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Motor Neuron Circuit

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Motor Neuron Circuit This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Development/Plasticity/Repair Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit Anders Enjin1, Sharn Perry1, Markus M Hilscher, Chetan Nagaraja, Martin Larhammar, Henrik Gezelius, Anders Eriksson, Katarina E Leão and Klas Kullander Department of Neuroscience, Uppsala University, Box 593, 751 24, Uppsala, Sweden DOI: 10.1523/JNEUROSCI.0949-16.2017 Received: 22 March 2016 Revised: 6 April 2017 Accepted: 25 April 2017 Published: 8 May 2017 Author contributions: KK and AE conceived the study. HG generated the Chrna2Cre mouse line. AE performed and analyzed molecular, extracellular electrophysiology and behavior experiments. CN performed and analyzed stretch reflex experiments. SP, MH and KEL performed and analyzed patch-clamp electrophysiology recordings. AEr and ML performed and analyzed molecular experiments and treadscan data. SP, AE and KK wrote the manuscript. This work was financed by grants from the Swedish Medical Research Council, Hållsten, Ländells, the Swedish Brain Foundation, the Swedish Foundation for Cooperation in Research and Higher Education, and CNPq- Brasil. AE present address: Department of Biology, Lund University, Naturvetarvägen 2, 223 62 Lund, Sweden. ML present address: Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA, KEL present address: Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil. The authors declare no competing financial interests. 1These authors contributed equally to this work Correspondence: Klas Kullander, Uppsala University, Box 593, 751 24, Uppsala Sweden, Fax: +46184714172, Email: [email protected] Cite as: J. Neurosci ; 10.1523/JNEUROSCI.0949-16.2017 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. 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