animals Article Bacillus Subtilis 29784 as a Feed Additive for Broilers Shifts the Intestinal Microbial Composition and Supports the Production of Hypoxanthine and Nicotinic Acid Pearl Choi 1, Lamya Rhayat 2, Eric Pinloche 2 , Estelle Devillard 2, Ellen De Paepe 3, Lynn Vanhaecke 3 , Freddy Haesebrouck 4 , Richard Ducatelle 1, Filip Van Immerseel 1,* and Evy Goossens 1,* 1 Livestock Gut Health Team, Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;
[email protected] (P.C.);
[email protected] (R.D.) 2 Adisseo France SAS, Center of Expertise and Research in Nutrition (CERN), 6 Route Noire, 03600 Commentry, France;
[email protected] (L.R.);
[email protected] (E.P.);
[email protected] (E.D.) 3 Laboratory of Chemical Analysis, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;
[email protected] (E.D.P.);
[email protected] (L.V.) 4 Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;
[email protected] * Correspondence:
[email protected] (F.V.I.);
[email protected] (E.G.) Simple Summary: Bacterial strains that are consumed by humans or by animals to promote health are called probiotics. In poultry, Bacillus strains are widely used as feed additives for this purpose. Citation: Choi, P.; Rhayat, L.; Although different modes of action have been proposed, studies showing effects on what metabolites Pinloche, E.; Devillard, E.; De Paepe, E.; Vanhaecke, L.; Haesebrouck, F.; the bacteria produce in a test tube, and whether these can also be found in the intestine of animals Ducatelle, R.; Van Immerseel, F.; that were given these strains as feed additives, are lacking.