Agents Classified by the IARC Monographs, Volumes 1–123
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Synthesis and Antitumor Evaluation of Novel Bis-Triaziquone Derivatives
Molecules 2009, 14, 2306-2316; doi:10.3390/molecules14072306 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article Synthesis and Antitumor Evaluation of Novel Bis-Triaziquone Derivatives Cheng Hua Huang 1,3, Hsien-Shou Kuo 2, Jia-Wen Liu 3 and Yuh-Ling Lin 3,* 1 Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei, Taiwan 2 Department of Biochemistry, Taipei Medical University, 250 Wu-Hsin St. Taipei, Taiwan 3 College of Medicine, Fu-Jen Catholic University, 510 Chung Cheng Rd., Hsin-Chuang, Taipei Hsien 24205, Taiwan * Author to whom correspondence should be addressed; E-mail: [email protected] Received: 30 April 2009; in revised form: 19 June 2009 / Accepted: 23 June 2009 / Published: 29 June 2009 Abstract: Aziridine-containing compounds have been of interest as anticancer agents since late 1970s. The design, synthesis and study of triaziquone (TZQ) analogues with the aim of obtaining compounds with enhanced efficacy and reduced toxicity are an ongoing research effort in our group. A series of bis-type TZQ derivatives has been prepared and their cytotoxic activities were investigated. The cytotoxicity of these bis-type TZQ derivatives were tested on three cancer lines, including breast cancer (BC-M1), oral cancer (OEC-M1), larynx epidermal cancer (Hep2) and one normal skin fibroblast (SF). Most of these synthetic derivatives displayed significant cytotoxic activities against human carcinoma cell lines, but weak activities against SF. Among tested analogues the bis-type TZQ derivative 1a showed lethal effects on larynx epidermal carcinoma cells (Hep2), with an LC50 value of 2.02 M, and also weak cytotoxic activity against SF cells with an LC50 value over 10 M for 24 hr treatment. -
Aldrich FT-IR Collection Edition I Library
Aldrich FT-IR Collection Edition I Library Library Listing – 10,505 spectra This library is the original FT-IR spectral collection from Aldrich. It includes a wide variety of pure chemical compounds found in the Aldrich Handbook of Fine Chemicals. The Aldrich Collection of FT-IR Spectra Edition I library contains spectra of 10,505 pure compounds and is a subset of the Aldrich Collection of FT-IR Spectra Edition II library. All spectra were acquired by Sigma-Aldrich Co. and were processed by Thermo Fisher Scientific. Eight smaller Aldrich Material Specific Sub-Libraries are also available. Aldrich FT-IR Collection Edition I Index Compound Name Index Compound Name 3515 ((1R)-(ENDO,ANTI))-(+)-3- 928 (+)-LIMONENE OXIDE, 97%, BROMOCAMPHOR-8- SULFONIC MIXTURE OF CIS AND TRANS ACID, AMMONIUM SALT 209 (+)-LONGIFOLENE, 98+% 1708 ((1R)-ENDO)-(+)-3- 2283 (+)-MURAMIC ACID HYDRATE, BROMOCAMPHOR, 98% 98% 3516 ((1S)-(ENDO,ANTI))-(-)-3- 2966 (+)-N,N'- BROMOCAMPHOR-8- SULFONIC DIALLYLTARTARDIAMIDE, 99+% ACID, AMMONIUM SALT 2976 (+)-N-ACETYLMURAMIC ACID, 644 ((1S)-ENDO)-(-)-BORNEOL, 99% 97% 9587 (+)-11ALPHA-HYDROXY-17ALPHA- 965 (+)-NOE-LACTOL DIMER, 99+% METHYLTESTOSTERONE 5127 (+)-P-BROMOTETRAMISOLE 9590 (+)-11ALPHA- OXALATE, 99% HYDROXYPROGESTERONE, 95% 661 (+)-P-MENTH-1-EN-9-OL, 97%, 9588 (+)-17-METHYLTESTOSTERONE, MIXTURE OF ISOMERS 99% 730 (+)-PERSEITOL 8681 (+)-2'-DEOXYURIDINE, 99+% 7913 (+)-PILOCARPINE 7591 (+)-2,3-O-ISOPROPYLIDENE-2,3- HYDROCHLORIDE, 99% DIHYDROXY- 1,4- 5844 (+)-RUTIN HYDRATE, 95% BIS(DIPHENYLPHOSPHINO)BUT 9571 (+)-STIGMASTANOL -
THIALULUMUNIUUS009752019B2 (12 ) United States Patent ( 10 ) Patent No
THIALULUMUNIUUS009752019B2 (12 ) United States Patent ( 10 ) Patent No. : US 9 , 752, 019 B2 Loya Enríquez et al. (45 ) Date of Patent: Sep . 5 , 2017 ( 54 ) COMPOSITE MATERIALS BASED ON 17 /00 ; CO8L 19 / 003; CO8L 75 / 04 ; CO8L RUBBERS , ELASTOMERS , AND THEIR 75 /06 ; CO8L 75 / 08 ; CO8L 75 / 10 ; CO8L RECYCLED 75/ 12 ; CO8L 75 / 14 ; CO8L 75 / 16 ; CO8L 67 / 06 ( 71) Applicants: KAUTEC TECHNOLOGIES, S . A . P . I . DE C . V . , Chihuahua (MX ) ; Centro de USPC 525 / 123 Investigación en Materiales See application file for complete search history . Avanzados , S . C . , Chihuahua (MX ) (72 ) Inventors : René Loya Enríquez, Chihuahua (56 ) References Cited (MX ) ; Grecia Andrea Bueno Herrera , U . S . PATENT DOCUMENTS Chihuahua (MX ) ; Sergio Gabriel Flores Gallardo , Chihuahua (MX ) ; 2 ,879 , 245 A 3 / 1959 Green Erasto Armando Zaragoza Contreras , 2 ,947 , 736 A * 8 / 1960 Lundberg . .. .. .. .. .. .. C08F 16 / 24 526 / 201 Chihuahua (MX ) ; Alejandro Vega 3 ,383 ,351 A * 5 / 1968 Stamberger . .. CO8F 8 / 30 Ríos , Chihuahua (MX ) ; Mónica Elvira 521/ 137 Mendoza Duarte , Chihuahua (MX ) ; 3 ,652 ,467 A 3 / 1972 Bunk et al. Erika Ivonne López Martínez , 3 ,681 , 267 A 8 / 1972 Mayne et al . Chihuahua (MX ) 3 , 801 ,421 A 4 / 1974 Allen et al. 4 ,038 , 341 A * 7 / 1977 Schwartz , Jr . .. .. C08F 299 /04 ( 73 ) Assignees : Kautec Technologies , S . A . P .I De C . V ., 523 /527 Chihuahua (MX ) ; Centro de 4 ,053 , 537 A * 10 / 1977 Ruprecht . .. .. B29D 99/ 0057 521/ 42 Investigacion en Materiales 4 ,244 , 841 A 1/ 1981 Frankland Avanzados, S . C , Chihuahua (MX ) 4 , 327 , 145 A * 4 / 1982 Mitani . -
California Proposition 65 Toxicity List
STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY 4-Mar-05 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and Chemical Type of Toxicity CAS No. Date Listed A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) cancer 26148685 1-Jan-90 Acetaldehyde cancer 75070 1-Apr-88 Acetamide cancer 60355 1-Jan-90 Acetazolamide developmental 59665 20-Aug-99 Acetochlor cancer 34256821 1-Jan-89 Acetohydroxamic acid developmental 546883 1-Apr-90 2-Acetylaminofluorene cancer 53963 1-Jul-87 Acifluorfen cancer 62476599 1-Jan-90 Acrylamide cancer 79061 1-Jan-90 Acrylonitrile cancer 107131 1-Jul-87 Actinomycin D cancer 50760 1-Oct-89 Actinomycin D developmental 50760 1-Oct-92 Adriamycin (Doxorubicin hydrochloride) cancer 23214928 1-Jul-87 AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide cancer 3688537 1-Jul-87 Aflatoxins cancer --- 1-Jan-88 Alachlor cancer 15972608 1-Jan-89 Alcoholic beverages, when associated with alcohol abuse cancer --- 1-Jul-88 Aldrin cancer 309002 1-Jul-88 All-trans retinoic acid developmental 302794 1-Jan-89 Allyl chloride Delisted October 29, 1999 cancer 107051 1-Jan-90 Alprazolam developmental 28981977 1-Jul-90 Altretamine developmental, male 645056 20-Aug-99 Amantadine hydrochloride developmental 665667 27-Feb-01 Amikacin sulfate developmental 39831555 1-Jul-90 2-Aminoanthraquinone cancer 117793 1-Oct-89 p -Aminoazobenzene cancer -
New Synthesis Routes for Production of Ε-Caprolactam by Beckmann
New synthesis routes for production of ε-caprolactam by Beckmann rearrangement of cyclohexanone oxime and ammoximation of cyclohexanone over different metal incorporated molecular sieves and oxide catalysts Von der Fakultät für Mathematik, Informatik und Naturwissenschaften der RWTH Aachen University zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigte Dissertation vorgelegt von Anilkumar Mettu aus Guntur/Indien Berichter: Universitätprofessor Dr. Wolfgang F. Hölderich Universitätprofessor Dr. Carsten Bolm Tag der mündlichen Prüfung: 29.01.2009 Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfügbar. Dedicated to my Parents This work reported here has been carried out at the Institute for Chemical Technolgy and Heterogeneous Catalysis der Fakultät für Mathematik, Informatik und Naturwissenschaften in the University of Technology, RWTH Aachen under supervision of Prof. Dr. Wolfgang F. Hölderich between June 2005 and August 2008. ACKNOWLEDGEMENTS I would like to express my deepest sence of gratitude to my supervisor Prof. Dr. rer. nat. W. F. Hölderich for giving me the opportunity to do my doctoral study in his group. His guidance and teaching classes have allowed me to grow and learn my subject during my Ph.d. He has provided many opportunities for me to increase my abilities as a researcher and responsibilities as a team member. I am grateful for the financial support of this work from Sumitomo Chemicals Co., Ltd, Niihama, Japan (Part One) and Uhde Inventa-Fischer GmBH, Berlin (Part Two). Our collaborators at Sumitomo Chemicals Co., Ltd (Dr. C. Stoecker) and Uhde Inventa- Fischer GmBH (Dr. R. Schaller and Dr. A. Pawelski) provided thoughtful guidance and suggestions for each project. -
Drug and Alcohol Withdrawal Clinical Practice Guidelines - NSW
Guideline Drug and Alcohol Withdrawal Clinical Practice Guidelines - NSW Summary To provide the most up-to-date knowledge and current level of best practice for the treatment of withdrawal from alcohol and other drugs such as heroin, and other opioids, benzodiazepines, cannabis and psychostimulants. Document type Guideline Document number GL2008_011 Publication date 04 July 2008 Author branch Centre for Alcohol and Other Drugs Branch contact (02) 9424 5938 Review date 18 April 2018 Policy manual Not applicable File number 04/2766 Previous reference N/A Status Active Functional group Clinical/Patient Services - Pharmaceutical, Medical Treatment Population Health - Pharmaceutical Applies to Area Health Services/Chief Executive Governed Statutory Health Corporation, Board Governed Statutory Health Corporations, Affiliated Health Organisations, Affiliated Health Organisations - Declared Distributed to Public Health System, Ministry of Health, Public Hospitals Audience All groups of health care workers;particularly prescribers of opioid treatments Secretary, NSW Health Guideline Ministry of Health, NSW 73 Miller Street North Sydney NSW 2060 Locked Mail Bag 961 North Sydney NSW 2059 Telephone (02) 9391 9000 Fax (02) 9391 9101 http://www.health.nsw.gov.au/policies/ space space Drug and Alcohol Withdrawal Clinical Practice Guidelines - NSW space Document Number GL2008_011 Publication date 04-Jul-2008 Functional Sub group Clinical/ Patient Services - Pharmaceutical Clinical/ Patient Services - Medical Treatment Population Health - Pharmaceutical -
(12) Patent Application Publication (10) Pub. No.: US 2009/0318437 A1 Gaeta Et Al
US 20090318437A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0318437 A1 Gaeta et al. (43) Pub. Date: Dec. 24, 2009 (54) SUBSTITUTED PYRAZOLO15-APYRIDINE (60) Provisional application No. 60/811,604, filed on Jun. COMPOUNDS AND THER METHODS OF 6, 2006. USE (76) Inventors: Federico C.A. Gaeta, Mountain Publication Classification View, CA (US); Matthew Gross, (51) Int. Cl. Vallejo, CA (US); Kirk W. A63L/437 (2006.01) Johnson, Moraga, CA (US) C07D 47L/04 (2006.01) Correspondence Address: C07D 413/14 (2006.01) King & Spalding LLP A 6LX 3/5.377 (2006.01) P.O. BOX 889 A6IP II/06 (2006.01) Belmont, CA 94002-0889 (US) (52) U.S. Cl. ...................... 514/233.2:546/121; 544/127; (21) Appl. No.: 12/482,307 514/3OO (22) Filed: Jun. 10, 2009 Related U.S. Application Data (57) ABSTRACT (62) Division of application No. 1 1/810,885, filed on Jun. 6, The present invention is directed to substituted pyrazolo 1.5- 2007, now Pat. No. 7,585,875. apyridines and related methods for their synthesis and use. Patent Application Publication Dec. 24, 2009 Sheet 1 of 2 US 2009/0318437 A1 log threshold withdrawal (mg x 10) s s t | yme as w (s (f) pouseul emerpum 909 Y Patent Application Publication Dec. 24, 2009 Sheet 2 of 2 US 2009/0318437 A1 s o O O war C SSm S.t c) is . E E C C a S. & S. is 25 &(2 52 > w- we t : : log threshold withdrawal (mg x 10) N CN N. -
The Chemotherapy of Malignant Disease -Practical and Experimental Considerations
Postgrad Med J: first published as 10.1136/pgmj.41.475.268 on 1 May 1965. Downloaded from POSTGRAD. MED. J. (1965), 41,268 THE CHEMOTHERAPY OF MALIGNANT DISEASE -PRACTICAL AND EXPERIMENTAL CONSIDERATIONS JOHN MATTHIAS, M.D., M.R.C.P., F.F.A., R.C.S. Physician, The Royal Marsden Hospital, London, S.W.3. THE TERM chemotherapy was introduced by positively charged alkyl (CH2) radicles of Ehrlich to describe the specific and effective the agent. treatment of infectious disease by chemical (a) The nitrogen mustards: mustine (HN2 substances. It is currently also applied to the 'nitrogen mustard', mechlorethamine, treatment of malignant disease. Unfortunately mustargen), trimustine (Trillekamin no aspect of tumour metabolism has been HN3), chlorambucil (Leukeran, phenyl discovered which has allowed the development butyric mustard), melphalan (Alkeran, of drugs capable of acting specifically upon the phenyl alanine mustard), uramustine malignant cell, so that cytotoxic drugs also (Uracil mustard), cyclophosphamide affect normal cells to a greater or lesser degree. (Endoxan or Cytoxan), mannomustine The most susceptible or sensitive of the normal (DegranoO). tissues are those with the highest rates of cell (b) The ethylenamines: tretamine (trie- turnover and include the haemopoietic and thanomelamine, triethylene melamine, lympho-reticular tissues, the gastro-intestinal TEM), thiotepa (triethylene thiopho- the the testis and the hair epithelium, ovary, sphoramide), triaziquone (Trenimon).by copyright. follicles. (c) The epoxides: triethyleneglycoldigly- Cancer chemotherapy may be said to encom- cidyl ether (Epodyl). pass all treatments of a chemical nature (d) The sulphonic acid esters: busulphan administered to patients with the purpose of (Myleran), mannitol myleran. restricting tumour growth or destroying tumour 2. -
Understanding Benzodiazephine Use, Abuse, and Detection
Siemens Healthcare Diagnostics, the leading clinical diagnostics company, is committed to providing clinicians with the vital information they need for the accurate diagnosis, treatment and monitoring of patients. Our comprehensive portfolio of performance-driven systems, unmatched menu offering and IT solutions, in conjunction with highly responsive service, is designed to streamline workflow, enhance operational efficiency and support improved patient care. Syva, EMIT, EMIT II, EMIT d.a.u., and all associated marks are trademarks of General Siemens Healthcare Diagnostics Inc. All Drugs other trademarks and brands are the Global Division property of their respective owners. of Abuse Siemens Healthcare Product availability may vary from Diagnostics Inc. country to country and is subject 1717 Deerfield Road to varying regulatory requirements. Deerfield, IL 60015-0778 Please contact your local USA representative for availability. www.siemens.com/diagnostics Siemens Global Headquarters Global Siemens Healthcare Headquarters Siemens AG Understanding Wittelsbacherplatz 2 Siemens AG 80333 Muenchen Healthcare Sector Germany Henkestrasse 127 Benzodiazephine Use, 91052 Erlangen Germany Abuse, and Detection Telephone: +49 9131 84 - 0 www.siemens.com/healthcare www.usa.siemens.com/diagnostics Answers for life. Order No. A91DX-0701526-UC1-4A00 | Printed in USA | © 2009 Siemens Healthcare Diagnostics Inc. Syva has been R1 R2 a leading developer N and manufacturer of AB R3 X N drugs-of-abuse tests R4 for more than 30 years. R2 C Now part of Siemens Healthcare ® Diagnostics, Syva boasts a long and Benzodiazepines have as their basic chemical structure successful track record in drugs-of-abuse a benzene ring fused to a seven-membered diazepine ring. testing, and leads the industry in the All important benzodiazepines contain a 5-aryl substituent ring (ring C) and a 1,4–diazepine ring. -
The Utilization of Ti-SBA-15 Catalyst in the Epoxidation of Allylic Alcohols
Reac Kinet Mech Cat (2012) 105:451–468 DOI 10.1007/s11144-011-0405-1 The utilization of Ti-SBA-15 catalyst in the epoxidation of allylic alcohols Agnieszka Wro´blewska • Edyta Makuch Received: 17 August 2011 / Accepted: 16 November 2011 / Published online: 2 December 2011 Ó The Author(s) 2011. This article is published with open access at Springerlink.com Abstract Ti-SBA-15, one of the latest titanium silicalite catalysts, has been pre- pared according to the literature by the direct hydrothermal synthesis using Pluronic 123 as structure-directing agent. The characterization of the catalyst was performed by means of the following methods: XRD, IR, UV–Vis, X-ray microanalysis and SEM. The catalytic properties of the Ti-SBA-15 catalyst have been tested in the epoxidation of allyl alcohol, methallyl alcohol, crotyl alcohol and 1-butene-3-ol with hydrogen peroxide. The process has been described by the following main functions: the selectivity to epoxide compound in relation to allylic compound consumed and the conversion of allylic compound. Keywords Ti-SBA-15 Á Allylic compounds Á Epoxide compounds Á Liquid-phase epoxidation Á Hydrogen peroxide Mathematics Subject Classification (2000) 32 Á 46 Á 92 JEL Classification I23 Á L65 Introduction Zeolites with titanium atoms in the structure have wide applications in oxidation processes (especially in epoxidation processes) which are carried out in the presence of hydrogen peroxide (oxidizing agent). To the group of these zeolites belong TS-1 and TS-2 catalysts—the first titanium silicalite catalysts [1, 2]. TS-1 and TS-2 are microporous materials with relatively small pore size (about 0.5 nm), which limits A. -
Synthesis of Functionalized Polyamide 6 by Anionic Ring-Opening Polymerization Deniz Tunc
Synthesis of functionalized polyamide 6 by anionic ring-opening polymerization Deniz Tunc To cite this version: Deniz Tunc. Synthesis of functionalized polyamide 6 by anionic ring-opening polymerization. Poly- mers. Université de Bordeaux; Université de Liège, 2014. English. NNT : 2014BORD0178. tel- 01281327 HAL Id: tel-01281327 https://tel.archives-ouvertes.fr/tel-01281327 Submitted on 2 Mar 2016 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Logo Université de cotutelle THÈSE PRÉSENTÉE POUR OBTENIR LE GRADE DE DOCTEUR DE L’UNIVERSITÉ DE BORDEAUX ET DE L’UNIVERSITÉ DE LIEGE ÉCOLE DOCTORALEDE SCIENCES CHIMIQUES (Université de Bordeaux) ÉCOLE DOCTORALE DE CHIMIE (Université de Liège) SPÉCIALITÉ POLYMERES Par Deniz TUNC Synthesis of functionalized polyamide 6 by anionic ring-opening polymerization Sous la direction de Stéphane CARLOTTI et Philippe LECOMTE Soutenue le 30 octobre 2014 Membres du jury: M. PERUCH, Frédéric Directeur de recherche, Université de Bordeaux Président M. HOOGENBOOM, Richard Professeur, Ghent University Rapporteur M. MONTEIL, Vincent Chargé de recherche, Université Claude Bernard Rapporteur M. YAGCI, Yusuf Professeur, Istanbul Technical University Examinateur M. AMEDURI, Bruno Directeur de recherche, Institut Charles Gerhardt Examinateur M. SERVANT, Laurent Professeur, Université de Bordeaux Invité Preamble This PhD had been performed within the framework of the IDS FunMat joint doctoral programme. -
A New Approach to Prepare Polyethylene Glycol Allyl Glycidyl Ether
E3S Web of Conferences 267, 02004 (2021) https://doi.org/10.1051/e3sconf/202126702004 ICESCE 2021 A new approach to prepare Polyethylene Glycol Allyl Glycidyl Ether Huizhen Wang1*, Ruiyang Xie1, Mingjun Chen1*, Weihao Deng1, Kaixin Zhang2, Jiaqin Liu1 1School of Science, Xihua University, Chengdu 610039, China; 2Chengdu Jingyiqiang Environmental Protection Technology Co., Ltd. Abstract. The polyethylene glycol allyl glycidyl ether (PGAGE) is an important intermediate for preparing silicone softener that can be synthesized from allyl alcohol polyoxyethylene ether and epichlorohydrin (ECH). The performance parameters including the concentration of ECH, initial boron trifluoride diethyl etherate (BFEE) as well as CaCl2 quality were investigated respectively. The optimum process parameters which can get high capping and low by-product rate are as follows: the ECH concentration is 2.0 M, the initial BFEE concentration is 1.65mM, and the CaCl2 dosage is 1.65g/L. Under these conditions, the maximal yield can be improved to 91.36%, the percent of capping rate is higher than 98.16%, the residual concentration of F- is only 0.63 mg/L. concentrated basic solution, in which the total yield was between 90%~91% by Matsuoka et al. [10] also use the 1 Introduction two-step reaction to synthesize AGE based on the reaction Polyethylene glycol allyl glycidyl ether (PGAGE) and the of allyl alcohol with ECH using BFEE as the catalyst. allyl polyoxyethylene ether (APEG), tethering with both Their results demonstrated that the yield reaches 82% alkene and epoxy groups, are widely used as fabric under the following condition: n (ECH) : n (allyl alcohol): finishing agent [1-2] , reactive diluent [3] , cross-linking (catalysis) = 1: (1~3) : (0.01~0.002).