOSE OF STUDY : Face is cosmetically important area of the body. Any change in skin colour or appearance of rash over the face affects an individual both in psychological and social aspects. Each facial dermatoses have its own clinical presentations and also own demographic variations. Therefore detailed knowledge about the dermatoses affecting the face is important. AIM To study the clinical features and different pattern of involvement of various facial dermatoses and their epidemiological aspects like age , sex distribution and occupation. MATERIALS AND METHODS 200 patients with facial dermatoses were selected from OPD of dermatology, Coimbatore Medical College Hospital, for a period of 1 year. In each patient, the details of name, age , sex and occupation were noted. A detailed history of symptoms and their duration were recorded. Complete general and dermatological examination was carried out in all the patients. Investigations like KOH examination , woods lamp examination and skin biopsy was carried out in relevant patients. RESULTS Among the 200 patients enrolled in this study 63% were females and 37% were males. Most common age group affected was 26-32 years. Majority of them were housewives (27.5%.). Seasonal variation was reported in 60% of cases. Among the various facial dermatoses , most commonly reported in this study was pilosebaceous diseases , followed by pigmentary disorders and infections. CONCLUSION : Most of the studies in the facial dermatoses were focused on the specific diseases, this study highlights the need for comprehensive studies in facial dermatoses. KEYWORDS : ACNE, MELASMA, Skin Tumors INTRODUCTION Face is an important area of concern in aspects of health and disease. Facial appearance of an individual provides primary identity to a person. Facial skin is more prone to UV rays , allergens , infections and cosmetics usage than any other parts in our body. Any lesions on the face provoke more anxiety and seeks early medical need. The various dermatological conditions that affect the face are pilosebaceous diseases, pigmentary disorders , infections , eczema , connective tissue diseases and immune bullous disorders. Some of them pertaining to face only and some of them are early manifestation of systemic diseases as well. Hence early identification of these diseases are helps in proper management. 1 REVIEW OF LITERATURE CLINICO EPIDEMIOLOGICAL STUDY OF FACIAL DERMATOSES AMONG ADULTS Facial appearance is a primary identity for an individual. Facial skin is differ from other regions of the skin because of its rich vascular supply and abundant sebaceous glands. The dermo epidermal junction of facial skin have a flattened profile with consequent
Load more

Recommended publications
  • Pathological Investigation of Rosacea with Particular Regard Of
    CORE Metadata, citation and similar papers at core.ac.uk Provided by White Rose E-theses Online A Clinico-Pathological Investigation of Rosacea with Particular Regard to Systemic Diseases Dr. Mustafa Hassan Marai Submitted in accordance with the requirements for the degree of Doctor of Medicine The University of Leeds School of Medicine May 2015 “I can confirm that the work submitted is my own and that appropriate credit has been given where reference has been made to the work of others” “This copy has been supplied on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement” May 2015 The University of Leeds Dr. Mustafa Hassan Marai “The right of Dr Mustafa Hassan Marai to be identified as Author of this work has been asserted by him in accordance with the Copyright, Designs and Patents Act 1988” Acknowledgement Firstly, I would like to thank all the patients who participate in my rosacea study, giving their time and providing me with all of the important information about their disease. This is helped me to collect all of my study data which resulted in my important outcome of my study. Secondly, I would like to thank my supervisor Dr Mark Goodfield, consultant Dermatologist, for his continuous support and help through out my research study. His flexibility, understanding and his quick response to my enquiries always helped me to relive my stress and give me more strength to solve the difficulties during my research. Also, I would like to thank Dr Elizabeth Hensor, Data Analyst at Leeds Institute of Molecular Medicine, Section of Musculoskeletal Medicine, University of Leeds for her understanding the purpose of my study and her help in analysing my study data.
    [Show full text]
  • Pathogenesis of Rosacea Anetta E
    REVIEW Pathogenesis of Rosacea Anetta E. Reszko, MD, PhD; Richard D. Granstein, MD Rosacea is a chronic, common skin disorder whose pathogenesis is incompletely understood. An inter- play of multiple factors, including genetic predisposition and environmental, neurogenic, and microbial factors, may be involved in the disease process. Rosacea subtypes, identified in the recently published standard classification system by the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea, may in fact represent different disease processes, and identifying subtypes may allow investigators to pursue more precisely focused studies. New developments in molecular biology and genetics hold promise for elucidating the interplay of the multiple factors involved in the pathogen- esis of rosacea, as well as providing the bases for potential new therapies. osacea is a common, chronic skin disorder and secondary features needed for the clinical diagnosis primarily affecting the central and con- of rosacea. Primary features include flushing (transient vex areas of COSthe face. The nose, cheeks, DERM erythema), persistent erythema, papules and pustules, chin, forehead, and glabella are the most and telangiectasias. Secondary features include burn- frequently affected sites. Less commonly ing and stinging, skin dryness, plaque formation, dry affectedR sites include the infraorbital, submental, and ret- appearance, edema, ocular symptoms, extrafacial mani- roauricular areas, the V-shaped area of the chest, and the festations, and phymatous changes. One or more of the neck, the back, and theDo scalp. Notprimary Copy features is needed for diagnosis.1 The disease has a variety of clinical manifestations, Several authors have theorized that rosacea progresses including flushing, persistent erythema, telangiecta- from one stage to another.2-4 However, recent data, sias, papules, pustules, and tissue and sebaceous gland including data on therapeutic modalities of various sub- hyperplasia.
    [Show full text]
  • Richtlijn Acneïforme Dermatosen
    Richtlijn Acneïforme dermatosen Richtlijn: Acneïforme dermatosen Colofon Richtlijn Acneïforme dermatosen © 2010, Nederlandse Vereniging voor Dermatologie en Venereologie (NVDV) Postbus 8552, 3503 RN Utrecht Telefoon: 030-2823180 E-mail: [email protected] Alle rechten voorbehouden. Niets uit deze uitgave mag worden verveelvoudigd of openbaar worden gemaakt, in enige vorm of op enige wijze, zonder voorafgaande schriftelijke toestemming van de Nederlandse Vereniging voor Dermatologie en Venereologie. Deze richtlijn is opgesteld door een daartoe geïnstalleerde werkgroep van de Nederlandse Vereniging voor Dermatologie en Venereologie. De richtlijn is vervolgens vastgesteld in de algemene ledenvergadering. De richtlijn vertegenwoordigt de geldende professionele standaard ten tijde van de opstelling van de richtlijn. De richtlijn bevat aanbevelingen van algemene aard. Het is mogelijk dat deze aanbevelingen in een individueel geval niet van toepassing zijn. De toepasbaarheid en de toepassing van de richtlijnen in de praktijk is de verantwoordelijkheid van de behandelend arts. Er kunnen zich feiten of omstandigheden voordoen waardoor het wenselijk is dat in het belang van de patiënt van de richtlijn wordt afgeweken. 1 Versie 18-06-2010 WERKGROEP Prof. dr. P.C.M. van de Kerkhof, dermatoloog, voorzitter werkgroep Mw. J.A. Boer, huidtherapeut Drs. R.J. Borgonjen, ondersteuner werkgroep Dr .J.J.E. van Everdingen, dermatoloog Mw. M.E.M. Janssen, huidtherapeut Drs. M. Kerzman, NHG/huisarts Dr. J. de Korte, dermatopsycholoog Drs. M.F.E. Leenarts, dermatoloog i.o. Drs. M.M.D. van der Linden, dermatoloog Dr. J.R. Mekkes, dermatoloog Drs. J.E. Mooij, promovendus dermatologie Drs. L. van ’t Oost, dermatoloog i.o. Dr. V. Sigurdsson, dermatoloog Mw. C. Swinkels, hidradenitis patiënten vereniging/patiëntvertegenwoordiger Drs.
    [Show full text]
  • (2006.01) Published: A61K9/08
    ) ( (51) International Patent Classification: Published: A61K 31/05 (2006.01) A61P 1 7/02 (2006.01) — with international search report (Art. 21(3)) A61K9/08 (2006.01) A61P29/00 (2006.01) A61P 1 7/00 (2006.01) (21) International Application Number: PCT/AU20 19/05005 1 (22) International Filing Date: 24 January 2019 (24.01.2019) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2018900226 24 January 2018 (24.01.2018) AU 62/621,225 24 January 2018 (24.01.2018) US 2018903600 25 September 2018 (25.09.2018) AU 62/736,052 25 September 2018 (25.09.2018) US (71) Applicant: BOTANIX PHARMACEUTICALS LTD [AU/AU]; 63 Aberdeen Street, Northbridge, Western Aus¬ tralia 6003 (AU). (72) Inventors: CALLAHAN, Matthew; One Kew Place, 150 Rouse Boulevard, Navy Yard Corporate Center, Philadel¬ phia, Pennsylvania 191 12 (US). THURN, Michael; 912 Kangaroobie Road, Kangaroobie, NSW 2800 (AU). (74) Agent: WRAYS PTY LTD; Level 7, 863 Hay Street, Perth, Western Australia 6000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available) : AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
    [Show full text]
  • Curriculum Vitae Clay J. Cockerell, M.D. Home
    CURRICULUM VITAE CLAY J. COCKERELL, M.D. HOME ADDRESS 4312 Arcady Avenue Dallas, Texas 75205 (214) 522-2610 WORK ADDRESS Cockerell & Associates-Dermpath Diagnostics Dermatopathology Laboratories 2330 Butler Street, Suite 115 Dallas, Texas 75235 Phone: (214) 530-5200, (800) 309-0000 Fax: (214) 530-5232 BIRTH DATE AND PLACE September 16, 1956, Houston, Texas MARITAL STATUS Married - Brenda West Cockerell Two children - Charles West Cockerell & Lillian Allene Cockerell COLLEGE EDUCATION 1974 – 1977 Texas Tech University Majors: Zoology, Microbiology, Chemistry No degree - entered Medical School via Early Decision Program GRADUATE EDUCATION 1977 - 1981 Baylor College of Medicine Degree - M.D. with honors, June 1981 POSTGRADUATE EDUCATION 1981-1982 Internship, Internal Medicine University of Washington Affiliated Hospitals, Seattle, Washington 1982-1985 Residency, Dermatology New York University Medical Center, New York, New York 1984-1985 Chief Resident, Dermatology New York University Medical Center, New York, New York 1985-1986 Fellowship, Dermatopathology New York University Medical Center, New York, New York OTHER TRAINING Sloan-Kettering Memorial Hospital, Pathology New York, New York Part-time clinical observer July 1986 - January 1987 Clay J. Cockerell, M.D. Updated 1/15/2018 Page 2 ACADEMIC APPOINTMENTS University of Texas Southwestern Medical Center Assistant Professor, Dermatology and Pathology, September 1988 - September 1992 Associate Professor, Dermatology and Pathology, September 1992 - September 1993 Clinical Associate Professor,
    [Show full text]
  • The Great Mimickers of Rosacea
    The Great Mimickers of Rosacea Jeannette Olazagasti, BS; Peter Lynch, MD; Nasim Fazel, MD, DDS Practice Points Rosacea is characterized by frequent flushing; persistent erythema (ie, lasting for at least 3 months); telangiectasia; and interspersed episodes of inflammation with swelling, papules, and pustules. Rosacea is most commonly seen in adults older than 30 years and is considered to have a strong hereditary component, as it is more commonly seen in individuals of Celtic and Northern European descent as well as those with fair skin. Although rosacea is one of the most common Rosacea Characteristics conditions treated by dermatologists, it also is Rosacea is a chroniccopy disorder affecting the central one of the most misunderstood. It is a chronic dis- parts of the face that is characterized by frequent order affecting the central parts of the face and flushing; persistent erythema (ie, lasting for at least is characterized by frequent flushing; persistent 3 months); telangiectasia; and interspersed epi- erythema (ie, lasting for at least 3 months); tel- sodes of inflammation with swelling, papules, and angiectasia; and interspersed episodes of inflam- pustules.not2 It is most commonly seen in adults older mation with swelling, papules, and pustules. than 30 years and is considered to have a strong Understanding the clinical variants and disease hereditary component, as it is more commonly seen course of rosacea is important to differentiateDo in individuals of Celtic and Northern European this entity from other conditions that can mimic descent as well as those with fair skin. Furthermore, rosacea. Herein we present several mimickers of approximately 30% to 40% of patients report a fam- rosacea that physicians should consider when ily member with the condition.2 diagnosing this condition.
    [Show full text]
  • Abscess, 600, 601F, 602 Apocrine Sweat Gland, 14–16
    3038r_ind_1023-1041 4/11/01 2:14 PM Page 1023 INDEX A Allergic phytodermatitis (APD), 26–28, Abscess, 600, 601f, 602 28f–29f apocrine sweat gland, 14–16, 15f, 17f Allopurinol, drug reaction to, 554 tuberculosis, metastatic, 661–662, 664, 666 ALM (acral lentiginous melanoma), 295–296, Acantholytic dermatosis, transient, 112, 113f 297f Acanthosis nigricans (AN), 82–83, 83f Alopecia classification, 82 nonscarring, 928–940 malignant, 82–83, 493, 493f–494f alopecia areata, 928–930, 929f, 931f ACD. See Allergic contact dermatitis alopecia totalis, 928 ACDRs (adverse cutaneous drug reactions). alopecia universalis, 928, 931f See Drug reactions anagen effluvium, 940, 940f ACE (angiotensin-converting enzyme) inhib- androgenetic alopecia, 932–936, 933f, itors, reactions to, 556 935f–936f Acetowhitening, 1015 neoplastica, 482 Acne keloidalis, 941, 945f telogen effluvium, 937–939, 938t–939t, Acne rosacea. See Rosacea 939f Acne vulgaris, 2–6, 3f, 5f, 7f scarring, 941, 942f–945f, 942t acne conglobata, 4 α1 antitrypsin-deficiency panniculitis, 146 acne fulminans, 4 Amiodarone-induced pigmentation, 566, 567f recalcitrant acne, 4 Amoxicillin drug reaction, 554 Acneform drug eruptions, 548 Ampicillin drug reaction, 553f, 554 Acral lentiginous melanoma (ALM), 295–296, Amyloidosis, systemic, 334–336, 335f, 337f 297f acquired, 334–336, 335f, 337f Acrochordon, 209f secondary, 334, 336 Acrodermatitis continua of Hallopeau, 69 AN. See Acanthosis nigricans Acrodermatitis enteropathica, 430–431, 432f Anagen effluvium, 940, 940f Acrosclerosis, 375f Anaphylaxis and anaphylactoid reactions, 547, ACTH-induced pigmentation, 568 556, 558 Actinic keratosis, 217, 219, 220f Angioedema and urticaria, 338–344, 339f, Actinic prurigo, 230, 234 341f–343f, 344t, 345f Acute febrile neutrophilic dermatosis. See drug reaction, 547, 556–558, 559f Sweet’s syndrome urticaria perstans, 393–394, 394f Acute retroviral syndrome (ARS), 912–915, urticarial vasculitis, 393–394, 394f 915f, 915t Angiokeratoma, 183f AD.
    [Show full text]
  • Otophyma: About a Case
    ACNE, ROSACEA, AND RELATED DISORDERS (INCLUDING HIDRADENITIS SUPPURATIVA) OTOPHYMA: ABOUT A CASE N Maya (1) - E Tababa (1) - Na Vashi (1) Boston University School Of Medicine, Department Of Dermatology, Boston, United States (1) Background: Phyma, a slowly progressive and disfiguring disorder of the face and ears, is generally considered to be an advanced form of rosacea. Interestingly, it may occur in patients with no other signs or symptoms of rosacea. It is caused by sebaceous gland hyperplasia and hypertrophy with surrounding fibrous tissue proliferation. Phyma typically affects the nose (rhinophyma); however, equivalent presentations can occur on the chin (gnatophyma), forehead (metophyma), ears (otophyma), and eyelids (blepharophyma). Although rhinophyma is ubiquitously seen in clinical practice, otophyma (rosaceous lymphedema of the ear) is much more rare and uncommonly reported in the literature. It presents as either unilateral or bilateral edematous ear involvement with or without coexisting facial rosacea. Observation: A 58-year-old Hispanic man presented for evaluation of a one-month history of asymptomatic enlarged ears. He denied any triggers or history of repeated trauma to the affected area. His past medical history was non-contributory and notably negative for thyroid disease, dermatomyositis, systemic lupus erythematosus, angioedema or sarcoidosis. Physical examination was notable for bilateral diffuse auricular enlargement with mild- moderate edema and without associated overlying erythema, scale, erosion or induration. No paresthesia or dysesthesia was noted. His facial skin was devoid of any other dermatologic conditions. Importantly, he had no other signs of rosacea. The differential diagnosis included leprosy, sarcoidosis and malignancy, particularly angiosarcoma. A punch biopsy of the right ear lobule was notable for a superficial perivascular and perifollicular lymphoplasmacytic infiltrate and papillary dermal edema, consistent with rosacea.
    [Show full text]
  • Dermatology 101: from Acne to Zebras and the Pearls in Between
    Dermatology 101: From Acne to Zebras and the Pearls in Between Dr Kyle Cullingham, BA, BSc, MSc, MD, FRCPC Dermatologist Skinsense Dermatology, Saskatoon,SK Assistant Professor University of Saskatchewan Disclosures Speaker: Dr Kyle Cullingham Relationships with commercial interests: Speakers Bureau/Honoraria: Abbvie, Allergan, Celgene, LEO Consulting Fees: Abbvie, Celgene, Galderma, Janssen, LEO, Novartis Conflict of Interest Declaration: Nothing to Disclose Presenter: Dr. Kyle Cullingham Title of Presentation:Dermatology for GPs I have no financial or personal relationship related to this presentation to disclose. Objectives Discuss some common dermatological concerns – focus on recognition, management, what’s new and pearls. Acne Clinical pearls Rosacea Psoriasis Eczema Interspersed with interesting real Dermatology cases with common pitfalls, red flags, or learning points. Time for questions/comments Acne disorder of the pilosebaceous unit affects certain areas of the body: face > trunk >> buttocks manifests during adolescence, but can occur at any stage of life comedones, papulopustules, nodules, cysts scarring can follow Epidemiology acne affects approximately 85% of adolescents onset during puberty (10-19 y/o); may appear after age 25 more severe in men higher incidence in caucasians and indigenous population inheritance: multifactorial; most patients with cystic acne have parental history of severe acne Pathogenesis Corneocyte Sebum Propionibacterium acnes Inflammatory cell Drugs Diet Recent JAAD review
    [Show full text]
  • Kazlouskaya V
    MINISTRY OF HEALTH OF REPUBLIC OF BELARUS GOMEL STATE MEDICAL UNIVERSITY V. V. Kazlouskaya SELECTED LECTURES ON DERMATOLOGY Manual for foreign medical students Gomel GSMU 2008 УДК 616.5 (075.8)=20 ББК 55.8 К 59 Рецензеты: заведующий кафедрой дерматовенерологии УО «Витебский государственный медицинский университет», доктор медицинских наук, профессор В. П. Адаскевич; заведующий кафедрой поликлинической терапии и общеврачебной практики с курсом дерматовенерологии УО «Гомельский государственный медицинский университет», кандидат медицинских наук, доцент Э. Н. Платошкин. Козловская, В. В. К 59 Курс лекций по дерматологии: учеб.-метод. пособие для студентов- медиков = Selected Lectures on Dermatology: manual for foreign medical students / В. В. Козловская. — Гомель: Учреждение образования «Го- мельский государственный медицинский университет», 2008. — 160 с. ISBN 978-985-506-210-4 Учебно-методическое пособие «Selected Lectures on Dermatology» представляет собой курс лекций по дерматологии, предназначенный для иностранных студентов 3 курса, обучающихся на английском языке. Лекции составлены в соответствии с типовой учебной программой и содержат основные разделы цикла дерматология. Утверждено и рекомендовано к изданию Центральным учебным научно- методическим советом учреждения образования «Гомельский государственный медицинский университет» 20 ноября 2008 г., протокол № 11. УДК 616.5 (075.8) ББК 55.8 ISBN 978-985-506-210-4 © Учреждение образования «Гомельский государственный медицинский университет», 2008 2 Abbreviations Used in the Book AA
    [Show full text]
  • UC Davis Dermatology Online Journal
    UC Davis Dermatology Online Journal Title Otophyma: a rare benign clinical entity mimicking leprosy Permalink https://escholarship.org/uc/item/41p4q5xq Journal Dermatology Online Journal, 21(3) Authors Shuster, Marina McWilliams, Ashley Giambrone, Danielle et al. Publication Date 2015 DOI 10.5070/D3213024280 Supplemental Material https://escholarship.org/uc/item/41p4q5xq#supplemental License https://creativecommons.org/licenses/by-nc-nd/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Volume 21 Number March 2015 Photo vignette Otophyma: a rare benign clinical entity mimicking leprosy Marina Shuster BA1, Ashley McWilliams BS2, Danielle Giambrone BS3, Omar Noor MD3, Jisun Cha MD3 Dermatology Online Journal 21 (3): 22 1Harvard Medical School 2Virginia Commonwealth University School of Medicine 3Rutgers- Robert Wood Johnson Medical School Correspondence: Danielle Giambrone Department of Dermatology Rutgers- Robert Wood Johnson Medical School 1 World’s Fair Drive Somerset, NJ 08873 Email: [email protected] Phone: 609-220-7710 Abstract Otophyma is a rare condition characterized by edematous deformation of the ear that is considered to be the end-stage of an inflammatory process such as rosacea and eczema. This report illustrates a case in an elderly male, originally thought to have leprosy. Biopsy revealed a nodular infiltration of inflammatory cells around adnexal structures and an intraepidermal cyst. No acid-fast organisms were identified. We present a patient who is of a different ethnic group than usually seen with this disease and provide a review of the clinical presentation, histopathological features, and management of this rare condition. Keywords: Otophyma, Leprosy, Rhinophyma, Rosacea Case synopsis A 62-year-old Filipino male presented for evaluation of his grossly enlarged ears.
    [Show full text]
  • The Treatment of Rosacea Anetta E
    Review The Treatment of Rosacea Anetta E. Reszko MD, PhD; Diane Berson MD Rosacea is a chronic condition affecting the facial and frequently ocular tissues. It is historically underdi- agnosed and affects people of all ethnicities, with higher overall prevalence in people of Celtic descent. The exact pathophysiology of rosacea is poorly understood. A variety of medical therapies, depending on the subtype, are available to treat the various signs and symptoms of rosacea. osacea is a common, chronic skin disorder differentiated from chronic sun damage and photoder- that frequently affects light-skinned white matitis. Papulopustular rosacea must be distinguished population. Overall prevalence of rosacea from acne vulgaris, seborrheic dermatitis, lupus miliaris ranges from less than 1% up to 10%. The disseminates faciei, collagen vascular diseases, perioral nose, cheeks, chin, forehead, and glabella dermatitis, and Demodex folliculitis. Differential diag- areR the most frequently affected sites. The disease has a nosis of ocular rosacea includes allergic conjunctivitis variety of clinical manifestations ranging from flushing, and blepharitis. persistent COSerythema, telangiectasias, papules, pustules, DERM Therapy of rosacea is centered on symptomatic and sebaceous gland hyperplasia. Significant psycho- improvement, including reduction of facial erythema logical stress and perceived diminished quality of life and number of inflammatory lesions; decrease in the often accompany this condition.1 The pathogenesis is number, duration and intensity
    [Show full text]