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PHYSIOLOGY NEWS summer 2008 | number 71 Why we bob up and down when we walk Hippocratic fingers Physiology 2008 Themed Meetings off to a flying start Renal cortex: physiological basis of glomerular and tubular diseases University of Bristol, UK 17–18 December 2007 photos by David Marples PHYSIOLOGY NEWS Editorial 3 Meetings The Society’s dog. ‘Rudolf Images of Bristol inside front cover Magnus gave me to Charles Cardiac & Respiratory Physiology Themed Meeting 4 Sherrington, who gave me to Welcome to Cambridge and PDN 5 Henry Dale, who gave me to The Physiological Society in October Living History 1942’ Hippocratic fingers John Dickinson 7 Soapbox Published quarterly by The Physiological Society Patently absurd? Michael Taggart 9 Contributions and queries A lecture in the life of ... Senior Publications Executive Standing room only in Glasgow David Allen, Brian Jewell 11 Linda Rimmer Features The Physiological Society Publications Office The strange origins of the Student’s t-test Angus Brown 13 P O Box 502, Cambridge CB1 0AL, UK Sensory vestibular information and vertebrate motor Tel: +44 (0)1223 400180 behaviour Daniel Eugène, Nicolas Vibert, Pierre-Paul Vidal 17 Fax: +44 (0)1223 246858 Nucleotide release and airway epithelial physiology Silvia Email: [email protected] Web site: http://www.physoc.org Kreda, Richard Boucher, Eduardo Lazarowski 19 Women utilize lipid as fuel more than men during exercise – Magazine Editorial Board is there a paradox? Gregory Henderson, George Brooks 22 Editor Why do we bob up and down while walking? Firas Massaad, Austin Elliott Thierry Lejeune, Christine Detrembleur 25 University of Manchester, Manchester, UK Exercise for liver health Jarna Hannukainen, Pirjo Nuutila, Kari Members Kalliokoski 29 Angus Brown The relatively high Ca2+ flux in Ca2+ sparks could be due to University of Nottingham, Nottingham, UK the Ca-binding protein calsequestrin in the sarcoplasmic Patricia de Winter reticulum Paul Pape, Karine Fénelon 31 University College London, London, UK Taste receptors and glucose absorption in the small intestine Sarah Hall George Kellett 34 Cardiff University, Cardiff, UK A chemical engineering perspective of the gut Patrick Janssen, Munir Hussain Roger Lentle 37 University of Bradford, Bradford, UK Force-frequency relation and myofilament Ca2+ sensitivity John Lee Regis Lamberts, Jolanda van der Velden, Ger Stienen 39 Rotherham General Hospital, Rotherham, UK Reports Thelma Lovick Launch of Cardiff Neurosciences Centre Vanessa Davies 41 University of Birmingham, Birmingham, UK Feeding signals to the hungry mind Stuart Hughes 42 Fiona Randall Research Defence Society Fiona Randall 42 Newcastle University, Newcastle upon Tyne, UK Oxford Pro-Test Rally Liz Bell 44 Bill Winlow MRC Showcase Thelma Lovick 45 Chameleon Communications International, London/ University of Liverpool, Liverpool, UK Letters to the Editor 47 Foreign Correspondents Education 48 John Hanrahan Affiliate News 51 McGill University, Montreal, Canada The Society’s journals John Morley Experimental Physiology Julian Paton, David Paterson 52 University of Western Sydney, NSW, Australia The NIH mandate Carol Huxley 54 © 2008 The Physiological Society Society News 54 ISSN 1476-7996 Biosciences Federation 55 The Physiological Society is registered in England as Unbelievable! 56 a company limited by guarantee: No 323575. Obituaries Registered office: PO Box 11319, London WC1X 8WQ Peter Raymond Lewis Ann Silver 57 Registered Charity: No 211585. Gertrude Falk Jonathan Ashmore, Lynn Bindman, Tony Gardner - Printed by The Lavenham Press Ltd Medwin, Sally Page 57 Christopher Bell Y S Bakhle, Veronica Campbell, Saoirse O’Sullivan 58 William Keatinge Margaret Bird 60 Book reviews 61 From the archives 63 Noticeboard 64 Front cover image from Massaad et al. (p. 25). PHYSIOLOGY NEWS Action points Guidelines for contributors In this issue Grants These guidelines are intended to assist Welcome to the Summer 2008 For full information on Members ’ authors in writing their contributions and Physiology News. to reduce the editing process. The and Affiliates’ Travel Grants, Non- Editorial Board of Physiology News tries to I am not sure how many times I have Society Symposia Grants, ensure that all articles are written in a written as Editor ‘This is our biggest Vacation Studentship Scheme, journalistic style so that they will have an ever issue’. While it is not something Departmental Seminar Scheme, immediate interest value for a wide we particularly strive for, if good Centres of Excellence, Foreign readership and will be comprehensible to non-experts. In particular, scientific material is abundant, we may make Guest Scheme and Junior articles should give a good overview of a the issue bigger. Or conversely, if we Fellowships visit: field rather than focus entirely on the are a bit short of content, smaller. http://www.physoc.org/grants authors’ own research. Obviously editors prefer ‘abundant’, Format of articles and I like to think this is where we Membership applications The main message or question posed should are with Physiology News. But Applications for Physiological be introduced in the first paragraph. The complacency has to be avoided, and background for the topic should then be Society membership are accepted it bears re-stating that we rely on you established, leading up to the conclusion. to provide the content. So keep throughout the year; applications Length of articles sending us your article ideas. are reviewed by the Membership This will be determined by the subject. Committee on a monthly basis Submission of articles As ever, this issue includes plenty of and a decision is normally made Authors should submit articles as a Word science features, plus some old within 15 working days of each document attached to an email. Illustrations favourites (Living History), and some should be sent as separate attachments (see deadline. For full details please below) and not embedded in the text. newer ones – e.g. our second ever visit: Illustrations and authors’ photographs Soapbox. Hopefully, something for http://www.physoc.org/membership Authors are encouraged to submit diagrams, every taste. drawings, photographs or other artwork with their articles and a photograph of the The issue also marks some Change of address author(s) should accompany submissions. anniversaries. It is 100 years since Members should inform the Illustrations and photographs may be colour Student’s t-test appeared, allowing Administration Office of any or black and white, prints, transparencies or statistical testing on small sample changes of address, telephone, tiff/jpeg files with a minimum resolution of 300 dpi. Electronic colour figures should be numbers, something of great fax or email address. Changes can saved in CMYK mode. significance for physiologists. And it be emailed to: [email protected] References is 130 years since the formal Authors are requested to keep the number of founding of the Cambridge references to a minimum – preferably no Physiological Laboratory, site Physiology News more than two or three. Please cite all (slightly re-badged) of The Society’s references in the style of The Journal of summer meeting. There can be few Deadlines Physiology (see Instructions to Authors at http://jp.physoc.org). better places than Cambridge in July Letters and articles and all other – weather permitting! – to look contributions for inclusion in the The Physiological Society permits the single copying of individual articles for private study or simultaneously into both the future, Autumn 2008 issue, No. 72, research. For permission to copy or reproduce for and the rich history and tradition, of should reach the Publications any other purpose contact [email protected]. our discipline. Office ([email protected]) by Opinions expressed in articles and letters submitted by, or commissioned from, Members, Affiliates or Austin Elliott 11 July 2008. Short news items outside bodies are not necessarily those of The and letters are encouraged, and Physiological Society. Editor can usually be included as late copy if space permits. Suggestions for articles Suggestions for future articles are welcome. Please contact either Brain science, the Senior Publications Executive addiction and or a member of the Editorial drugs Board of Physiology News (see Students may need to be tested for contents page for details). brain- boosting drugs as they become more widely Physiology News online used by healthy people, says a report Physiology News online: from the Academy of http://www.physoc.org Medical Sciences (www.acmedsci.ac.uk) EDITORIAL PN 3 The NIH mandate and changed and there is not too much subscription cancellations. Another to worry about. concern is that if subscription The Physiological income is reduced, publishers will Society However, there may be worrying be less able to invest in the longer term implications for The technology underpinning online From 7 April this year, the Society if the exclusivity of our publishing, with consequences for following US legislation became journal content is eroded ease of access and secure mandatory: further.The patient’s lobby in the archiving. US is powerful and active and will The Director of the National continue to press for earlier free The Society works with Wiley- Institutes of Health shall require access to primary research articles. Blackwell to publish J Physiol and that all investigators funded by the For both of our journals earlier Experimental Physiology and this NIH submit or have submitted for open