University of Vermont ScholarWorks @ UVM Graduate College Dissertations and Theses Dissertations and Theses 2008 Neuroplasticity of Micturition Reflex aP thways with Cyclophosphamide-Induced Cystitis Mary Beth Klinger University of Vermont Follow this and additional works at: https://scholarworks.uvm.edu/graddis Recommended Citation Klinger, Mary Beth, "Neuroplasticity of Micturition Reflex aP thways with Cyclophosphamide-Induced Cystitis" (2008). Graduate College Dissertations and Theses. 123. https://scholarworks.uvm.edu/graddis/123 This Dissertation is brought to you for free and open access by the Dissertations and Theses at ScholarWorks @ UVM. It has been accepted for inclusion in Graduate College Dissertations and Theses by an authorized administrator of ScholarWorks @ UVM. For more information, please contact
[email protected]. NEUROPLASTICITY OF MICTURITION REFLEX PATHWAYS WITH CYCLOPHOSPHAMIDE-INDUCED CYSTITIS A Dissertation Presented by Mary Beth Klinger to The Faculty of the Graduate College of The University of Vermont In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Specializing in Anatomy and Neurobiology October, 2008 Accepted by the Faculty of the Graduate College, The University of Vermont, in partial fulfillment of the requirements for the degree of Doctor of Philosophy, specializing in Anatomy and Neurobiology. Dissertation Examination Committee: Advisor ~a>~detA. vizard &.D. awe, Ph.D. r ;; 2'':l'"X ChailpersOn Mark T. Nelson, Ph.D. Vice President for Research and Dean of Graduate Studies Date: July 14,2008 Abstract Micturition requires the precise reciprocal function of the urinary bladder and urethral outlet. Perhaps due to this degree of precision, micturition is prone to dysfunction with injury or disease. One such disease, interstitial cystitis (IC)/painful bladder syndrome (PBS), is characterized by urinary urgency, frequency and pelvic pain.