Everything You've Heard About Agile Development Is Wrong
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An Efficient Way for Statistical Review Using the Rshiny Application
PhUSE EU Connect 2018 Paper AD03 An Efficient Way for Statistical Review Using the RShiny Application Adarsh Nagare, Cytel, Pune, India Sameer Bamnote, Cytel, Pune, India ABSTRACT Statisticians often need to review critical reports before study submissions. Many reports include outputs based on statistical testing or model-based analysis. To ensure the accuracy of these reports, most of the time the Statistician needs to writes independent code. In case of tight timelines, it may not be feasible and quality of review can be impacted. To address this we describe use of an application that can save time for the Statistician. This application was created using open-source software R and Shiny, providing an efficient, time saving solution for review of critical statistical outputs without the need for extensive code writing. The aim is to review results for t-tests, AN(C)OVA, their non-parametric alternatives and model-based analysis which are performed in SAS®. User has flexibility to provide input data in excel, csv or SAS format. User can select the statistical test (or specify the model) as per requirement and statistical outputs will be just a click away. This paper demonstrates the application with a variety of illustrations. INTRODUCTION The authors work with clients from clinical research and FMCG field as Statisticians. As a part of the role we have to deal with programmers routinely to do the desired work (i.e. Tables, Listings and Figures) required for various reports. Most of the time, as a Statistician we need to validate the results for modelling or statistical tests or cross check them by writing independent code to ensure accuracy of the results, prior to the submissions. -
Precollimator for X-Ray Telescope (Stray-Light Baffle) Mindrum Precision, Inc Kurt Ponsor Mirror Tech/SBIR Workshop Wednesday, Nov 2017
Mindrum.com Precollimator for X-Ray Telescope (stray-light baffle) Mindrum Precision, Inc Kurt Ponsor Mirror Tech/SBIR Workshop Wednesday, Nov 2017 1 Overview Mindrum.com Precollimator •Past •Present •Future 2 Past Mindrum.com • Space X-Ray Telescopes (XRT) • Basic Structure • Effectiveness • Past Construction 3 Space X-Ray Telescopes Mindrum.com • XMM-Newton 1999 • Chandra 1999 • HETE-2 2000-07 • INTEGRAL 2002 4 ESA/NASA Space X-Ray Telescopes Mindrum.com • Swift 2004 • Suzaku 2005-2015 • AGILE 2007 • NuSTAR 2012 5 NASA/JPL/ASI/JAXA Space X-Ray Telescopes Mindrum.com • Astrosat 2015 • Hitomi (ASTRO-H) 2016-2016 • NICER (ISS) 2017 • HXMT/Insight 慧眼 2017 6 NASA/JPL/CNSA Space X-Ray Telescopes Mindrum.com NASA/JPL-Caltech Harrison, F.A. et al. (2013; ApJ, 770, 103) 7 doi:10.1088/0004-637X/770/2/103 Basic Structure XRT Mindrum.com Grazing Incidence 8 NASA/JPL-Caltech Basic Structure: NuSTAR Mirrors Mindrum.com 9 NASA/JPL-Caltech Basic Structure XRT Mindrum.com • XMM Newton XRT 10 ESA Basic Structure XRT Mindrum.com • XMM-Newton mirrors D. de Chambure, XMM Project (ESTEC)/ESA 11 Basic Structure XRT Mindrum.com • Thermal Precollimator on ROSAT 12 http://www.xray.mpe.mpg.de/ Basic Structure XRT Mindrum.com • AGILE Precollimator 13 http://agile.asdc.asi.it Basic Structure Mindrum.com • Spektr-RG 2018 14 MPE Basic Structure: Stray X-Rays Mindrum.com 15 NASA/JPL-Caltech Basic Structure: Grazing Mindrum.com 16 NASA X-Ray Effectiveness: Straylight Mindrum.com • Correct Reflection • Secondary Only • Backside Reflection • Primary Only 17 X-Ray Effectiveness Mindrum.com • The Crab Nebula by: ROSAT (1990) Chandra 18 S. -
X-Ray and Gamma-Ray Variability of NGC 1275
galaxies Article X-ray and Gamma-ray Variability of NGC 1275 Varsha Chitnis 1,*,† , Amit Shukla 2,*,† , K. P. Singh 3 , Jayashree Roy 4 , Sudip Bhattacharyya 5, Sunil Chandra 6 and Gordon Stewart 7 1 Department of High Energy Physics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India 2 Discipline of Astronomy, Astrophysics and Space Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Indore 453552, India 3 Indian Institute of Science Education and Research Mohali, Knowledge City, Sector 81, SAS Nagar, Manauli 140306, India; [email protected] 4 Inter-University Centre for Astronomy and Astrophysics, Ganeshkhind, Pune 411 007, India; [email protected] 5 Department of Astronomy and Astrophysics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India; [email protected] 6 Centre for Space Research, North-West University, Potchefstroom 2520, South Africa; [email protected] 7 Department of Physics and Astronomy, The University of Leicester, University Road, Leicester LE1 7RH, UK; [email protected] * Correspondence: [email protected] (V.C.); [email protected] (A.S.) † These authors contributed equally to this work. Received: 30 June 2020; Accepted: 24 August 2020; Published: 28 August 2020 Abstract: Gamma-ray emission from the bright radio source 3C 84, associated with the Perseus cluster, is ascribed to the radio galaxy NGC 1275 residing at the centre of the cluster. Study of the correlated X-ray/gamma-ray emission from this active galaxy, and investigation of the possible disk-jet connection, are hampered because the X-ray emission, particularly in the soft X-ray band (2–10 keV), is overwhelmed by the cluster emission. -
Executive Summary
The Boston University Astronomy Department Annual Report 2010 Chair: James Jackson Administrator: Laura Wipf 1 2 TABLE OF CONTENTS Executive Summary 5 Faculty and Staff 5 Teaching 6 Undergraduate Programs 6 Observatory and Facilities 8 Graduate Program 9 Colloquium Series 10 Alumni Affairs/Public Outreach 10 Research 11 Funding 12 Future Plans/Departmental Needs 13 APPENDIX A: Faculty, Staff, and Graduate Students 16 APPENDIX B: 2009/2010 Astronomy Graduates 18 APPENDIX C: Seminar Series 19 APPENDIX D: Sponsored Project Funding 21 APPENDIX E: Accounts Income Expenditures 25 APPENDIX F: Publications 27 Cover photo: An ultraviolet image of Saturn taken by Prof. John Clarke and his group using the Hubble Space Telescope. The oval ribbons toward the top and bottom of the image shows the location of auroral activity near Saturn’s poles. This activity is analogous to Earth’s aurora borealis and aurora australis, the so-called “northern” and “southern lights,” and is caused by energetic particles from the sun trapped in Saturn’s magnetic field. 3 4 EXECUTIVE SUMMARY associates authored or co-authored a total of 204 refereed, scholarly papers in the disciplines’ most The Department of Astronomy teaches science to prestigious journals. hundreds of non-science majors from throughout the university, and runs one of the largest astronomy degree The funding of the Astronomy Department, the Center programs in the country. Research within the for Space Physics, and the Institute for Astrophysical Astronomy Department is thriving, and we retain our Research was changed this past year. In previous years, strong commitment to teaching and service. only the research centers received research funding, but last year the Department received a portion of this The Department graduated a class of twelve research funding based on grant activity by its faculty. -
Solar Orbiter and Sentinels
HELEX: Heliophysical Explorers: Solar Orbiter and Sentinels Report of the Joint Science and Technology Definition Team (JSTDT) PRE-PUBLICATION VERSION 1 Contents HELEX Joint Science and Technology Definition Team .................................................................. 3 Executive Summary ................................................................................................................................. 4 1.0 Introduction ........................................................................................................................................ 6 1.1 Heliophysical Explorers (HELEX): Solar Orbiter and the Inner Heliospheric Sentinels ........ 7 2.0 Science Objectives .............................................................................................................................. 8 2.1 What are the origins of the solar wind streams and the heliospheric magnetic field? ............. 9 2.2 What are the sources, acceleration mechanisms, and transport processes of solar energetic particles? ........................................................................................................................................ 13 2.3 How do coronal mass ejections evolve in the inner heliosphere? ............................................. 16 2.4 High-latitude-phase science ......................................................................................................... 19 3.0 Measurement Requirements and Science Implementation ........................................................ 20 -
Volume8, Issue11(1) November 2018
International Journal of Management, IT & Engineering Vol. 8 Issue 11(1), November 2018, ISSN: 2249-0558 Impact Factor: 7.119 Journal Homepage: http://www.ijmra.us, Email: [email protected] Double-Blind Peer Reviewed Refereed Open Access International Journal - Included in the International Serial Directories Indexed & Listed at: Ulrich's Periodicals Directory ©, U.S.A., Open J-Gage as well as in Cabell’s Directories of Publishing Opportunities, U.S.A Industrial Unrest and National Development (A Study of Selected Non-Union-Dominated Manufacturing Firms in South East Nigeria) OKEKE, MARCEL CHINEMERE (PhD) Abstract This study investigated the effect of industrial unrest on national development by studying selected non-union dominated manufacturing firms in South East Nigeria. It adopted survey research design and collected data from primary sources with structured questionnaire. Relevant literature was reviewed based on conceptual, theoretical, and empirical frameworks. The population was 509 comprising managers and employees selected purposively through stratified random method from the five states. The study used complete enumeration Four hundred and thirteen (413) out of the 509 copies of the questionnaire distributed were correctly completed, returned and used for the analysis indicating a response rate of 81%. Data were presented with tables and research questions were presented with statistically weighted means and standard deviation applied to the Likert scale items. Two hypotheses were formulated and tested with t-test statistic for difference in two means at 0.05 level of significance and 411 degrees of freedom. The results indicated that the managers and workers admitted that the items relating to the causes of industrial unrest were prevalent in the society. -
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When Django is too bloated Specialized Web-Applications with Werkzeug EuroPython 2017 – Rimini, Italy Niklas Meinzer @NiklasMM Gotthard Base Tunnel Photographer: Patrick Neumann Python is amazing for web developers! ● Bottle ● BlueBream ● CherryPy ● CubicWeb ● Grok ● Nagare ● Pyjs ● Pylons ● TACTIC ● Tornado ● TurboGears ● web2py ● Webware ● Zope 2 Why would I want to use less? ● Learn how stuff works Why would I want to use less? ● Avoid over-engineering – Wastes time and resources – Makes updates harder – It’s a security risk. Why would I want to use less? ● You want to do something very specific ● Plan, manage and document chemotherapy treatments ● Built with modern web technology ● Used by hospitals in three European countries Patient Data Lab Data HL7 REST Pharmacy System Database Printers Werkzeug = German for “tool” ● Developed by pocoo team @ pocoo.org – Flask, Sphinx, Jinja2 ● A “WSGI utility” ● Very lightweight ● No ORM, No templating engine, etc ● The basis of Flask and others Werkzeug Features Overview ● WSGI – WSGI 1.0 compatible, WSGI Helpers ● Wrapping of requests and responses ● HTTP Utilities – Header processing, form data parsing, cookies ● Unicode support ● URL routing system ● Testing tools – Testclient, Environment builder ● Interactive Debugger in the Browser A simple Application A simple Application URL Routing Middlewares ● Separate parts of the Application as wsgi apps ● Combine as needed Request Static files DB Part of Application conn with DB access User Dispatcher auth Part of Application without DB access Response HTTP Utilities ● Work with HTTP dates ● Read and dump cookies ● Parse form data Using the test client Using the test client - pytest fixtures Using the test client - pytest fixtures Interactive debugger in the Browser Endless possibilities ● Connect to a database with SQLalchemy ● Use Jinja2 to render documents ● Use Celery to schedule asynchronous tasks ● Talk to 3rd party APIs with requests ● Make syscalls ● Remote control a robot to perform tasks at home Thank you! @NiklasMM NiklasMM Photographer: Patrick Neumann. -
Particle Background for Equatorial Low Earth Orbit (ELEO)
Particle background for Equatorial Low Earth Orbit (ELEO) Yashvi Sharma August 11, 2020 1 Introduction An important consideration for X-ray and Gamma ray missions is the particle background environ- ment. Focusing telescopes with lower effective area are only background limited at the fainter end of sensitivity. On the other hand, collimators and concentrators have larger effective area hence there primary concern is to both limit and model the background to get better sensitivity. It can be achieved through employing shielding systems and careful modeling of radiation environment (see figure ?? for state of the art simulation efforts) and choosing the orbit in accordance with science objectives and background limitations. Low Earth Orbit (LEO) is the most commonly used orbit for imaging satellites, communication satellites (network) and many different space telescopes (Hubble, AGILE, ASTROSAT, etc.) and space stations (ISS, Tiangong-2). It is defined to be less than 2000 km in altitude or with less than 128 minutes period and with eccentricity within 0.25. Thus, it requires less energy for satellite placement (although does require frequent orbital corrections due to orbital decay), provides good bandwidth and low latency for communication (although the window for communication is short due to smaller orbits) and is more easily accessible for servicing of space stations and satellites. Moreover, it is between the Earth's upper atmosphere and inner Van Allen radiation belt to keep the high energy particle background to the minimum. Figure 1: Simulated background environment using MGGPOD 1 2 Particle Background for ELEO missions The particle background for an unshielded detector in LEO is primarily made up of cosmic diffuse radiation (below 150 keV) and albedo glow of Earth from interaction of cosmic rays with atmosphere (above 150 keV). -
Hubble Space Telescope and Optical Data on SDSSJ0804+5103 (EZ Lyn) One Year After Outburst
Hubble Space Telescope and Optical Data on SDSSJ0804+5103 (EZ Lyn) One Year After Outburst Dean M. Townsley – University of California et al. Deposited 08/23/2018 Citation of published version: Szkody, P., et al. (2013): Hubble Space Telescope and Optical Data on SDSSJ0804+5103 (EZ Lyn) One Year After Outburst. The Astronomical Journal, 145(5). http://dx.doi.org/10.1088/0004-6256/145/5/121 © 2013. The American Astronomical Society. All rights reserved. Printed in the U.S.A The Astronomical Journal, 145:121 (6pp), 2013 May doi:10.1088/0004-6256/145/5/121 C 2013. The American Astronomical Society. All rights reserved. Printed in the U.S.A. HUBBLE SPACE TELESCOPE AND OPTICAL DATA ON SDSSJ0804+5103 (EZ Lyn) ONE YEAR AFTER OUTBURST∗ Paula Szkody1, Anjum S. Mukadam1, Edward M. Sion2,BorisT.Gansicke¨ 3, Arne Henden4, and Dean Townsley5 1 Department of Astronomy, University of Washington, Seattle, WA 98195, USA; [email protected], [email protected] 2 Department of Astronomy & Astrophysics, Villanova University, Villanova, PA 19085, USA; [email protected] 3 Department of Physics, University of Warwick, Coventry CV4 7AL, UK; [email protected] 4 AAVSO, 49 Bay State Road, Cambridge, MA 02138, USA; [email protected] 5 Department of Physics & Astronomy, University of Alabama, Tuscaloosa, AL 35487, USA; [email protected] Received 2012 November 20; accepted 2013 February 25; published 2013 March 19 ABSTRACT We present an ultraviolet (UV) spectrum and light curve of the short orbital period cataclysmic variable EZ Lyn obtained with the Cosmic Origins Spectrograph on the Hubble Space Telescope 14 months after its dwarf nova outburst, along with ground-based optical photometry. -
Enhanced Vasculogenic Capacity Induced by 5-Fluorouracil Chemoresistance in a Gastric Cancer Cell Line
International Journal of Molecular Sciences Article Enhanced Vasculogenic Capacity Induced by 5-Fluorouracil Chemoresistance in a Gastric Cancer Cell Line Sara Peri 1,† , Alessio Biagioni 2,† , Giampaolo Versienti 2, Elena Andreucci 2 , Fabio Staderini 1 , Giuseppe Barbato 1 , Lisa Giovannelli 3 , Francesco Coratti 1, Nicola Schiavone 2,*, Fabio Cianchi 1,* , Laura Papucci 2,‡ and Lucia Magnelli 2,‡ 1 Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy; sara.peri@unifi.it (S.P.); fabio.staderini@unifi.it (F.S.); [email protected] (G.B.); [email protected] (F.C.) 2 Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy; alessio.biagioni@unifi.it (A.B.); giampaolo.versienti@unifi.it (G.V.); e.andreucci@unifi.it (E.A.); laura.papucci@unifi.it (L.P.); lucia.magnelli@unifi.it (L.M.) 3 Department of Neuroscience, Psychology, Drug Research and Children’s Health, University of Florence, Viale Pieraccini, 6-50139 Firenze, Italy; lisa.giovannelli@unifi.it * Correspondence: nicola.schiavone@unifi.it (N.S.); fabio.cianchi@unifi.it (F.C.); Tel.: +39-055-275-1309 (N.S.); +39-055-412-029 (F.C.) † S.P. and A.B. contributed equally as first authors. ‡ L.P. and L.M. contributed equally as last authors. Abstract: Chemotherapy is still widely used as a coadjutant in gastric cancer when surgery is not Citation: Peri, S.; Biagioni, A.; possible or in presence of metastasis. During tumor evolution, gatekeeper mutations provide a Versienti, G.; Andreucci, E.; Staderini, selective growth advantage to a subpopulation of cancer cells that become resistant to chemotherapy. -
Self-Adapting Software for Cyberphysical Systems
Self-Adapting Software for Cyberphysical Systems Gabe Fierro Electrical Engineering and Computer Sciences University of California, Berkeley Technical Report No. UCB/EECS-2021-159 http://www2.eecs.berkeley.edu/Pubs/TechRpts/2021/EECS-2021-159.html June 2, 2021 Copyright © 2021, by the author(s). All rights reserved. Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise, to republish, to post on servers or to redistribute to lists, requires prior specific permission. Self-Adapting Software for Cyberphysical Systems by Gabriel Tomas Fierro A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Computer Science in the Graduate Division of the University of California, Berkeley Committee in charge: Professor David E. Culler, Chair Professor Joseph M. Hellerstein Associate Professor Stefano Schiavon Spring 2021 Self-Adapting Software for Cyberphysical Systems Copyright 2021 by Gabriel Tomas Fierro 1 Abstract Self-Adapting Software for Cyberphysical Systems by Gabriel Tomas Fierro Doctor of Philosophy in Computer Science University of California, Berkeley Professor David E. Culler, Chair The built environment | the buildings, utilities, infrastructure, cities and other constructed elements of the anthropocene | is becoming increasingly digitized. The complex array of equipment, sensors and other devices in these environments constitute cyberphysical systems which produce an incredible volume of data. However, this cyberphysical data is hard to ac- cess and understand because of the extreme heterogeneity and scale of the built environment: essentially every cyberphysical system is a custom-built “one-off" collection of equipment, devices and data sources that has been continually operated, retrofitted, expanded and main- tained over years, decades and centuries. -
39 44 Commentary
COMMENTARY Summer reading An Earth systems science agency 39 44 LETTERS I BOOKS I POLICY FORUM I EDUCATION FORUM I PERSPECTIVES Published papers are the currency of sci- LETTERS ence, and scientists need to do more to make edited by Jennifer Sills the publishing process more rapid, rational, and equitable, as well as less painful and frustrat- ing. We scientists have created the problems Painful Publishing discussed here, and it is up to us to fix them. MARTIN RAFF,1 ALEXANDER JOHNSON,2 BIOMEDICAL SCIENCE HAS NEVER BEEN MORE EXCITING OR PRODUCTIVE. RESEARCH TOOLS PETER WALTER3 have become increasingly powerful, and progress continues to accelerate. Yet, these are stressful 1Emeritus Professor, Department of Biology, University times for many biomedical scientists, because competition for grant support, jobs, and publish- College London, London WC1E 6BT, UK. 2Department of ing in the most prestigious journals is also accelerating. The stress associated with publishing Microbiology and Immunology, University of California, San Francisco, CA 94158, USA. 3Howard Hughes Medical experimental results—a process that can take as long as obtaining the results in the first place— Institute and Department of Biochemistry and Biophysics, can drain much of the joy from practicing science. University of California, San Francisco, CA 94158, USA. One problem with the current publication process arises from the overwhelming importance given to papers published in high-impact journals such as Science. Sadly, career advancement on July 29, 2008 can depend more on where you publish than what you publish. Consequently, authors are so The Enemy Within keen to publish in these select journals that THE NEWS OF THE WEEK STORY BY D.