Hazard Summary Identification Reason For

Common Name: AMYL NITRITE

CAS Number: 110-46-3 RTK Substance number: 0132 DOT Number: UN 1113 Date: March 1987 Revised: September 2000 ------

HAZARD SUMMARY * Amyl Nitrite can affect you when breathed in and by * Exposure to hazardous substances should be routinely passing through your skin. evaluated. This may include collecting personal and area * Contact can irritate the skin and eyes and may cause air samples. You can obtain copies of sampling results blurred vision. from your employer. You have a legal right to this * Breathing Amyl Nitrite can irritate the nose and throat information under OSHA 1910.1020. causing coughing and wheezing. * If you think you are experiencing any work-related health * Exposure to Amyl Nitrite can cause nausea, vomiting, problems, see a doctor trained to recognize occupational weakness, confusion, restlessness and convulsions. diseases. Take this Fact Sheet with you. * High levels can interfere with the ability of the blood to carry Oxygen causing headache, fatigue, dizziness, and a WORKPLACE EXPOSURE LIMITS blue color to the skin and lips (methemoglobinemia). No occupational exposure limits have been established for Higher levels can cause trouble breathing, collapse and Amyl Nitrite. This does not mean that this substance is not even death. harmful. Safe work practices should always be followed. * Repeated exposure may damage the blood cells causing a low blood count (anemia). * It should be recognized that Amyl Nitrite can be absorbed * Amyl Nitrite is a HIGHLY FLAMMABLE and through your skin, thereby increasing your exposure. REACTIVE chemical and a DANGEROUS FIRE and EXPLOSION HAZARD. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust IDENTIFICATION ventilation at the site of chemical release. If local exhaust Amyl Nitrite is a yellowish liquid with a strong, fruity odor. ventilation or enclosure is not used, respirators should be It is used to make pharmaceuticals, perfumes and other worn. chemicals. * Wear protective work clothing. * Wash thoroughly immediately after exposure to Amyl REASON FOR CITATION Nitrite and at the end of the workshift. * Amyl Nitrite is on the Hazardous Substance List because * Post hazard and warning information in the work area. In it is cited by DOT and NFPA. addition, as part of an ongoing education and training * This chemical is on the Special Health Hazard Substance effort, communicate all information on the health and List because it is FLAMMABLE and REACTIVE. safety hazards of Amyl Nitrite to potentially exposed * Definitions are provided on page 5. workers.

HOW TO DETERMINE IF YOU ARE BEING EXPOSED The New Jersey Right to Know Act requires most employers to label chemicals in the workplace and requires public employers to provide their employees with information and training concerning chemical hazards and controls. The federal OSHA Hazard Communication Standard, 1910.1200, requires private employers to provide similar training and information to their employees.

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This Fact Sheet is a summary source of information of all Request copies of your medical testing. You have a legal potential and most severe health hazards that may result from right to this information under OSHA 1910.1020. exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to WORKPLACE CONTROLS AND PRACTICES any of the potential effects described below. ------Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most HEALTH HAZARD INFORMATION effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at Acute Health Effects the site of chemical release. Isolating operations can also The following acute (short-term) health effects may occur reduce exposure. Using respirators or protective equipment is immediately or shortly after exposure to Amyl Nitrite: less effective than the controls mentioned above, but is sometimes necessary. * Contact can irritate the skin and eyes and may cause blurred vision. In evaluating the controls present in your workplace, consider: * Breathing Amyl Nitrite can irritate the nose and throat (1) how hazardous the substance is, (2) how much of the causing coughing and wheezing. substance is released into the workplace and (3) whether * Exposure to Amyl Nitrite can cause nausea, vomiting, harmful skin or eye contact could occur. Special controls weakness, confusion, restlessness and convulsions. should be in place for highly toxic chemicals or when * High levels can interfere with the ability of the blood to significant skin, eye, or breathing exposures are possible. carry Oxygen causing headache, fatigue, dizziness, and a blue color to the skin and lips (methemoglobinemia). In addition, the following controls are recommended: Higher levels can cause trouble breathing, collapse and even death. * Where possible, automatically pump liquid Amyl Nitrite from drums or other storage containers to process Chronic Health Effects containers. The following chronic (long-term) health effects can occur at * Before entering a confined space where Amyl Nitrite may some time after exposure to Amyl Nitrite and can last for be present, check to make sure that an explosive months or years: concentration does not exist.

Cancer Hazard Good WORK PRACTICES can help to reduce hazardous * Amyl Nitrite may cause mutations (genetic changes). exposures. The following work practices are recommended: Whether or not it poses a cancer or reproductive hazard needs further study. * Workers whose clothing has been contaminated by Amyl Nitrite should change into clean clothing promptly. Reproductive Hazard * Contaminated work clothes should be laundered by * According to the information presently available to the individuals who have been informed of the hazards of New Jersey Department of Health and Senior Services, exposure to Amyl Nitrite. Amyl Nitrite has not been tested for its ability to affect * Eye wash fountains should be provided in the immediate reproduction. work area for emergency use. * If there is the possibility of skin exposure, emergency Other Long-Term Effects shower facilities should be provided. * Repeated exposure may damage the blood cells causing a * On skin contact with Amyl Nitrite, immediately wash or low blood count (anemia). shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have MEDICAL contacted Amyl Nitrite, whether or not known skin contact has occurred. Medical Testing * Do not eat, smoke, or drink where Amyl Nitrite is If symptoms develop or overexposure is suspected, the handled, processed, or stored, since the chemical can be following is recommended: swallowed. Wash hands carefully before eating, drinking, smoking, or using the toilet. * Blood methemoglobin level. * Complete blood count. PERSONAL PROTECTIVE EQUIPMENT

Any evaluation should include a careful history of past and WORKPLACE CONTROLS ARE BETTER THAN present symptoms with an exam. Medical tests that look for PERSONAL PROTECTIVE EQUIPMENT. However, for damage already done are not a substitute for controlling some jobs (such as outside work, confined space entry, jobs exposure. done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate.

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OSHA 1910.132 requires employers to determine the * Metal containers involving the transfer of Amyl Nitrite appropriate personal protective equipment for each hazard and should be grounded and bonded. to train employees on how and when to use protective * Use only non-sparking tools and equipment, especially equipment. when opening and closing containers of Amyl Nitrite. * Wherever Amyl Nitrite is used, handled, manufactured, or The following recommendations are only guidelines and may stored, use explosion-proof electrical equipment and not apply to every situation. fittings.

Clothing QUESTIONS AND ANSWERS * Avoid skin contact with Amyl Nitrite. Wear protective gloves and clothing. Safety equipment suppliers/ Q: If I have acute health effects, will I later get chronic manufacturers can provide recommendations on the most health effects? protective glove/clothing material for your operation. A: Not always. Most chronic (long-term) effects result * All protective clothing (suits, gloves, footwear, headgear) from repeated exposures to a chemical. should be clean, available each day, and put on before work. Q: Can I get long-term effects without ever having short- * Safety equipment manufacturers recommend Polyvinyl term effects? Alcohol as a protective material. A: Yes, because long-term effects can occur from repeated exposures to a chemical at levels not high enough to Eye Protection make you immediately sick. * Wear indirect-vent, impact and splash resistant goggles when working with liquids. Q: What are my chances of getting sick when I have been * Wear a face shield along with goggles when working with exposed to chemicals? corrosive, highly irritating or toxic substances. A: The likelihood of becoming sick from chemicals is increased as the amount of exposure increases. This is Respiratory Protection determined by the length of time and the amount of IMPROPER USE OF RESPIRATORS IS DANGEROUS. material to which someone is exposed. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, Q: When are higher exposures more likely? requirements for worker training, respirator fit testing and A: Conditions which increase risk of exposure include medical exams, as described in OSHA 1910.134. physical and mechanical processes (heating, pouring, spraying, spills and evaporation from large surface areas * Where the potential for overexposure exists, use a such as open containers), and "confined space" MSHA/NIOSH approved supplied-air respirator with a full exposures (working inside vats, reactors, boilers, small facepiece operated in a pressure-demand or other positive- rooms, etc.). pressure mode. For increased protection use in combination with an auxiliary self-contained breathing Q: Is the risk of getting sick higher for workers than for apparatus operated in a pressure-demand or other positive- community residents? pressure mode. A: Yes. Exposures in the community, except possibly in cases of fires or spills, are usually much lower than those HANDLING AND STORAGE found in the workplace. However, people in the community may be exposed to contaminated water as * Prior to working with Amyl Nitrite you should be trained well as to chemicals in the air over long periods. This on its proper handling and storage. may be a problem for children or people who are already * Amyl Nitrite is not compatible with OXIDIZING ill. AGENTS (such as PERCHLORATES, PEROXIDES, PERMANGANATES, CHLORATES, NITRATES, Q: Don't all chemicals cause cancer? CHLORINE, BROMINE and FLUORINE); STRONG A: No. Most chemicals tested by scientists are not cancer- ACIDS (such as HYDROCHLORIC, SULFURIC and causing. NITRIC); STRONG BASES (such as SODIUM HYDROXIDE and POTASSIUM HYDROXIDE); Q: What are the likely health problems from chemicals ALCOHOLS; ANTIPYRINE; ALKALINE which cause mutations? CARBONATES; POTASSIUM IODIDE; BROMIDE; and A: There are two primary health concerns associated with FERROUS SALTS. mutagens: (1) cancers can result from changes induced * Store in tightly closed containers in a cool, well-ventilated in cells and, (2) adverse reproductive and developmental area away from HEAT, AIR and LIGHT. outcomes can result from damage to the egg and sperm * Sources of ignition, such as smoking and open flames, are cells.

prohibited where Amyl Nitrite is used, handled, or stored in a manner that could create a potential fire or explosion hazard. AMYL NITRITE page 4 of 6

Q: What are the likely health problems from chemicals ------which cause mutations? The following information is available from: A: There are two primary health concerns associated with mutagens: (1) cancers can result from changes induced New Jersey Department of Health and Senior Services in cells and, (2) adverse reproductive and developmental Occupational Health Service outcomes can result from damage to the egg and sperm PO Box 360 cells. Trenton, NJ 08625-0360 (609) 984-1863 (609) 292-5677 (fax)

Web address: http://www.state.nj.us/health/eoh/odisweb/

Industrial Hygiene Information Industrial hygienists are available to answer your questions regarding the control of chemical exposures using exhaust ventilation, special work practices, good housekeeping, good hygiene practices, and personal protective equipment including respirators. In addition, they can help to interpret the results of industrial hygiene survey data.

Medical Evaluation If you think you are becoming sick because of exposure to chemicals at your workplace, you may call personnel at the Department of Health and Senior Services, Occupational Health Service, who can help you find the information you need.

Public Presentations Presentations and educational programs on occupational health or the Right to Know Act can be organized for labor unions, trade associations and other groups.

Right to Know Information Resources The Right to Know Infoline (609) 984-2202 can answer questions about the identity and potential health effects of chemicals, list of educational materials in occupational health, references used to prepare the Fact Sheets, preparation of the Right to Know survey, education and training programs, labeling requirements, and general information regarding the Right to Know Act. Violations of the law should be reported to (609) 984-2202. ------

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DEFINITIONS

ACGIH is the American Conference of Governmental A mutagen is a substance that causes mutations. A mutation Industrial Hygienists. It recommends upper limits (called is a change in the genetic material in a body cell. Mutations TLVs) for exposure to workplace chemicals. can lead to birth defects, miscarriages, or cancer.

A carcinogen is a substance that causes cancer. NAERG is the North American Emergency Response Guidebook. It was jointly developed by Transport Canada, The CAS number is assigned by the Chemical Abstracts the United States Department of Transportation and the Service to identify a specific chemical. Secretariat of Communications and Transportation of Mexico. It is a guide for first responders to quickly identify the specific A combustible substance is a solid, liquid or gas that will or generic hazards of material involved in a transportation burn. incident, and to protect themselves and the general public during the initial response phase of the incident. A corrosive substance is a gas, liquid or solid that causes irreversible damage to human tissue or containers. NCI is the National Cancer Institute, a federal agency that determines the cancer-causing potential of chemicals. DEP is the New Jersey Department of Environmental Protection. NFPA is the National Fire Protection Association. It classifies substances according to their fire and explosion DOT is the Department of Transportation, the federal agency hazard. that regulates the transportation of chemicals. NIOSH is the National Institute for Occupational Safety and EPA is the Environmental Protection Agency, the federal Health. It tests equipment, evaluates and approves respirators, agency responsible for regulating environmental hazards. conducts studies of workplace hazards, and proposes standards to OSHA. A fetus is an unborn human or animal. NTP is the National Toxicology Program which tests A flammable substance is a solid, liquid, vapor or gas that chemicals and reviews evidence for cancer. will ignite easily and burn rapidly. OSHA is the Occupational Safety and Health Administration, The flash point is the temperature at which a liquid or solid which adopts and enforces health and safety standards. gives off vapor that can form a flammable mixture with air. PEOSHA is the Public Employees Occupational Safety and HHAG is the Human Health Assessment Group of the federal Health Act, a state law which sets PELs for New Jersey public EPA. employees.

IARC is the International Agency for Research on Cancer, a ppm means parts of a substance per million parts of air. It is a scientific group that classifies chemicals according to their measure of concentration by volume in air. cancer-causing potential. A reactive substance is a solid, liquid or gas that releases A miscible substance is a liquid or gas that will evenly energy under certain conditions. dissolve in another. A teratogen is a substance that causes birth defects by mg/m3 means milligrams of a chemical in a cubic meter of damaging the fetus. air. It is a measure of concentration (weight/volume). TLV is the Threshold Limit Value, the workplace exposure MSHA is the Mine Safety and Health Administration, the limit recommended by ACGIH. federal agency that regulates mining. It also evaluates and approves respirators. The vapor pressure is a measure of how readily a liquid or a solid mixes with air at its surface. A higher vapor pressure indicates a higher concentration of the substance in air and therefore increases the likelihood of breathing it in.

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Common Name: AMYL NITRITE ======DOT Number: UN 1113 FOR LARGE SPILLS AND FIRES immediately call your fire NAERG Code: 129 department. You can request emergency information from the CAS Number: 110-46-3 following:

CHEMTREC: (800) 424-9300 Hazard rating NJDHSS NFPA NJDEP HOTLINE: 1-877-WARN-DEP FLAMMABILITY 4 Not Rated ======

REACTIVITY - 2 FLAMMABLE AND REACTIVE FIRST AID

POISONOUS GASES ARE PRODUCED IN FIRE In NJ, for POISON INFORMATION call 1-800-764-7661 CONTAINERS MAY EXPLODE IN FIRE

Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; Eye Contact 3=serious; 4=severe * Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. FIRE HAZARDS Skin Contact * Amyl Nitrite is a FLAMMABLE LIQUID. * Quickly remove contaminated clothing. Immediately wash * Use dry chemical, CO2, alcohol or polymer foam contaminated skin with large amounts of soap and water. extinguishers, as water may not be effective in fighting fires. * POISONOUS GASES ARE PRODUCED IN FIRE, Breathing including Nitrogen Oxides. * Remove the person from exposure. * CONTAINERS MAY EXPLODE IN FIRE. * Begin rescue breathing (using universal precautions) if * Use water spray to keep fire-exposed containers cool. breathing has stopped and CPR if heart action has stopped. * Amyl Nitrite may ignite combustibles (wood, paper, and * Transfer promptly to a medical facility. oil). * Vapors may travel to a source of ignition and flash back. PHYSICAL DATA * Amyl Nitrite forms explosive mixtures on contact with AIR and LIGHT. o o * If employees are expected to fight fires, they must be trained Flash Point: 50 F (10 C) and equipped as stated in OSHA 1910.156. Water Solubility: Insoluble

SPILLS AND EMERGENCIES OTHER COMMONLY USED NAMES

If Amyl Nitrite is spilled or leaked, take the following steps: Chemical Name: Nitrous Acid, 3-Methyl Butyl Ester * Evacuate persons not wearing protective equipment from Other Names: area of spill or leak until clean-up is complete. Isopentyl Alcohol Nitrite; Aspiral; Nitramyl * Remove all ignition sources. * Cover with an activated charcoal adsorbent and place in ------covered containers for disposal. Not intended to be copied and sold for commercial * Ventilate and wash area after clean-up is complete. purposes. * Keep Amyl Nitrite out of a confined space, such as a sewer, ------because of the possibility of an explosion, unless the sewer NEW JERSEY DEPARTMENT OF HEALTH AND is designed to prevent the build-up of explosive SENIOR SERVICES concentrations. Right to Know Program * It may be necessary to contain and dispose of Amyl Nitrite PO Box 368, Trenton, NJ 08625-0368 as a HAZARDOUS WASTE. Contact your state (609) 984-2202 Department of Environmental Protection (DEP) or your ------regional office of the federal Environmental Protection

Agency (EPA) for specific recommendations. * If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.