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BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available BMJ Open: first published as 10.1136/bmjopen-2020-041173 on 3 May 2021. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 27, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-041173 on 3 May 2021. Downloaded from Health outcomes in international migrant children: Protocol for a systematic review Journal: BMJ Open ManuscriptFor ID peerbmjopen-2020-041173 review only Article Type: Protocol Date Submitted by the 01-Jun-2020 Author: Complete List of Authors: Armitage, Alice; UCL, Institute of Child Health Heys, Michelle; University College London Institute of Child Health, University College London Institute of Child Health Lut, Irina; UCL, Institute of child health Hardelid, Pia; UCL Institute of Child Health, Centre for Paediatric Epidemiology and Biostatistics PAEDIATRICS, Health policy < HEALTH SERVICES ADMINISTRATION & Keywords: MANAGEMENT, PUBLIC HEALTH http://bmjopen.bmj.com/ on September 27, 2021 by guest. Protected copyright. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 19 BMJ Open 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2020-041173 on 3 May 2021. Downloaded from 5 6 7 8 9 I, the Submitting Author has the right to grant and does grant on behalf of all authors of the Work (as defined 10 in the below author licence), an exclusive licence and/or a non-exclusive licence for contributions from authors 11 who are: i) UK Crown employees; ii) where BMJ has agreed a CC-BY licence shall apply, and/or iii) in accordance 12 with the terms applicable for US Federal Government officers or employees acting as part of their official 13 duties; on a worldwide, perpetual, irrevocable, royalty-free basis to BMJ Publishing Group Ltd (“BMJ”) its 14 licensees and where the relevant Journal is co-owned by BMJ to the co-owners of the Journal, to publish the 15 Work in this journal and any other BMJ products and to exploit all rights, as set out in our licence. 16 17 The Submitting Author accepts and understands that any supply made under these terms is made by BMJ to 18 the Submitting Author Forunless you peer are acting as review an employee on behalf only of your employer or a postgraduate 19 student of an affiliated institution which is paying any applicable article publishing charge (“APC”) for Open 20 Access articles. Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 http://bmjopen.bmj.com/ 37 38 39 40 41 42 43 44 on September 27, 2021 by guest. Protected copyright. 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 19 1 | P a g e 1 2 3 DR ALICE ARMITAGE (Orcid ID: 0000-0001-6972-3651) 4 BMJ Open: first published as 10.1136/bmjopen-2020-041173 on 3 May 2021. Downloaded from 5 6 7 Article type: Protocol for systematic review 8 9 10 11 12 13 Health outcomes in international migrant children: 14 Protocol for a systematic review 15 16 17 18 For peer review only 19 20 21 22 Authors: Alice Armitage1, Michelle Heys1, Irina Lut1, Pia Hardelid1 23 24 25 26 Email addresses: [email protected], [email protected], [email protected], 27 [email protected] 28 29 30 1 31 Guarantor: Pia Hardelid 32 33 34 1. Population, Policy & Practice Dept, UCL GOS Institute of Child Health, Faculty of Pop 35 Health Sciences, UCL 36 http://bmjopen.bmj.com/ 37 38 39 Correspondence to: 40 41 Dr Alice Armitage 42 UCL Great Ormond Street Institute of Child Health 43 30 Guilford St, Holborn, London WC1N 1EH 44 Tel: 020 7242 9789 on September 27, 2021 by guest. Protected copyright. 45 [email protected] 46 47 rythemaassociated multiforme with COVID-19 and Kawasaki infection disease in children 48 Keywords: Transients and migrants, Global health, Pediatrics, Population Health, Systematic 49 Review 50 51 52 53 Tables: 1 54 Figures: 0 55 56 Appendices: 1 57 58 59 Word count: 2680 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 19 BMJ Open 2 | P a g e 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2020-041173 on 3 May 2021. Downloaded from 5 6 Abstract 7 Introduction 8 Migration status is a key determinant of health, but health outcomes among migrant children 9 and young people (CYP), i.e. those aged under 18 years, are poorly understood. A ‘healthy- 10 11 migrant’ effect has been demonstrated among adults, but evidence for the presence of the 12 same effect in CYP is lacking. No large studies or reviews exist reporting comprehensive or 13 holistic outcomes among migrant CYP. We aim identify and synthesise original quantitative 14 research on health of migrant CYP to explore the relations between migration status and 15 16 health outcomes. 17 18 Methods and analysisFor peer review only 19 A search of Pubmed/Medline, Embase and Cochrane and grey literatures sites will be 20 undertaken for any original quantitative research on health outcomes of migrant CYP 21 22 published from 01/01/2000 onwards. Outcomes will be categorised as: mortality, 23 communicable diseases, non-communicable diseases, nutritional status, mental health, 24 disability, vaccine coverage, and accidental and non-accidental injuries (including assault and 25 abuse). Search results will be screened against inclusion criteria and presented in a PRISMA 26 27 flow diagram. 28 29 The Newcastle-Ottawa Scale (NOS) assessment tool will be used to assess study quality. If 30 feasible, depending on study availability data heterogeneity (explored using I2 statistic), 31 32 results will be pooled for meta-analysis. If sufficient data are available, a priori defined sub- 33 group analyses will be undertaken. A narrative quantitative synthesis will be presented, 34 taking account of study quality and assessed risk of bias. 35 36 http://bmjopen.bmj.com/ 37 Ethics and dissemination 38 Formal ethical approval will not be sought as we will be accessing data already in the public 39 domain. This review will be submitted for publication in a high impact journal and presented 40 at international conferences. The results of this work will be shared with the groups of 41 migrant children as part of an ongoing engagement project. 42 43 This protocol has been submitted to the International Prospective Register for Systematic 44 on September 27, 2021 by guest. Protected copyright. 45 Reviews (PROSPERO), registration number is awaited. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 19 3 | P a g e 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2020-041173 on 3 May 2021. Downloaded from 5 6 Strengths and limitations of this study 7 8 This protocol is written in line with PRISMA-P reporting guidelines for systematic review 9 protocols1. 10 11 This systematic review will address a clear research gap on health outcomes of migrant 12 children and young people (CYP). 13 14 Well-established systematic review methodology will allow evidence-based 15 16 recommendations for policy around migrant children based on available data and identify key 17 gaps in the research evidence. 18 For peer review only 19 Review conclusions are likely to be limited by the quality and quantity of available studies. 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 http://bmjopen.bmj.com/ 37 38 39 40 41 42 43 44 on September 27, 2021 by guest. Protected copyright. 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 5 of 19 BMJ Open 4 | P a g e 1 2 3 Introduction 4 BMJ Open: first published as 10.1136/bmjopen-2020-041173 on 3 May 2021.
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