Chronic Fatigue
ME London 2020 Dietrich Klinghardt MD, PhD www.KlinghardtInstitute.com A Future Without ME/CFS London, 15th February 2020 Myalgic encephalomyelitis: international consensus criteria (abbreviated) Carruthers, Bruce M., et al. "Myalgic encephalomyelitis: international consensus criteria." Journal of internal medicine 270.4 (2011): 327-338. A. Post-exertional neuroimmune exhaustion B. Neurological impairments • Neurocognitive impairments: difficulty processing information, slowed thought, impaired concentration, confusion, disorientation, cognitive overload, difficulty with making decisions, slowed speech, acquired or exertional dyslexia • Pain • Sleep disturbance • Neurosensory, perceptual and motor disturbances C. Immune, gastro‐intestinal and genito-urinary Impairments D. Energy production/transportation impairments (at least one symptom) • Cardiovascular:e.g. inability to tolerate an upright position, postural orthostatic tachycardia syndrome, palpitations with or without cardiac arrhythmias • Respiratory:e.g. air hunger • Loss of thermostatic stability: subnormal body temperature, marked diurnal fluctuations; sweating episodes, recurrent feelings of feverishness with or without low grade fever, cold extremities A Future Without ME/CFS London, 15th February 2020 The field is wide open: there is no known single cause of ME nor an agreed-upon lab test Open Medicine Foundation® 2016 ME/CFS and related chronic complex diseases Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a life-altering and complex multi-system disease that can present as an array of different symptoms that may change over time and differ from patient to patient. The most common symptoms of ME/CFS are post-exertional malaise, unrefreshing sleep, profound fatigue, cognitive impairment, orthostatic intolerance, and pain. The cause of ME/CFS is currently unknown, but a combination of genetic and environmental factors appear to be relevant.
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