International Journal of Molecular Sciences Article Enhanced Vasculogenic Capacity Induced by 5-Fluorouracil Chemoresistance in a Gastric Cancer Cell Line Sara Peri 1,† , Alessio Biagioni 2,† , Giampaolo Versienti 2, Elena Andreucci 2 , Fabio Staderini 1 , Giuseppe Barbato 1 , Lisa Giovannelli 3 , Francesco Coratti 1, Nicola Schiavone 2,*, Fabio Cianchi 1,* , Laura Papucci 2,‡ and Lucia Magnelli 2,‡ 1 Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy; sara.peri@unifi.it (S.P.); fabio.staderini@unifi.it (F.S.);
[email protected] (G.B.);
[email protected] (F.C.) 2 Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy; alessio.biagioni@unifi.it (A.B.); giampaolo.versienti@unifi.it (G.V.); e.andreucci@unifi.it (E.A.); laura.papucci@unifi.it (L.P.); lucia.magnelli@unifi.it (L.M.) 3 Department of Neuroscience, Psychology, Drug Research and Children’s Health, University of Florence, Viale Pieraccini, 6-50139 Firenze, Italy; lisa.giovannelli@unifi.it * Correspondence: nicola.schiavone@unifi.it (N.S.); fabio.cianchi@unifi.it (F.C.); Tel.: +39-055-275-1309 (N.S.); +39-055-412-029 (F.C.) † S.P. and A.B. contributed equally as first authors. ‡ L.P. and L.M. contributed equally as last authors. Abstract: Chemotherapy is still widely used as a coadjutant in gastric cancer when surgery is not Citation: Peri, S.; Biagioni, A.; possible or in presence of metastasis. During tumor evolution, gatekeeper mutations provide a Versienti, G.; Andreucci, E.; Staderini, selective growth advantage to a subpopulation of cancer cells that become resistant to chemotherapy.