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Viamet Reports Positive Results from Interim Analysis of REVIVE Phase 2B Trial of VT-1161 in Recurrent Vulvovaginal Candidiasis
Viamet Reports Positive Results from Interim Analysis of REVIVE Phase 2b Trial of VT-1161 in Recurrent Vulvovaginal Candidiasis -Interim Results Demonstrate Strong Clinical Benefit and Favorable Safety Profile- -Final Data Expected in Fourth Quarter of 2016- RESEARCH TRIANGLE PARK, N.C., March 9, 2016, – Viamet Pharmaceuticals, Inc. today reported positive results from a planned interim analysis of REVIVE (Recurrent Vulvovaginal Candidiasis Inhibition: an Oral VT-1161 Tablet Evaluation), its ongoing Phase 2b clinical trial of VT-1161 for the treatment of recurrent vulvovaginal candidiasis, or RVVC. RVVC is defined as three or more episodes of acute vulvovaginal candidiasis, or AVVC (commonly referred to as a vaginal yeast infection), in a 12-month period. VT-1161, the company’s lead product candidate, is a highly potent and selective, orally available inhibitor of fungal CYP51. “It is estimated that RVVC affects 5% to 8% of U.S. women during their child-bearing years and has a significant negative impact on quality of life,” commented Robert Schotzinger, M.D., Ph.D., CEO of Viamet. “Despite the number of women affected by this disease, we are not aware of any approved therapies for RVVC in the U.S. VT-1161 has demonstrated a high degree of potency against Candida species, the causative fungal pathogens responsible for RVVC, a robust oral pharmacokinetic profile, and a favorable safety profile in previous studies. These attributes, coupled with the positive interim results from our REVIVE trial, suggest that VT-1161 has the potential to be a highly effective treatment option for patients with RVVC.” REVIVE is a randomized, double-blind, placebo-controlled, 48-week clinical trial of VT-1161 in patients with RVVC. -
Supporting Information
Supporting Information Bachelier and Friedman 10.1073/pnas.1104697108 Table S1. Initiation of more than one female gametophyte per ovule in basal angiosperms Taxon Multiple female gametophytes References Amborellaceae No 1–4 Hydatellaceae Variable 5 and 6 Nymphaeaceae Variable 7–9 Cabombaceae Variable 8 and 10 Austrobaileyaceae No 11 Illiciaceae (incl. Schisandraceae) Variable 12–15 Trimeniaceae Variable 16–18 and this study Chloranthaceae Rare 4 and 18–22 Laurales Variable 18 and 23–27 Magnoliales No 27–31 Canellales Rare 30 and 32–37 Piperales Rare 38–44 Ceratophyllaceae Variable 45 Character states: No means that initiation of more than one female gametophyte per ovule has not been reported as yet, rare means that initiation of more than one female gametophyte per ovule has only been reported one time, and variable means that initiation of more than one female gametophyte per ovule has been reported to occur more than one time in some but not all studies. 1. Friedman WE, Ryerson KC (2009) Reconstructing the ancestral female gametophyte of angiosperms: Insights from Amborella and other ancient lineages of flowering plants. Am J Bot 96:129–143. 2. Friedman WE (2006) Embryological evidence for developmental lability during early angiosperm evolution. Nature 441:337–340. 3. Tobe H, Jaffré T, Raven PH (2000) Embryology of Amborella (Amborellaceae): Descriptions and polarity of character states. J Plant Res 113:271–280. 4. Yamada T, Tobe H, Imaichi R, Kato M (2001) Developmental morphology of the ovules of Amborella trichopoda (Amborellaceae) and Chloranthus serratus (Chloranthaceae). Bot J Linn Soc 137:277–290. 5. Rudall PJ, et al. -
Candida & Nutrition
Candida & Nutrition Presented by: Pennina Yasharpour, RDN, LDN Registered Dietitian Dickinson College Kline Annex Email: [email protected] What is Candida? • Candida is a type of yeast • Most common cause of fungal infections worldwide Candida albicans • Most common species of candida • C. albicans is part of the normal flora of the mucous membranes of the respiratory, gastrointestinal and female genital tracts. • Causes infections Candidiasis • Overgrowth of candida can cause superficial infections • Commonly known as a “yeast infection” • Mouth, skin, stomach, urinary tract, and vagina • Oropharyngeal candidiasis (thrush) • Oral infections, called oral thrush, are more common in infants, older adults, and people with weakened immune systems • Vulvovaginal candidiasis (vaginal yeast infection) • About 75% of women will get a vaginal yeast infection during their lifetime Causes of Candidiasis • Humans naturally have small amounts of Candida that live in the mouth, stomach, and vagina and don't cause any infections. • Candidiasis occurs when there's an overgrowth of the fungus RISK FACTORS WEAKENED ASSOCIATED IMUMUNE SYSTEM FACTORS • HIV/AIDS (Immunosuppression) • Infants • Diabetes • Elderly • Corticosteroid use • Antibiotic use • Contraceptives • Increased estrogen levels Type 2 Diabetes – Glucose in vaginal secretions promote Yeast growth. (overgrowth) Treatment • Antifungal medications • Oral rinses and tablets, vaginal tablets and suppositories, and creams. • For vaginal yeast infections, medications that are available over the counter include creams and suppositories, such as miconazole (Monistat), ticonazole (Vagistat), and clotrimazole (Gyne-Lotrimin). • Your doctor may prescribe a pill, fluconazole (Diflucan). The Candida Diet • Avoid carbohydrates: Supporters believe that Candida thrives on simple sugars and recommend removing them, along with low-fiber carbohydrates (eg, white bread). -
Oral Thrush A
Oral thrush A. Introduction Oral thrush occurs when a yeast infection develops on the inside of your mouth and on your tongue. This condition is also known as oral candidiasis, oropharyngeal candidiasis, or, simply, thrush. The Candida albicans (C. albicans) fungus causes oral thrush. Candida is a normal organism in your mouth, but sometimes it can overgrow and cause symptoms. Oral thrush most often occurs in infants and toddlers. Oral thrush is typically mild and rarely causes complications. However, the condition can be problematic for those with weakened immune systems. B. Signs and Symtoms Oral thrush is usually harmless. It's common in babies and older people with dentures. It can be easily treated with medicines bought from a pharmacy. Adults Your mouth is red inside and you have white patches When you wipe off the white patches, they leave red spots that can bleed Other symptoms in adults are: 1.cracks at the corners of the mouth 2.not tasting things properly 3.an unpleasant taste in the mouth 4.pain inside the mouth (for example, a sore tongue or sore gums) 5.difficulty eating and drinking Oral thrush in adults isn't contagious. Babies A white coating on the tongue like cottage cheese – this can't be rubbed off easily Sometimes there are white spots in their mout Other symptoms in babies are: 1.they don't want to feed 2.nappy rash Babies can pass oral thrush on through breastfeeding. This can cause nipple thrush in mothers. C. Treatment Treatment for oral thrush varies depending on your age and overall health. -
Fungal Infection
Fungal Infection What is a Fungus? A Fungus is a tiny microorganism that belongs to the eukaryotic group and is ubiquitous in nature. They can be found in the soil, plants, decaying organic matter, damp places, and also in humans and animals. They include yeast, moulds, mushrooms and several others out of which some are pathogenic to humans. What is Fungal Infection? Fungal infection, also known as mycosis, is a broad term to describe various disease conditions caused by different types of fungi. Sometimes, fungi that aren’t present in the normal flora can colonize and induce an infection. Or the disruption of normal flora can lead to a fungal infection. Fungal infections can affect anyone at any age. If it spreads, then the treatment and control of these infections become extremely challenging. What are the different types of Fungal Infections? There are several types of fungal infections that can cause serious damage to health. Some of the common types of fungal infections are as follows: Ringworm infections Nail infections Athlete’s foot Vaginal yeast infections Oral thrush Jock itch 1 Scalp infections, etc. The fungus can also cause a full-blown infection, sinus infections and deep lung infections. What are the signs and symptoms of different Fungal Infections? The signs and symptoms of different fungal infections widely vary from each other, and some of them are discussed below: Signs and symptoms of Ringworm infections- Formation of a red ring-like patch, development of blisters around the affected area, itching and burning sensation. Signs and symptoms of Nail infections- Discoloration of nails, destruction of their normal shape, brittle nails, a feeling of pain and pressure in the affected area. -
TISSUE INJURY INDUCED by CANDIDA ALBICANS Menstrual Period Occurring on the 26Th Day of "She's More Active," "Doesn't Sit and Hold Her Treatment
Tissue Injury Induced By Candida Albicans Mental and Neurologic Manifestations C. Orian Truss, M.D.I Introduction body complexes or the presence of "auto- Medical research of the past several decades antibodies" to one's own tissues are but two has greatly expanded our knowledge of the examples. deranged chemistry and physiology that The same "dead end" is reached, however, characterize many individual disease states. Yet when the search for a virus or other antigenic most diseases have stubbornly resisted the agent is unfruitful. The evidence indicates that massive effort to unlock the secret of their an immunologic response is taking place and etiologies. We learn more and more about the is in some way involved in the disease abnormalities of function that result in clinical process, but the antigenic agent continues to symptoms and signs, but continue to be frustrated elude discovery. in our effort to discover the identity of the factor Or we may postulate that the immunologic initiating the departure from normal function. It is process occurs secondary to toxic damage to a unfortunate that the list of such diseases is headed tissue, leading to autoantibodies and perhaps by those that are the most frequent cause of to antigen-antibody complex deposition. But disability and death. Among them would be again, such a toxin escapes detection, if it atherosclerosis, most often clinically expressed as exists. hypertension, heart attacks, and strokes; In presenting selected, cases treated during malignancies, "auto-immune" diseases, arthritis, the past 16 years, I hope to call attention to muscle-wasting diseases, mental and neurologic Candida Albicans as a possible candidate for disorders, and many others. -
(Clotrimazole Vaginal Cream USP 1%) Clotrimaderm Vaginal 3
PRODUCT MONOGRAPH Clotrimaderm Vaginal 6 (Clotrimazole Vaginal Cream USP 1%) Clotrimaderm Vaginal 3 (Clotrimazole Vaginal Cream USP 2%) Clotrimaderm External Cream (Clotrimazole Vaginal Cream USP 1%) Antifungal Agent Taro Pharmaceuticals Inc. Date of Preparation: 130 East Drive January 27, 2020 Brampton, Ontario L6T 1C1 Control #232921 Page 1 of 22 Table of Contents PART I: HEALTH PROFESSIONAL INFORMATION ................................................................ 3 SUMMARY PRODUCT INFORMATION ...................................................................................... 3 INDICATIONS AND CLINICAL USE ........................................................................................... 3 CONTRAINDICATIONS ................................................................................................................. 3 WARNINGS AND PRECAUTIONS ............................................................................................... 3 ADVERSE REACTIONS ................................................................................................................. 4 DRUG INTERACTIONS .................................................................................................................. 5 DOSAGE AND ADMINISTRATION ............................................................................................. 5 OVERDOSAGE ................................................................................................................................. 6 ACTION AND CLINICAL PHARMACOLOGY ...................................................................... -
Downregulation of Fungal Cytochrome C Peroxidase Expression by Antifungal Quinonemethide Triterpenoids
J Appl Biol Chem (2016) 59(4), 281−284 Online ISSN 2234-7941 http://dx.doi.org/10.3839/jabc.2016.048 Print ISSN 1976-0442 Article: Bioactive Materials Downregulation of fungal cytochrome c peroxidase expression by antifungal quinonemethide triterpenoids Woo-Duck Seo1 · Dong-Yeol Lee2 · Ki Hun Park2 · Jin-Hyo Kim2 Received: 23 May 2016 / Accepted: 29 June 2016 / Published Online: 31 December 2016 © The Korean Society for Applied Biological Chemistry 2016 Abstract To handle the development of antifungal drug resistance, are reported to possess several biological activities such as the development of new structural modules and new modes of anticancer, anti-inflammatory, antimalarial, antioxidant, antiviral, action for antifungals have been highlighted recently. Here, the and insecticidal activities (Luo et al. 2005; Brinker et al. 2007; antifungal activity of quinonemethidal triterpenoids such as Gao et al. 2007; Su et al. 2009; Ryu et al. 2010) as well as celastrol, dihydrocelastrol, iguestein, pristimerin, and tingenone antifungal activity (Dos Santos et al. 2010). Furthermore, these isolated from Tripterygium regelii were identified (MIC 0.269- triterpenoids induced an increase in intracellular reactive oxygen 19.02 µM). C. glabrata was the most susceptible to quinonemethide species (ROS) and mitochondrial dysfunction (Byun et al. 2009), among the tested fungi. Furthermore, quinonemethide suppressed and the quinonemethide moiety with electrochemical potential is cyctochrome c peroxidase expression dramatically, decreasing regarded as a key component of the triterpenoid (Ryu et al. 2010). fungal viability caused by the accumulation of hydrogen peroxide. Despite the many biological activities of quinonemethide triterpenoid, Thus, cyctochrome c peroxidase downregulation of quinonemethide the structure-based antifungal activity with quinomethide triterpenoid may be a key mode of action for antifungals. -
Vaginal Yeast Infection a Vaginal Yeast Infection Is an Infection of the Vagina, Most Commonly Due to the Fungus Candida Albicans
5285 Anthony Wayne Drive, Detroit, MI 48202 (P) 313-577-5041 | (F) 313-577-9581 health.wayne.edu Vaginal Yeast Infection A vaginal yeast infection is an infection of the vagina, most commonly due to the fungus Candida albicans. Causes, incidence, and risk factors Most women have a vaginal yeast infection at some time. Candida albicans is a common type of fungus. It is often found in small amounts in the vagina, mouth, digestive tracts, and on the skin. Usually it does not cause disease or symptoms. Candida and the many other germs that normally live in the vagina keep each other in balance. However, sometimes the number of Candida albicans increases, leading to a yeast infection. A yeast infection can happen if you are: • Taking antibiotics used to treat other types of infections. Antibiotics change the normal balance between germs in the vagina by decreasing the number of protective bacteria. • Pregnant • Obese • Have diabetes A yeast infection is not a sexually transmitted illness. However, some men will develop symptoms such as itching and a rash on the penis after having sexual contact with an infected partner. Having many vaginal yeast infections may be a sign of other health problems. Other vaginal infections and discharges can be mistaken for vaginal yeast infection. Symptoms • Pain with intercourse • Painful urination • Redness and swelling of the vulva • Vaginal and labial itching, burning • Abnormal Vaginal Discharge • Ranges from a slightly watery, white discharge to a thick, white, chunky discharge (like cottage cheese) Signs and Tests A pelvic examination will be done. It may show swelling and redness of the skin of the vulva, in the vagina, and on the cervix. -
VAGINITIS, CANDIDAL (Vaginal Yeast Infection)
VAGINITIS, CANDIDAL (Vaginal Yeast Infection) BASIC INFORMATION • If you have diabetes, adhere strictly to your treatment DESCRIPTION program. • Avoid antibiotics unless prescribed by the doctor. Infection or inflammation of the vagina caused by a EXPECTED OUTCOME yeast-like fungus (usually Candida albicans). It is Usually curable after 1 to 2 weeks of treatment (some- the second most common vaginitis in the U.S. times less). (bacterial vaginitis is the most common). POSSIBLE COMPLICATIONS FREQUENT SIGNS AND SYMPTOMS • Secondary bacterial infections of the vagina and other Severity of the following symptoms varies among pelvic organs. women and from time to time in the same woman. • In some cases, the vaginitis becomes chronic. • White, “curdy” vaginal discharge (resembles TREATMENT lumps of cottage cheese). The odor may be GENERAL MEASURES unpleasant, but not foul. • Diagnostic tests may include laboratory studies of • Swollen, red, tender, itching vaginal lips (labia) vaginal discharge, Pap smear and pelvic examination. and surrounding skin. • Drug therapy will be directed to the specific organism. • Burning on urination. Treatment for your sexual partner may be recommended • Change in vaginal color from pale pink to red. also. It is best not to do self-treatment for the disorder • Pain during sexual intercourse (dyspareunia). until the specific cause is determined. CAUSES • Don’t douche unless prescribed for you. The fungus Candida lives in small numbers in a • If urinating causes burning, urinate through a tubular healthy vagina, rectum and mouth. When the device, such as a toilet-paper roll or plastic cup with the bottom cut out or pour a cup of warm water over the vagina’s hormone and pH balance is disturbed, the genital area while you urinate. -
Prevalence and Antifungal Susceptibility Patterns of Yeast Isolates at the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana
British Microbiology Research Journal 2(1): 10-22, 2012 SCIENCEDOMAIN international www.sciencedomain.org Prevalence and Antifungal Susceptibility Patterns of Yeast Isolates at the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana P. K. Feglo 1* and P. Narkwa 1 1Department of Clinical Microbiology, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Received 17th September 2011 Research Article Accepted 13 th November 2011 Online Ready 9th January 2012 ABSTRACT Aims : To determine the prevalence of yeast species and their antifungal susceptibility profiles at Komfo Anokye Teaching Hospital (KATH), Kumasi. Study Design : Cross-sectional design. Methodology : This study was conducted in 2009 at the bacteriology laboratory at KATH, Kumasi, Ghana. In six-months, 528 clinical samples comprising 186(35%) high vaginal swabs, 109(21%) cerebrospinal fluid, 127(24%) urine and 106(20%) sputum were cultured on sabouraud dextrose agar. Yeast growths were identified by their characteristics, indian- ink staining and germ tube test and then confirmed with the API ID 32 C test kits. Antifungal susceptibility tests were performed using ATB™ FUNGUS 3 test kit. Results : Out of 528 samples tested 67 yielded yeasts giving a prevalence of 12.7%. Candida albicans was the commonest species isolated with a prevalence of 33(49.3%) followed by Candida glabrata 12(17.9%) , Candida tropicalis 8(11.9%), Candida dubliniensis 4(6%), Candida krusei 3(4.5%) and Candida sake 2(3%) , whilst Candida guilliermondii and Candida parapsilosis prevalence was 1(1.5%) each and Cryptococcus neoformans prevalence was 3(4.5%). All the isolates were susceptible to flucytosine, amphotericin B, fluconazole, itraconazole and voriconazole except C. -
Title Studies on the Lignins of Podocarpus, Gnetum, Drimys and Pseudowintera Author(S)
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Kyoto University Research Information Repository Studies on the Lignins of Podocarpus, Gnetum, Drimys and Title Pseudowintera Author(s) SHIO, Toru; HIGUCHI, Takayoshi Wood research : bulletin of the Wood Research Institute Kyoto Citation University (1978), 63: 1-10 Issue Date 1978-01-20 URL http://hdl.handle.net/2433/53368 Right Type Departmental Bulletin Paper Textversion publisher Kyoto University Studies on the Lignins of Podocarpus, Gnetum, Drimys and Pseudowintera* Torn SHIO** and Takayoshi HIGUCHI** Abstract--The lignins of 7 species in Podocarpaceae, 2 Gnetum's, a Drimys and 2 Pseu dowintera's are characterized in respect of methoxyl content, IR spectrum, acidolysis, and permanganate oxidation of the ethylated wood powder. The relative absorptivities (AlA 1505 em-I) of characteristic maxima, and the ratio of syringyl component to guaiacyl component in acidolysis and permanganate oxidation showed that Podocarpus lignin is mostly composed of guaiacyl lignin and that lignins of Gnetum, Pseudowintera and Drimys are composed of guaiacyl-syringyl lignins with increasing amounts of syringyl component in order. Introduction CREIGHTON and HIBBERTD found that lignins of Gnetum and some of Podocarpus give both vanillin and syringaldehyde in nitrobenzene oxidation, and are composed of guaiacyl-syringyl lignin. It is known, however, that the lignins of other species of Podocarpus e. g. P. macrophylla, P. chinensis and P. nagi yield no detectable syring aldehyde in nitrobenzene oxidation and are composed of guaiacyl lignin. The lignin of Gnetales which contains both tracheids and vessels as in angiosperm woods gives both vanillin and syringaldehyde and a characteristic IR spectrum of typical angiosperm wood lignin2).