Bachelor of Pharmacy
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Europæisk Patentskrift
(19) DANMARK (1°) DK/EP 2968225 T3 (12) Oversættelse af europæisk patentskrift Patent- og Varemærkestyrelsen (51) lnt.CI.: A 61 K 31/137 (2006.01) A 61 K 9/00 (2006.01) A 61 K 31/245 (2006.01) A 61 K 31/445 (2006.01) A 61 K 31/519 (2006.01) A 61 K 31/52 (2006.01) A 61 P 43/00 (2006.01) (45) Oversættelsen bekendtgjort den: 2019-05-27 (80) Dato for Den Europæiske Patentmyndigheds bekendtgørelse om meddelelse af patentet: 2019-02-20 (86) Europæisk ansøgning nr.: 14719486.4 (86) Europæisk indleveringsdag: 2014-03-17 (87) Den europæiske ansøgnings publiceringsdag: 2016-01-20 (86) International ansøgning nr.: US2014030372 (87) Internationalt publikationsnr.: WO2014145580 (30) Prioritet: 2013-03-15 US 201361789054 P (84) Designerede stater: AL AT BE BG CH CY CZ DE DK EE ES Fl FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (73) Patenthaver: The Children's Medical Center Corporation, 55 Shattuck Street, Boston, Massachusetts 02115, USA (72) Opfinder: BERDE, Charles, 14 Doran Road, Bookline, MA 02146, USA KOHANE, Daniel S., 119 Willard Street, Newton, MA 02461, USA (74) Fuldmægtig i Danmark: AWA Denmark A/S, Strandgade 56,1401 København K, Danmark (54) Benævnelse: NEOSAXITOXINKOMBINATIONSFORMULERINGER TIL FORLÆNGET LOKALANÆSTESI (56) Fremdragne publikationer: WO-A2-98/51290 ALBERTO J. RODRIGUEZ-NAVARRO ET AL: "Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker", NEUROTOXICITY RESEARCH, vol. 16, no. 4, 28 July 2009 (2009-07-28), pages 408-415, XP055122925, ISSN: 1029-8428, DOI: 10.1007/s12640-009- 9092-3 cited in the application Anonymous: "NCT01786655 on 2013_02_11: ClinicalTrials.gov Archive",, 11 February 2013 (2013-02-11), XP055122935, Retrieved from the Internet: URL:http://clinicaltrials.gov/archive/NCTO 1786655/2013_02_11 [retrieved on 2014-06-12] CHARLES B. -
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics Molecular Determinants of Ligand Selectivity for the Human Multidrug And Toxin Extrusion Proteins, MATE1 and MATE-2K Bethzaida Astorga, Sean Ekins, Mark Morales and Stephen H Wright Department of Physiology, University of Arizona, Tucson, AZ 85724, USA (B.A., M.M., and S.H.W.) Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay-Varina NC 27526, USA (S.E.) Supplemental Table 1. Compounds selected by the common features pharmacophore after searching a database of 2690 FDA approved compounds (www.collaborativedrug.com). FitValue Common Name Indication 3.93897 PYRIMETHAMINE Antimalarial 3.3167 naloxone Antidote Naloxone Hydrochloride 3.27622 DEXMEDETOMIDINE Anxiolytic 3.2407 Chlordantoin Antifungal 3.1776 NALORPHINE Antidote Nalorphine Hydrochloride 3.15108 Perfosfamide Antineoplastic 3.11759 Cinchonidine Sulfate Antimalarial Cinchonidine 3.10352 Cinchonine Sulfate Antimalarial Cinchonine 3.07469 METHOHEXITAL Anesthetic 3.06799 PROGUANIL Antimalarial PROGUANIL HYDROCHLORIDE 100MG 3.05018 TOPIRAMATE Anticonvulsant 3.04366 MIDODRINE Antihypotensive Midodrine Hydrochloride 2.98558 Chlorbetamide Antiamebic 2.98463 TRIMETHOPRIM Antibiotic Antibacterial 2.98457 ZILEUTON Antiinflammatory 2.94205 AMINOMETRADINE Diuretic 2.89284 SCOPOLAMINE Antispasmodic ScopolamineHydrobromide 2.88791 ARTICAINE Anesthetic 2.84534 RITODRINE Tocolytic 2.82357 MITOBRONITOL Antineoplastic Mitolactol 2.81033 LORAZEPAM Anxiolytic 2.74943 ETHOHEXADIOL Insecticide 2.64902 METHOXAMINE Antihypotensive Methoxamine -
Local Anesthetics
Local Anesthetics Introduction and History Cocaine is a naturally occurring compound indigenous to the Andes Mountains, West Indies, and Java. It was the first anesthetic to be discovered and is the only naturally occurring local anesthetic; all others are synthetically derived. Cocaine was introduced into Europe in the 1800s following its isolation from coca beans. Sigmund Freud, the noted Austrian psychoanalyst, used cocaine on his patients and became addicted through self-experimentation. In the latter half of the 1800s, interest in the drug became widespread, and many of cocaine's pharmacologic actions and adverse effects were elucidated during this time. In the 1880s, Koller introduced cocaine to the field of ophthalmology, and Hall introduced it to dentistry Overwiev Local anesthetics (LAs) are drugs that block the sensation of pain in the region where they are administered. LAs act by reversibly blocking the sodium channels of nerve fibers, thereby inhibiting the conduction of nerve impulses. Nerve fibers which carry pain sensation have the smallest diameter and are the first to be blocked by LAs. Loss of motor function and sensation of touch and pressure follow, depending on the duration of action and dose of the LA used. LAs can be infiltrated into skin/subcutaneous tissues to achieve local anesthesia or into the epidural/subarachnoid space to achieve regional anesthesia (e.g., spinal anesthesia, epidural anesthesia, etc.). Some LAs (lidocaine, prilocaine, tetracaine) are effective on topical application and are used before minor invasive procedures (venipuncture, bladder catheterization, endoscopy/laryngoscopy). LAs are divided into two groups based on their chemical structure. The amide group (lidocaine, prilocaine, mepivacaine, etc.) is safer and, hence, more commonly used in clinical practice. -
Local Anesthetics – Substances with Multiple Application in Medicine
ISSN 2411-958X (Print) European Journal of January-April 2016 ISSN 2411-4138 (Online) Interdisciplinary Studies Volume 2, Issue 1 Local Anesthetics – Substances with Multiple Application in Medicine Rodica SÎRBU Ovidius University of Constanta, Faculty of Pharmacy, Campus Corp B, University Alley No. 1, Constanta, Romania Emin CADAR UMF Carol Davila Bucharest, Faculty of Pharmacy, Str. Traian Vuia No. 6, Sector 2, Bucharest, Romania Cezar Laurențiu TOMESCU Ovidius University of Constanta, Faculty of Medicine, Campus Corp B, University Alley No. 1, Constanta, Romania Cristina-Luiza ERIMIA Corresponding author, [email protected] Ovidius University of Constanta, Faculty of Pharmacy, Campus Corp B, University Alley No. 1, Constanta, Romania Stelian PARIS Ovidius University of Constanta, Faculty of Pharmacy, Campus Corp B, University Alley No. 1, Constanta, Romania Aneta TOMESCU Ovidius University of Constanta, Faculty of Medicine, Campus Corp B, University Alley No. 1, Constanta, Romania Abstract Local anesthetics are substances which, by local action groups on the runners, cause loss of reversible a painful sensation, delimited corresponding to the application. They allow small surgery, short in duration and the endoscopic maneuvers. May be useful in soothe teething pain of short duration and in the locking of the nervous disorders in medical care. Local anesthesia is a process useful for the carrying out of surgery and of endoscopic maneuvers, to soothe teething pain in certain conditions, for depriving the temporary structures peripheral nervous control. Reversible locking of the transmission nociceptive, the set of the vegetative and with a local anesthetic at the level of the innervations peripheral nerve, roots and runners, a trunk nervous, around the components of a ganglion or coolant is cefalorahidian practice anesthesia loco-regional. -
Medicinal Chemistry – II Theory Course Code: 17YBH501
School: Pharmaceutical Sciences Programme: B.Pharmacy Year : Third Year Semester - V Course: Medicinal Chemistry – II Theory Course Code: 17YBH501 Theory: 3Hrs/Week Max.University Theory Examination:75 Marks Max. Time for Theory Exam.:3 Hrs Continuous Internal Assessment: 25 Marks Objectives 1 Understand the chemistry of drugs with respect to their pharmacological activity 2 Understand the drug metabolic pathways, adverse effect and therapeutic value of drugs 3 Know the Structural Activity Relationship of different class of drugs 4 Study the chemical synthesis of selected drugs 5 Importance of physicochemical properties and metabolism of drugs. Details Unit Study of the development of the following classes of drugs, Classification, Hours Number mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted (*) 1 Antihistaminic agents: Histamine, receptors and their distribution in the 10 humanbody H1–antagonists:Diphenhydramine hydrochloride*,Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolynsodium H2-antagonists: Cimetidine*, Famotidine, -
B Pharm Syllabus
THE TAMILNADU Dr. M.G.R. MEDICAL UNIVERSITY CHENNAI-600 032 REGULATIONS AND SYLLABUS B. PHARMACY DEGREE COURSE 2009-2010 2 THE TAMILNADU Dr. M.G.R. MEDICAL UNIVERSITY CHENNAI – 600 032 B. PHARMACY COURSE S.No. Description Page No. 1. Short Title and Commencement 5 2. Eligibility for admission 5 3. Other Criteria 6 4. National Open School Qualification 7 5. Vocational Course 7 6. Re-appearance of failed candidates 7 7. Qualification for admission into direct II year B.Pharmacy course 8 8. Age limit for admission 8 9. Physical Fitness Certificate 8 10. Eligibility Certificate 8 11. Website as Voluntary Blood Donors 8 12. Cut-off Date for Admission to Examination 9 13. Registration 9 14. Duration of the Course 9 15. Commencement of the Course 9 16. Curriculum 9 17. Medium of Instruction 9 18. Working days in the Academic Year 9 19. Attendance required for admission to examinations 9 20. Internal Assessment 10 B. Pharmacy Syllabus and2 Regulations 2009-2010 3 S.No. Description Page No. 21. Subjects of Study: 10 FIRST B.PHARM: 1. Pharmaceutical Inorganic Chemistry 21 2. Pharmaceutical Organic Chemistry 24 3. Anatomy, Physiology and Health Education 26 4. Bio-chemistry 28 5. Biostatistics and Computer Applications 30 SECOND B.PHARM: 1. Physical Pharmaceutics 32 1. Pharmaceutical Analysis and Physical Chemistry 34 3. Advanced Pharmaceutical Organic Chemistry 37 4. Pharmaceutical Technology 39 5. Pharmacy Practice and Pathophysiology 41 THIRD B.PHARM: 1. Pharmacognosy and Phyto chemistry 43 2. Medical Chemistry – I 46 3. Pharmaceutical Dosage Forms and Cosmetic Technology 50 4. Pharmacology – I 52 5. -
Drug and Medication Classification Schedule
KENTUCKY HORSE RACING COMMISSION UNIFORM DRUG, MEDICATION, AND SUBSTANCE CLASSIFICATION SCHEDULE KHRC 8-020-1 (11/2018) Class A drugs, medications, and substances are those (1) that have the highest potential to influence performance in the equine athlete, regardless of their approval by the United States Food and Drug Administration, or (2) that lack approval by the United States Food and Drug Administration but have pharmacologic effects similar to certain Class B drugs, medications, or substances that are approved by the United States Food and Drug Administration. Acecarbromal Bolasterone Cimaterol Divalproex Fluanisone Acetophenazine Boldione Citalopram Dixyrazine Fludiazepam Adinazolam Brimondine Cllibucaine Donepezil Flunitrazepam Alcuronium Bromazepam Clobazam Dopamine Fluopromazine Alfentanil Bromfenac Clocapramine Doxacurium Fluoresone Almotriptan Bromisovalum Clomethiazole Doxapram Fluoxetine Alphaprodine Bromocriptine Clomipramine Doxazosin Flupenthixol Alpidem Bromperidol Clonazepam Doxefazepam Flupirtine Alprazolam Brotizolam Clorazepate Doxepin Flurazepam Alprenolol Bufexamac Clormecaine Droperidol Fluspirilene Althesin Bupivacaine Clostebol Duloxetine Flutoprazepam Aminorex Buprenorphine Clothiapine Eletriptan Fluvoxamine Amisulpride Buspirone Clotiazepam Enalapril Formebolone Amitriptyline Bupropion Cloxazolam Enciprazine Fosinopril Amobarbital Butabartital Clozapine Endorphins Furzabol Amoxapine Butacaine Cobratoxin Enkephalins Galantamine Amperozide Butalbital Cocaine Ephedrine Gallamine Amphetamine Butanilicaine Codeine -
Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0 -
US5760077.Pdf
IIIIUSOO5760.077A United States Patent (19) 11) Patent Number: 5,760,077 Shahinian, Jr. 45) Date of Patent: *Jun. 2, 1998 54 TOPICAL OPHTHALMIC ANALGESIC Jean Daniel Arbour, M.D., et al, Should We Patch Corneal PREPARATIONS FOR SUSTANED AND Erosions?. Arch Opgthalmol., vol. 115, 313-317. (Mar. EXTENDED CORNEALANALGESA 1997). 76) Inventor: Lee Shahinian, Jr. 1506 Country Club A K Brahma, et al., Topical Analgesia For Superficial Dr., Los Altos, Calif. 94024 Corneal Injuries, J Accid Emerg Med, 13:186-188. (1996). * Notice: The term of this patent shall not extend beyond the expiration date of Pat. No. Steve A. Arshinoff, M.D.. et al., Pharmacotherapy of Pho 5,610,184. torefractive Keratectomy, J. Cataract Refract Sur. vol. 22. 1037-1044 (Oct. 1996). 21 Appl. No.: 816,762 22 Filed: Mar 11, 1997 Primary Examiner-Zohreh Fay Related U.S. Application Data Attorney, Agent, or Firm-Hana Verny 63 Continuation-in-part of Ser. No. 415,184, Apr. 3, 1995, Pat. 57 ABSTRACT No. 5,610,184, which is a continuation-in-part of Ser. No. 183,186, Jan. 14, 1994, abandoned. A preparation suitable for sustained and extended corneal (S1) Int. Cl. ............... A61K 31/24 analgesia and for repeated administration consisting of 52 U.S. Cl. ........................... 514/540: 514/563; 514/912 ultralow nontoxic subanaesthetic concentrations of local 58 Field of Search ..................................... 514/540, 563. anesthetic agents. A method for corneal analgesia has a fast 514/912 onset of pain relief and extended duration of the corneal 56) References Cited analgesia for several months without accompanying toxic PUBLICATIONS symptoms by administering to a patient an ophthalmic analgesic solution containing a local anesthetic agent in Steve Arshinoff, M.D., Use of Topical Nonsteroidal Anti inflammatory Drugs in Excimer Laser Photorefractive Kera Subanesthetic concentration. -
Epinephrine and Phenylephrine with Procaine, Carbocaine, and Lidocaine
University of Nebraska Medical Center DigitalCommons@UNMC MD Theses Special Collections 5-1-1964 Comparison of length of anesthesia using the vasoconstrictors : epinephrine and phenylephrine with procaine, carbocaine, and lidocaine Merrill A. Godfrey University of Nebraska Medical Center This manuscript is historical in nature and may not reflect current medical research and practice. Search PubMed for current research. Follow this and additional works at: https://digitalcommons.unmc.edu/mdtheses Part of the Medical Education Commons Recommended Citation Godfrey, Merrill A., "Comparison of length of anesthesia using the vasoconstrictors : epinephrine and phenylephrine with procaine, carbocaine, and lidocaine" (1964). MD Theses. 17. https://digitalcommons.unmc.edu/mdtheses/17 This Thesis is brought to you for free and open access by the Special Collections at DigitalCommons@UNMC. It has been accepted for inclusion in MD Theses by an authorized administrator of DigitalCommons@UNMC. For more information, please contact [email protected]. COMPARISON OF LENGTH OF ANESTHESIA USING THE VASOCONSTRICTORS, EPINEPHRINE AND PHENYLEPHRINE, WITH PROCAINE, CARBOCAINE, AND LIDOCAINE Merrill Anderson Godfrey Submitted in Partial Fulfillment for the Degree of Doctor of Medicine College of Medicine, University of Nebraska January 30, 1964 Omaha, Nebraska '-_._------- TABLE OF CONTENTS Page I. Introduction.. 1 A. Background of Local Anesthetics. 1 B. Drug Description 4 1. Procaine ••• 4 2. Lidocaine • • • • • • • • • • • 4 3. Carbocaine • • • • • • • • • • • 5 4. Epinephrine • • • 5 5. Phenylephrine 6 II. Purposes of Study • • • • • • • • • • 7 III. Method • 8 A. Test Substances • • 8 B. Procedure . .. 8 C. Method of Testing 9 IV. Results and Discussion • • 10 V. Conclusions 15 VI. Summa ry • . • • .. .. • • . 17 VII. Acknowledgement 19 VIII. Tables IX. -
(12) United States Patent (10) Patent No.: US 6,746,689 B2 Fischer Et Al
USOO674.6689B2 (12) United States Patent (10) Patent No.: US 6,746,689 B2 Fischer et al. (45) Date of Patent: *Jun. 8, 2004 (54) INTRADERMAL-PENETRATION AGENTS 5,863,941 A 1/1999 Liedtke FOR TOPCAL LOCAL ANESTHETIC 5,919,479 A 7/1999 Zhang et al. ADMINISTRATION 5,922,340 A 7/1999 Berde et al. 5,955,112 A 9/1999 Kaplan (75) Inventors: Susi7- Ely. Nuits E. 6,455,0666,120,792 AB1 * 9/20029/2000 JuniFischer et al. Mason, Flemington, NJ (US) FOREIGN PATENT DOCUMENTS (73) Assignee: EpiOept Corporation, Englewood WO WO 93/12744 7/1993 Cliff. NJ (US) WO WO95/ 31.188 11/1995 s WO WO 97/439 89 11/1997 (*) Notice: Subject to any disclaimer, the term of this W W s: 2: past isis'', adjusted under 35 WO WO 01/41746 6/2001 a -- y U dayS. OTHER PUBLICATIONS This patent is Subject to a terminal dis- Berkovitch et al., 1995, “Use of a Eutectic Mixture of Local claimer. Anesthetics for Prolonged Subcutaneous Drug Administra tion”, J. Clin. Pharmacol. 35:295–297. (21) Appl. No.: 10/201,901 Curatolo, 1987, “The Lipoidal Permeability Barriers of the Skin and Alimentary Tract', Pharmaceut. Res. 4:271-277. (22) Filed: Jul. 25, 2002 Klein and Penneys, 1988, “Aloe Vera”, J. Am. Acad. Der (65) Prior Publication Data matol. 18: 714-720. Lubens et al., 1974, "Anesthetic Patch for Painful Proce US 2003/0138505 A1 Jul. 24, 2003 dures Such AS Minor Operations”, Am. J. Dis. Child. O O 128:192-194. Related U.S. -
Stembook 2018.Pdf
The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.