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The Journal of Pulmonary Technique

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The Journal of Pulmonary Technique 7PMVNF/VNCFS"VHVTU4FQUFNCFS 5IF+PVSOBMPG1VMNPOBSZ5FDIOJRVF may mean the end of VENTILATOR-INDUCED LUNG INJURY. HAMILTON MEDICAL has started and continues to lead the quest for PATIENT SAFETY AND STAFF EFFECTIVENESS. Physicians, Respiratory Care Professionals and Nurses work hard every day to care for the patients that we all serve. Despite their best efforts, patients on ventilators are routinely harmed in the process. Ventilator-Induced Lung Injury is fact. Hamilton Medical wants to change that. We are leading the charge to create a standard of care where Intelligent Ventilation protects the patient from harm, reduces chances for errors and promotes better staff effectiveness. Dear Friends and Colleagues, Those of you who know me will understand the unconventional nature of my actions. Who gives some VP “suit” (a joke, since I rarely wear one) the idea that he should use valuable ad space as a bully pulpit? I do. I could not come up with a catchy, visually exciting marketing piece, so I decided to have a simple conversation with you. I consider the Hamilton Medical team on a quest to increase the safety of mechanical ventilation and increase the efficiency of the healthcare system. Hamilton Medical was the first company to offer closed-loop control mechanical ventilation and we still lead the market today. The last year has been a turning point for Intelligent Ventilation. Hamilton Medical has been working with key experts in the specialty of respiratory care to better understand the mechanisms to provide the SAFETY and EFFECTIVENESS of Intelligent Ventilation to as many leading edge clinicians and facilities as possible. What a huge success! Hamilton Medical would like to publicly thank those early adopters in healthcare that saw the benefits to the PATIENT and adopted the widespread use of Intelligent Ventilation. Their courage to look past inconsequential issues on a ventilator like touch screens (for example) and focus on what was the best for the PATIENT has created a new direction in healthcare that will benefit many. Why do some very important non-biased industry sources rate Hamilton Medical as top in the industry? Why do some very prestigious health care professionals use Hamilton ventilators when it is far easier to buy “what everyone else does”? Why does my staff pride itself in working “Hamilton Half Days”; insane hours that keep them away from family and friends for extended periods in order to further our cause? Why are our key clinicians eager to offer their assistance in helping Hamilton make Intelligent Ventilation THE standard of care? We are on the right track, that’s why. We are focused on the patient, that’s why. We all agree that we can improve both the art and science of respiratory care, that’s why. We are looking for those clinical experts and leading edge facilities that want to join Hamilton Medical at the forefront of the industry. I want to combine the power of like minds to help patients. Contact me. I will send you a book on Closed Loop Control Mechanical Ventilation and a complete set of clinical documentation that proves our point. You will also receive a voucher valid for free tuition to a 2007 Clinical Experts Workshop that Hamilton Medical offers to our clinical leaders. That’s OK… not all of you will agree with me. We are looking for the top 10% who “get it”. Look for Hamilton Medical to continue to introduce new elements to INTELLIGENT VENTILATION. If you think we are ahead of the curve now, wait until you see what develops over the next few years. Sincerely, David Costa Vice President, Hamilton Medical, Inc. [email protected] hamilton AS06 comp.indd 1 7/5/06 11:05:16 AM ©2006 Abbott Laboratories B1134/MARCH 2006 LITHO IN USA (No. 1040) When all controlled studies were pooled, there was no BRIEF SUMMARY: Please see package difference in intracranial hemorrhage. However, in one of insert for full prescribing information. the single-dose rescue studies and one of the multiple- ® dose prevention studies, the rate of intracranial hemor- SURVANTA rhage was significantly higher in SURVANTA patients than (beractant)beractant control patients (63.3% v 30.8%, P = 0.001; and 48.8% v intratracheal suspension 34.2%, P = 0.047, respectively). The rate in a Treatment IND involving approximately 8100 infants was lower than in Sterile Suspension/For Intratracheal Use Only the controlled trials. PUBLISHED SIX TIMES EACH YEAR BY INDICATIONS AND USAGE In the controlled clinical trials, there was no effect of SURVANTA is indicated for prevention and treatment (“res- SURVANTA on results of common laboratory tests: white cue”) of Respiratory Distress Syndrome (RDS) (hyaline blood cell count and serum sodium, potassium, bilirubin, Goldstein and Associates, Inc. membrane disease) in premature infants. SURVANTA sig- creatinine. nificantly reduces the incidence of RDS, mortality due to More than 4300 pretreatment and post-treatment 10940 Wilshire Blvd., Suite 600 RDS and air leak complications. serum samples from approximately 1500 patients were tested by Western Blot Immunoassay for antibodies to sur- Prevention factant-associated proteins SP-B and SP-C. No IgG or IgM Los Angeles, CA 90024 USA In premature infants less than 1250 g birth weight or with antibodies were detected. evidence of surfactant deficiency, give SURVANTA as soon Several other complications are known to occur in pre- TEL: 310-443-4109 as possible, preferably within 15 minutes of birth. mature infants. The following conditions were reported in Rescue the controlled clinical studies. The rates of the complica- FAX: 310-443-4110 To treat infants with RDS confirmed by x-ray and requiring tions were not different in treated and control infants, and mechanical ventilation, give SURVANTA as soon as possi- none of the complications were attributed to SURVANTA. E-MAIL: ble, preferably by 8 hours of age. Respiratory: lung consolidation, blood from the endotra- [email protected] cheal tube, deterioration after weaning, respiratory decom- CONTRAINDICATIONS WEBSITE: None known. pensation, subglottic stenosis, paralyzed diaphragm, respi- www.respiratorytherapy.ca ratory failure. WARNINGS Cardiovascular: hypotension, hypertension, tachy- PUBLISHER: Alan Hickey SURVANTA is intended for intratracheal use only. cardia, ventricular tachycardia, aortic thrombosis, cardiac SURVANTA CAN RAPIDLY AFFECT OXYGENATION AND failure, cardio-respiratory arrest, increased apical pulse, LUNG COMPLIANCE. Therefore, its use should be restrict- EDITOR: Les Plesko persistent fetal circulation, air embolism, total anomalous ed to a highly supervised clinical setting with immediate pulmonary venous return. availability of clinicians experienced with intubation, venti- ASSOCIATE EDITORS: Carol Brass lator management, and general care of premature infants. Gastrointestinal: abdominal distention, hemorrhage, Infants receiving SURVANTA should be frequently moni- intestinal perforations, volvulus, bowel infarct, feeding Lauren Gabbaian tored with arterial or transcutaneous measurement of sys- intolerance, hepatic failure, stress ulcer. temic oxygen and carbon dioxide. Renal: renal failure, hematuria. DURING THE DOSING PROCEDURE, TRANSIENT Deborah Odell EPISODES OF BRADYCARDIA AND DECREASED OXYGEN Hematologic: coagulopathy, thrombocytopenia, dissemi- SATURATION HAVE BEEN REPORTED. If these occur, stop nated intravascular coagulation. Linda Todd the dosing procedure and initiate appropriate measures to Central Nervous System: seizures. alleviate the condition. After stabilization, resume the dos- DESIGN AND PRODUCTION MANAGEMENT: ing procedure. Endocrine/Metabolic: adrenal hemorrhage, inappropriate ADH secretion, hyperphosphatemia. PRECAUTIONS http://accugraphics.net General Musculoskeletal: inguinal hernia. Rales and moist breath sounds can occur transiently after Systemic: fever, deterioration. PRESIDENT AND CEO: administration. Endotracheal suctioning or other remedial Steve Goldstein action is not necessary unless clear-cut signs of airway Follow-Up Evaluations obstruction are present. To date, no long-term complications or sequelae of Increased probability of post-treatment nosocomial SURVANTA therapy have been found. sepsis in SURVANTA-treated infants was observed in the Single-Dose Studies Circulation, Coverage, Advertising Rates: Complete controlled clinical trials (Table 1). The increased risk for Six-month adjusted-age follow-up evaluations of 232 details regarding circulation, coverage, advertising rates, sepsis among SURVANTA-treated infants was not associat- infants (115 treated) demonstrated no clinically important ed with increased mortality among these infants. The differences between treatment groups in pulmonary and space sizes, and similar information are available to causative organisms were similar in treated and control neurologic sequelae, incidence or severity of retinopathy of infants. There was no significant difference between prematurity, rehospitalizations, growth, or allergic manifes- prospective advertisers. Closing date is 45 days preceding groups in the rate of post-treatment infections other than tations. sepsis. date of issue. Use of SURVANTA in infants less than 600 g Multiple-Dose Studies birth weight or greater than 1750 g birth weight has Six-month adjusted-age follow-up evaluations have been Change of Address notices should be sent promptly to not been evaluated in controlled trials. There is no completed in 631 (345 treated) of 916 surviving infants. controlled experience with use of SURVANTA in There were significantly less
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