This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.
Research Articles: Development/Plasticity/Repair
Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit
Anders Enjin1, Sharn Perry1, Markus M Hilscher, Chetan Nagaraja, Martin Larhammar, Henrik Gezelius, Anders Eriksson, Katarina E Leão and Klas Kullander Department of Neuroscience, Uppsala University, Box 593, 751 24, Uppsala, Sweden
DOI: 10.1523/JNEUROSCI.0949-16.2017
Received: 22 March 2016
Revised: 6 April 2017
Accepted: 25 April 2017
Published: 8 May 2017
Author contributions: KK and AE conceived the study. HG generated the Chrna2Cre mouse line. AE performed and analyzed molecular, extracellular electrophysiology and behavior experiments. CN performed and analyzed stretch reflex experiments. SP, MH and KEL performed and analyzed patch-clamp electrophysiology recordings. AEr and ML performed and analyzed molecular experiments and treadscan data. SP, AE and KK wrote the manuscript.
This work was financed by grants from the Swedish Medical Research Council, Hållsten, Ländells, the Swedish Brain Foundation, the Swedish Foundation for Cooperation in Research and Higher Education, and CNPq- Brasil. AE present address: Department of Biology, Lund University, Naturvetarvägen 2, 223 62 Lund, Sweden. ML present address: Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA, KEL present address: Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil. The authors declare no competing financial interests.
1These authors contributed equally to this work
Correspondence: Klas Kullander, Uppsala University, Box 593, 751 24, Uppsala Sweden, Fax: +46184714172, Email: [email protected]
Cite as: J. Neurosci ; 10.1523/JNEUROSCI.0949-16.2017
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Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process.
Copyright © 2017 the authors
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