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Evaluation of Anti-Inflammatory, Anti-Pyretic, Analgesic, And Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera Mahamane Haïdara, Adama Dénou, Mohamed Haddad, Aïssata Camara, Korotoumou Traoré, Agnès Aubouy, Geneviève Bourdy, Rokia Sanogo To cite this version: Mahamane Haïdara, Adama Dénou, Mohamed Haddad, Aïssata Camara, Korotoumou Traoré, et al.. Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera. Planta Medica International Open, Thieme, 2020, 07 (02), pp.e58 - e67. 10.1055/a-1142-7072. hal-03113936 HAL Id: hal-03113936 https://hal.archives-ouvertes.fr/hal-03113936 Submitted on 18 Jan 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Published online: 2020-04-23 Original Papers Thieme Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera Authors Mahamane Haïdara1, 2 * , Adama Dénou2 * , Mohamed Haddad1 , Aïssata Camara1, 3, Korotoumou Traoré4, Agnès Aubouy1, Geneviève Bourdy1, Rokia Sanogo2, 5 Affiliations Dr. Mohamed Haddad 1 UMR 152 PHARMA-DEV, Université de Toulouse, IRD, UMR 152 PHARMA-DEV UPS, France Université de Toulouse, IRD, UPS 2 Faculté de Pharmacie, Université des Sciences, des 31400 Toulouse Techniques et des Technologies, Bamako, Mali France 3 Institute for Research and Development of Medicinal and Tel.: + 33 5 62 25 98 11, Fax: + 33 5 62 25 98 02 Food Plants of Guinea (IRDPMAG), Dubréka, Guinea [email protected] 4 Aidemet ONG, Bamako, Mali 5 Département de Médecine Traditionnelle (DMT), Institut Abstract National de Recherche en Santé Publique (INRSP), In Mali, improved traditional medicines [“Médicaments Tradi- Bamako, Mali tionnels Améliorés”] are prepared from traditionally used me- dicinal plants. Recently, the Department of Traditional Medicine Key words has identifiedTerminalia macroptera Guill. & Perr. (Combreta- Terminalia macroptera, Combretaceae, Médicaments ceae) as a potential candidate for an improved traditional med- Traditionnels Améliorés/improved traditional medicines, icine. T. macroptera is a West African medicinal plant used in Mali medicinal plant antipyretic, anti-inflammatory, hepatopro- against various health disorders, with more than 30 different tective indications mentioned by traditional healers, including hepatitis, gonorrhea, fever, pain relief, and various infectious diseases received 07.10.2019 (Helicobacter pylori-associated diseases). To date, validation of revised 18.03.2020 most of the biological activities of has been mainly carried out accepted 19.03.2020 in vitro, except for antimalarial activities. In this study, the poten- Bibliography tial anti-inflammatory, antipyretic, analgesic, and hepatoprotec- DOI https://doi.org/10.1055/a-1142-7072 tive properties of T. macroptera were investigated in different Planta Med Int Open 2020; 7: e58–e67 murine models. Administration of T. macroptera ethanolic root © Georg Thieme Verlag KG Stuttgart · New York and leaf extracts in rats significantly reduced pyrexia, pain, in- ISSN 2509-9264 flammation, and hepatic marker enzymes such as alanine ami- notransferase, aspartate aminotransferase, and alkaline phos- Correspondence phatase in the different murine models used (p < 0.05). A Dr. Mahamane Haidara phytochemical screening of T. macroptera revealed the presence Faculté de Pharmacie of tannins, flavonoids, saponins, anthracene derivatives, sterols, Université des Sciences triterpenes, and sugars in both leaf and root extracts as the main des Techniques et des Technologies phytochemical compounds. This was confirmed by qualitative BP 1805 analysis, liquid chromatography coupled with high-resolution Bamako mass spectrometry. T. macroptera extracts demonstrated inter- Mali esting in vivo antipyretic, analgesic, anti-inflammatory, and Tel.: + 223 76 01 90 68, Fax: + 223 20 29 04 08 / + 223 20 29 hepatoprotective activities. Therefore, T. macroptera should be 04 18 proposed and further evaluated as a potential improved tradi- [email protected] tional medicine for the treatment of liver-related disorders and for the relief of pain and fever. * These authors contributed equally to this work. e58 Haïdara M et al. Evaluation of Anti-inflammatory, Anti-pyretic,. Planta Med Int Open 2020; 7: e58–e67 Introduction ulatory effects (▶Table 3). Only two in vivo studies have been car- Research on medicinal plants in Mali has been dynamic since po- ried out [2]. In a recent study, our team demonstrated the ability litical independence in 1960. In 1968, the Department of Tradi- of T. macroptera roots (TMR) and leaves (TML) to limit Plasmodium tional Medicine (DMT) was created under the authority of the Min- parasitemia and to increase survival in two murine models of un- istry of Health. One of the objectives of the DMT is to assess the bi- complicated and cerebral malaria, respectively. In addition, we ological activities of medicinal plants used in traditional medicine, demonstrated that according to the Organization for Economic Co- and to formulate and produce phytomedicines based on improved operation and Development’s (OECD) Globally Harmonized System traditional medicines called MTAs “Médicaments Traditionnels of Classification, both extracts were non-toxic orally [3]. The same Améliorés”. MTAs are categorized into four types. The require- batch of T. macroptera was used in both studies. ments to get an official marketing authorization vary according to In order to complete these data and to investigate some of the the category (▶Table 1). The basic requirement is documenting ethnopharmacological claims, especially the use of T. macroptera the traditional uses of the remedy, its safety and efficacy, indicat- as an antipyretic, anti-inflammatory, hepatoprotective, and anal- ing its standardized dosage, and providing quality control data. gesic agent, our team conducted the first recordedin vivo studies Today, the majority of registered MTAs are classified as Category 2, for to evaluate these properties. The study aims to provide a stronger which clinical trial data is not mandatory [1]. Recently, the DMT research basis for the potential future use of T. macroptera as an identifiedTerminalia macroptera Guill. & Perr. (Combretaceae) as a MTA in Mali. potential candidate for an M T A . T h i s plant is widely used in West African countries to treat many health disorders, although research that proves biological activity Results and Discussion remains scarce. Eleven publications reported the traditional use of At present, the following chemical labelling and classification of different parts of the plant in the treatment of disorders such as acute systemic toxicity, based on oral LD50 values, are from the rec- liver disease, malaria, urinary tract infection, diarrhea, pain, fever, ommendations of the Globally Harmonized System of Classification and wounds (▶Table 2). In vitro antibacterial, antifungal, antiplas- [OECD, 2008], and ranked as: very toxic, ≤ 5 mg/kg; toxic, > 5 ≤ 50 modial, antitrypanosomal, leishmanicidal, and antiviral activities mg/kg; harmful, > 50 ≤ 500 mg/kg; and no label, > 500 ≤ 2000 mg/ have been previously reported in the roots, leaves, and bark of this kg [4]. In our previous work [3], oral administration of TML and TMR species. Reported in vitro biological activities include antioxidant, at a dose of 2000 mg/kg did not cause mortality among experi- enzyme inhibition, antiproliferative, hemolytic, and immunomod- mental animals. This indicates that the LD50s of TML and TMR are ▶Table 1 MTA classes according to the Ministry of Health Regulation in Mali and requested items for marketing authorization delivery [1]. MTA class 1 2 3 4 Description Traditional medicine Traditional medicine Standardized Molecules purified prepared by a traditional currently used in the extracts prepared from traditional health practitioner for an community, prepared in advance medicines individual patient with fresh in advance, and following following or dried raw materials, with composed of crude scientific research scientific research a short shelf life raw materials Requested Covering letter1 X X X X items for Samples2 X X X X marketing Administrative dossier3 X X X X authorization 4 delivery Pharmaceutical dossier X X Expert analytical report5 X X X Pharmacology and toxicology X X dossier6 Clinical dossier7 X X Expert report on traditional X X X X use8 Fees9 X X X X 1Addressed to the Ministry of Health, including the name and address of the manufacturer. 2Ten samples as sold. 3Registration form of the manufacturer and memoranda of understanding between the manufacturer and a research institution. 4Complete monograph(s) of the plant’s component(s). Method and stages of preparation and production and Expert report on Good Manufacturing Practices. 5Quality control method for raw materials. Results of stability and quality control tests of raw materials and excipients. Method and results of quality control during production. Quality control results of the finished product. Stability tests results of the finished
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