(12) United States Patent (10) Patent No.: US 8,771,966 B2

(12) United States Patent (10) Patent No.: US 8,771,966 B2

US00877 1966B2 (12) UnitedO States Patent (10) Patent No.: US 8,771,966 B2 Dennis et al. (45) Date of Patent: Jul. 8, 2014 (54) IMMUNO-PET IMAGING OF ANTIBODIES RE30,985 E 6/1982 Cartaya AND IMMUNOCONUGATES AND USES 3. E. A 3. 3: RCai Ca.al THEREFOR 4,364,866 A 12/1982 Asai et al. 4,371.533. A 2, 1983 Akimoto et al. (71) Applicant: Genentech, Inc., South San Francisco, 4.419,446 A 12/1983 Howley et al. CA (US) 4.424,219 A 1/1984 Hashimoto et al. 4.450,254 A 5/1984 Isley et al. (72) Inventors: Mark Dennis, San Carlos, CA (US); Jan 3.288 A 12.8 s Marik, Hillsborough, CA (US); Paul 4657.866 A 4, 1987 RW, Polakis, Mill Valley, CA (US); Bonnee 4,676.980 A 6, 1987 Segal et al. Rubinfeld, Danville, CA (US); Simon 4,767,704 A 8/1988 Cleveland et al. Williams, Redwood City, CA (US) 4,816,567 A 3/1989 Cabilly et al. 4,927,762 A 5, 1990 Darfler (73) Assignee: Genentech, Inc., South San Francisco, 4,965,1994,933,294 A 10/19906, 1990 CaponWaterfield et al. et al. CA (US) 4,970,198 A 1 1/1990 Lee et al. 4,975,278 A 12/1990 Senter et al. (*) Notice: Subject to any disclaimer, the term of this 5,053,394 A 10/1991 Ellestad et al. patent is extended or adjusted under 35 Sis A 3. 3: Fi trometal U.S.C. 154(b) by 0 days. 5,122,469 A 6/1992 MatherISO et al. 5,208,020 A 5/1993 Chari et al. (21) Appl. No.: 13/692,888 5,264.365 A 1 1/1993 Georgiou et al. 5,316,757 A 5/1994 Sherry et al. (22) Filed: Dec. 3, 2012 5,342,606 A 8/1994 Sherry et al. 5,362,852 A 11/1994 Geoghegan (65) Prior Publication Data 5,385,893 A 1, 1995 Kiefer 5,401,638 A 3, 1995 Carney et al. US 2013/O157289 A1 Jun. 20, 2013 5,416,064 A 5/1995 Chari et al. 5,428,139 A 6/1995 Kiefer et al. 5,428, 155 A 6/1995 Sherry et al. Related U.S. Application Data 5,462,725 A 10, 1995 Kiefer et al. (63) Continuation of application No. (Continued) PCT/US2011/038923, filed on Jun. 2, 2011. FOREIGN PATENT DOCUMENTS (60) Provisional application No. 61/351,195, filed on Jun. 3, 2010 EP OOO3O89 B1 8, 1981 s EP O404 097 6, 1990 (51) Int. Cl. (Continued) GOIN33/53 (2006.01) (52) U.S. Cl. OTHER PUBLICATIONS USPC ............................................. 435/7.1; 435/7.2 (58) Field of Classification Search Aerts et al., “Disparity between in vivo EGFR expression and Zr None labeled cetuximab uptake assessed with PET'J Nucl Med. 50: 123 See application file for complete search history. 131 (2009). Albert et al., “Direct synthesis of DOTA-DPhe-octreotide and (56) References Cited (DOTA-DPhe'.Tyr-octreotide (SMT487): Two conjugates for sys temic delivery of radiotherapeutical nuclides to Somatostatin recep U.S. PATENT DOCUMENTS tor positive tumors in man” Bioorg Med Chem Lett 8:1207-1210 ( 1998). 3,720,760 A 3, 1973 Bennich et al. 3,773.919 A 11, 1973 Boswell et al. (Continued) 3,896,111 A 7/1975 Kupchan et al. 4,137,230 A 1/1979 Hashimoto et al. 4.248,8704,151,042 A 4/19792/1981 HigashideMiyashita etet al. Primary Examinerin a Jacob Cheu 4,256,746 A 3/1981 Miyashita et al. (74) Attorney, Agent, or Firm — Jessica L. Richardson 4,260,608 A 4, 1981 Miyashita et al. 4,265,814 A 5, 1981 Hashimoto et al. 4,275,149 A 6, 1981 Litman et al. (57) ABSTRACT 4.294,757 A 10, 1981 Asai 388 3. A 33. Siski, etal Anti-STEAP-1 antibodies and immunoconjugates thereofare 43.08.269 A 12/1981 Miyashita et al. provided. Methods of using anti-STEAP-1 antibodies and 4,309.428 A 1/1982 Miyashita et al. immunoconjugates thereof are provided. Methods of detect 1.33- K - A 3.18: EMSea ea.1 ing or determining the presence of STEAP-1 proteins are 4,317,821 A 3/1982 Miyashita et al. provided. 4,318,980 A 3/1982 Boguslaski et al. 4.322,348 A 3, 1982 Asai et al. 4.331,598 A 5/1982 Hasegawa et al. 9 Claims, 51 Drawing Sheets US 8,771,966 B2 Page 2 (56) References Cited FOREIGN PATENT DOCUMENTS U.S. PATENT DOCUMENTS EP O 425 235 B1 9, 1996 EP 1391213 A1 2, 2004 5,480,990 A 1/1996 Kiefer et al. WO 87/OO.195 A1 1, 1987 5,500,362 A 3, 1996 Robinson et al. WO 90,03430 A1 4f1990 5,508,192 A 4, 1996 Georgiou et al. WO 91/00360 A1 1, 1991 5,545,806 A 8/1996 Lonberg et al. WO 91705264 A1 4f1991 5,545,807 A 8, 1996 Surani et al. WO 91 10741 A1 7, 1991 5,569,825 A 10/1996 Lonberg et al. WO 92fOO373 A1 1, 1992 5,571,894 A 11/1996 Wells et al. WO 92.09690 A2 6, 1992 5,585,089 A 12/1996 Queen et al. WO 93,01161 A1 1, 1993 5,587,458 A 12/1996 King et al. WO 93,06213 A1 4f1993 5,606,040 A 2f1997 McGahren et al. WO 93,08829 A1 5, 1993 5,624,821 A 4/1997 Winter et al. WO 93.16.185 A2 8, 1993 5,625,126 A 4/1997 Lonberg et al. WO 93.21232 A1 10, 1993 5,633,425 A 5/1997 Lonberg et al. WO 94/11026 A2 5, 1994 5,635,483. A 6, 1997 Pettit et al. WO 94.29351 A2 12, 1994 5,641,870 A 6, 1997 Rinderknecht et al. WO 94.29351 A3 12?1994 5,648,237 A 7, 1997 Carter WO 96.O7754 A1 3, 1996 5,648,260 A 7, 1997 Winter et al. WO 96.O7754 R3 3, 1996 5,661,016 A 8/1997 Lonberg et al. WO 96.33735 A1 10, 1996 5,663,149 A 9, 1997 Pettit et al. WO 96.34096 A1 10, 1996 5,693,762 A 12/1997 Queen et al. WO 98.24893 A2 6, 1998 5,712.374. A 1/1998 Kuntsmann et al. WO 98.58964 12/1998 5,714,586 A 2, 1998 Kunstmann et al. WO 99.22764 A1 5, 1999 5,731, 168 A 3, 1998 Carter et al. WO 99,51642 A1 10, 1999 5,739,116 A 4, 1998 Hamann et al. WO OO/42O72 T 2000 5,739,277 A 4, 1998 Presta et al. WO 006 1739 A1 10, 2000 5,739,294 A 4, 1998 Kiefer et al. WO 01.00245 A2 1, 2001 5,750,660 A 5, 1998 Kiefer et al. WO 01.00245 A3 1, 2001 5,767,237 A 6, 1998 Sakakibara et al. WO O1/29246 A1 4/2001 5,767.285 A 6, 1998 Hamann et al. WO Of 45746 A2 6, 2001 5,770,701 A 6, 1998 McGahren et al. WO Of 45746 A3 6, 2001 5,770,710 A 6, 1998 McGahren et al. WO 02/088172 A2 11/2002 5,773,001 A 6, 1998 Hamann et al. WO 02/088172 A3 11, 2002 5,780,588 A 7, 1998 Pettit et al. WO O2/O88172 R1 11 2002 5,807,715 A 9, 1998 Morrison et al. WO O3,O11878 A2 2, 2003 5,821,337 A 10, 1998 Carter et al. WO O3,O11878 A3 2, 2003 5,834,456 A 11/1998 Kiefer et al. WO 03/043583 A2 5, 2003 5,834,597 A 11/1998 Tso et al. WO 03/043583 A3 5, 2003 5,840,523 A 11/1998 Simmons et al. WO 03/084570 A1 10, 2003 5,869,046 A 2f1999 Presta et al. WO O3,0851.19 A1 10, 2003 5,877,296 A 3, 1999 Hamann et al. WO 2004/OO 1993 A1 12/2003 6,027,888 A 2/2000 Georgiou et al. WO 2004/O10957 A2 2, 2004 6,083,715 A 7/2000 Georgiou et al. WO 2004/O10957 A3 2, 2004 6,124,431 A 9, 2000 Sakakibara et al. WO 2004/032828 A2 4/2004 6,165,745 A 12/2000 Ward et al. WO 2004/032828 A3 4/2004 6,194.551 B1 2/2001 Idusogie et al. WO 2004/043493 A1 5, 2004 6,329,503 B1 12/2001 Afar et al. WO 2004/056312 A2 T 2004 6,372,907 B1 4/2002 Lee et al. WO 2005/035586 A1 4/2005 6,441,163 B1 8, 2002 Chari et al. WO 2005/035778 A1 4/2005 6,528,624 B1 3/2003 Idusogie et al. WO 2005037992 A2 4/2005 6,602,677 B1 8, 2003 Wood et al. WO 2005/053742 A1 6, 2005 6,602,684 B1 8/2003 Umana et al. WO 2005/081711 A2 9, 2005 6,737,056 B1 5, 2004 Presta WO 2006/034488 A2 3, 2006 6,821,505 B2 11/2004 Ward WO 2006/034488 A3 3, 2006 6,824,780 B1 1 1/2004 Devaux et al. WO 2007/01 1968 A2 1, 2007 7,521,541 B2 4/2009 Eigenbrot et al. WO 2007/01 1968 A3 1, 2007 2002/0164328 A1 11/2002 Shinkawa et al.

View Full Text

Details

  • File Type
    pdf
  • Upload Time
    -
  • Content Languages
    English
  • Upload User
    Anonymous/Not logged-in
  • File Pages
    164 Page
  • File Size
    -

Download

Channel Download Status
Express Download Enable

Copyright

We respect the copyrights and intellectual property rights of all users. All uploaded documents are either original works of the uploader or authorized works of the rightful owners.

  • Not to be reproduced or distributed without explicit permission.
  • Not used for commercial purposes outside of approved use cases.
  • Not used to infringe on the rights of the original creators.
  • If you believe any content infringes your copyright, please contact us immediately.

Support

For help with questions, suggestions, or problems, please contact us