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US 2020/0368491 A1 Poltorak ( 43 ) Pub US 20200368491A1 IN ( 19 ) United States ( 12 ) Patent Application Publication ( 10 ) Pub . No .: US 2020/0368491 A1 Poltorak ( 43 ) Pub . Date : Nov. 26 , 2020 ( 54 ) DEVICE , METHOD , AND APP FOR Publication Classification FACILITATING SLEEP ( 51 ) Int. CI . A61M 21/02 ( 2006.01 ) ( 71 ) Applicant: Neuroenhancement Lab , LLC , ( 52 ) U.S. CI . Suffern , NY ( US ) CPC A61M 21/02 ( 2013.01 ) ; A61M 2021/0044 ( 72 ) Inventor: Alexander Poltorak , Monsey, NY (US ) ( 2013.01 ) ( 57 ) ABSTRACT A device , system , and method for facilitating a sleep cycle ( 21 ) Appl. No .: 16 / 883,541 in a subject, comprising selecting a waveform from a plurality of waveforms derived from brainwaves of at least ( 22 ) Filed : May 26 , 2020 one sleeping donor, wherein said waveform corresponds to at least one specific stage of sleep ; and stimulating the subject with at least one stimulus, wherein said at least one Related U.S. Application Data stimulus is at least one of an auditory stimulus and a visual ( 60 ) Provisional application No. 62 / 862,656 , filed on Jun . stimulus modulated with the selected waveform to entrain 17 , 2019 , provisional application No. 62 / 852,877 , the brain of the subject with the selected waveform to filed on May 24 , 2019 . facilitate sleep in the subject. Identify a mental state of a first subject The mental state of the first subject is a sleep Yes Capture brain activity patterns reflecting the sleep state from the first subject Store the brain activity patterns of the sleep state in a non - volatile memory Retrieve the brain activity patterns of the sleep state from the non - volatile memory Induce sleep sate in the second subject by replicating the brain activity patterns of the first subject in the second subject Verify that the second subject is asleep Patent Application Publication Nov. 26 , 2020 Sheet 1 of 38 US 2020/0368491 A1 Identify a mental state Identify a mental state of a first subject of a first subject No The mental state of No The mental state of the first subject is a the first subject is a sleep awake Yes Yes Capture brain activity Capture brain activity patterns reflecting the patterns reflecting the sleep waking state of the first state from the first subject subject 15 Store the brain activity Store the brain activity patterns of the sleep state patterns of the waking state in a non - volatile memory in a non - volatile memory 35 Retrieve the brain activity Retrieve the brain activity patterns of the sleep state patterns of the waking state from the non - volatile from the non - volatile memory memory Induce sleep sate Preventing a sleep sate in the second subject by in the second subject by replicating the brain activity replicating the brain activity patterns of the first subject patterns of the first subject in the second subject in the second subject Verify that the second Verify that the second subject is asleep subject is awake Fig . 1 Fig . 2 Patent Application Publication Nov. 26 , 2020 Sheet 2 of 38 US 2020/0368491 A1 Identify a sleep stage of a first subject Record an EEG / MEG of of a sleeping healthy donor NO The sleep stage of the first subject is a Process the recorded EEG / desired sleep stage MEG to remove noise Yes Save the processed EEG / MEG of the donor Record brainwaves of the first subject in a non - volatile memory Identify at least one Retrieve the processed EEG / dominant frequency in the MEG of the donor from the recorded brainwaves non - volatile memory Modulate sad at least one dominant frequency on at " Playback " the processed least one stimulus EEG / MEG to a recipient via transcranial electrical magnetic stimulation to improve quality of sleep in Replicate the sleeping stage the recipient of the first subject in the second subject by stimulating the second subject with said at least one stimulus ] Verify that the sleep stage of the second subject is the desired sleep stage Fig . 3 Fig . 4 Patent Application Publication Nov. 26 , 2020 Sheet 3 of 38 US 2020/0368491 A1 Record a multi - channel EEG / MEG of of a plurality of healthy Record a multi - channel EEG / sleeping donors MEG of of a plurality of healthy sleeping donors Process the recorded multi channel EEG / MEG recordings to remove noise Process the recorded multi channel EEG / MEG recordings to remove noise Train a neural network on the recorded EEG /MEG recordings of the plurality of Perform PCA on the EEG / healthy donors to identify MEG recordings to identify characteristic frequencies characteristic frequencies associated with sleep stages associated with sleep stages Create a database of sleep Create a database of sleep stage and their characteristic stage and their characteristic frequencies frequencies Fig . 5 Fig . 6 Patent Application Publication Nov. 26 , 2020 Sheet 4 of 38 US 2020/0368491 A1 Record an EEG / MEG of Record a set of brain activity cycles of a first subject being in a from a first subject desirable phase of the circadian rhythm 2 ? tag the brain activity cycles with context which Process the recorded EEG / precedes or accompanies the brain activity cycles MEG to remove noise and / or compress the data 270 process the recorded set of brain activity cycles to normalize at one amplitude, frequency or time delay of Save the processed EEG / a brainwave pattern represented in the set of brain MEG of the first subject activity cycles in a non -volatile memory preserve at least one modulation pattem imposed on a synchronized brainwave pattem representing Retrieve the processed EEG / coordination between ensembles of neurons MEG of the first subject from the non - volatile memory select a record of the processed recorded set of brain activity cycles Decompress the EEG / MEG of the first subject retrieved from the non generate a stimulus for a second subject, comprising at volatile memory least the at least one modulation pattern imposed on the synchronized bramwave pattern representing coordination between ensembles of neurons " Play back " the processed EEG /MEG to a second subject via transcranial adaptively feedback cotrolling the stimulus for the electrical /magnetic second subject based on at least a brainwave state of stimulation in order to the second subject, said generating being controlled to induce the desirable phase synchronize the brainwave state of the second subject of the circadian rhythm in with respect to the synchronized brainwave pattern of the second subject the first subject reflected in the selected record Fig . 7 Fig. 8 Patent Application Publication Nov. 26 , 2020 Sheet 5 of 38 US 2020/0368491 A1 Identify a sleep stage Identify a desired mental of a first subject state Identify a mental state of a subject NO The sleep stage of the first subject is desired stage Identify a phase of a dominant brainwave characteristic of the mental state of the subject Yes Capture brain activity Apply a stimulus to the patterns reflecting the sleep subject to change the mental stage from the first subject state of the subject to the desired mental state , while synchronizing the phase of the stimulus with the phase Store the brain activity of the brainwaves of the patterns of the sleep stage subject in a non- volatile memory Verify that the second Retrieve the brain activity subject is in the desired patterns of the sleep stage asleep stage from the non - volatile memory Induce sleep stage in the second subject by replicating the brain activity Fig . 10 patterns of the first subject in the second subject Verify that the second subject is in the desired asleep stage Fig . 9 Patent Application Publication Nov. 26 , 2020 Sheet 6 of 38 US 2020/0368491 A1 Open the app on a smartphone, sleeping donor, the waveform corresponding to a specific stage Choose sound delivery through ***** Play the chosen sound Play the chosen sound *** organic wavefom on the Fig . 11 Patent Application Publication Nov. 26 , 2020 Sheet 7 of 38 US 2020/0368491 A1 app on a smartphone , tablet Open the app on a device 1310 or another mobile or wearable Choose light saitings (69 .: 1220 settings ( e.g. , color, intensity , sound , volume ) Choose an organic waveform a sleeping donor, the waveform 1230 corresponding to a specific Choose an organic stage of sleep or a completa sleep cycle brainwaves of a sleeping Choose light delivery through donor , the waveform ambient light source of corresponding to a specific wireless LEDs positioned on stage of sleep or a complete sleep cycle Tuin on sleep stimulation by projecting the light modulated 1250 waveform through ambient light Choose light and sound or LEDs positioned near the delivery through the device or wirelessly Fig . 12 Turn on sleep stimulation using synchronized light the chosen organic Fig . 13 Patent Application Publication Nov. 26 , 2020 Sheet 8 of 38 US 2020/0368491 A1 1510 Open the app on a mobile or personal 3000027 Download from the renule servas a Choose light and /or sound 1420 last waveform used based on the 1520 Settings (eg , color, intensity, sleep biometric data recoved from sound , volume ) the subject during previous Choose a waveform derived from the brainwaves of a 1540 sleeping donor, the waveform 1430 Choose light andior sound delivery corresponding to a specific through the device or wirelessly stage of sleep or a complete sleep cycle Turn on seco stimulation using synchronized light andior sound Choose light andior sound 1440 modulated with the chosen organic delivery through the device or Wirelessly Turn on sleep stimulation data from the subject and transinit using synchronized light and / or sound module. th analysis the chosen organic wavefom . Record Gand or other from ihe subject to measure the 1570 biometric data from the subject effecóveness of the stimulation*** and adjust the wavefor accordingly to to the device or cloud of improve the effec of simulation .
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