Sistema De Eliminación Extracorpórea De Co2 Minimamente Invasiva

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Sistema De Eliminación Extracorpórea De Co2 Minimamente Invasiva SISTEMA DE ELIMINACIÓN EXTRACORPÓREA DE CO2 MINIMAMENTE INVASIVA WWW.CARDIOLINKGROUP.COM SISTEMA DE ELIMINACIÓN EXTRACORPÓREA DE CO 2 MINIMAMENTE INVASIVA INDICACIONES: La respiración celular produce CO 2 continuamente. En casos de insuficiencia respiratoria alveolar, se puede desencadenar un aumento de dióxido de carbono (hipercapnia) y como consecuencia, una disminución significante en el pH (acidosis respiratoria). La corrección de ambas podría conseguirse mediante técnicas convencionales, pero no siempre es suficiente: En pacientes con acidosis respiratoria refractaria al soporte de VNI, la eliminación extracorpórea de CO 2 permite la extensión con dicho EXACERBACIÓN EPOC soporte, evitando la intubación, sedación y ventilación mecánica, con un menor riesgo de infecciones nosocomiales.5 En paciente con SDRA e hipercapnia severa refractaria con ventilación 1,2 mecánica protectora, la eliminación extracorpórea de CO2 permite SDRA limitar el volumen y la presión de la ventilación mecánica, evitando daños pulmonares como barotrauma y volutrauma 3 En pacientes que desarrollan disfunción primaria de injerto 6 postquirúrgico, asociado con hipercapnia severa, la eliminación TRASPLANTE PULMONAR extracorpórea de CO2 permite limitar la alta presión y volumen de la ventilación, y por tanto, evitar daños al órgano trasplantado. En presencia de lesiones tisulares del sistema respiratorio (fístula LESIÓN TISULAR broncopleural, ruptura de tráquea o daño diafragmático), la posibilidad de reducir el volumen y la presión en la ventilación, acelera la cicatrización 8,9 En pacientes con daño cerebral y fallo respiratorio, la eliminación de 7 CO 2 extracorpórea ayuda a controlar la presión intracraneal, además DAÑO CEREBRAL de los límites de presión y volúmenes de ventilación y el daño TRAUMÁTICO potencial inducido por la ventilación mecánica en el pulmón. SISTEMA DE ELIMINACIÓN EXTRACORPÓREA DE CO 2 MINIMAMENTE INVASIVA MÉTODO: El CO2 producido constantemente por la respiración celular (250 ml/min) se equilibra a través de la ventilación alveolar, gracias a un flujo de 4 L/min de aire aproximado. INSUFICIENCIA RESPIRATORIA O2 HIPOXEMIA - FALLO RESPIRATORIO POR OXIGENACIÓN INSUFICIENTE CO2 HIPERCAPNIA - FALLO EN VENTILACIÓN EXACERBACIÓN EPOC VNI SISTEMA DE ELIMINACIÓN EXTRACORPÓREA DE CO2 MINIMAMENTE INVASIVA SÍNDROME DISTRÉS RESPIRATORIO AGUDO ECCO2 -R D A D I S N E T N I 300 200 100 0 400 2000 4000 Flujo sanguíneo ml/min SISTEMA DE ELIMINACIÓN EXTRACORPÓREA DE CO MINIMAMENTE INVASIVA 2 COMPOSICIÓN Y CARACTERÍSTICAS BOMBA PERISTÁLTICA BAJO FLUJO : 450 ml/min FLUJO DE AIRE FLUJO DE EXTRACCIÓN CO2 GRÁFICO EVOLUCIÓN DE FLUJO EXTRACCIÓN CO2 SUMINISTRO AIRE MEDICINAL MEDICIÓN EXACTA DE CO 2 EXTRAÍDO Membrana semipermeable de Polimetilpenteno Recubrimiento de Fosforilcolina SUPERFICIE 1,8 m2 Volumen de cebado: 125 ml CAPACIDAD DE EXTRACCIÓN CO2 >100 ml/min CE para LF-ECCO -R durante 5 días 2 ELEVADA capacidad de extracción extracorpórea de CO (>100 ml/min) 2 MÍNIMA invasividad (flujo < 500ml/min) FÁCIL manejo Volumen de cebado REDUCIDO AUSENCIA de pérdida de calor BARRIDO automático de gas SISTEMA DE ELIMINACIÓN EXTRACORPÓREA DE CO MINIMAMENTE INVASIVA 2 LF-ECCO 2 -R V S . ECMO NO INVASIVO INVASIVO BOMBA PERISTÁLTICA BOMBA CENTRÍFUGA CATÉTER DOBLE LUZ < 14 Fr CATÉTER DOBLE LUZ > 15 Fr UN SOLO CATÉTER DOBLE CATÉTER CONEXIONES LUER-LOCK CONEXIONES ECMO < 450 ml/min > 2L/min SISTEMA DE ELIMINACIÓN EXTRACORPÓREA DE CO2 MINIMAMENTE INVASIVA PRODUCTOS Y REFERENCIAS BIBLIOGRAFÍA 1. The acute respiratory distress syndrome network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Eng J Med 2000; 342 (18): 103-1308. 2. Hager DN, Krishnan JA, Hayden DL et al. Tidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High. Am J Respir Crit Care Med 2005; 172: 1241-1245. 3. Determann RM, Royakkers A, Wolthuis EK et al. Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care 2010; 14: R1-R14. 4. Confalonieri M, Garuti G, Cattaruzza MS et al. A chart of failure risk for noninvasive ventilation in patients with COPD exacerbation. Eur Respir J 2005; 25: 348-355. 5. Conti G, Antonelli M, Navalesi P et al. Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial. Int Care Med 2002; 28(12): 1701-7. 6. Prekker ME, Nath DS, Walker AR. Validation of the proposed International Society for Heart and Lung Transplantation grading system for primary graft dysfunction after lung transplantation. J Heart Lung Transplant 2006; 25(4): 371-8. 7. Brian JE. Carbon Dioxide and the Cerebral Circulation. Anesthesiology 1998; 88(5): 1365-86. 8. Kolobov T, Gattinoni L, Tomlinson TA et al. Control of breathing using an extracorporeal membrane lung. Anesthesiology 1977; 46: 138-141. 9. Baumann MH, Sahn SA. Medical management and therapy of bronchopleural fistulas in the mechanically ventilated patient. Chest 1990; 97: 721-8. 10. Schinco MA, Formosa VA, Santora TA. Ventilatory management of a bronchopleural fistula following thoracic surgery. Respir Care 1998; 43: 1064-9. 11. Gattinoni L, Carlesso E, Langer T. Towards ultraprotective mechanical ventilation. Curr Opin Anaesthesiol 2012; 25(2): 141-7. BIBLIOGRAFÍA PROLUNG® “SISTEMA DE EXTRACCIÓN DE CO2 EXTRACORPÓREO MÍNIMAMENTE INVASIVO PARA SOPORTE VENTILATORIO” [1-17] 1. Romay, E. and R. Ferrer, Extracorporeal CO2 removal: Technical and physiological fundaments and principal indications. Med Intensiva, 2015. EXACERBACIÓN EPOC 2. Duscio, E., et al., Extracorporeal CO2 Removal: The Minimally Invasive Approach, Theory, and Practice. Crit Care Med, 2018. 3. Arcaro, G. and A. Vianello, The Successful Management of a Patient With Exacerbation of Non-Cystic Fibrosis Bronchiectasis and Bilateral Fibrothorax Using a Venovenous Extracorporeal Carbon Dioxide Removal System. Respir Care, 2014. 4. Morelli, A., et al., Extracorporeal CO2 removal in hypercapnic patients who fail noninvasive ventilation and refuse endotracheal intubation: a case series, in ESICM LIVES 2015. 2015, Intensive Care Medicine Experimental: Berlin. p. A824. 5. Pastore, A., et al., LFVVECCO2-R in COPD exacerbations: experience in two patients, in SIAARTI. 2013a: Rome. 6. Pisani, L., N. Corcione, and S. Nava, Management of acute hypercapnic respiratory failure. Curr Opin Crit Care, 2016. 7. Sucre, M.J., et al., Perché trattare il paziente BPCO in rianimazione con la decapneizzazione extracorporea, in SIAARTI. 2013a: Rome. BIBLIOGRAFÍA PROLUNG® “SISTEMA DE EXTRACCIÓN DE CO2 EXTRACORPÓREO MÍNIMAMENTE INVASIVO PARA SOPORTE VENTILATORIO” [1-17] SDRA Y LESIONES PULMONARES ASOCIADAS A VENTILACIÓN MECÁNICA 8. Hilty, M.P., et al., Low flow veno-venous extracorporeal CO2 removal for acute hypercapnic respiratory failure. Minerva Anestesiol, 2017. 9. Pastore, A., et al., LFVVECCO2-R to provide "lung rest" in lesions of respiratory system: experience in one patient, in SIAARTI. 2013b: Rome. 10. Pisani, L., et al., Effects of Extracorporeal CO2 Removal on Inspiratory Effort and Respiratory Pattern in Patients Who Fail Weaning from Mechanical Ventilation. Am J Respir Crit Care Med, 2015. 192(11): p. 1392-4. 11. Sucre, M.J., et al., A type A (H1N1) influenza with ARDS treated with low-flow venovenous extracorporeal CO2 removal system, in SIAART. 2013b: Roma. 12. Visconti, F., et al., Usefulness of a VV extracorporeal CO2 removal device (ProLung) in severe pneumonia complicated by refractory bronchospasm, in 31th International Vicenza Course on Critical Care Nephrology. 2013: Vicenza. TRASPLANTE PULMONAR 13. Ruberto, F., et al., Low-flow veno-venous extracorporeal CO2 removal: first clinical experience in lung transplant recipients. Int J Artif Organs, 2014. 37(12): p. 911-7. 14. Soluri-Martins, A., et al., How to minimise ventilator-induced lung injury in transplanted lungs: The role of protective ventilation and other strategies. Eur J AnAase spthreessioel,n 2t0e15d. by Stephen Chan 15. Vianello, A., et al., Extracorporeal CO2 removal for refractory hypercapnia in the event of acute respiratory failure. Minerva Pneumol., 2015. 54: p. 103-110. 16.F oVriaenwelolor, dA .,b eyt al., Successful management of acute respiratory failure in an idiopathic pulmonary fibrosis patient using an extracorporeal carbon dioxide removal sysAtenmd. rSearwco iPdohsais,n vasculitis and diffuse lung diseases, 2016. 33: p. 186-190. 17. Bergantino, B., et al., Extracorporeal carbon dioxide removal: a new low flow veno- veRnoeusse daervciche ibny lung transplantation, in ESICM. 2012: Lisbon. Andrea Chang +Model MEDIN-810; No. of Pages 6 ARTICLE IN PRESS Med Intensiva. 2015;xxx(xx):xxx---xxx www.elsevier.es/medintensiva REVISIÓN Eliminación extracorpórea de CO2: fundamentos fisiológicos y técnicos y principales indicaciones a a,b,∗ E. Romay y R. Ferrer a Servicio de Medicina Intensiva, Hospital Universitario Mútua de Terrassa, Universidad de Barcelona, Terrassa, Barcelona, Espana˜ b Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Espana˜ Recibido el 29 de mayo de 2015; aceptado el 2 de junio de 2015 PALABRAS CLAVE Resumen Recientemente las mejoras tecnológicas han permitido reducir la complejidad de Respiración artificial; los dispositivos de oxigenación por membrana extracorpórea, dando paso al desarrollo de dis- Dióxido de carbono;
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