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(12) United States Patent (10) Patent No.: US 8,771,966 B2

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(12) United States Patent (10) Patent No.: US 8,771,966 B2 US00877 1966B2 (12) UnitedO States Patent (10) Patent No.: US 8,771,966 B2 Dennis et al. (45) Date of Patent: Jul. 8, 2014 (54) IMMUNO-PET IMAGING OF ANTIBODIES RE30,985 E 6/1982 Cartaya AND IMMUNOCONUGATES AND USES 3. E. A 3. 3: RCai Ca.al THEREFOR 4,364,866 A 12/1982 Asai et al. 4,371.533. A 2, 1983 Akimoto et al. (71) Applicant: Genentech, Inc., South San Francisco, 4.419,446 A 12/1983 Howley et al. CA (US) 4.424,219 A 1/1984 Hashimoto et al. 4.450,254 A 5/1984 Isley et al. (72) Inventors: Mark Dennis, San Carlos, CA (US); Jan 3.288 A 12.8 s Marik, Hillsborough, CA (US); Paul 4657.866 A 4, 1987 RW, Polakis, Mill Valley, CA (US); Bonnee 4,676.980 A 6, 1987 Segal et al. Rubinfeld, Danville, CA (US); Simon 4,767,704 A 8/1988 Cleveland et al. 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