A Short, Stereocontrolled Synthesis of Strychnine'
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Stilbene Synthesis by Mizoroki–Heck Coupling Reaction Under Microwave Irradiation
An effective Pd nanocatalyst in aqueous media: stilbene synthesis by Mizoroki–Heck coupling reaction under microwave irradiation Carolina S. García, Paula M. Uberman and Sandra E. Martín* Full Research Paper Open Access Address: Beilstein J. Org. Chem. 2017, 13, 1717–1727. INFIQC-CONICET- Universidad Nacional de Córdoba, Departamento doi:10.3762/bjoc.13.166 de Química Orgánica, Facultad de Ciencias Químicas, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA, Córdoba, Received: 25 April 2017 Argentina Accepted: 04 August 2017 Published: 18 August 2017 Email: Sandra E. Martín* - [email protected] Associate Editor: L. Vaccaro * Corresponding author © 2017 García et al.; licensee Beilstein-Institut. License and terms: see end of document. Keywords: aqueous reaction medium; MAOS; Mizoroki–Heck reaction; Pd nanoparticle; sustainable organic synthesis Abstract Aqueous Mizoroki–Heck coupling reactions under microwave irradiation (MW) were carried out with a colloidal Pd nanocatalyst stabilized with poly(N-vinylpyrrolidone) (PVP). Many stilbenes and novel heterostilbenes were achieved in good to excellent yields starting from aryl bromides and different olefins. The reaction was carried out in a short reaction time and with low catalyst loading, leading to high turnover frequency (TOFs of the order of 100 h−1). The advantages like operational simplicity, high robust- ness, efficiency and turnover frequency, the utilization of aqueous media and simple product work-up make this protocol a great option for stilbene syntheses by Mizoroki–Heck reaction. Introduction Palladium-catalyzed reactions have emerged as an important basic types of Pd-catalyzed reactions, particularly the vinyl- tool for organic synthesis. Among them, cross-coupling and ation of aryl/vinyl halides or triflates [7-10], explored not only coupling reactions have been broadly applied for C–C and in the inter- and intramolecular version [2,11-13], but also in C–heteroatom bond formation [1-6]. -
IV (Advance Organic Synthesis and Supramolecular Chemistry and Carbocyclic Rings) Module No and 9: Protection and Deprotection Title Module Tag CHE P14 M9
Subject Chemistry Paper No and Title 14: Organic Chemistry –IV (Advance Organic Synthesis and Supramolecular Chemistry and carbocyclic rings) Module No and 9: Protection and deprotection Title Module Tag CHE_P14_M9 CHEMISTRY Paper No. 14: Organic Chemistry –IV (Advance Organic Synthesis and Supramolecular Chemistry and carbocyclic rings) Module No. 9: Protection and deprotection Table of Content 1. Learning outcomes 2. Introduction 3. Protecting groups for carbonyl compounds 4. Protecting groups for alcohols 5. Protecting groups for amines 6. Summary CHEMISTRY Paper No. 14: Organic Chemistry –IV (Advance Organic Synthesis and Supramolecular Chemistry and carbocyclic rings) Module No. 9: Protection and deprotection 1. Learning Outcomes After studying this module, you shall be able to Know about protecting groups. Study the characteristics of protecting groups. Understand the functional group protection. Know the protection of important functional groups. 2. Introduction Protection and deprotection is an important part of organic synthesis. During the course of synthesis, we many times desire to perform reaction at only one of the two functional groups in any single organic molecules. For example, in an organic compound possessing two functional groups like ester and ketone, we have to perform reaction at only ester group, them the keto group needs to be protected. If we want to reduce the ester group, then keto group will also get reduced. To avoid this type of complications, protection and deprotection of functional groups are necessary. 3. Protecting groups for carbonyl compounds The protecting groups allow the masking of a particular functional group where a specified reaction is not to be performed. The protection is required as it interferes with another reaction. -
Mechanisms of the Mizoroki-Heck Reaction
P1: OTA c01 JWBK261-Oestreich December 16, 2008 10:9 Printer: Yet to come 1 Mechanisms of the Mizoroki–Heck Reaction Anny Jutand Departement´ de Chimie, Ecole Normale Superieure,´ CNRS, 24 Rue Lhomond, Paris Cedex 5, France 1.1 Introduction The palladium-catalysed Mizoroki–Heck reaction is the most efficient route for the vinyla- tion of aryl/vinyl halides or triflates. This reaction, in which a C C bond is formed, proceeds in the presence of a base (Scheme 1.1) [1, 2]. Nonconjugated alkenes are formed in re- actions involving cyclic alkenes (Scheme 1.2) [1e, 2a,c,e,g] or in intramolecular reactions (Scheme 1.3) [2b,d–g] with creation of stereogenic centres. Asymmetric Mizoroki–Heck reactions may be performed in the presence of a chiral ligand [2]. The Mizoroki–Heck reaction has been intensively developed from a synthetic and mechanistic point of view, as expressed by the impressive number of reviews and book chapters [1, 2]. In the late 1960s, Heck reported that arylated alkenes were formed in the reaction of alkenes with a stoichiometric amount of [Ar–Pd Cl] or [Ar–Pd–OAc], generated in situ by reacting ArHgCl with PdCl2 or ArHgOAc with Pd(OAc)2 respectively [3]. A mechanism was proposed which involves a syn migratory insertion of the alkene into the Ar–Pd bond, followedbyasyn β-hydride elimination of a hydridopalladium [HPdX] (X = Cl, OAc) (Scheme 1.4a). In the case of cyclic alkenes, in which no syn β-hydride is available, a syn β-hydride elimination occurs, leading to a nonconjugated alkene (Scheme 1.4b). -
Regiocontrol in the Heck-Reaction and Fast Fluorous Chemistry
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 244 _____________________________ _____________________________ Regiocontrol in the Heck-Reaction and Fast Fluorous Chemistry BY KRISTOFER OLOFSSON ACTA UNIVERSITATIS UPSALIENSIS UPPSALA 2001 Dissertation for the Degree of Doctor of Philosophy (Faculty of Pharmacy) in Organic Pharmaceutical Chemistry presented at Uppsala University in 2001. Abstract Olofsson, K. 2001. Regiocontrol in the Heck-Reaction and Fast Fluorous Chemistry. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 244. 74 pp. Uppsala. ISBN 91–554–4883–6 The palladium-catalysed Heck-reaction has been utilised in organic synthesis, where the introduction of aryl groups at the internal, β-carbon of different allylic substrates has been performed with high regioselectivity. The β-stabilising effect of silicon enhances the regiocontrol in the internal arylation of allyltrimethylsilane, while a coordination between palladium and nitrogen induces very high regioselectivities in the arylation of N,N-dialkylallylamines and the Boc-protected allylamine, producing β-arylated arylethylamines, which are of interest for applications in medicinal chemistry. Phthalimido-protected allylamines are arylated with poor to moderate regioselectivity. Single-mode microwave heating can reduce the reaction times of Heck-, Stille- and radical mediated reactions drastically from approximately 20 hours to a few minutes with, in the majority of cases, retained, high -
Chapter 3. the Concept of Protecting Functional Groups
Chapter 3. The Concept of Protecting Functional Groups When a chemical reaction is to be carried out selectively at one reactive site in a multifunctional compound, other reactive sites must be temporarily blocked. A protecting group must fulfill a number of requirements: • The protecting group reagent must react selectively (kinetic chemoselectivity) in good yield to give a protected substrate that is stable to the projected reactions. • The protecting group must be selectively removed in good yield by readily available reagents. • The protecting group should not have additional functionality that might provide additional sites of reaction. 3.1 Protecting of NH groups Primary and secondary amines are prone to oxidation, and N-H bonds undergo metallation on exposure to organolithium and Grignard reagents. Moreover, the amino group possesses a lone pair electrons, which can be protonated or reacted with electrophiles. To render the lone pair electrons less reactive, the amine can be converted into an amide via acylation. N-Benzylamine Useful for exposure to organometallic reagents or metal hydrides Hydrogenolysis Benzylamines are not cleaved by Lewis acid Pearlman’s catalyst Amides Basicity of nitrogen is reduced, making them less susceptible to attack by electrophilic reagent The group is stable to pH 1-14, nucleophiles, organometallics (except organolithium reagents), catalytic hydrogenation, and oxidation. Cleaved by strong acid (6N HCl, HBr) or diisobutylaluminum hydride Carbamates Behave like a amides, hence no longer act as nucleophile Stable to oxidizing agents and aqueous bases but may react with reducing agents. Iodotrimethylsilane is often the reagent for removal of this protecting group Stable to both aqueous acid and base Benzoyloxycarbonyl group for peptide synthesis t-butoxycarbonyl group(Boc) is inert to hydrogenolysis and resistant to bases and nucleophilic reagent. -
Heck Reaction Chem 115
Myers The Heck Reaction Chem 115 Reviews: Felpin, F.-X.; Nassar-Hardy, L.; Le Callonnec, F.; Fouquet, E.Tetrahedron 2011, 67, 2815–2831. • Pd(II) is reduced to the catalytically active Pd(0) in situ, typically through the oxidation of a Belestskaya, I. P.; Cheprakov, A. V. Chem. Rev. 2000, 100, 3009–3066. phosphine ligand. • Intramolecular: Link, J. T.; Overman, L. E. In Metal-catalyzed Cross-coupling Reactions, Diederich, F., and Pd(OAc)2 + H2O + nPR3 + 2R'3N Pd(PR3)n-1 + O=PR3 + 2R'3N•HOAc Eds.; Wiley-VCH: New York, 1998, pp. 231–269. Gibson, S. E.; Middleton, R. J. Contemp. Org. Synth. 1996, 3, 447–471. Ozawa, F.; Kubo, A.; Hayashi, T. Chemistry Lett. 1992, 2177–2180. • Asymmetric: McCartney, D.; Guiry, P. J. Chem. Soc. Rev. 2011, 40, 5122–5150. • Ag+ / Tl+ salts irreversibly abstract a halide ion from the Pd complex formed by oxidative • Solid phase: addition. Reductive elimination from the cationic complex is probably irreversible. Franzén, R. Can. J. Chem. 2000, 78, 957–962. • Dehydrogenative: • An example of a proposed mechanism involving cationic Pd: Le Bras, J.; Muzart, J. Chem. Rev. 2011, 111, 1170–1214. General transformation: Pd catalyst Ph–Br Ph CH3O2C CH3O2C Pd(II) or Pd(0) catalyst Ag+ R' R–X + R' + HX base R R = alkenyl, aryl, allyl, alkynyl, benzyl X = halide, triflate R' = alkyl, alkenyl, aryl, CO R, OR, SiR 2 3 Pd(II) AgHCO 2 L; 2 e – • Proposed mechanism involving neutral Pd: 3 – reductive elimination AgCO3 Ph–Br oxidative addition Pd(0)L2 Mechanism: Pd catalyst + Ph–Br Ph H–Pd(II)L2 Ph–Pd(II)L2–Br CH3O2C CH3O2C Ph Ag + CH3O2C Pd(II) KHCO + KBr 2 L; 2 e – AgBr 3 syn elimination + halide abstraction Pd(II)L2 reductive elimination oxidative addition H + K2CO3 Ph–Br H Ph–Pd(II)L2 Pd(0)L2 CH3O2C Ph H + Pd(II)L2 H–Pd(II)L2–Br Ph–Pd(II)L2–Br H Ph CH3O2C syn elimination CH3O2C H internal rotation syn addition CH3O2C H Ph CH3O2C Pd(II)L2Br syn addition H Pd(II)L2Br H H CH O C Ph 3 2 Ph CH3O2C H H H Abelman, M. -
Photoremovable Protecting Groups
1348_C69.fm Page 1 Monday, October 13, 2003 3:22 PM 69 Photoremovable Protecting Groups 69.1 Introduction ..................................................................... 69-1 69.2 Historical Review.............................................................. 69-2 o-Nitrobenzyl • Benzoin • Phenacyl • Coumaryl and Arylmethyl 69.3 Carboxylic Acids............................................................. 69-17 o-Nitrobenzyl • Coumaryl • Phenacyl • Benzoin • Other Richard S. Givens 69.4 Phosphates and Phosphites ........................................... 69-23 o-Nitrobenzyl • Coumaryl • Phenacyl • Benzoin University of Kansas 69.5 Sulfates and Other Acids................................................ 69-26 Peter G. Conrad, II 69.6 Alcohols, Thiols, and N-Oxides .................................... 69-27 University of Kansas o-Nitrobenzyl • Thiopixyl and Coumaryl • Benzoin • Other Abraham L. Yousef 69.7 Phenols and Other Weak Acids..................................... 69-36 o-Nitrobenzyl • Benzoin University of Kansas 69.8 Amines ............................................................................ 69-37 Jong-Ill Lee o-Nitrobenzyl • Benzoin Derivatives • Arylsulfonamides University of Kansas 69.9 Conclusion...................................................................... 69-40 69.1 Introduction Photoremovable protecting groups are enjoying a resurgence of interest since their introduction by Kaplan1a and Engels1b in the late 1970s. A review of published work since 19932 is timely and will provide information about -
1 Stilbenes Preparation and Analysis
j1 1 Stilbenes Preparation and Analysis 1.1 General The name for stilbene (1,2-diphenylethylene) was derived from the Greek word stilbos, which means shining. There are two isomeric forms of 1,2-diphenylethylene: (E)-stilbene (trans-stilbene), which is not sterically hindered, and (Z)-stilbene (cis-stilbene), which is sterically hindered and therefore less stable. trans-stilbene cis-stilbene (E)-Stilbene has a melting point of about 125 C, while the melting point of (Z)-stilbene is 6 C. Stilbene is a relatively unreactive colorless compound practically insoluble in water [1]. trans-Stilbene isomerizes to cis-stilbene under the influence of light. The reverse path can be induced by heat or light. The stilbene feature is associated with intense absorption and fluorescence properties, which correspond to the excitation of p-electrons of the conjugated ethenediyl group into pà orbitals, as well as some other dynamic processes. The excited singlet state behavior of fl trans-stilbene is governed by uorescence from the S1 state that effectively competes with isomerization. This phenomenon of photochromism, namely, trans–cis photo- isomerization of stilbene derivatives, can be readily monitored by a single steady-state fluorescence technique. A necessary stage in the olefinic photoisomerization process, in the singlet or triplet excited state, involves twisting (about the former double bond) of stilbene fragments relative to one another. The chemistry and photochemistry of stilbenes have been extensively investigated for decades and have been reviewed [2–25]. Stilbene derivatives are synthesized relatively easily, are usually thermally and chemically stable, and possess absorption and fluorescence properties that are Stilbenes. -
Intramolecular Carbonickelation of Alkenes
Intramolecular carbonickelation of alkenes Rudy Lhermet, Muriel Durandetti* and Jacques Maddaluno* Full Research Paper Open Access Address: Beilstein J. Org. Chem. 2013, 9, 710–716. Laboratoire COBRA, CNRS UMR 6014 & FR 3038, Université de doi:10.3762/bjoc.9.81 Rouen, INSA de Rouen, 1 rue Tesnières, 76821 Mont St Aignan Cedex, France Received: 14 January 2013 Accepted: 14 March 2013 Email: Published: 12 April 2013 Muriel Durandetti* - [email protected]; Jacques Maddaluno* - [email protected] This article is part of the Thematic Series "Carbometallation chemistry". * Corresponding author Guest Editor: I. Marek Keywords: © 2013 Lhermet et al; licensee Beilstein-Institut. alkenes; carbometallation; carbonickelation; cyclization; Heck-type License and terms: see end of document. reaction; nickel catalysis Abstract The efficiency of the intramolecular carbonickelation of substituted allylic ethers and amines has been studied to evaluate the influ- ence of the groups borne by the double bond on this cyclization. The results show that when this reaction takes place, it affords only the 5-exo-trig cyclization products, viz. dihydrobenzofurans or indoles. Depending on the tethered heteroatom (O or N), the outcome of the cyclization differs. While allylic ethers are relatively poor substrates that undergo a side elimination and need an intracyclic double bond to proceed, allylic amines react well and afford indoline and indole derivatives. Finally, the synthesis of the trinuclear ACE core of a morphine-like skeleton was achieved by using NiBr2bipy catalysis. Introduction Carbometalation is a reaction involving the addition of an thesis of pharmaceutical and agrochemical intermediates using organometallic species to a nonactivated alkene or alkyne nonactivated olefins with high regio- and stereoselectivity [7]. -
A Protecting Group Must Fulfill a Number of Requirements
Chapter 3. The Concept of Protecting Functional Groups When a chemical reaction is to be carried out selectively at one reactive site in a multifunctional compound, other reactive sites must be temporarily blocked. A protecting group must fulfill a number of requirements: • The protecting group reagent must react selectively (kinetic chemoselectivity) in good yield to give a protected substrate that is stable to the projected reactions. • The protecting group must be selectively removed in good yield by readily available reagents. • The protecting group should not have additional functionality that might provide additional sites of reaction. 1 3.1 Protecting of NH groups Primary and secondary amines are prone to oxidation, and N-H bonds undergo metallation on exposure to organolithium and Grignard reagents. Moreover, the amino group possesses a lone pair electrons, which can be protonated or reacted with electrophiles. To render the lone pair electrons less reactive, the amine can be converted into an amide via acylation. N-Benzylamine Useful for exposure to organometallic reagents or metal hydrides Hydrogenolysis Benzylamines are not cleaved by Lewis acid Pearlman’s catalyst 2 Amides Basicity of nitrogen is reduced, making them less susceptible to attack by electrophilic reagent The group is stable to pH 1-14, nucleophiles, organometallics (except organolithium reagents), catalytic hydrogenation, and oxidation. Cleaved by strong acid (6N HCl, HBr) or diisobutylaluminum hydride Carbamates Behave like a amides, hence no longer act as nucleophile Stable to oxidizing agents and aqueous bases but may react with reducing agents. Iodotrimethylsilane is often the reagent for removal of this protecting group Stable to both aqueous acid and base Benzoyloxycarbonyl group for peptide synthesis 3 t-butoxycarbonyl group(Boc) is inert to hydrogenolysis and resistant to bases and nucleophilic reagent. -
Formal Synthesis of (+/-) Morphine Via an Oxy-Cope/Claisen/Ene Reaction Cascade
Formal Synthesis of (+/-) Morphine via an Oxy-Cope/Claisen/Ene Reaction Cascade by Joel Marcotte Submitted to the Faculty of Graduate and Postdoctoral Studies In partial fulfillment of the requirements for the degree of Master of Science The University of Ottawa August, 2012 © Joel Marcotte, Ottawa, Canada, 2012 ABSTRACT For years now, opium alkaloids and morphinans have been attractive synthetic targets for numerous organic chemists due to their important biological activity and interesting molecular architecture. Morphine is one of the most potent analgesic drugs used to alleviate severe pain. Our research group maintains a longstanding interest in tandem pericyclic reactions such as the oxy-Cope/Claisen/ene reaction cascade and their application to the total synthesis of complex natural products. Herein we report the ventures towards the formal synthesis of (+/-)-morphine based on the novel tandem oxy- Cope/Claisen/ene reaction developed in our laboratory. These three highly stereoselective pericyclic reactions occurring in a domino fashion generate the morphinan core structure 2 via precursor 1 after only 7 steps. The formal synthesis culminated in the production of 3 after a total of 18 linear steps, with an overall yield of 1.0%, successfully intersecting two previous syntheses of the alkaloids, namely the ones of Taber (2002) and Magnus (2009). ii À ma famille, sans qui rien de cela n’aurait été possible iii ACKNOWLEDGEMENTS I would like to start by thanking my supervisor Dr. Louis Barriault, who has been my mentor in chemistry for the past three years. I am grateful for his guidance, patience and encouragements, especially when facing the many challenges that awaited me on this project. -
Chapter 1 the Basic Chemistry of Organopalladium Compounds
Chapter 1 The Basic Chemistry of Organopalladium Compounds 1.1 Characteristic Features of Pd-Promoted or -Catalyzed Reactions There are several features which make reactions involving Pd catalysts and reagents particularly useful and versatile among many transition metals used for organic synthesis. Most importantly, Pd catalysts offer an abundance of possibilities of carbon–carbon bond formation. Importance of the carbon–carbon bond forma- tion in organic synthesis needs no explanation. No other transition metals can offer such versatile methods of the carbon–carbon bond formations as Pd. Tol- erance of Pd catalysts and reagents to many functional groups such as carbonyl and hydroxy groups is the second important feature. Pd-catalyzed reactions can be carried out without protection of these functional groups. Although reactions involving Pd should be carried out carefully, Pd reagents and catalysts are not very sensitive to oxygen and moisture, and even to acid in many reactions catalyzed by Pd–phosphine complexes. It is enough to apply precautions to avoid oxidation of coordinated phosphines, and this can be done easily. On the other hand, the Ni(0) complex is extremely sensitive to oxygen. Of course, Pd is a noble metal and expensive. Its price frequently fluctuates drastically. A few years ago, Pd was more expensive than Pt and Au but cheaper than Rh. As of October 2003, the comparative prices of the noble metals were: Pd (1), Au (1.8), Rh (2.8), Pt (3.3), Ru (0.2). Recently the price of Pd has dropped dramatically, and Pt is currently the most expensive noble metal. Also, the toxicity of Pd has posed no serious problem so far.